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Otago Medical School staff profiles

Associate Professor Timothy Yandle

PositionResearch Associate Professor
DepartmentDepartment of Medicine (UOC)
QualificationsBSc(Hons) PhD(Cant)
Research summaryCardioendocrinology

Research

Tim Yandle is a biochemist and senior member of the Christchurch Heart Institute. He established the CHI biochemistry laboratory that provides analytical support for many of the Institute's research studies. His research interests include the identification of secreted and circulating forms of peptide hormones and their metabolism. These studies have identified new peptides in blood that are now used to diagnose heart disease.

Publications

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry. Advance online publication. doi: 10.1373/clinchem.2019.302547

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341

Liew, O. W., Yandle, T. G., Chong, J. P. C., Ng, Y. X., Frampton, C. M., Ng, T. P., … Richards, A. M. (2016). High-sensitivity sandwich ELISA for plasma NT-proUcn2: Plasma concentrations and relationship to mortality in heart failure. Clinical Chemistry, 62(6), 856-865. doi: 10.1373/clinchem.2015.252932

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

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Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry. Advance online publication. doi: 10.1373/clinchem.2019.302547

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341

Liew, O. W., Yandle, T. G., Chong, J. P. C., Ng, Y. X., Frampton, C. M., Ng, T. P., … Richards, A. M. (2016). High-sensitivity sandwich ELISA for plasma NT-proUcn2: Plasma concentrations and relationship to mortality in heart failure. Clinical Chemistry, 62(6), 856-865. doi: 10.1373/clinchem.2015.252932

Yandle, T. G., & Richards, A. M. (2015). B-Type natriuretic peptide circulating forms: Analytical and bioactivity issues [Invited critical review]. Clinica Chimica Acta, 448, 195-205. doi: 10.1016/j.cca.2015.07.004

Lampinen, K. H., Rönnback, M., Groop, P.-H., Nicholls, M. G., Yandle, T. G., & Kaaja, R. J. (2014). Increased plasma norepinephrine levels in previously pre-eclamptic women. Journal of Human Hypertension, 28(4), 269-273. doi: 10.1038/jhh.2013.84

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). Endogenous ouabain is not ouabain. Hypertension, 64, 680-683. doi: 10.1161/hypertensionaha.114.03919

Mahagamasekera, P. G., Ruygrok, P. N., Palmer, S. C., Richards, A. M., Ansell, G. S., Nicholls, M. G., Pemberton, C. J., Lewis, L. K., & Yandle, T. G. (2014). B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: Evidence for degradation before secretion. Clinical Chemistry, 60(3), 549-558. doi: 10.1373/clinchem.2013.210435

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Pilbrow, A. P., Cordeddu, L., Cameron, V. A., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Foo, R. S.-Y. (2014). Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. International Journal of Cardiology, 176, 375-385. doi: 10.1016/j.ijcard.2014.07.068

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Palmer, S. C., Troughton, R. W., & Richards, A. M. (2013). Comparison of immunoassays for NTproBNP conducted on three analysis systems: Milliplex, Elecsys and RIA. Clinical Biochemistry, 46(4-5), 388-390. doi: 10.1016/j.clinbiochem.2012.11.022

Adem, A., Al Haj, A., Benedict, S., Yasin, J., Nagelkerke, N., Nyberg, F., Yandle, T. G., Frampton, C. M., Lewis, L. K., Nicholls, M. G., & Kazzam, E. (2013). ANP and BNP responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system. PLoS ONE, 8(3), e57806. doi: 10.1371/journal.pone.0057806

Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059

Palmer, B. R., Frampton, C. M., Skelton, L., Yandle, T. G., Doughty, R. N., Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients. Journal of Cardiovascular Electrophysiology, 23(3), 319-324. doi: 10.1111/j.1540-8167.2011.02192.x

Pemberton, C. J., Siriwardena, M., Kleffmann, T., Ruygrok, P., Palmer, S. C., Yandle, T. G., & Richards, A. M. (2012). First identification of circulating Prepro-A-Type natriuretic peptide (PreproANP) signal peptide fragments in humans: Initial assessment as cardiovascular biomarkers. Clinical Chemistry, 58(4), 757-767. doi: 10.1373/clinchem.2011.176990

