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Otago Medical School staff profiles

Dr Sabine Hessler

PositionPostdoctoral Fellow
DepartmentDepartment of Physiology
Research summaryNeuroendocrinology

Research

I work as a postdoctoral fellow in Prof Allan Herbison's and Dr Rebecca Campbell's lab where I am investigating the interaction of arcuate nucleus neurons with gonadotropin-releasing hormone (GnRH) neurons in the preoptic area (POA) in acute mouse brain slices using electrophysiology in combination with optogenetics.

Publications

Ziminski, J. J., Hessler, S., Margetts-Smith, G., Sieburg, M. C., Crombag, H. S., & Koya, E. (2017). Changes in appetitive associative strength modulates nucleus accumbens, but not orbitofrontal cortex neuronal ensemble excitability. Journal of Neuroscience, 37(12), 3160-3170. doi: 10.1523/JNEUROSCI.3766-16.2017

Lehnert, S., Hartmann, S., Hessler, S., Adelsberger, H., Huth, T., & Alzheimer, C. (2016). Ion channel regulation by β-secretase BACE1: Enzymatic and non-enzymatic effects beyond Alzheimer’s disease. Channels, 10(5), 365-378. doi: 10.1080/19336950.2016.1196307

Hessler, S., Zheng, F., Hartmann, S., Rittger, A., Lehnert, S., Völkel, M., … Alzheimer, C. (2015). β-secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion. Journal of Neuroscience, 35(8), 3298-3311. doi: 10.1523/JNEUROSCI.3127-14.2015

Agsten, M., Hessler, S., Lehnert, S., Volk, T., Rittger, A., Hartmann, S., … Huth, T. (2015). BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs). Journal of Molecular & Cellular Cardiology, 89(Part B), 335-348. doi: 10.1016/j.yjmcc.2015.10.006

Brauner, J., Hessler, S., Groemer, T. W., Alzheimer, C., & Huth, T. (2014). Risperidone inhibits voltage-gated sodium channels. European Journal of Pharmacology, 728, 100-106. doi: 10.1016/j.ejphar.2014.01.062

Journal - Research Article

Ziminski, J. J., Hessler, S., Margetts-Smith, G., Sieburg, M. C., Crombag, H. S., & Koya, E. (2017). Changes in appetitive associative strength modulates nucleus accumbens, but not orbitofrontal cortex neuronal ensemble excitability. Journal of Neuroscience, 37(12), 3160-3170. doi: 10.1523/JNEUROSCI.3766-16.2017

Hessler, S., Zheng, F., Hartmann, S., Rittger, A., Lehnert, S., Völkel, M., … Alzheimer, C. (2015). β-secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion. Journal of Neuroscience, 35(8), 3298-3311. doi: 10.1523/JNEUROSCI.3127-14.2015

Agsten, M., Hessler, S., Lehnert, S., Volk, T., Rittger, A., Hartmann, S., … Huth, T. (2015). BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs). Journal of Molecular & Cellular Cardiology, 89(Part B), 335-348. doi: 10.1016/j.yjmcc.2015.10.006

Brauner, J., Hessler, S., Groemer, T. W., Alzheimer, C., & Huth, T. (2014). Risperidone inhibits voltage-gated sodium channels. European Journal of Pharmacology, 728, 100-106. doi: 10.1016/j.ejphar.2014.01.062

Vetter, I., Hein, A., Sattler, S., Hessler, S., Touska, F., Bressan, E., … Zimmermann, K. (2013). Amplified cold transduction in native nociceptors by M-channel inhibition. Journal of Neuroscience, 33(42), 16627-16641. doi: 10.1523/JNEUROSCI.1473-13.2013

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Journal - Research Other

Lehnert, S., Hartmann, S., Hessler, S., Adelsberger, H., Huth, T., & Alzheimer, C. (2016). Ion channel regulation by β-secretase BACE1: Enzymatic and non-enzymatic effects beyond Alzheimer’s disease. Channels, 10(5), 365-378. doi: 10.1080/19336950.2016.1196307

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