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Otago Medical School staff profiles

Associate Professor Esko Wiltshire

PositionAssociate Professor
DepartmentDepartment of Paediatrics and Child Health (UOW)
QualificationsMB ChB DipObst (Otago) Dip Paed (Auck) FRACP
Research summaryPaediatrics and diabetes

Research

Associate Professor Wiltshire's primary areas of research involve investigation of the acute and chronic complications of diabetes, particularly their pathophysiology and early development, and also treatment. In this work Associate Professor Wiltshire has a major collaboration with Professor J Couper in South Australia. The aims of this research are to identify factors involved in the early pathogenesis of the vascular complications of diabetes, when interventions will have the greatest effect.

In addition Associate Professor Wiltshire is a collaborator in the Australasian arm of 'TrialNet', a major international collaboration investigating treatments to prevent type 1 diabetes, and collaborates with Professor K Donaghue in Sydney, addressing aspects of autonomic dysfunction in children with diabetes.

IIn addition, Associate Professor Wiltshire has interests in other aspects of clinical paediatric endocrinology and metabolism, and has published scientific articles concerning clinical aspects of paediatric bone/calcium homeostasis, adrenal function and mitochondrial disease.

Publications

Peña, A. S., Wiltshire, E., MacKenzie, K., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2006). Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children. Journal of Clinical Endocrinology & Metabolism, 91(11), 4467-4471.

MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2006). Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics, 118, 242-253.

Peña, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care, 30(8), 2122-2127.

Newton, K. H., Wiltshire, E. J., & Elley, C. R. (2009). Pedometers and text messaging to increase physical activity: Randomized controlled trial of adolescents with type 1 diabetes. Diabetes Care, 32(5), 813-815. doi: 10.2337/dc08-1974

Calvo, S. E., Tucker, E. J., Compton, A. G., Kirby, D. M., Crawford, G., Burtt, N. P., … Wiltshire, E., … Mootha, V. K. (2010). High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nature Genetics, 42(10), 851-858. doi: 10.1038/ng.659

Journal - Research Article

McTavish, L., & Wiltshire, E. (2011). Effective treatment of hypoglycemia in children with type 1 diabetes: A randomized controlled clinical trial. Pediatric Diabetes, 12(4pt2), 381-387. doi: 10.1111/j.1399-5448.2010.00725.x

Calvo, S. E., Tucker, E. J., Compton, A. G., Kirby, D. M., Crawford, G., Burtt, N. P., … Wiltshire, E., … Mootha, V. K. (2010). High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nature Genetics, 42(10), 851-858. doi: 10.1038/ng.659

Peña, A. S., Belobrajdic, D. P., Wiltshire, E., Gent, R., Hirte, C., & Couper, J. (2010). Adiponectin relates to smooth muscle function and folate in obese children. International Journal of Pediatric Obesity, 5(2), 185-191. doi: 10.3109/17477160903111748

MacKenzie, K. E., Wiltshire, E. J., Peña, A. S., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2009). Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes. Pediatric Diabetes, 10(1), 44-51. doi: 10.1111/j.1399-5448.2008.00456.x

Newton, K. H., Wiltshire, E. J., & Elley, C. R. (2009). Pedometers and text messaging to increase physical activity: Randomized controlled trial of adolescents with type 1 diabetes. Diabetes Care, 32(5), 813-815. doi: 10.2337/dc08-1974

Wiltshire, E. J., Mohsin, F., Chan, A., & Donaghue, K. C. (2008). Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes. Pediatric Diabetes, 9(4, Part II), 348-353.

Wiltshire, E., Davidzon, G., DiMauro, S., Akman, H. O., Sadleir, L., Haas, L., Zuccollo, J., McEwen, A., & Thorburn, D. R. (2008). Juvenile Alpers disease. Archives of Neurology, 65(1), 121-124. doi: 10.1001/archneurol.2007.14

Gleeson, H., Wiltshire, E., Briody, J., Hall, J., Chaitow, J., Sillence, D., … Munns, C. (2008). Childhood chronic recurrent multifocal osteomyelitis: Pamidronate therapy decreases pain and improves vertebral shape. Journal of Rheumatology, 35(4), 707-712.

Fox, L., Sadowsky, J., Pringle, K. C., Kidd, A., Murdoch, J., Cole, D. E. C., & Wiltshire, E. (2007). Neonatal hyperparathyroidism and pamidronate therapy in an extremely premature infant. Pediatrics, 120(5), e1350-e1354.

Wilson, C., Kerruish, N. J., Wilcken, B., Wiltshire, E., & Webster, D. (2007). The failure to diagnose inborn errors of metabolism in New Zealand: The case for expanded newborn screening. New Zealand Medical Journal, 120(1262). Retrieved from http://journal.nzma.org.nz/journal/120-1262/2727/content.pdf

Peña, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care, 30(8), 2122-2127.

Wiltshire, E. J., Newton, K., & McTavish, L. (2006). Unrecognised hypoglycaemia in children and adolescents with type 1 diabetes using the continuous glucose monitoring system: Prevalence and contributors. Journal of Paediatrics & Child Health, 42, 758-763.

Scott, A., Toomath, R., Bouchier, D., Bruce, R., Crook, N., Carroll, D., … Lunt, H., Wiltshire, E., & Wu, D. (2006). First national audit of the outcomes of care in young people with diabetes in New Zealand: High prevalence of nephropathy in Māori and Pacific Islanders. New Zealand Medical Journal, 119(1235). Retrieved from http://journal.nzma.org.nz/journal/119-1235/2015/content.pdf

Peña, A. S., Wiltshire, E., MacKenzie, K., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2006). Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children. Journal of Clinical Endocrinology & Metabolism, 91(11), 4467-4471.

MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2006). Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics, 118, 242-253.

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Journal - Research Other

Gallego, P. H., Wiltshire, E., & Donaghue, K. C. (2007). Identifying children at particular risk of long-term diabetes complications. Pediatric Diabetes, 8(Suppl. 6), 40-48.

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