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Otago Medical School staff profiles

Dr Dianne Sika-Paotonu

PositionAssociate Dean Pacific/Senior Lecturer
DepartmentDepartment of Pathology and Molecular Medicine (UOW)
Research summaryCancer; Acute Rheumatic Fever; Rheumatic Heart Disease; Pacific health

Research

Dr Dianne Sika-Paotonu is the Scientific Lead for the Rheumatic Fever and Penicillin Research Programme based in New Zealand and the Associate Dean (Pacific) at the University of Otago, Wellington. She is also a member of the Royal Society Te Apārangi Council and Health Research Council of New Zealand (HRC) Pacific Health Research Committee. She holds service and leadership responsibilities within the Pacific community and is an HRC Pacific Emerging Research Fellow, and recent recipient of the Sir Thomas Davis Te Patu Kite Rangi Ariki Health Research Fellowship from HRC. Dianne is also a member of the Takiala Pacific Leadership Network within the Health Sciences Division and Pacific Academic Staff Caucus Committee for the University of Otago. She sits on numerous local and University of Otago based Committees, in addition to International Governance Boards. She also functions as Chair and Convenor for Rheumatic Fever and Penicillin related Pacific Research Advisory Groups.

Selected major projects within the Rheumatic Fever related Penicillin Research portfolio that Dianne is currently leading include: Benzathine Penicillin G (BPG) Reformulation Preferences study for children and young people receiving secondary prophylaxis with BPG, the BPG Pharmacokinetics Study in New Zealand, the Reformulation Preferences of health professionals administering BPG for Rheumatic Fever prevention and the perspectives of Families with a Child/Young person receiving BPG injections for Rheumatic Fever prevention. These projects among other, are contributing to global collaborations and efforts to reformulate BPG for Rheumatic Fever prevention. This work is also extending into the Pacific Region in partnership with Pacific Researchers and Collaborators based in Oceania.

Publications

Hand, R. M., Salman, S., Newall, N., Vine, J., Page-Sharp, M., Bowen, A. C., … Sika-Paotonu, D., … Carapetis, J. (2019). A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: New insights for improved secondary prophylaxis strategies. Journal of Antimicrobial Chemotherapy. Advance online publication. doi: 10.1093/jac/dkz076

Sika-Paotonu, D., Beaton, A., & Carapetis, J. (2018). Epidemiology and global burden of rheumatic heart disease. In A. J. Camm, T. F. Lüscher, G. Maurer & P. W. Serruys (Eds.), The ESC textbook of cardiovascular medicine. (3rd ed.) Oxford, UK: Oxford University Press. doi: 10.1093/med/9780198784906.003.0065

Robertson, S. P., Harré Hindmarsh, J., Berry, S., Cameron, V. A., Cox, M. P., Dewes, O., … Matisoo-Smith, E., … Sika-Paotonu, D., … Merriman, T. R., … Wilcox, P. (2018). Genomic medicine must reduce, not compound, health inequities: The case for hauora-enhancing genomic resources for New Zealand. New Zealand Medical Journal, 131(1480), 81-89. Retrieved from https://www.nzma.org.nz/journal

Sika-Paotonu, D., Beaton, A., Raghu, A., Steer, A., & Carapetis, J. (2017). Acute rheumatic fever and rheumatic heart disease. In J. J. Ferretti, D. L. Stevens & V. A. Fischetti (Eds.), Streptococcus pyogenes: Basic biology to clinical manifestations. (pp. 771-826). Oklahoma, OK: University of Oklahoma Health Sciences Center. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK425394/

Sika-Paotonu, D., Robinson, B., & Maling, T. (2017). Engaging postgraduate students undertaking clinical pharmacology using GoSoapBox for problem-based learning [Syllabus selections: Innovative learning activities]. Journal of Nursing Education, 56(9), 575-576. doi: 10.3928/01484834-20170817-14

