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Otago Medical School staff profiles

Dr Lynley Lewis

PositionSenior Research Fellow
DepartmentDepartment of Medicine (UOC)
QualificationsBSc(Hons)(Cant) MapplSc(Linc) PhD(Otago)
Research summaryCardioendocrinology

Research

Current Roles:
  • Method development and validation of analytical methods in the CCERG Biochemistry Laboratory
  • Maintenance of quality standards and documentation to ISO15189 specifications

Research Interests:

  • Actions and interactions of vasoactive peptides in vascular cells
  • Development of immunoassays for measurement of vasoactive peptides
  • Metabolism of vasoactive peptides in vivo and in vitro

Publications

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Justice, T. D., Hammer, G. L., Davey, R. J., Paramalingam, N., Guelfi, K. J., Lewis, L., … Fournier, P. A. (2015). Effect of antecedent moderate-intensity exercise on the glycemia-increasing effect of a 30-sec maximal sprint: A sex comparison. Physiological Reports, 3(5), 12386. doi: 10.14814/phy2.12386

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). Endogenous ouabain is not ouabain. Hypertension, 64, 680-683. doi: 10.1161/hypertensionaha.114.03919

Mahagamasekera, P. G., Ruygrok, P. N., Palmer, S. C., Richards, A. M., Ansell, G. S., Nicholls, M. G., Pemberton, C. J., Lewis, L. K., & Yandle, T. G. (2014). B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: Evidence for degradation before secretion. Clinical Chemistry, 60(3), 549-558. doi: 10.1373/clinchem.2013.210435

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). [Response to letter re Endogenous ouabain is not ouabain]. Hypertension, 64. Retrieved from http://hyper.ahajournals.org/content/64/4/680/reply#hypertensionaha_el_351

Chapter in Book - Research

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

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Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Justice, T. D., Hammer, G. L., Davey, R. J., Paramalingam, N., Guelfi, K. J., Lewis, L., … Fournier, P. A. (2015). Effect of antecedent moderate-intensity exercise on the glycemia-increasing effect of a 30-sec maximal sprint: A sex comparison. Physiological Reports, 3(5), 12386. doi: 10.14814/phy2.12386

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). Endogenous ouabain is not ouabain. Hypertension, 64, 680-683. doi: 10.1161/hypertensionaha.114.03919

Mahagamasekera, P. G., Ruygrok, P. N., Palmer, S. C., Richards, A. M., Ansell, G. S., Nicholls, M. G., Pemberton, C. J., Lewis, L. K., & Yandle, T. G. (2014). B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: Evidence for degradation before secretion. Clinical Chemistry, 60(3), 549-558. doi: 10.1373/clinchem.2013.210435

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Palmer, S. C., Troughton, R. W., & Richards, A. M. (2013). Comparison of immunoassays for NTproBNP conducted on three analysis systems: Milliplex, Elecsys and RIA. Clinical Biochemistry, 46(4-5), 388-390. doi: 10.1016/j.clinbiochem.2012.11.022

Adem, A., Al Haj, A., Benedict, S., Yasin, J., Nagelkerke, N., Nyberg, F., Yandle, T. G., Frampton, C. M., Lewis, L. K., Nicholls, M. G., & Kazzam, E. (2013). ANP and BNP responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system. PLoS ONE, 8(3), e57806. doi: 10.1371/journal.pone.0057806

Scott, N. J. A., Cameron, V. A., Raudsepp, S., Lewis, L. K., Simpson, E. R., Richards, A. M., & Ellmers, L. J. (2012). Generation and characterization of a mouse model of the metabolic syndrome: Apolipoprotein E and aromatase double knockout mice. American Journal of Physiology: Endocrinology & Metabolism, 302, E576-E584. doi: 10.1152/ajpendo.00222.2011

Ali, M. A., Adem, A., Chandranath, I. S., Benedict, S., Pathan, J. Y., Nagelkerke, N., … Lewis, L. K., Yandle, T. G., Nicholls, M. G., Frampton, C. M., & Kazzam, E. (2012). Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system. PLoS ONE, 7(5), e37299. doi: 10.1371/journal.pone.0037299

Braithwaite, J. E., Yandle, T. G., Nicholls, M. G., & Lewis, L. K. (2012). Interference by o-phenanthroline in the radioimmunoassay of angiotensin II in small volume blood samples. Clinical Biochemistry, 45(1-2), 168-170. doi: 10.1016/j.clinbiochem.2011.10.008

Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429

Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203

Troughton, R. W., Lewis, L. K., Yandle, T. G., Pemberton, C. J., & Nicholls, M. G. (2011). B-type natriuretic peptides: Looking to the future. Annals of Medicine, 43(3), 188-197. doi: 10.3109/07853890.2010.526630

Nicholls, M. G., Lewis, L. K., Yandle, T. G., Lord, G., Mckinnon, W., & Hilton, P. J. (2009). Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy? Journal of Hypertension, 27(1), 3-8. doi: 10.1097/HJH.0b013e32831101d1

Nicholls, M. G., Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2003). Adrenomedullin in heart failure. Hypertension Research, 26(Suppl.), S135-S140. doi: 10.1291/hypres.26.S135

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2003). Endothelin-1 directly modulates its own secretion: Studies utilising the cell immunoblot technique. Regulatory Peptides, 113, 149-153.

