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Otago Medical School staff profiles

Dr Sam Norton

PositionPostdoctoral Fellow
DepartmentDepartment of Microbiology and Immunology
Research summaryTumour immunology

Research

My PhD research was on characterising macrophages in colorectal cancer and in developing a pipeline for the analysis of mass cytometry data from clinical samples. My Post-Doctoral work with A/P Ros Kemp is expanding on this by further developing analytical tools for analysis of large datasets produced from cutting-edge machines, such as mass cytometers.

Publications

Norton, S., & Kemp, R. (2019). Computational analysis of high-dimensional mass cytometry data from clinical tissue samples. In H. M. McGuire & T. M. Ashhurst (Eds.), Mass cytometry: Methods and protocols: Methods in molecular biology (Vol. 1989). (pp. 295-308). New York, NY: Human Press. doi: 10.1007/978-1-4939-9454-0_19

Norton, S. E., Ward-Hartstonge, K. A., McCall, J. L., Leman, J. K. H., Taylor, E. S., Munro, F., Black, M. A., … Kemp, R. A. (2019). High-dimensional mass cytometric analysis reveals an increase in effector regulatory T cells as a distinguishing feature of colorectal tumors. Journal of Immunology, 202, 1871-1884. doi: 10.4049/jimmunol.1801368

Norton, S. E., Dunn, E. T. J., McCall, J. L., Munro, F., & Kemp, R. A. (2016). Gut macrophage phenotype is dependent on the tumor microenvironment in colorectal cancer. Clinical & Translational Immunology, 5(4), e76. doi: 10.1038/cti.2016.21

Parayath, N. N., Nehoff, H., Norton, S. E., Highton, A. J., Taurin, S., Kemp, R. A., & Greish, K. (2016). Styrene maleic acid-encapsulated paclitaxel micelles: Antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model. International Journal of Nanomedicine, 11, 3979-3991. doi: 10.2147/IJN.S110251

Norton, S. E., Ward-Hartstonge, K. A., Taylor, E. S., & Kemp, R. A. (2015). Immune cell interplay in colorectal cancer prognosis. World Journal of Gastrointestinal Oncology, 7(10), 221-232. doi: 10.4251/wjgo.v7.i10.221

Chapter in Book - Research

Norton, S., & Kemp, R. (2019). Computational analysis of high-dimensional mass cytometry data from clinical tissue samples. In H. M. McGuire & T. M. Ashhurst (Eds.), Mass cytometry: Methods and protocols: Methods in molecular biology (Vol. 1989). (pp. 295-308). New York, NY: Human Press. doi: 10.1007/978-1-4939-9454-0_19

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Journal - Research Article

Norton, S. E., Ward-Hartstonge, K. A., McCall, J. L., Leman, J. K. H., Taylor, E. S., Munro, F., Black, M. A., … Kemp, R. A. (2019). High-dimensional mass cytometric analysis reveals an increase in effector regulatory T cells as a distinguishing feature of colorectal tumors. Journal of Immunology, 202, 1871-1884. doi: 10.4049/jimmunol.1801368

Norton, S. E., Dunn, E. T. J., McCall, J. L., Munro, F., & Kemp, R. A. (2016). Gut macrophage phenotype is dependent on the tumor microenvironment in colorectal cancer. Clinical & Translational Immunology, 5(4), e76. doi: 10.1038/cti.2016.21

Parayath, N. N., Nehoff, H., Norton, S. E., Highton, A. J., Taurin, S., Kemp, R. A., & Greish, K. (2016). Styrene maleic acid-encapsulated paclitaxel micelles: Antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model. International Journal of Nanomedicine, 11, 3979-3991. doi: 10.2147/IJN.S110251

Norton, S. E., Ward-Hartstonge, K. A., Taylor, E. S., & Kemp, R. A. (2015). Immune cell interplay in colorectal cancer prognosis. World Journal of Gastrointestinal Oncology, 7(10), 221-232. doi: 10.4251/wjgo.v7.i10.221

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