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Otago Medical School staff profiles

Associate Professor Bruce Russell

PositionAssociate Professor
DepartmentDepartment of Microbiology and Immunology
Research summaryParasitology

Research

Vivax Malaria (or Relapsing Malaria) is the most widely distributed, difficult to diagnose and treat cause of human malaria. Our laboratory focuses in of the biology of the parasite Plasmodium vivax (the cause of vivax malaria) and how we can kill it using therapeutics or vaccinations. To do this we have developed key ex vivo tools and methods to examine P. vivax drug susceptibility and reticulocyte invasion. These methods are optimised for use in malaria endemic regions. We also utilise a continuous culture of P. cynomolgi (an excellent model of P. vivax) to study the molecular mechanisms underlying P. vivax pathobiology. In addition to vivax malaria we also contend research into the biology and epidemiology of protozoal parasites of importance to human health in New Zealand.

Publications

Liew, J. W. K., binti Mahpot, R., Dzul, S., bin Abdul Razak, H. A., binti Ahmad Shah Azizi, N. A., binti Kamarudin, M., Russell, B., … Lau, Y. L. (2018). Importance of proactive malaria case surveillance and management in Malaysia. American Journal of Tropical Medicine & Hygiene, 98(6), 1709-1713. doi: 10.4269/ajtmh.17-1010

Han, J.-H., Cho, J.-S., Cheng, Y., Muh, F., Yoo, W. G., Russell, B. M., … Han, E.-T. (2018). Plasmodium vivax merozoite surface protein 1 paralog as a mediator of parasite adherence to reticulocytes. Infection & Immunity. Advance online publication. doi: 10.1128/IAI.00239-18

Cravo, P., Machado, R. B., Leite, J. A., Leda, T., Suwanarusk, R., Bittencourt, N., … Russell, B., … Costa, F. T. M. (2018). In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate. Malaria Journal, 17, 20. doi: 10.1186/s12936-017-2144-x

Fraschka, S. A., Filarsky, M., Hoo, R., Niederwieser, I., Yan Yam, X., Brancucci, N. M. B., … Russell, B., … Voss, T. S. (2018). Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites. Cell Host & Microbe, 23(3), 407-420. doi: 10.1016/j.chom.2018.01.008

Htuna, K. S., Fong, Y., Kyaw, A. A., Aung, S. T., Oo, K. Z., Zaw, T., … Russell, B., Cook, G. M., Aung, H. L., & Hlaing, T. M. (2018). Microbiome dataset from the upper respiratory tract of patients living with HIV, HIV/TB and TB from Myanmar. Data in Brief, 21, 354-357. doi: 10.1016/j.dib.2018.10.003

Chapter in Book - Research

Li, A., Rénia, L., Lim, C. T., & Russell, B. (2013). Atomic force microscopy of Plasmodium-infected red blood cells: Detecting and localizing single molecular recognition events. In R. Ménard (Ed.), Malaria: Methods and protocols: Methods in molecular biology (Vol. 923). (2nd ed.) (pp. 299-305). Humana Press. doi: 10.1007/978-1-62703-026-7_21

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Journal - Research Article

Liew, J. W. K., binti Mahpot, R., Dzul, S., bin Abdul Razak, H. A., binti Ahmad Shah Azizi, N. A., binti Kamarudin, M., Russell, B., … Lau, Y. L. (2018). Importance of proactive malaria case surveillance and management in Malaysia. American Journal of Tropical Medicine & Hygiene, 98(6), 1709-1713. doi: 10.4269/ajtmh.17-1010

Htuna, K. S., Fong, Y., Kyaw, A. A., Aung, S. T., Oo, K. Z., Zaw, T., … Russell, B., Cook, G. M., Aung, H. L., & Hlaing, T. M. (2018). Microbiome dataset from the upper respiratory tract of patients living with HIV, HIV/TB and TB from Myanmar. Data in Brief, 21, 354-357. doi: 10.1016/j.dib.2018.10.003

