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Otago Medical School staff profiles

Dr Clint Gray

PositionResearch Fellow
DepartmentDepartment of Paediatrics and Child Health (UOW)
Research summaryPrematurity; cardiovascular risk

Research

Dr Gray's current research projects involve using pressure myography to examine preterm vascular function in offspring and placenta. He is also working on projects looking at the effects of maternal diet on the uterine environment, blastocyst development, microRNA and gene expression. Utilising Proteomics and metabolomics he is also looking at the effects of preterm birth on liver function and the effects of maternal fructose (sugar-sweetened beverage) consumption on offspring liver development and predisposition to NAFLD.

Publications

Shaw, J. C., Dyson, R. M., Palliser, H. K., Gray, C., Berry, M. J., & Hirst, J. J. (2018). Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs. Pediatric Research. Advance online publication. doi: 10.1038/s41390-018-0185-7

Morrison, J. L., Berry, M. J., Botting, K. J., Darby, J. R. T., Frasch, M. G., Gatford, K. L., … Gray, C. L., … Tellam, R. L. (2018). Improving pregnancy outcomes in humans through studies in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology. Advance online publication. doi: 10.1152/ajpregu.00391.2017

Morrison, J. L., Botting, K. J., Darby, J. R. T., David, A. L., Dyson, R. M., Gatford, K. L., Gray, C., … Berry, M. J. (2018). Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. Journal of Physiology, 596(23), 5535-5569. doi: 10.1113/JP274948

Saito-Benz, M., Gray, C., Tzeng, Y.-C., Atkinson, G., & Berry, M. J. (2018). Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates [Brief report]. Acta Paediatrica. Advance online publication. doi: 10.1111/apa.14631

Gray, C., McCowan, L. M., Patel, R., Taylor, R. S., & Vickers, M. H. (2017). Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: A pilot study. Scientific Reports, 7, 815. doi: 10.1038/s41598-017-00713-8

Journal - Research Article

Shaw, J. C., Dyson, R. M., Palliser, H. K., Gray, C., Berry, M. J., & Hirst, J. J. (2018). Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs. Pediatric Research. Advance online publication. doi: 10.1038/s41390-018-0185-7

Morrison, J. L., Botting, K. J., Darby, J. R. T., David, A. L., Dyson, R. M., Gatford, K. L., Gray, C., … Berry, M. J. (2018). Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. Journal of Physiology, 596(23), 5535-5569. doi: 10.1113/JP274948

Morrison, J. L., Berry, M. J., Botting, K. J., Darby, J. R. T., Frasch, M. G., Gatford, K. L., … Gray, C. L., … Tellam, R. L. (2018). Improving pregnancy outcomes in humans through studies in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology. Advance online publication. doi: 10.1152/ajpregu.00391.2017

Gray, C., McCowan, L. M., Patel, R., Taylor, R. S., & Vickers, M. H. (2017). Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: A pilot study. Scientific Reports, 7, 815. doi: 10.1038/s41598-017-00713-8

Albert, B. B., Vickers, M. H., Gray, C., Reynolds, C. M., Segovia, S. A., Derraik, J. G. B., … Cutfield, W. S. (2017). Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring. Scientific Reports, 7, 5595. doi: 10.1038/s41598-017-05793-0

Berry, M. J., Saito-Benz, M., Gray, C., Dyson, R. M., Dellabarca, P., Ebmeier, S., … Elder, D. E., & Richardson, V. F. (2017). Outcomes of 23- and 24-weeks gestation infants in Wellington, New Zealand: A single centre experience. Scientific Reports, 7, 12769. doi: 10.1038/s41598-017-12911-5

Segovia, S. A., Vickers, M. H., Gray, C., Zhang, X., & Reynolds, C. M. (2017). Conjugated linoleic acid supplementation improves maternal high fat diet-induced programming of metabolic dysfunction in adult male rat offspring. Scientific Reports, 7, 6663. doi: 10.1038/s41598-017-07108-9

Albert, B. B., Vickers, M. H., Gray, C., Reynolds, C. M., Segovia, S. A., Derraik, J. G. B., … Cutfield, W. S. (2016). Oxidized fish oil in rat pregnancy causes high newborn mortality and increases maternal insulin resistance. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 311(3), R497-R504. doi: 10.1152/ajpregu.00005.2016

