Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Otago Medical School staff profiles

Dr Kirsty Danielson

PositionLecturer
DepartmentDepartment of Surgery and Anaesthesia (Wellington)
QualificationsBBmedSc PhD
Research summaryColorectal cancer; disease biomarkers

Research

I completed both my BBMedSc and PhD at Victoria University of Wellington before undertaking a post-doctoral fellowship at Beth Israel Deaconess Medical Centre, Harvard Medical School in Boston, USA. My research during this time focused on the use of extracellular vesicles and small non-coding RNAs in the plasma as functional biomarkers for cardiovascular and metabolic disease. In 2017 I returned to Wellington and joined the University of Otago as a Lecturer in the Department of Surgery and Anaesthesia.

My current research interests include the use of extracellular vesicles and RNA as plasma biomarkers for risk stratification and prediction of response to therapy in patient groups, and their mechanisms of function in cellular models of disease. Working with surgeons based at University of Otago and Wellington Hospital as a part of the Surgical Cancer Research Group, I am involved in several projects investigating novel biomarkers in colorectal cancer.

Publications

Murillo, O. D., Thistlethwaite, W., Rozowsky, J., Subramanian, S. L., Lucero, R., Shah, N., … Danielson, K. M., … Milosavljevic, A. (2019). ExRNA Atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids. Cell, 177, 463-477. doi: 10.1016/j.cell.2019.02.018

Srinivasan, S., Yeri, A., Cheah, P. S., Chung, A., Danielson, K., De Hoff, P., … Laurent, L. C. (2019). Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation. Cell, 177, 446-462. doi: 10.1016/j.cell.2019.03.024

Danielson, K. M., Shah, R., Yeri, A., Liu, X., Garcia, F. C., Silverman, M., … Das, S. (2018). Plasma circulating extracellular RNAs in left ventricular remodeling post-myocardial infarction. EBioMedicine. Advance online publication. doi: 10.1016/j.ebiom.2018.05.013

Manning, S., & Danielson, K. M. (2018). The immunomodulatory role of tumour-derived extracellular vesicles in colorectal cancer. Immunology & Cell Biology, 96(7), 733-741. doi: 10.1111/imcb.12038

Danielson, K. M., Rubio, R., Abderazzaq, F., Das, S., & Wang, Y. E. (2017). High throughput sequencing of extracellular RNA from human plasma. PLoS ONE, 12(1), e0164644. doi: 10.1371/journal.pone.0164644

Chapter in Book - Research

Kivell, B. M., & Danielson, K. (2016). Neurological effects of nicotine, tobacco, and particulate matter. In V. R. Preedy (Ed.), Neuropathology of drug addictions and substance misuse (Vol. 1: Foundations of understanding, tobacco, alcohol, cannabinoids and opioids). (pp. 115-122). London, UK: Academic Press. doi: 10.1016/B978-0-12-800213-1.00011-0

^ Top of page

Journal - Research Article

Murillo, O. D., Thistlethwaite, W., Rozowsky, J., Subramanian, S. L., Lucero, R., Shah, N., … Danielson, K. M., … Milosavljevic, A. (2019). ExRNA Atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids. Cell, 177, 463-477. doi: 10.1016/j.cell.2019.02.018

Srinivasan, S., Yeri, A., Cheah, P. S., Chung, A., Danielson, K., De Hoff, P., … Laurent, L. C. (2019). Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation. Cell, 177, 446-462. doi: 10.1016/j.cell.2019.03.024

Danielson, K. M., Shah, R., Yeri, A., Liu, X., Garcia, F. C., Silverman, M., … Das, S. (2018). Plasma circulating extracellular RNAs in left ventricular remodeling post-myocardial infarction. EBioMedicine. Advance online publication. doi: 10.1016/j.ebiom.2018.05.013

Manning, S., & Danielson, K. M. (2018). The immunomodulatory role of tumour-derived extracellular vesicles in colorectal cancer. Immunology & Cell Biology, 96(7), 733-741. doi: 10.1111/imcb.12038

Danielson, K. M., Rubio, R., Abderazzaq, F., Das, S., & Wang, Y. E. (2017). High throughput sequencing of extracellular RNA from human plasma. PLoS ONE, 12(1), e0164644. doi: 10.1371/journal.pone.0164644

Shah, R., Murthy, V., Pacold, M., Danielson, K., Tanriverdi, K., Larson, M. G., … Freedman, J. E. (2017). Extracellular RNAs are associated with insulin resistance and metabolic phenotypes. Diabetes Care, 40(4), 546-553. doi: 10.2337/dc16-1354

Jones, A., Danielson, K. M., Benton, M. C., Ziegler, O., Shah, R., Stubbs, R. S., … Macartney-Coxson, D. (2017). miRNA signatures of insulin resistance in obesity. Obesity, 25(10), 1734-1744. doi: 10.1002/oby.21950

Freedman, J. E., Gerstein, M., Mick, E., Rozowsky, J., Levy, D., Kitchen, R., … Danielson, K., … Tanriverdi, K. (2016). Diverse human extracellular RNAs are widely detected in human plasma. Nature Communications, 7, 11106. doi: 10.1038/ncomms11106

Shah, R. V., Murthy, V. L., Allison, M. A., Ding, J., Budoff, M., Frazier-Wood, A. C., … Danielson, K., … Mozaffarian, D. (2016). Diet and adipose tissue distributions: The Multi-Ethnic Study of Atherosclerosis. Nutrition, Metabolism & Cardiovascular Diseases, 26(3), 185-193. doi: 10.1016/j.numecd.2015.12.012

Danielson, K. M., Estanislau, J., Tigges, J., Toxavidis, V., Camacho, V., Felton, E. J., … Ghiran, I. (2016). Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry. PLoS ONE, 11(1), e0144678. doi: 10.1371/journal.pone.0144678

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., … Das, S. (2015). Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study. Circulation, 131(25), 2202-2216. doi: 10.1161/CIRCULATIONAHA.114.013220

Danielson, K., Putt, F., Truman, P., & Kivell, B. M. (2014). The effects of nicotine and tobacco particulate matter on dopamine uptake in the rat brain. Synapse, 68(2), 45-60. doi: 10.1002/syn.21715

Danielson, K., Truman, P., & Kivell, B. M. (2011). The effects of nicotine and cigarette smoke on the monoamine transporters. Synapse, 65(9), 866-879. doi: 10.1002/syn.20914

^ Top of page

Journal - Research Other

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., … Das, S. (2016). Response to letter regarding article, "Circulating MicroRNA-30d is Associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study". Circulation, 133(6), e389-e390. doi: 10.1161/CIRCULATIONAHA.115.019228

Quesenberry, P. J., Aliotta, J., Camussi, G., Abdel-Mageed, A. B., Wen, S., Goldberg, L., … Danielson, K., … Dooner, M. (2015). Potential functional applications of extracellular vesicles: A report by the NIH Common Fund Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles, 4(1), 27575. doi: 10.3402/jev.v4.27575

Laurent, L. C., Abdel-Mageed, A. B., Adelson, P. D., Arango, J., Balaj, L., Breakefield, X., … Danielson, K., … Gould, S. (2015). Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles, 4(1), 26533. doi: 10.3402/jev.v4.26533

Danielson, K. M., & Das, S. (2014). Extracellular vesicles in heart disease: Excitement for the future? Exosomes & Microvesicles, 2, 1. doi: 10.5772/58390

More publications...