Fraschka, S. A., Filarsky, M., Hoo, R., Niederwieser, I., Yan Yam, X., Brancucci, N. M. B., … Russell, B., … Voss, T. S. (2018). Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites. Cell Host & Microbe, 23(3), 407-420. doi: 10.1016/j.chom.2018.01.008

Cravo, P., Machado, R. B., Leite, J. A., Leda, T., Suwanarusk, R., Bittencourt, N., … Russell, B., … Costa, F. T. M. (2018). In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate. Malaria Journal, 17, 20. doi: 10.1186/s12936-017-2144-x

Han, J.-H., Cho, J.-S., Cheng, Y., Muh, F., Yoo, W. G., Russell, B. M., … Han, E.-T. (2018). Plasmodium vivax merozoite surface protein 1 paralog as a mediator of parasite adherence to reticulocytes. Infection & Immunity. Advance online publication. doi: 10.1128/IAI.00239-18

Chu, T. T. T., Sinha, A., Malleret, B., Suwanarusk, R., Park, J. E., Naidu, R., … Russell, B., & Chandramohanadas, R. (2018). Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. British Journal of Haematology, 180(1), 118-133. doi: 10.1111/bjh.14976

Gruszczyk, J., Kanjee, U., Chan, L.-J., Menant, S., Malleret, B., Lim, N. T. Y., … Russell, B., … Tham, W.-H. (2018). Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science, 359(6371), 48-55. doi: 10.1126/science.aan1078

Barber, B. E., Russell, B., Grigg, M. J., Zhang, R., Williams, T., Amir, A., … Yeo, T. W. (2018). Reduced red blood cell deformability in Plasmodium knowlesi malaria. Blood Advances, 2(4), 433-443. doi: 10.1182/bloodadvances.2017013730

Basilico, N., Parapini, S., Sparatore, A., Romeo, S., Misiano, P., Vivas, L., … Russell, B., Suwanarusk, R., … Taramelli, D. (2017). In vivo and in vitro activities and ADME-Tox profile of a quinolizidine-modified 4-aminoquinoline: A potent anti-P. falciparum and Anti-P. vivax blood-stage antimalarial. Molecules, 22(12), 2102. doi: 10.3390/molecules22122102

Kosaisavee, V., Suwanarusk, R., Chua, A. C. Y., Kyle, D. E., Malleret, B., Zhang, R., … Ong, J. J. Y., … Russell, B. (2017). Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi. Blood, 130(11), 1357-1363. doi: 10.1182/blood-2017-02-764787

Pang, S.-C., Andolina, C., Malleret, B., Christensen, P. R., Lam‑Phua, S.-G., Abdul Razak, M. A. B., … Russell, B., … Nosten, F. (2017). Singapore's Anopheles sinensis Form A is susceptible to Plasmodium vivax isolates from the western Thailand-Myanmar border. Malaria Journal, 16(1), 465. doi: 10.1186/s12936-017-2114-3

Dembele, L., Ang, X., Chavchich, M., Bonamy, G. M. C., Selva, J. J., Lim, M. Y.-X., … Russell, B. M., … Bifani, P. (2017). The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Scientific Reports, 7(1), 2325. doi: 10.1038/s41598-017-02440-6

Bancone, G., Malleret, B., Suwanarusk, R., Cowwiwat, N., Chu, C. S., McGready, R., … Russell, B. (2017). Asian G6PD-Mahidol reticulocytes sustain normal Plasmodium vivax development. Journal of Infectious Diseases, 216(2), 263-266. doi: 10.1093/infdis/jix278

Rocha, M. V., Françoso, K. S., Lima, L. C., Camargo, T. M., Machado, R. L. D., Costa, F. T. M., … Russell, B., … Soares, I. S. (2017). Generation, characterization and immunogenicity of a novel chimeric recombinant protein based on Plasmodium vivax AMA-1 and MSP119. Vaccine, 35(8), 2463-2472. doi: 10.1016/j.vaccine.2017.03.023

