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Otago Medical School staff profiles

Gill Hughes

PositionAssistant Research Fellow
DepartmentDepartment of Physiology

Publications

Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology. Advance online publication. doi: 10.1113/EP087437

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology. Advance online publication. doi: 10.1113/ep087054

McRobb, L. S., McGrath, K. C. Y., Tsatralis, T., Liong, E. C., Tan, J. T. M., Hughes, G., … Heather, A. K. (2017). Estrogen receptor control of atherosclerotic calcification and smooth muscle cell osteogenic differentiation. Arteriosclerosis, Thrombosis, & Vascular Biology, 37(6), 1127-1137. doi: 10.1161/atvbaha.117.309054

Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Journal - Research Article

Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology. Advance online publication. doi: 10.1113/EP087437

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology. Advance online publication. doi: 10.1113/ep087054

McRobb, L. S., McGrath, K. C. Y., Tsatralis, T., Liong, E. C., Tan, J. T. M., Hughes, G., … Heather, A. K. (2017). Estrogen receptor control of atherosclerotic calcification and smooth muscle cell osteogenic differentiation. Arteriosclerosis, Thrombosis, & Vascular Biology, 37(6), 1127-1137. doi: 10.1161/atvbaha.117.309054

Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Han, S. Y., Gray, E., Hughes, G., Brown, C. H., & Schwenke, D. O. (2014). Increased sympathetic drive during the onset of hypertension in conscious Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 466(3), 459-466. doi: 10.1007/s00424-013-1338-5

Josephs, T. M., Liptak, M. D., Hughes, G., Lo, A., Smith, R. M., Wilbanks, S. M., … Ledgerwood, E. C. (2013). Conformational change and human cytochrome c function: Mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination. Journal of Biological Inorganic Chemistry, 18, 289-297. doi: 10.1007/s00775-012-0973-1

Morison, I. M., Cramer Bordé, E. M., Cheesman, E. J., Cheong, P. L., Holyoake, A. J., Fichelson, S., Weeks, R. J., Lo, A., Davies, S. M. K., Wilbanks, S. M., Fagerlund, R. D., Ludgate, M. W., da Silva Tatley, F. M., Coker, M. S. A., Bockett, N. A., Hughes, G., Pippig, D. A., Smith, M. P., … Ledgerwood, E. C. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics, 40(4), 387-389. doi: 10.1038/ng.103

Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radical Biology & Medicine, 44(6), 1001-1009. doi: 10.1016/j.freeradbiomed.2007.11.017

Hughes, G., Murphy, M. P., & Ledgerwood, E. C. (2005). Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor κB to modulate tumour necrosis factor-induced apoptosis: Evidence from mitochondria-targeted antioxidants. Biochemical Journal, 389, 83-89.

Smith, R. A. J., Kelso, G. F., Blaikie, F. H., Porteous, C. M., Ledgerwood, E. C., Hughes, G., … Filipovska, A., & Murphy, M. P. (2003). Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences. Biochemical Society Transactions, 31, 1295-1299.

Murphy, M. P., Echtay, K. S., Blaikie, F. H., Asin-Cayuela, J., Cochemé, H. M., Green, K., … Hughes, G., … Smith, R. A. J., & Brand, M. D. (2003). Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation. Journal of Biological Chemistry, 278(49), 48534-48545.

Kelso, G. F., Porteous, C. M., Hughes, G., Ledgerwood, E. C., Gane, A. M., Smith, R. A. J., & Murphy, M. P. (2002). Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants. Annals of the New York Academy of Sciences, 959, 263-274.

Lin, T.-K., Hughes, G., Muratovska, A., Blaikie, F. H., Brookes, P. S., Darley-Usmar, V., Smith, R. A. J., & Murphy, M. P. (2002). Specific Modification of Mitochondrial Protein Thiols in Response to Oxidative Stress. Journal of Biological Chemistry, 277(19), 17048-17056.

Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001). Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapopotic properties. Journal of Biological Chemistry, 276(7), 4588-4596.

Swain, A., Jeffery, P., Hughes, G., & Nowitz, M. R. (2001). Another cause for bilateral haemorrhagic otorrhoea following trauma. Emergency Medicine, 13, 247-250.

Scarlett, J. L., Sheard, P. W., Hughes, G., Ledgerwood, E. C., Ku, H.-H., & Murphy, M. P. (2000). Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells. FEBS Letters, 475, 267-272.

Appleby, R. D., Porteous, W. K., Hughes, G., James, A. M., Shannon, D., Wei, Y.-H., & Murphy, M. P. (1999). Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA. European Journal of Biochemistry, 262(1), 108-116.

McNaughton, J. C., Cockburn, D. J., Hughes, G., Jones, W. A., Laing, N. G., Ray, P. N., Stockwell, P. A., & Petersen, G. B. (1998). Is gene deletion in eukaryotes sequence-dependent? A study of nine deletion junctions and nineteen other deletion breakpoints in intron 7 of the human dystrophin gene. Gene, 222, 41-51.

McNaughton, J. C., Hughes, G., Jones, W. A., Stockwell, P. A., Klamut, H. J., & Petersen, G. B. (1997). The evolution of an intron: analysis of a long, deletion-prone intron in the human dystrophin gene. Genomics, 40(2), 294-304.

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