Pileggi, C. A., Hedges, C. P., Segovia, S. A., Markworth, J. F., Durainayagam, B. R., Gray, C., … Cameron-Smith, D. (2016). Maternal high fat diet alters skeletal muscle mitochondrial catalytic activity in adult male rat offspring. Frontiers in Physiology, 7, 546. doi: 10.3389/fphys.2016.00546

Pileggi, C. A., Segovia, S. A., Markworth, J. F., Gray, C., Zhang, X. D., Milan, A. M., … Cameron-Smith, D. (2016). Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 310(5), R432-R439. doi: 10.1152/ajpregu.00351.2015

Gray, C., Gardiner, S. M., Elmes, M., & Gardner, D. S. (2016). Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring. British Journal of Nutrition, 115(4), 594-604. doi: 10.1017/S0007114515004936

Mumme, K., Gray, C., Reynolds, C. M., Vickers, M. H., Harrison, C. J., Stanley, J. L., … Sulek, K. (2016). Maternal-fetal hepatic and placental metabolome profiles are associated with reduced fetal growth in a rat model of maternal obesity. Metabolomics, 12(5), 83. doi: 10.1007/s11306-016-1014-9

Gray, C., Vickers, M. H., Dyson, R. M., Reynolds, C. M., & Berry, M. J. (2015). Magnesium sulfate has sex-specific, dose-dependent vasodilator effects on preterm placental vessels. Biology of Sex Differences, 6, 22. doi: 10.1186/s13293-015-0040-z

Reynolds, C. M., Segovia, S. A., Zhang, X. D., Gray, C., & Vickers, M. H. (2015). Maternal high-fat diet-induced programing of gut taste receptor and inflammatory gene expression in rat offspring is ameliorated by CLA supplementation. Physiological Reports, 3(10), e12588. doi: 10.14814/phy2.12588

Reynolds, C. M., Vickers, M. H., Harrison, C. J., Segovia, S. A., & Gray, C. (2015). Maternal high fat and/or salt consumption induces sex‐specific inflammatory and nutrient transport in the rat placenta. Physiological Reports, 3(5), e12399. doi: 10.14814/phy2.12399

Berry, M., Gray, C., Wright, K., Dyson, R., & Wright, I. (2015). Premature guinea pigs: A new paradigm to investigate the late-effects of preterm birth. Journal of Developmental Origins of Health & Disease, 6(2), 143-148. doi: 10.1017/S2040174414000592

Gray, C., Vickers, M. H., Segovia, S. A., Zhang, X. D., & Reynolds, C. M. (2015). A maternal high fat diet programmes endothelial function and cardiovascular status in adult male offspring independent of body weight, which is reversed by maternal conjugated linoleic acid (CLA) supplementation. PLoS ONE, 10(2), e0115994. doi: 10.1371/journal.pone.0115994

Segovia, S. A., Vickers, M. H., Zhang, X. D., Gray, C., & Reynolds, C. M. (2015). Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring. Journal of Nutritional Biochemistry, 26(12), 1448-1457. doi: 10.1016/j.jnutbio.2015.07.013

Gray, C., Harrison, C. J., Segovia, S. A., Reynolds, C. M., & Vickers, M. H. (2015). Maternal salt and fat intake causes hypertension and sustained endothelial dysfunction in fetal, weanling and adult male resistance vessels. Scientific Reports, 5, 09753. doi: 10.1038/srep09753

Li, M., Reynolds, C. M., Gray, C., & Vickers, M. H. (2015). Preweaning GH treatment normalizes body growth trajectory and reverses metabolic dysregulation in adult offspring after maternal undernutrition. Endocrinology, 156(9), 3228-3238. doi: 10.1210/en.2015-1041

Li, M., Reynolds, C. M., Sloboda, D. M., Gray, C., & Vickers, M. H. (2015). Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring. Journal of Nutritional Biochemistry, 26(3), 267-276. doi: 10.1016/j.jnutbio.2014.10.015

Reynolds, C. M., Gray, C., Li, M., Segovia, S. A., & Vickers, M. H. (2015). Early life nutrition and energy balance disorders in offspring in later life. Nutrients, 7(9), 8090-8111. doi: 10.3390/nu7095384

