Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Otago Medical School staff profiles

Dr Nadia Mitchell

PositionPostdoctoral Fellow
DepartmentDepartment of Radiology (UOC)
Research summaryBatten disease

Research

Dr Nadia Mitchell is working on a treatment for Batten disease, a fatal inherited childhood neurodegenerative disorder. She leads preclinical gene therapy trials in two naturally occurring sheep models of the disease. Nadia is supervised by Professor Anthony Butler.

Publications

Ella, A., Barriére, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., & Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9(3), 44-51. doi: 10.1093/af/vfz024

Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018). Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy. Advance online publication. doi: 10.1016/j.ymthe.2018.07.015

Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., … Palmer, D. N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain & Behavior. Advance online publication. doi: 10.1002/brb3.1096

Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R. J., & Melzer, T. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology. Advance online publication. doi: 10.1259/bjr.20170593

Best, H. L., Neverman, N. J., Wicky, H. E., Mitchell, N. L., Leitch, B., & Hughes, S. M. (2017). Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics. Neurobiology of Disease, 100, 62-74. doi: 10.1016/j.nbd.2017.01.001

Journal - Research Article

Ella, A., Barriére, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., & Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9(3), 44-51. doi: 10.1093/af/vfz024

Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018). Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy. Advance online publication. doi: 10.1016/j.ymthe.2018.07.015

Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., … Palmer, D. N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain & Behavior. Advance online publication. doi: 10.1002/brb3.1096

Best, H. L., Neverman, N. J., Wicky, H. E., Mitchell, N. L., Leitch, B., & Hughes, S. M. (2017). Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics. Neurobiology of Disease, 100, 62-74. doi: 10.1016/j.nbd.2017.01.001

Perentos, N., Martins, A. Q., Cumming, R. J. M., Mitchell, N. L., Palmer, D. N., Sawiak, S. J., & Morton, A. J. (2016). An EEG investigation of sleep homeostasis in healthy and CLN5 Batten disease affected sheep. Journal of Neuroscience, 36(31), 8238-8249. doi: 10.1523/JNEUROSCI.4295-15.2016

Perentos, N., Martins, A. Q., Watson, T. C., Bartsch, U., Mitchell, N. L., Palmer, D. N., … Morton, A. J. (2015). Translational neurophysiology in sheep: Measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep. Brain, 138(4), 862-874. doi: 10.1093/brain/awv026

Sawiak, S. J., Perumal, S. R., Rudiger, S. R., Matthews, L., Mitchell, N. L., McLaughlin, C. J., … Palmer, D. N., … Morton, A. J. (2015). Rapid and progressive regional brain atrophy in CLN6 Batten disease affected sheep measured with longitudinal magnetic resonance imaging. PLoS ONE, 10(7), e0132331. doi: 10.1371/journal.pone.0132331

Amorim, I. S., Mitchell, N. L., Palmer, D. N., Sawiak, S. J., Mason, R., Wishart, T. M., & Gillingwater, T. H. (2015). Molecular neuropathology of the synapse in sheep with CLN5 Batten disease. Brain & Behavior, 5(11), e00401. doi: 10.1002/brb3.401

Palmer, D. N., Neverman, N. J., Chen, J. Z., Chang, C.-T., Houweling, P. J., Barry, L. A., … Hughes, S. M., & Mitchell, N. L. (2015). Recent studies of ovine neuronal ceroid lipofuscinoses from BARN, the Batten Animal Research Network. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1852(10, Part B), 2279-2286. doi: 10.1016/j.bbadis.2015.06.013

Hughes, S. M., Hope, K. M., Xu, J. B., Mitchell, N. L., & Palmer, D. N. (2014). Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy. Neurobiology of Disease, 62, 543-550. doi: 10.1016/j.nbd.2013.11.011

Linterman, K. S., Palmer, D. N., Kay, G. W., Barry, L. A., Mitchell, N. L., McFarlane, R. G., Black, M. A., … Hughes, S. M. (2011). Lentiviral-mediated gene transfer to the sheep brain: Implications for gene therapy in Batten disease. Human Gene Therapy, 22(8), 1011-1020. doi: 10.1089/hum.2011.026

^ Top of page

Journal - Research Other

Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R. J., & Melzer, T. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology. Advance online publication. doi: 10.1259/bjr.20170593

More publications...