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2002). Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. Journal of Endocrinology, 175, 225-232.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98.

Nicholls, M. G., Lainchbury, J. G., Lewis, L. K., McGregor, D. O., Richards, A. M., Troughton, R. W., & Yandle, T. G. (2001). Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in man. Peptides, 22(11), 1745-1752.

Troughton, R. W., Frampton, C. M., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2001). Differing thresholds for modulatory effects of adrenomedullin infusion on hemodynamic and hormone responses to angiotensin II and adrenocorticotrophic hormone in healthy volunteers. Clinical Science, 101, 103-109.

Nicholls, M. G., Lainchbury, J. G., Lewis, L. K., McGregor, D. O., Richards, A. M., Troughton, R. W., & Yandle, T. G. (2001). Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a man. Peptides, 22, 1745-1752.

Troughton, R. W., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Hemodynamic, hormone, and urinary effects of adrenomedullin infusion in essential hypertension. Hypertension, 36, 588-593.

Lainchbury, J. G., Troughton, R. W., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Haemodynamic, hormonal and renal effects of short-term adrenomedullin infusion in healthy volunteers. Journal of Clinical Endocrinology & Metabolism, 85, 1016-1020.

Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1999). The role of adrenomedullin. American Journal of Hypertension, 12(2 Part 1), 166-173.

Lainchbury, J. G., Nicholls, M. G., Espiner, E. A., Yandle, T. G., Lewis, L. K., & Richards, A. M. (1999). Bioactivity and interactions of adrenomedullin and brain natriuretic peptide in patients with heart failure. Hypertension, 34(1), 70-75.

Lai, K. N., Leung, J. C., Yeung, V. T. F., Lewis, L. K., & Nicholls, M. G. (1998). Gene transcription and synthesis of adrenomedullin by cultured human renal cells. Biochemical & Biophysical Research Communications, 244(2), 567-572.

Lewis, L. K., Smith, M. W., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1998). Adrenomedullin (1-52) measured in human plasma by radioimmunoassay: plasma concentration, adsorption and storage. Clinical Chemistry, 44(3), 571-577.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Cooper, G. J., Coy, D. H., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation, 96(6), 1983-1990.

Lewis, L. K., Smith, M., Brennan, S. O., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Degradation of human adrenomedullin (1-52) by plasma membrane enzymes and identification of metabolites. Peptides, 18(5), 733-739.

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. L. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Clinical & Experimental Pharmacology & Physiology, 24(11), 807-813.

Lainchbury, J. G., Cooper, G. J. S., Coy, D. H., Jiang, N. Y., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Adrenomedullin: A hypotensive hormone in man. Clinical Science, 92(5), 467-472.

Pidgeon, G. B., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1996). Endogenous ouabain, sodium balance and blood pressure. Journal of Hypertension, 14, 169-171.

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Charles, C. J., Rademaker, M. T., Lynn, K. L., … Lewis, L. K., & Yandle, T. G. (1996). Chronic ouabain infusion does not cause hypertension in sheep. American Journal of Physiology: Endocrinology & Metabolism, 270(3), E386-E392.

Lewis, L. K., Yandle, T. G., Lewis, J. G., Richards, A. M., Pidgeon, G. B., Kaaja, R. J., & Nicholls, M. G. (1996). Diabetes mellitus in older patients. Drugs & Aging, 6, 401-407.

Nicholls, M. G., Richards, A. M., Lewis, L. K., & Yandle, T. G. (1995). Ouabain: a new steroid hormone? Lancet, 346, 1381-1382.

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Journal - Research Other

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). [Response to letter re Endogenous ouabain is not ouabain]. Hypertension, 64. Retrieved from http://hyper.ahajournals.org/content/64/4/680/reply#hypertensionaha_el_351

Richards, A. M., Nicholls, M. G., Lewis, L., & Lainchbury, J. G. (1996). Adrenomedullin [Editorial review]. Clinical Science, 91(1), 3-16. doi: 10.1042/cs0910003

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