Claser, C., Chang, Z. W., Russell, B., & Rénia, L. (2017). Adaptive immunity is essential in preventing recrudescence of Plasmodium yoelii malaria parasites after artesunate treatment. Cellular Microbiology, 19(11), e12763. doi: 10.1111/cmi.12763

Amir, A., Russell, B., Liew, J. W. K., Moon, R. W., Fong, M. Y., Vythilingam, I., … Lau, Y. L. (2016). Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human. Scientific Reports, 6, 24623. doi: 10.1038/srep24623

Cho, J.-S., Russell, B., Kosasaivee, V., Zhang, R., Colin, Y., Bertrand, O., … Malleret, B. (2016). Unambiguous determination of Plasmodium vivax reticulocyte invasion by flow cytometry. International Journal for Parasitology, 46(1), 31-39. doi: 10.1016/j.ijpara.2015.08.003

Zhu, L., Mok, S., Imwong, M., Jaidee, A., Russell, B., Nosten, F., … Bozdech, Z. (2016). New insights into the Plasmodium vivax transcriptome using RNA-Seq. Scientific Reports, 6, 20498. doi: 10.1038/srep20498

Auburn, S., Serre, D., Pearson, R. D., Amato, R., Sriprawat, K., To, S., … Suwanarusk, R., Russell, B., … Price, R. N. (2016). Genomic analysis reveals a common breakpoint in amplifications of the Plasmodium vivax multidrug resistance 1 locus in Thailand. Journal of Infectious Diseases, 214(8), 1235-1242. doi: 10.1093/infdis/jiw323

Zhang, R., Suwanarusk, R., Malleret, B., Cooke, B. M., Nosten, F., Lau, Y.-L., … Russell, B. (2016). A basis for rapid clearance of circulating ring-stage malaria parasites by the spiroindolone KAE609. Journal of Infectious Diseases, 213(1), 100-104. doi: 10.1093/infdis/jiv358

Zhang, R., Lee, W.-C., Lau, Y.-L., Albrecht, L., Lopes, S. C. P., Costa, F. T. M., Suwanarusk, R., … Russell, B. (2016). Rheopathologic consequence of Plasmodium vivax rosette formation. PLoS Neglected Tropical Diseases, 10(8), e0004912. doi: 10.1371/journal.pntd.0004912

Li, J. L., Lim, C. H., Tay, F. W., Goh, C. C., Devi, S., Malleret, B., … Russell, B., … Ng, L. G. (2016). Neutrophils self-regulate immune complex-mediated cutaneous inflammation through CXCL2. Journal of Investigative Dermatology, 136(2), 416-424. doi: 10.1038/jid.2015.410

Woodrow, C. J., Wangsing, C., Sriprawat, K., Christensen, P. R., Nosten, F., Rénia, L., Russell, B., & Malleret, B. (2015). Comparison between flow cytometry, microscopy, and lactate dehydrogenase-based enzyme-linked immunosorbent assay for Plasmodium falciparum drug susceptibility testing under field conditions. Journal of Clinical Microbiology, 53(10), 3296-3303. doi: 10.1128/JCM.01226-15

Leite, J. A., Bargieri, D. Y., Carvalho, B. O., Albrecht, L., Lopes, S. C. P., Kayano, A. C. A. V., … Russell, B. M., … Costa, F. T. M. (2015). Immunization with the MAEBL M2 domain protects against lethal Plasmodium yoelii infection. Infection & Immunity, 83(10), 3781-3792. doi: 10.1128/IAI.00262-15