Braithwaite, J. E., Yandle, T. G., Nicholls, M. G., & Lewis, L. K. (2012). Interference by o-phenanthroline in the radioimmunoassay of angiotensin II in small volume blood samples. Clinical Biochemistry, 45(1-2), 168-170. doi: 10.1016/j.clinbiochem.2011.10.008

Patel, K., Rademaker, M. T., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T. G., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166(6), 1916-1925. doi: 10.1111/j.1476-5381.2012.01904.x

Ali, M. A., Adem, A., Chandranath, I. S., Benedict, S., Pathan, J. Y., Nagelkerke, N., … Lewis, L. K., Yandle, T. G., Nicholls, M. G., Frampton, C. M., & Kazzam, E. (2012). Responses to dehydration in the one-humped camel and effects of blocking the renin-angiotensin system. PLoS ONE, 7(5), e37299. doi: 10.1371/journal.pone.0037299

Ellis, K. L., Palmer, B. R., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Pilbrow, A. P., Skelton, L., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2012). Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. Journal of Human Hypertension, 27, 237-244. doi: 10.1038/jhh.2012.24

Ellis, K. L., Pilbrow, A. P., Potter, H. C., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Palmer, B. R., Skelton, L., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). Association between endothelin type A receptor haplotypes and mortality in coronary heart disease. Personalized Medicine, 9(3), 341-349. doi: 10.2217/PME.12.10

Pawar, R., Kemp, W., Roberts, S., Krum, H., Yandle, T., & Hardikar, W. (2011). Urotensin II levels are an important marker for the severity of portal hypertension in children. Journal of Pediatric Gastroenterology & Nutrition, 53(1), 88-92. doi: 10.1097/MPG.0b013e3182153900

Ellis, K. L., Newton-Cheh, C., Wang, T. J., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Skelton, L., Davis, N., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2011). Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes. Journal of Molecular & Cellular Cardiology, 50(4), 695-701. doi: 10.1016/j.yjmcc.2011.01.010

Prickett, T. C. R., Bothwell, J. C., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Pharmacodynamic responses of plasma and tissue C-type natriuretic peptide to GH: Correlation with linear growth in GH-deficient rats. Journal of Endocrinology, 15, 217-225. doi: 10.1530/joe-11-0387

Troughton, R. W., Lewis, L. K., Yandle, T. G., Pemberton, C. J., & Nicholls, M. G. (2011). B-type natriuretic peptides: Looking to the future. Annals of Medicine, 43(3), 188-197. doi: 10.3109/07853890.2010.526630

Ellis, K. L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Skelton, L., Thomson, J. A., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011). Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease. Circulation: Cardiovascular Genetics, 4(6), 636-646. doi: 10.1161/circgenetics.111.960336

Schouten, B. J., Prickett, T. C. R., Hooper, A. A., Hooper, G. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Central and peripheral forms of C-type natriuretic peptide (CNP): Evidence for differential regulation in plasma and cerebrospinal fluid. Peptides, 32(4), 797-804. doi: 10.1016/j.peptides.2011.01.013

Jarvis, M. D., Palmer, B. R., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., … Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients. Clinical & Experimental Pharmacology & Physiology, 37(2), 193-198. doi: 10.1111/j.1440-1681.2009.05261.x

Prickett, T. C. R., Ryan, J. F., Wellby, M., Barrell, G. K., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: Evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. Metabolism, 59(6), 796-801. doi: 10.1016/j.metabol.2009.09.026

Ellis, K. L., Pilbrow, A. P., Frampton, C. M., Doughty, R. N., Whalley, G. A., Ellis, C. J., Palmer, B. R., Skelton, L., Yandle, T. G., Palmer, S. C., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2010). A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circulation: Cardiovascular Genetics, 3(3), 286-293. doi: 10.1161/circgenetics.109.917443

Tang, W. H. W., Shrestha, K., Martin, M. G., Borowski, A. G., Jasper, S., Yandle, T. G., Richards, A. M., … Troughton, R. W. (2010). Clinical significance of endogenous vasoactive neurohormones in chronic systolic heart failure. Journal of Cardiac Failure, 16(8), 635-640. doi: 10.1016/j.cardfail.2010.03.011