Li, M., Reynolds, C. M., Segovia, S. A., Gray, C., & Vickers, M. H. (2015). Developmental programming of nonalcoholic fatty liver disease: The effect of early life nutrition on susceptibility and disease severity in later life. BioMed Research International, 2015, 437107. doi: 10.1155/2015/437107

Reynolds, C. M., Segovia, S. A., Zhang, X. D., Gray, C., & Vickers, M. H. (2015). Conjugated linoleic acid supplementation during pregnancy and lactation reduces maternal high-fat-diet-induced programming of early-onset puberty and hyperlipidemia in female rat offspring. Biology of Reproduction, 92(2), 40. doi: 10.1095/biolreprod.114.125047

Reynolds, C. M., Li, M., Gray, C., & Vickers, M. H. (2014). Early-life growth hormone treatment to offspring of undernourished mothers alters metabolic parameters in primary adipocytes in adulthood. Growth Factors, 32(1), 34-40. doi: 10.3109/08977194.2013.870169

Reynolds, C. M., Vickers, M. H., Harrison, C. J., Segovia, S. A., & Gray, C. (2014). High fat and/or high salt intake during pregnancy alters maternal meta-inflammation and offspring growth and metabolic profiles. Physiological Reports, 2(8), e12110. doi: 10.14814/phy2.12110

Segovia, S. A., Vickers, M. H., Gray, C., & Reynolds, C. M. (2014). Maternal obesity, inflammation, and developmental programming. BioMed Research International, 2014, 418975. doi: 10.1155/2014/418975

Gray, C., Li, M., Patel, R., Reynolds, C. M., & Vickers, M. H. (2014). Let-7 miRNA profiles are associated with the reversal of left ventricular hypertrophy and hypertension in adult male offspring from mothers undernourished during pregnancy after preweaning growth hormone treatment. Endocrinology, 155(12), 4808-4817. doi: 10.1210/en.2014-1567

Reynolds, C. M., Li, M., Gray, C., & Vickers, M. H. (2013). Preweaning growth hormone treatment ameliorates adipose tissue insulin resistance and inflammation in adult male offspring following maternal undernutrition. Endocrinology, 154(8), 2676-2686. doi: 10.1210/en.2013-1146

Gray, C., Li, M., Reynolds, C. M., & Vickers, M. H. (2013). Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy. PLoS ONE, 8(1), e53505. doi: 10.1371/journal.pone.0053505

Reynolds, C. M., Li, M., Gray, C., & Vickers, M. H. (2013). Pre-weaning growth hormone treatment ameliorates bone marrow macrophage inflammation in adult male rat offspring following maternal undernutrition. PLoS ONE, 8(7), e68262. doi: 10.1371/journal.pone.0068262

Gray, C., Al-Dujaili, E. A., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J. M., & Gardner, D. S. (2013). Excess maternal salt intake produces sex-specific hypertension in offspring: Putative roles for kidney and gastrointestinal sodium handling. PLoS ONE, 8(8), e72682. doi: 10.1371/journal.pone.0072682

Gray, C., Long, S., Green, C., Gardiner, S. M., Craigon, J., & Gardner, D. S. (2013). Maternal fructose and/or salt intake and reproductive outcome in the rat: Effects on growth, fertility, sex ratio, and birth order. Biology of Reproduction, 89(3), 51. doi: 10.1095/biolreprod.113.109595

Li, M., Reynolds, C. M., Sloboda, D. M., Gray, C., & Vickers, M. H. (2013). Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity. PLoS ONE, 8(10), e76961. doi: 10.1371/journal.pone.0076961

Rhodes, P., Craigon, J., Gray, C., Rhind, S. M., Loughna, P. T., & Gardner, D. S. (2009). Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PLoS ONE, 4(10), e7393. doi: 10.1371/journal.pone.0007393

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Journal - Research Other

Saito-Benz, M., Gray, C., Tzeng, Y.-C., Atkinson, G., & Berry, M. J. (2018). Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates [Brief report]. Acta Paediatrica. Advance online publication. doi: 10.1111/apa.14631

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