Malleret, B., Li, A., Zhang, R., Tan, K. S. W., Suwanarusk, R., Claser, C., … Russell, B. (2015). Plasmodium vivax: Restricted tropism and rapid remodeling of CD71-positive reticulocytes. Blood, 125(8), 1314-1324. doi: 10.1182/blood-2014-08-596015

de Cassan, S. C., Shakri, A. R., Llewellyn, D., Elias, S. C., Cho, J. S., Goodman, A. L., … Suwanarusk, R., … Russell, B. M., … Draper, S. J. (2015). Preclinical assessment of viral vectored and protein vaccines targeting the Duffy-binding protein region II of Plasmodium vivax. Frontiers in Immunology, 6, 348. doi: 10.3389/fimmu.2015.00348

Suwanarusk, R., Russell, B., Ong, A., Sriprawat, K., Chu, C. S., PyaePhyo, A., … Renia, L. (2015). Methylene blue inhibits the asexual development of vivax malaria parasites from a region of increasing chloroquine resistance. Journal of Antimicrobial Chemotherapy, 70(1), 124-129. doi: 10.1093/jac/dku326

Claser, C., Malleret, B., Peng, K., Bakocevic, N., Gun, S. Y., Russell, B., … Rénia, L. (2014). Rodent Plasmodium-infected red blood cells: Imaging their fates and interactions within their hosts. Parasitology International, 63(1), 187-194. doi: 10.1016/j.parint.2013.07.012

Lee, W.-C., Malleret, B., Lau, Y.-L., Mauduit, M., Fong, M.-Y., Cho, J. S., Suwanarusk, R., … Russell, B. (2014). Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes. Blood, 123(18), e100-e109. doi: 10.1182/blood-2013-12-541698

Kuhen, K. L., Chatterjee, A. K., Rottmann, M., Gagaring, K., Borboa, R., Buenviaje, J., … Russell, B., Suwanarusk, R., … Diagana, T. T. (2014). KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial Agents & Chemotherapy, 58(9), 5060-5067. doi: 10.1128/AAC.02727-13

Vicentin, E. C., Françoso, K. S., Rocha, M. V., Lourtov, D., dos Santos, F. L., Kubrusly, F. S., … Russell, B., & Soares, I. S. (2014). Invasion-inhibitory antibodies elicited by immunization with Plasmodium vivax apical membrane antigen-1 expressed in Pichia pastoris yeast. Infection & Immunity, 82(3), 1296-1307. doi: 10.1128/IAI.01169-13

Chandramohanadas, R., Basappa, Russell, B., Liew, K., Yau, Y. H., Chong, A., … Preiser, P. (2014). Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevents host invasion of divergent Plasmodial species. Journal of Infectious Diseases, 210(10), 1616-1626. doi: 10.1093/infdis/jiu296

Ch'ng, J.-H., Lee, Y.-Q., Gun, S. Y., Chia, W.-N., Chang, Z.-W., Wong, L.-K., … Russell, B., … Tan, K.-S. W. (2014). Validation of a chloroquine-induced cell death mechanism for clinical use against malaria. Cell Death & Disease, 5(6), e1305. doi: 10.1038/cddis.2014.265

Loh, C. C.-Y., Suwanarusk, R., Lee, Y. Q., Chang, K. W. K., Choy, K.-Y., Rénia, L., Russell, B., … Chow, L. M. C. (2014). Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag- CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. PLoS ONE, 9(10), e0110800. doi: 10.1371/journal.pone.0110800

Lopes, S. C. P., Albrecht, L., Carvalho, B. O., Siqueira, A. M., Thomson-Luque, R., Nogueira, P. A., … Russell, B. M., … Costa, F. T. M. (2014). Paucity of Plasmodium vivax mature schizonts in peripheral blood is associated with their increased cytoadhesive potential. Journal of Infectious Diseases, 209(9), 1403-1407. doi: 10.1093/infdis/jiu018

Ch'ng, J.-H., Mok, S., Bozdech, Z., Lear, M. J., Boudhar, A., Russell, B., … Tan, K. S.-W. (2013). A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria. Scientific Reports, 3, 1734. doi: 10.1038/srep01734