Shrestha, K., Troughton, R. W., Borowski, A. G., Yandle, T. G., Richards, A. M., Klein, A. L., & Tang, W. H. W. (2010). Plasma corin levels provide minimal prognostic utility incremental to natriuretic peptides in chronic systolic heart failure. Journal of Cardiac Failure, 16(8), 621-627. doi: 10.1016/j.cardfail.2010.03.010

Lainchbury, J. G., Troughton, R. W., Strangman, K. M., Frampton, C. M., Pilbrow, A., Yandle, T. G., … Nicholls, M. G., & Richards, A. M. (2010). N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: Results from the BATTLESCARRED (NT-proBNP-assisted treatment to lessen serial cardiac readmissions and death) trial. JACC, 55(1), 53-60. doi: 10.1016/j.jacc.2009.02.095

Siriwardena, M., Kleffmann, T., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). B-type natriuretic peptide signal peptide circulates in human blood. Evaluation as a potential biomarker of cardiac ischemia. Circulation, 122, 255-264. doi: 10.1161/CIRCULATIONAHA.109.909937

Nicholls, M. G., Lewis, L. K., Yandle, T. G., Lord, G., Mckinnon, W., & Hilton, P. J. (2009). Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy? Journal of Hypertension, 27(1), 3-8. doi: 10.1097/HJH.0b013e32831101d1

Chen, Y.-H., Yandle, T. G., Richards, A. M., & Palmer, S. C. (2009). Urotensin II immunoreactivity in the human circulation: Evidence for widespread tissue release. Clinical Chemistry, 55(11), 2040-2048. doi: 10.1373/clinchem.2009.131748

Palmer, S. C., Prickett, T. C. R., Espiner, E. A., Yandle, T. G., & Richards, A. M. (2009). Regional release and clearance of C-type natriuretic peptides in the human circulation and relation to cardiac function. Hypertension, 54(3), 612-618. doi: 10.1161/HYPERTENSIONAHA.109.135608

Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2009). Intermedin (Adrenomedullin-2): A potential protective role in human aortic endothelial cells. Cellular Physiology & Biochemistry, 23(1-3), 97-108.

Palmer, S. C., Endre, Z. H., Richards, A. M., & Yandle, T. G. (2009). Characterization of NT-proBNP in human urine. Clinical Chemistry, 55(6), 1126-1134. doi: 10.1373/clinchem.2008.121673

Wright, S. P., Doughty, R. N., Frampton, C. M., Gamble, G. D., Yandle, T. G., & Richards, A. M. (2009). Plasma urocortin 1 in human heart failure. Circulation: Heart Failure, 2(5), 465-471. doi: 10.1161/circheartfailure.108.840207

Palmer, S. C., Yandle, T. G., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2009). Regional clearance of amino-terminal pro-brain natriuretic peptide from human plasma. European Journal of Heart Failure, 11, 832-839. doi: 10.1093/eurjhf/hfp099

McNeill, B. A., Barrell, G. K., Wellby, M., Prickett, T. C. R., Yandle, T. G., & Espiner, E. A. (2009). C-type natriuretic peptide forms in pregnancy: Maternal plasma profiles during ovine gestation correlate with placental and fetal maturation. Endocrinology, 150(10), 4777-4783. doi: 10.1210/en.2009-0176

Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., … Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31

Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j.peptides.2009.07.023

Palmer, S. C., Yandle, T. G., Frampton, C. M., Troughton, R. W., Nicholls, M. G., & Richards, A. M. (2009). Renal and cardiac function for long-term (10 year) risk stratification after myocardial infarction. European Heart Journal, 30, 1486-1494. doi: 10.1093/eurheartj/ehp132

Hillock, R. J., Frampton, C. M., Yandle, T. G., Troughton, R. W., Lainchbury, J. G., & Richards, A. M. (2008). B-type natriuretic peptide infusions in acute myocardial infarction. Heart, 94(5), 617-622. doi: 10.1136/hrt.2006.110239

Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Skelton, L., Nicholls, M. G., & Richards, A. M. (2008). Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. European Heart Journal, 29, 2489-2496. doi: 10.1093/eurheartj/ehn383

