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Otago Medical School staff profiles

Associate Professor Ivan Sammut

PositionAssociate Professor
DepartmentDepartment of Pharmacology and Toxicology
QualificationsBSc(Hons) PhD
Research summaryPharmacological Targets in Cardiovascular and Renal Disease

Research

Interests: cardiomyopathies, ischaemic heart disease, heart failure, ischaemic neurodegeneration, mitochondrial dysfunction and heme oxygenase

Main areas of Research:

  • Cardiac and Renal failure following MI.
  • Apoptosis and Mitochondrial Dysfunction Consequent to Ischaemia-Reperfusion Injury in Organ Grafts/Vascular Ligation Models.
  • Protection Of Myocardial Function and Mitochondrial Energetics from Ischaemia-Reperfusion Injury.
  • Mitochondrial Pathophysiology in Neurodegeneration and Stroke Injury
  • Neuroprotective Effects of Pharmacological Agents following Hypoxia-Ischaemia-induced Brain Damage.
  • Cardiovascular Effects following Hypoxia-Ischaemia-Induced Brain Damage.
  • Vascular Pathophysiology

Publications

Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f

Read, M. I., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. British Journal of Pharmacology, 172, 4626-4638. doi: 10.1111/bph.13132

Read, M. I., McCann, D. M., Millen, R. N., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Progressive development of cardiomyopathy following altered autonomic activity in status epilepticus. American Journal of Physiology: Heart & Circulatory Physiology, 309(9), H1554-H1564. doi: 10.1152/ajpheart.00256.2015

Yao, Y., Fomison-Nurse, I. C., Harrison, J. C., Walker, R. J., Davis, G., & Sammut, I. A. (2014). Chronic bilateral renal denervation attenuates renal injury in a transgenic rat model of diabetic nephropathy. American Journal of Physiology: Renal Physiology, 307, F251-F262. doi: 10.1152/ajprenal.00578.2013

Yao, Y., Davis, G., Harrison, J. C., Walker, R. J., & Sammut, I. A. (2017). Renal functional responses in diabetic nephropathy following chronic bilateral renal denervation. Autonomic Neuroscience, 204, 98-104. doi: 10.1016/j.autneu.2016.09.019

Journal - Research Article

Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f

Yao, Y., Davis, G., Harrison, J. C., Walker, R. J., & Sammut, I. A. (2017). Renal functional responses in diabetic nephropathy following chronic bilateral renal denervation. Autonomic Neuroscience, 204, 98-104. doi: 10.1016/j.autneu.2016.09.019

Read, M. I., McCann, D. M., Millen, R. N., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Progressive development of cardiomyopathy following altered autonomic activity in status epilepticus. American Journal of Physiology: Heart & Circulatory Physiology, 309(9), H1554-H1564. doi: 10.1152/ajpheart.00256.2015

Read, M. I., Harrison, J. C., Kerr, D. S., & Sammut, I. A. (2015). Atenolol offers better protection than clonidine against cardiac injury in kainic acid-induced status epilepticus. British Journal of Pharmacology, 172, 4626-4638. doi: 10.1111/bph.13132

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Kumari, S., Sammut, I. A., & Giles, G. I. (2014). The design of nitric oxide donor drugs: S-nitrosothiol tDodSNO is a superior photoactivated donor in comparison to GSNO and SNAP. European Journal of Pharmacology, 737, 168-176. doi: 10.1016/j.ejphar.2014.05.012

Read, M. I., Andreianova, A. A., Harrison, J. C., Goulton, C. S., Sammut, I. A., & Kerr, D. S. (2014). Cardiac electrographic and morphological changes following status epilepticus: Effect of clonidine. Seizure, 23(1), 55-61. doi: 10.1016/j.seizure.2013.09.012

Yao, Y., Fomison-Nurse, I. C., Harrison, J. C., Walker, R. J., Davis, G., & Sammut, I. A. (2014). Chronic bilateral renal denervation attenuates renal injury in a transgenic rat model of diabetic nephropathy. American Journal of Physiology: Renal Physiology, 307, F251-F262. doi: 10.1152/ajprenal.00578.2013

Garrett, A. T., Goosens, N. G., Rehrer, N. J., Patterson, M. J., Harrison, J., Sammut, I., & Cotter, J. D. (2014). Short-term heat acclimation is effective and may be enhanced rather than impaired by dehydration. American Journal of Human Biology, 26(3), 311-320. doi: 10.1002/ajhb.22509

Sutherland, B. A., Harrison, J. C., Nair, S. M., & Sammut, I. A. (2013). Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia. Current Drug Targets, 14(1), 56-73. doi: 10.2174/138945013804806433

Winburn, I. C., Gunatunga, K., McKernan, R. D., Walker, R. J., Sammut, I. A., & Harrison, J. C. (2012). Cell damage following carbon monoxide releasing molecule exposure: Implications for therapeutic applications. Basic & Clinical Pharmacology & Toxicology, 111(1), 31-41. doi: 10.1111/j.1742-7843.2012.00856.x

Sutherland, B. A., Shaw, O. M., Clarkson, A. N., Winburn, I. C., Errington, A. C., Dixon, C. L., Lees, G., Sammut, I. A., & Appleton, I. (2011). Tin protoporphyrin provides protection following cerebral hypoxia-ischemia: Involvement of alternative pathways. Journal of Neuroscience Research, 89(8), 1284-1294. doi: 10.1002/jnr.22661

Nair, S. M., Rahman, R. M. A., Clarkson, A. N., Sutherland, B. A., Taurin, S., Sammut, I. A., & Appleton, I. (2011). Melatonin treatment following stroke induction modulates L-arginine metabolism. Journal of Pineal Research, 51(3), 313-323. doi: 10.1111/j.1600-079X.2011.00891.x

Vranyac-Tramoundanas, A., Harrison, J. C., Sawant, P. M., Kerr, D. S., & Sammut, I. A. (2011). Ischemic cardiomyopathy following seizure induction by domoic acid. American Journal of Pathology, 179(1), 141-154. doi: 10.1016/j.ajpath.2011.03.017

Vranyac-Tramoundanas, A., Harrison, J. C., Clarkson, A. N., Kapoor, M., Winburn, I. C., Kerr, D. S., & Sammut, I. A. (2008). Domoic acid impairment of cardiac energetics. Toxicological Sciences, 105(2), 395-407. doi: 10.1093/toxsci/kfn132

Clarkson, A. N., Liu, H., Schiborra, F., Shaw, O., Sammut, I. A., Jackson, D. M., & Appleton, I. (2007). Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. Brain Research, 1171, 111-121.

Clarkson, A. N., Clarkson, J., Jackson, D. M., & Sammut, I. A. (2007). Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. Neuroscience, 144, 547-561.

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