Auburn, S., Marfurt, J., Maslen, G., Campino, S., Ruano Rubio, V., Manske, M., … Russell, B., … Price, R. N. (2013). Effective preparation of Plasmodium vivax field isolates for high-throughput whole genome sequencing. PLoS ONE, 8(1), e53160. doi: 10.1371/journal.pone.0053160

McNamara, C. W., Lee, M. C. S., Lim, C. S., Lim, S. H., Roland, J., Nagle, A., … Suwanarusk, R., Russell, B., … Winzeler, E. A. (2013). Targeting Plasmodium PI(4)K to eliminate malaria. Nature, 504(7479), 248-253. doi: 10.1038/nature12782

Lee, W.-C., Russell, B., Lau, Y.-L., Fong, M.-Y., Chu, C., Sriprawat, K., … Suwanarusk, R., … Renia, L. (2013). Giemsa-stained wet mount based method for reticulocyte quantification: A viable alternative in resource limited or malaria endemic settings. PLoS ONE, 8(4), e60303. doi: 10.1371/journal.pone.0060303

Malleret, B., Xu, F., Mohandas, N., Suwanarusk, R., Chu, C., Leite, J. A., … Russell, B. (2013). Significant biochemical, biophysical and metabolic diversity in circulating human cord blood reticulocytes. PLoS ONE, 8(10), e76062. doi: 10.1371/journal.pone.0076062

Bitencourt, A. R., Vicentin, E. C., Jimenez, M. C., Ricci, R., Leite, J. A., Costa, F. T., … Russell, B., … Soares, I. S. (2013). Antigenicity and immunogenicity of Plasmodium vivax merozoite surface protein-3. PLoS ONE, 8(2), e56061. doi: 10.1371/journal.pone.0056061

Russell, B., Malleret, B., Suwanarusk, R., Anthony, C., Kanlaya, S., Lau, Y. L., … Renia, L. (2013). Field-based flow cytometry for ex vivo characterization of Plasmodium vivax and P. falciparum antimalarial sensitivity. Antimicrobial Agents & Chemotherapy, 57(10), 5170-5174. doi: 10.1128/AAC.00682-13

Russell, B., Suwanarusk, R., Malleret, B., Costa, F. T. M., Snounou, G., Baird, J. K., … Rénia, L. (2012). Human ex vivo studies on asexual Plasmodium vivax: The best way forward. International Journal for Parasitology, 42(12), 1063-1070. doi: 10.1016/j.ijpara.2012.08.010

Hwang, J., Jaroensuk, J., Leimanis, M. L., Russell, B., McGready, R., Day, N., … Imwong, M. (2012). Long-term storage limits PCR-based analyses of malaria parasites in archival dried blood spots. Malaria Journal, 11(339). doi: 10.1186/1475-2875-11-339

Rénia, L., Howland, S. W., Claser, C., Gruner, A. C., Suwanarusk, R., Teo, T.-H., Russell, B., & Ng, L. F. P. (2012). Cerebral malaria: Mysteries at the blood-brain barrier. Virulence, 3(2), 193-201. doi: 10.4161/viru.19013

Kosaisavee, V., Lek-Uthai, U., Suwanarusk, R., Grüner, A. C., Russell, B., Nosten, F., … Snounou, G. (2012). Genetic diversity in new members of the reticulocyte binding protein family in Thai Plasmodium vivax isolates. PLoS ONE, 7(3), e32105. doi: 10.1371/journal.pone.0032105

Costa, F. T. M., Lopes, S. C. P., Albrecht, L., Ataíde, R., Siqueira, A. M., D'Souza, R. M., Russell, B., … Lacerda, M. V. G. (2012). On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field. International Journal for Parasitology, 42(12), 1099-1105. doi: 10.1016/j.ijpara.2012.08.007

Borlon, C., Russell, B., Sriprawat, K., Suwanarusk, R., Erhart, A., Renia, L., … D'Alessandro, U. (2012). Cryopreserved Plasmodium vivax and cord blood reticulocytes can be used for invasion and short term culture. International Journal for Parasitology, 42(2), 155-160. doi: 10.1016/j.ijpara.2011.10.011

Phanpoowong, T., Lek-Uthai, U., Thongrungkiat, S., Komalamisra, N., Sriswat, R., Russell, B., & Renia, L. (2012). Dengue-2 virus carrying capacity of Thai Aedes aegypti strains with different susceptibility to deltamethrin. Southeast Asian Journal of Tropical Medicine & Public Health, 43(3), 634-639.