Charles, C. J., Katafuchi, T., Yandle, T. G., & Minamino, N. (2008). Identification and biological activity of ovine and caprine calcitonin receptor-stimulating peptides 1 and 2. Journal of Endocrinology, 198(2), 429-437. doi: 10.1677/JOE-08-0106

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2008). Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. American Heart Journal, 156(4), 752-758. doi: 10.1016/j.ahj.2008.06.013

Prickett, T. C. R., Dixon, B., Frampton, C., Yandle, T. G., Richards, A. M., Espiner, E. A., & Darlow, B. A. (2008). Plasma amino-terminal pro C-type natriuretic peptide in the neonate: Relation to gestational age and postnatal linear growth. Journal of Clinical Endocrinology & Metabolism, 93(1), 225-232. doi: 10.1210/jc.2007-1815

Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2008). Regulation of endothelin-1 release from human endothelial cells by sex steroids and angiotensin-II. Peptides, 29(6), 1057-1061.

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2008). Effect of sex steroids on plasma C-type natriuretic peptide forms: Stimulation by oestradiol in lambs and adult sheep. Journal of Endocrinology, 199(3), 481-487. doi: 10.1677/JOE-08-0267

Ellmers, L. J., Scott, N. J. A., Medicherla, S., Pilbrow, A. P., Bridgman, P. G., Yandle, T. G., Richards, A. M., … Cameron, V. A. (2008). Transforming growth factor-β blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction. Endocrinology, 149(11), 5828-5834. doi: 10.1210/en.2008-0165

Baird, T. E., Palmer, B. R., Frampton, C. M., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2007). Association of the aldosterone synthase gene C-344T polymorphism with risk factors and survival in a post-myocardial infarction cohort. Journal of Human Hypertension, 21, 256-258.

Kemp, W., Krum, H., Colman, J., Bailey, M., Yandle, T., Richards, M., & Roberts, S. (2007). Urotensin II: A novel vasoactive mediator linked to chronic liver disease and portal hypertension. Liver International, 27(9), 1232-1239.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2007). Urocortin 2 infusion in human heart failure. European Heart Journal, 28(21), 2589-2597.

Troughton, R. W., Richards, A. M., Yandle, T. G., Frampton, C. M., & Nicholls, M. G. (2007). The effects of medications on circulating levels of cardiac natriuretic peptides. Annals of Medicine, 39(4), 242-260.

Olney, R. C., Prickett, T. C. R., Yandle, T. G., Espiner, E. A., Han, J. C., & Mauras, N. (2007). Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: Effects of puberty, testosterone, and growth hormone. Journal of Clinical Endocrinology & Metabolism, 92(11), 4294-4298. doi: 10.1210/jc.2007-0567

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in healthy humans: Hemodynamic, neurohormonal, and renal responses. JACC, 49(4), 461-471.

Bang, A. S., Soule, S. G., Yandle, T. G., Richards, A. M., & Pemberton, C. J. (2007). Characterisation of proghrelin peptides in mammalian tissue and plasma. Journal of Endocrinology, 192, 313-323.

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2007). Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension, 49(2), 322-327.

Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency. Biochimie, 89, 21-29.

Prickett, T. C. R., Rumball, C. W. H., Buckley, A. J., Bloomfield, F. H., Yandle, T. G., Harding, J. E., & Espiner, E. A. (2007). C-type natriuretic peptide forms in the ovine fetal and maternal circulations: Evidence for independent regulation and reciprocal response to undernutrition. Endocrinology, 148(8), 4015-4022.

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2007). Response of plasma CNP forms to acute anabolic and catabolic interventions in growing lambs. American Journal of Physiology: Endocrinology & Metabolism, 292, E1395-E1400. doi: 10.1152/ajpendo.00469.2006

Pearson, L. J., Rait, C., Nicholls, M. G., Yandle, T. G., & Evans, J. J. (2006). Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II. Journal of Endocrinology, 191(1), 171-177.

Davis, M. E., Richards, A. M., Nicholls, M. G., Yandle, T. G., Frampton, C. M., & Troughton, R. W. (2006). Introduction of metoprolol increases plasma B-type cardiac natriuretic peptides in mild, stable heart failure. Circulation, 113(7), 977-985.

Collins, R. P., Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2006). Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients. American Heart Journal, 152(2), 312-320.

