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Otago Medical School staff profiles

Dr Rebekah Bower

PositionPostdoctoral Fellow
DepartmentDepartment of Pharmacology and Toxicology
QualificationsPhD BSc
Research summaryMolecular processes of normal physiology and pathophysiology of various human diseases

Research

I recently completed my PhD studying the molecular mechanisms of the metabolic hormone amylin, which has clinical significance towards the treatment of metabolic disease.

My background is in peptide chemistry, GPCR pharmacology, and cell-based in vitro assay techniques with the aim to contribute towards drug development efforts for diseases greatly impacting our modern world.

Presently I have started as a Postdoctoral Research Fellow here at the University of Otago with a new focus towards understanding the molecular mechanisms of lung and prostate cancers to further drug development efforts in these arenas. My research will include in vivo mouse models and characterisation of a metastatic cancer cell line with the ultimate aim of guiding drug development efforts targeting metastatic cancer cell phenotypes.

Publications

Hendrikse, E. R., Bower, R. L., Hay, D. L., & Walker, C. S. (2019). Molecular studies of CGRP and the CGRP family of peptides in the central nervous system. Cephalagia, 39(3), 403-419. doi: 10.1177/0333102418765787

Akter, R., Bower, R. L., Abedini, A., Schmidt, A. M., Hay, D. L., & Raleigh, D. P. (2018). Amyloidogenicity, cytotoxicity and receptor activity of bovine amylin; Implications for xenobiotic transplantation and the design of non-toxic amylin variants. ACS Chemical Biology. Advance online publication. doi: 10.1021/acschembio.8b00690

Bower, R. L., & Hay, D. L. (2016). Amylin structure-function relationships and receptor pharmacology: Implications for amylin mimetic drug development. British Journal of Pharmacology, 173(12), 1883-1898. doi: 10.1111/bph.13496

Yule, L. R., Bower, R. L., Kaur, H., Kowalczyk, R., Hay, D. L., & Brimble, M. A. (2016). Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry. Organic & Biomolecular Chemistry, 14(23), 5238-5245. doi: 10.1039/c6ob00850j

Bower, R. L., Eftekhari, S., Waldvogel, H. J., Faull, R. L. M., Tajti, J., Edvinsson, L., … Walker, C. S. (2016). Mapping the calcitonin receptor in human brain stem. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 310(9), R788-R793. doi: 10.1152/ajpregu.00539.2015

Journal - Research Article

Akter, R., Bower, R. L., Abedini, A., Schmidt, A. M., Hay, D. L., & Raleigh, D. P. (2018). Amyloidogenicity, cytotoxicity and receptor activity of bovine amylin; Implications for xenobiotic transplantation and the design of non-toxic amylin variants. ACS Chemical Biology. Advance online publication. doi: 10.1021/acschembio.8b00690

Bower, R. L., & Hay, D. L. (2016). Amylin structure-function relationships and receptor pharmacology: Implications for amylin mimetic drug development. British Journal of Pharmacology, 173(12), 1883-1898. doi: 10.1111/bph.13496

Bower, R. L., Eftekhari, S., Waldvogel, H. J., Faull, R. L. M., Tajti, J., Edvinsson, L., … Walker, C. S. (2016). Mapping the calcitonin receptor in human brain stem. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 310(9), R788-R793. doi: 10.1152/ajpregu.00539.2015

Yule, L. R., Bower, R. L., Kaur, H., Kowalczyk, R., Hay, D. L., & Brimble, M. A. (2016). Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry. Organic & Biomolecular Chemistry, 14(23), 5238-5245. doi: 10.1039/c6ob00850j

Walker, C. S., Eftekhari, S., Bower, R. L., Wilderman, A., Insel, P. A., Edvinsson, L., … Hay, D. L. (2015). A second trigeminal CGRP receptor: Function and expression of the AMY1 receptor. Annals of Clinical & Translational Neurology, 2(6), 595-608. doi: 10.1002/acn3.197

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Journal - Research Other

Hendrikse, E. R., Bower, R. L., Hay, D. L., & Walker, C. S. (2019). Molecular studies of CGRP and the CGRP family of peptides in the central nervous system. Cephalagia, 39(3), 403-419. doi: 10.1177/0333102418765787

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