Kaewpongsri, S., Sriprawat, K., Suwanarusk, R., Kyle, D. E., Lek-Uthai, U., Leimanis, M., … Russell, B., … Renia, L. (2011). The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum. Antimicrobial Agents & Chemotherapy, 55(3), 1300-1304. doi: 10.1128/AAC.01103-10

Mok, S., Imwong, M., MacKinnon, M. J., Sim, J., Ramadoss, R., Yi, P., … Russell, B., … Bozdech, Z. (2011). Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics, 12, 391. doi: 10.1186/1471-2164-12-391

Rijken, M. J., Boel, M. E., Russell, B., Imwong, M., Leimanis, M. L., Phyo, A. P., … Nosten, F. (2011). Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand. Malaria Journal, 10, 113. doi: 10.1186/1475-2875-10-113

Bouillet, L. E. M., Dias, M. O., Dorigo, N. A., Moura, A. D., Russell, B., Nosten, F., … Bruna-Romero, O. (2011). Long-term humoral and cellular immune responses elicited by a heterologous Plasmodium vivax apical membrane antigen 1 protein prime/adenovirus boost immunization protocol. Infection & Immunity, 79(9), 3642-3652. doi: 10.1128/IAI.05048-11

Phyo, A. P., Lwin, K. M., Price, R. N., Ashley, E. A., Russell, B., Sriprawat, K., … Nosten, F. (2011). Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: A randomized controlled trial. Clinical Infectious Diseases, 53(10), 977-984. doi: 10.1093/cid/cir631

Malleret, B., Claser, C., Ong, A. S. M., Suwanarusk, R., Sriprawat, K., Howland, S. W., Russell, B., … Rénia, L. (2011). A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development. Scientific Reports, 1, 118. doi: 10.1038/srep00118

Russell, B., Suwanarusk, R., Borlon, C., Costa, F. T. M., Chu, C. S., Rijken, M. J., … Rénia, L. (2011). A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood, 118(13), e74-e81. doi: 10.1182/blood-2011-04-348748

Proux, S., Suwanarusk, R., Barends, M., Zwang, J., Price, R. N., Leimanis, M., … Russell, B., … Snounou, G. (2011). Considerations on the use of nucleic acid-based amplification for malaria parasite detection. Malaria Journal, 10, 323. doi: 10.1186/1475-2875-10-323

Price, R. N., Marfurt, J., Chalfein, F., Kenangalem, E., Piera, K. A., Tjitra, E., … Russell, B. (2010). In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax. Antimicrobial Agents & Chemotherapy, 54(12), 5146-5150. doi: 10.1128/AAC.00801-10

Carvalho, B. O., Lopes, S. C. P., Nogueira, P. A., Orlandi, P. P., Bargieri, D. Y., Blanco, Y. C., … Russell, B., Suwanarusk, R., … Costa, F. T. M. (2010). On the cytoadhesion of Plasmodium vivax—infected erythrocytes. Journal of Infectious Diseases, 202(4), 638-647. doi: 10.1086/654815

Leimanis, M. L., Jaidee, A., Sriprawat, K., Kaewpongsri, S., Suwanarusk, R., Barends, M., … Russell, B., … Nosten, F. (2010). Plasmodium vivax susceptibility to ferroquine. Antimicrobial Agents & Chemotherapy, 54(5), 2228-2230. doi: 10.1128/AAC.01572-09