Charles, C. J., Prickett, T. C. R., Espiner, E. A., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Regional sampling and the effects of experimental heart failure in sheep: Differential responses in A, B and C-type natriuretic peptides. Peptides, 27(1), 62-68. doi: 10.1016/j.peptides.2005.06.019

Obineche, E. N., Pathan, J. Y., Fisher, S., Prickett, T. C. R., Yandle, T. G., Frampton, C. M., Cameron, V. A., & Nicholls, M. G. (2006). Natriuretic peptide and adrenomedullin levels in chronic renal failure and effects of peritoneal dialysis. Kidney International, 69(1), 152-156.

Richards, M., Nicholls, M. G., Espiner, E. A., Lainchbury, J. G., Troughton, R. W., Elliott, J., Frampton, C. M., Crozier, I. G., Yandle, T. G., … for the Christchurch Cardioendocrine Research Group and the Australia-New Zealand Heart Failure Group. (2006). Comparison of B-type natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease. JACC, 47(1), 52-60. doi: 10.1016/j.jacc.2005.06.085

Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Plasma urocortin 1 in sheep: Regional sampling and effects of experimental heart failure. Peptides, 27, 1801-1805.

Lainchbury, J. G., Troughton, R. W., Frampton, C. M., Yandle, T. G., Hamid, A., Nicholls, M. G., & Richards, A. M. (2006). NTproBNP-guided drug treatment for chronic heart failure: Design and methods in the ″BATTLESCARRED″ trial. European Journal of Heart Failure, 8(5), 532-538.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2005). Effect of urocortin I infusion in humans with stable congestive cardiac failure. Clinical Science, 109(4), 381-388. doi: 10.1042/CS20050079

Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2005). Urotensin II: Evidence for cardiac, hepatic and renal production. Peptides, 26, 2211-2214. doi: 10.1016/j.peptides.2005.03.043

Liew, O. W., Chong, J. P. C., Yandle, T. G., & Brennan, S. O. (2005). Preparation of recombinant thioredoxin fused N-terminal proCNP: Analysis of enterokinase cleavage products reveals new enterokinase cleavage sites. Protein Expression & Purification, 41, 332-340.

Prickett, T. C. R., Lynn, A. M., Barrell, G. K., Darlow, B. A., Cameron, V. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2005). Amino-terminal proCNP: A putative marker of cartilage activity in postnatal growth. Pediatric Research, 58(2), 334-340.

Pemberton, C. J., Raudsepp, S. D., Yandle, T. G., Cameron, V. A., & Richards, A. M. (2005). Plasma cardiotrophin-1 is elevated in human hypertension and stimulated by ventricular stretch. Cardiovascular Research, 68(1), 109-117.

Loukovaara, S., Immonen, I. J., Yandle, T. G., Nicholls, G., Hiilesmaa, V. K., & Kaaja, R. J. (2005). Vasoactive mediators and retinopathy during type 1 diabetic pregnancy. Acta Ophthalmologica Scandinavica, 83(1), 57-62. doi: 10.1111/j.1600-0420.2005.00384.x

Gill, D., Troughton, R. W., Yandle, T. G., Frampton, C. M., Richards, M., Lainchbury, J. G., & Nicholls, M. G. (2004). Vigorous response in plasma N-terminal pro-brain natriuretic peptide (NT-BNP) to acute myocardial infarction. Clinical Science, 106(2), 135-139.

Troughton, R. W., Prior, D. L., Pereira, J. J., Martin, M., Fogarty, A. M., Morehead, A., Yandle, T. G., Richards, A. M., … Klein, A. L. (2004). Plasma B-type natriuretic peptide levels in systolic heart failure: Importance of left ventricular diastolic function and right ventricular systolic function. JACC, 43(3), 416-422. doi: 10.1016/j.jacc.2003.08.046

Wright, S. P., Prickett, T. C., Doughty, R. N., Frampton, C., Gamble, G. D., Yandle, T. G., … Richards, M. (2004). Amino-terminal pro-C-type natriuretic peptide in heart failure. Hypertension, 43(1), 94-100.

