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Otago Medical School staff profiles

Dr Martina Paumann-Page

PositionResearch Fellow
DepartmentDepartment of Pathology and Biomedical Science (Christchurch)
Research summaryFree radicals

Research

Dr Martina Paumann-Page is interested in how reactions of mammalian peroxidases are involved in health and disease. The main focus of her research is to investigate what role human peroxidasin plays in invasive metastatic melanoma and fibrosis.

Publications

Sevcnikar, B., Paumann-Page, M., Hofbauer, S., Pfanzagl, V., Furtmüller, P. G., & Obinger, C. (2020). Reaction of human peroxidasin 1 compound I and compound II with one-electron donors. Archives of Biochemistry & Biophysics, 681, 108267. doi: 10.1016/j.abb.2020.108267

Sevcnikar, B., Schaffner, I., Chaung, C. Y., Gamon, L., Paumann-Page, M., Hofbauer, S., … Obinger, C. (2020). The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes. Archives of Biochemistry & Biophysics. Advance online publication. doi: 10.1016/j.abb.2020.108443

Bathish, B., Paumann-Page, M., Paton, L. N., Kettle, A. J., & Winterbourn, C. C. (2020). Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry. Advance online publication. doi: 10.1074/jbc.RA120.014504

Bathish, B., Turner, R., Paumann-Page, M., Kettle, A. J., & Winterbourn, C. C. (2018). Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation. Archives of Biochemistry & Biophysics, 646, 120-127. doi: 10.1016/j.abb.2018.03.038

Grishkovskaya, I., Paumann-Page, M., Tscheliessnig, R., Stampler, J., Hofbauer, S., Soudi, M., … Obinger, C. (2017). Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation. Journal of Biological Chemistry, 292(20), 8244-8261. doi: 10.1074/jbc.M117.775031

Journal - Research Article

Sevcnikar, B., Paumann-Page, M., Hofbauer, S., Pfanzagl, V., Furtmüller, P. G., & Obinger, C. (2020). Reaction of human peroxidasin 1 compound I and compound II with one-electron donors. Archives of Biochemistry & Biophysics, 681, 108267. doi: 10.1016/j.abb.2020.108267

Bathish, B., Paumann-Page, M., Paton, L. N., Kettle, A. J., & Winterbourn, C. C. (2020). Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry. Advance online publication. doi: 10.1074/jbc.RA120.014504

Sevcnikar, B., Schaffner, I., Chaung, C. Y., Gamon, L., Paumann-Page, M., Hofbauer, S., … Obinger, C. (2020). The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes. Archives of Biochemistry & Biophysics. Advance online publication. doi: 10.1016/j.abb.2020.108443

Bathish, B., Turner, R., Paumann-Page, M., Kettle, A. J., & Winterbourn, C. C. (2018). Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation. Archives of Biochemistry & Biophysics, 646, 120-127. doi: 10.1016/j.abb.2018.03.038

Grishkovskaya, I., Paumann-Page, M., Tscheliessnig, R., Stampler, J., Hofbauer, S., Soudi, M., … Obinger, C. (2017). Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation. Journal of Biological Chemistry, 292(20), 8244-8261. doi: 10.1074/jbc.M117.775031

Paumann-Page, M., Katz, R.-S., Bellei, M., Schwartz, I., Edenhofer, E., Sevcnikar, B., … Obinger, C. (2017). Pre-steady-state kinetics reveal the substrate specificity and mechanism of halide oxidation of truncation human peroxidasin 1. Journal of Biological Chemistry, 292(11), 4583-4592. doi: 10.1074/jbc.M117.775213

Soudi, M., Paumann-Page, M., Delporte, C., Pirker, K. F., Bellei, M., Edenhofer, E., … Obinger, C. (2015). Multidomain human peroxidasin 1 is a highly glycosylated and stable homotrimeric high spin ferric peroxidase. Journal of Biological Chemistry, 290(17), 10876-10890. doi: 10.1074/jbc.M114.632273

Chapman, A. L. P., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I., Paumann-Page, M. E., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Journal of Biological Chemistry, 288(9), 6465-6477. doi: 10.1074/jbc.M112.418970

Paumann-Page, M., Furtmüller, P. G., Hofbauer, S., Paton, L. N., Obinger, C., & Kettle, A. J. (2013). Inactivation of human myeloperoxidase by hydrogen peroxide. Archives of Biochemistry & Biophysics, 539(1), 51-62. doi: 10.1016/j.abb.2013.09.004

Burner, U., Obinger, C., Paumann, M., Furtmuller, P. G., & Kettle, A. J. (1999). Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. Journal of Biological Chemistry, 274, 9494-9592. doi: 10.1074/jbc.274.14.9494

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