Rottmann, M., McNamara, C., Yeung, B. K. S., Lee, M. C. S., Zou, B., Russell, B., … Suwanarusk, R., … Diagana, T. T. (2010). Spiroindolones, a potent compound class for the treatment of malaria. Science, 329(5996), 1175-1180. doi: 10.1126/science.1193225

Nasveld, P. E., Edstein, M. D., Reid, M., Brennan, L., Harris, I. E., Kitchener, S. J., … Tafenoquine Study Team, including Russell, B. (2010). Randomized, double-blind study of the safety, tolerability, and efficacy of tafenoquine versus mefloquine for malaria prophylaxis in nonimmune subjects. Antimicrobial Agents & Chemotherapy, 54(2), 792-798. doi: 10.1128/AAC.00354-09

Sriprawat, K., Kaewpongsri, S., Suwanarusk, R., Leimanis, M. L., Lek-Uthai, U., Phyo, A. P., … Russell, B., … Nosten, F. (2009). Effective and cheap removal of leukocytes and platelets from Plasmodium vivax infected blood. Malaria Journal, 8, 115. doi: 10.1186/1475-2875-8-115

Anstey, N. M., Russell, B., Yeo, T. W., & Price, R. N. (2009). The pathophysiology of vivax malaria. Trends in Parasitology, 25(5), 220-227. doi: 10.1016/j.pt.2009.02.003

Hasugian, A. R., Tjitra, E., Ratcliff, A., Siswantoro, H., Kenangalem, E., Wuwung, R. M., … Russell, B., … Price, R. N. (2009). In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax. Antimicrobial Agents & Chemotherapy, 53(3), 1094-1099. doi: 10.1128/AAC.01511-08

Lek-Uthai, U., Suwanarusk, R., Ruengweerayut, R., Skinner-Adams, T. S., Nosten, F., Gardiner, D. L., … Russell, B. (2008). Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. Antimicrobial Agents & Chemotherapy, 52(7), 2435-2441. doi: 10.1128/AAC.00169-08

Russell, B., Chalfein, F., Prasetyorini, B., Kenangalem, E., Piera, K., Suwanarusk, R., … Price, R. N. (2008). Determinants of in vitro drug susceptibility testing of Plasmodium vivax. Antimicrobial Agents & Chemotherapy, 52(3), 1040-1045. doi: 10.1128/AAC.01334-07

Bozdech, Z., Mok, S., Hu, G., Imwong, M., Jaidee, A., Russell, B., … Preiser, P. R. (2008). The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. PNAS, 105(42), 16290-16295. doi: 10.1073/pnas.0807404105

Sharrock, W. W., Suwanarusk, R., Lek-Uthai, U., Edstein, M. D., Kosaisavee, V., Travers, T., … Russell, B. (2008). Plasmodium vivax trophozoites insensitive to chloroquine. Malaria Journal, 7, 94. doi: 10.1186/1475-2875-7-94

Suksumek, N., Leelawat, K., Leelawat, S., Russell, B., & Lek-Uthai, U. (2008). TaqMan real-time PCR assay for specific detection of Opisthorchis viverrini DNA in Thai patients with hepatocellular carcinoma and cholangiocarcinoma. Experimental Parasitology, 119(2), 217-224. doi: 10.1016/j.exppara.2008.01.018

Suwanarusk, R., Chavchich, M., Russell, B., Jaidee, A., Chalfein, F., Barends, M., … Price, R. N. (2008). Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax. Journal of Infectious Diseases, 198(10), 1558-1564. doi: 10.1086/592451

Suwanarusk, R., Russell, B., Chavchich, M., Chalfein, F., Kenangalem, E., Kosaisavee, V., … Price, R. N. (2007). Chloroquine resistant Plasmodium vivax: In vitro characterisation and association with molecular polymorphisms. PLoS ONE, 2(10), e1089. doi: 10.1371/journal.pone.0001089

Boonma, P., Christensen, P. R., Suwanarusk, R., Price, R. N., Russell, B., & Lek-Uthai, U. (2007). Comparison of three molecular methods for the detection and speciation of Plasmodium vivax and Plasmodium falciparum. Malaria Journal, 6, 124. doi: 10.1186/1475-2875-6-124

Auliff, A., Wilson, D. W., Russell, B., Gao, Q., Chen, Q., Anh, L. N., … Cheng, Q. (2006). Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs. American Journal of Tropical Medicine & Hygiene, 75(4), 617-621.