Yandle, T., Fisher, S., Livesey, J., Espiner, E., Richards, M., & Nicholls, G. (2004). Exponential increase in clinical use of plasma brain natriuretic peptide (BNP) assays. New Zealand Medical Journal, 117(1197). Retrieved from http://journal.nzma.org.nz/journal/117-1197/956/content.pdf

Kaaja, R. J., Leinonen, A., Moore, P., Yandle, T., Frampton, C. M., & Nicholls, M. G. (2004). Effect of changes in body posture on vasoactive hormones in pre-eclamptic women. Journal of Human Hypertension, 18(11), 789-794. doi: 10.1038/sj.jhh.1001743

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin-1 infusion in normal humans. Journal of Clinical Endocrinology & Metabolism, 89(3), 1402-1409.

Prickett, T. C., Kaaja, R. J., Nicholls, M. G., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2004). N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation. Clinical Science, 106(5), 535-540.

Troughton, R. W., Frampton, C. M., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2003). Plasma amino-terminal B-type natriuretic peptide measured by Elecsys 2010 assay in a trial of hormone-guided treatment for heart failure. Clinical Chemistry, 49(7), 1212-1215.

Palmer, B. R., Pilbrow, A. P., Yandle, T. G., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Cameron, V. A. (2003). Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after myocardial infarction. JACC, 41(5), 729-736. doi: 10.1016/S0735-1097(02)02927-3

Gerber, I. L., Stewart, R. A., Legget, M. E., West, T., French, R. L., Sutton, T. M., Yandle, T. G., … Richards, A. M., & White, H. D. (2003). Increased plasma natriuretic peptide levels reflect symptom onset in aortic stenosis. Circulation, 107, 1884-1890.

Sutton, T. M., Stewart, R. A., Gerber, I. L., West, T. M., Richards, A. M., Yandle, T. G., & Kerr, A. J. (2003). Plasma natriuretic peptide levels increase with symptoms and severity of mitral regurgitation. JACC, 41(12), 2280-2287.

Pemberton, C. J., Wimalasena, P., Yandle, T. G., Soule, S. G., & Richards, A. M. (2003). C-terminal pro-ghrelin peptides are present in the human circulation. Biochemical & Biophysical Research Communications, 310(2), 567-573.

Espiner, E. A., Ross, D., Yandle, T. G., Richards, A. M., & Hunt, P. J. (2003). Predicting surgically remedial primary aldosteronism: Role of adrenal scanning, posture testing, and adrenal vein sampling. Journal of Clinical Endocrinology & Metabolism, 88(8), 3637-3644.

Livesey, J. H., Yandle, T. G., Evans, M. J., & Ellis, M. J. (2003). Estimation of lot-to-lot relative potency in the preparation of radioimmunoassay calibrators. Journal of Immunoassay & Immunochemistry, 24(3), 243-263. doi: 10.1081/IAS-120022935

Nicholls, M. G., Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2003). Adrenomedullin in heart failure. Hypertension Research, 26(Suppl.), S135-S140. doi: 10.1291/hypres.26.S135

Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2003). Endothelin-1 directly modulates its own secretion: Studies utilising the cell immunoblot technique. Regulatory Peptides, 113, 149-153.

Fung, J. W. H., Yu, C. M., Yip, G., Chan, S., Yandle, T. G., Richards, A. M., Nicholls, M. G., & Sanderson, J. E. (2003). Effect of beta blockade (carvedilol or metoprolol) on activation of the renin-angiotensin-aldosterone system and natriuretic peptides in chronic heart failure. American Journal of Cardiology, 92, 406-410.

McGregor, D. O., Buttimore, A. L., Lynn, K. L., Yandle, T., & Nicholls, M. G. (2003). Effects of long and short hemodialysis on endothelial function: A short term study. Kidney International, 63(2), 709-715.

Wright, S. P., Doughty, R. N., Pearl, A., Gamble, G. D., Whalley, G. A., Walsh, H., … Yandle, T. G., Richards, A. M., & Sharpe, N. (2003). Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: A randomized, controlled trial. JACC, 42(10), 1793-1800. doi: 10.1016/j.jacc.2003.05.011

Lainchbury, J. G., Campbell, E., Frampton, C. M., Yandle, T. G., Nicholls, M. G., & Richards, A. M. (2003). Brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath. JACC, 42(4), 728-735. doi: 10.1016/S0735-1097(03)00787-3

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