Kosaisavee, V., Suwanarusk, R., Nosten, F., Kyle, D. E., Barrends, M., Jones, J., … Russell, B., & Lek-Uthai, U. (2006). Plasmodium vivax: Isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved isolates. Experimental Parasitology, 114(1), 34-39. doi: 10.1016/j.exppara.2006.02.006

Kitchener, S., Nasveld, P., Russell, B. M., & Elmes, N. (2003). An outbreak of malaria in a forward battalion on active service in East Timor. Military Medicine, 168(6), 457-459.

Russell, B. M., Udomsangpetch, R., Rieckmann, K. H., Kotecka, B. M., Coleman, R. E., & Sattabongkot, J. (2003). Simple in vitro assay for determining the sensitivity of Plasmodium vivax isolates from fresh human blood to antimalarials in areas where P. vivax is endemic. Antimicrobial Agents & Chemotherapy, 47(1), 170-173. doi: 10.1128/AAC.47.1.170-173.2003

Russell, B. M., Muir, L. E., Weinstein, P., & Kay, B. H. (1996). Surveillance of the mosquito Aedes aegypti and its biocontrol with the copepod Mesocyclops aspericornis in Australian wells and gold mines. Medical & Veterinary Entomology, 10(2), 155-160. doi: 10.1111/j.1365-2915.1996.tb00722.x

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Journal - Research Other

Aung, H. L., Nyunt, W. W., Fong, Y., Russell, B., Cook, G. M., & Aung, S. T. (2018). Acquired resistance to antituberculosis drugs. Emerging Infectious Diseases, 24(11), 2134. doi: 10.3201/eid2411.180465

Malleret, B., Rénia, L., & Russell, B. (2017). The unhealthy attraction of Plasmodium vivax to reticulocytes expressing transferrin receptor 1 (CD71). International Journal for Parasitology, 47(7), 379-383. doi: 10.1016/j.ijpara.2017.03.001

Russell, B. M., & Cooke, B. M. (2017). The rheopathobiology of Plasmodium vivax and other important primate malaria parasites. Trends in Parasitology, 33(4), 321-334. doi: 10.1016/j.pt.2016.11.009

Imwong, M., Russell, B., Suwanarusk, R., Nzila, A., Leimanis, M. L., Sriprawat, K., … Renia, L. (2011). Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax [Brief report]. Journal of Infectious Diseases, 203(2), 207-210. doi: 10.1093/infdis/jiq024

Handayani, S., Chiu, D. T., Tjitra, E., Kuo, J. S., Lampah, D., Kenangalem, E., … Russell, B. (2009). High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. Journal of Infectious Diseases, 199(3), 445-450. doi: 10.1086/596048

Russell, B., Suwanarusk, R., & Lek-Uthai, U. (2006). Plasmodium vivax genetic diversity: Microsatellite length matters [Update]. Trends in Parasitology, 22(9), 399-401. doi: 10.1016/j.pt.2006.06.013

Chen, N., Russell, B., Fowler, E., Peters, J., & Cheng, Q. (2002). Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1. Journal of Infectious Diseases, 185(3), 405-406. doi: 10.1086/338470

Chen, N., Russell, B., Staley, J., Kotecka, B., Nasveld, P., & Cheng, Q. (2001). Sequence polymorphisms in pfcrt are strongly associated with chloroquine resistance in Plasmodium falciparum. Journal of Infectious Diseases, 183(10), 1543-1545. [Letter].

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