Chapter in Book - Research

Sika-Paotonu, D., Beaton, A., & Carapetis, J. (2018). Epidemiology and global burden of rheumatic heart disease. In A. J. Camm, T. F. Lüscher, G. Maurer & P. W. Serruys (Eds.), The ESC textbook of cardiovascular medicine. (3rd ed.) Oxford, UK: Oxford University Press. doi: 10.1093/med/9780198784906.003.0065

Sika-Paotonu, D., Beaton, A., Raghu, A., Steer, A., & Carapetis, J. (2017). Acute rheumatic fever and rheumatic heart disease. In J. J. Ferretti, D. L. Stevens & V. A. Fischetti (Eds.), Streptococcus pyogenes: Basic biology to clinical manifestations. (pp. 771-826). Oklahoma, OK: University of Oklahoma Health Sciences Center. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK425394/

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Journal - Research Article

Hand, R. M., Salman, S., Newall, N., Vine, J., Page-Sharp, M., Bowen, A. C., … Sika-Paotonu, D., … Carapetis, J. (2019). A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: New insights for improved secondary prophylaxis strategies. Journal of Antimicrobial Chemotherapy. Advance online publication. doi: 10.1093/jac/dkz076

Cornwall, J., Robinson, B., & Sika-Paotonu, D. (2016). The availability of clinical anatomy in postgraduate nursing education in New Zealand. Anatomy, 10(2), 138-142. doi: 10.2399/ana.16.022

Delahunt, B., Sika-Paotonu, D., Bethwaite, P. B., Jordan, T. W., Magi-Galluzzi, C., Zhou, M., … Srigley, J. R. (2011). Grading of clear cell renal cell carcinoma should be based on nucleolar prominence. American Journal of Surgical Pathology, 35(8), 1134-1139. doi: 10.1097/PAS.0b013e318220697f

Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Simkins, H. M. A., & Hermans, I. F. (2011). Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. PLoS ONE, 6(3), e17657. doi: 10.1371/journal.pone.0017657

Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Dickgreber, N., Farrand, K. J., Ronchese, F., & Hermans, I. F. (2010). Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand. Immunology & Cell Biology, 88(5), 596-604. doi: 10.1038/icb.2010.9

Delahunt, B., Sika-Paotonu, D., Bethwaite, P. B., McCredie, M. R. E., Martignoni, G., Eble, J., & Jordan, T. W. (2007). Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. American Journal of Surgical Pathology, 31(6), 957-960.

Sika-Paotonu, D., Bethwaite, P. B., McCredie, M. R. E., William, J. T., & Delahunt, B. (2006). Nucleolar grade but not Fuhrman grade is applicable to papillary renal cell carcinoma. American Journal of Surgical Pathology, 30(9), 1091-1096. doi: 10.1097/01.pas.0000209833.69972.2b

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Journal - Research Other

Robertson, S. P., Harré Hindmarsh, J., Berry, S., Cameron, V. A., Cox, M. P., Dewes, O., … Matisoo-Smith, E., … Sika-Paotonu, D., … Merriman, T. R., … Wilcox, P. (2018). Genomic medicine must reduce, not compound, health inequities: The case for hauora-enhancing genomic resources for New Zealand. New Zealand Medical Journal, 131(1480), 81-89. Retrieved from https://www.nzma.org.nz/journal

Sika-Paotonu, D., Robinson, B., & Maling, T. (2017). Engaging postgraduate students undertaking clinical pharmacology using GoSoapBox for problem-based learning [Syllabus selections: Innovative learning activities]. Journal of Nursing Education, 56(9), 575-576. doi: 10.3928/01484834-20170817-14

Delahunt, B., Bethwaite, P. B., Miller, R. J., Sika-Paotonu, D., & Srigley, J. R. (2010). Re: Fuhrman grade provides higher prognostic accuracy than nucleolar grade for papillary renal cell carcinoma [Letter to the editor/errata]. Journal of Urology, 185(1), 356-357. doi: 10.1016/j.juro.2010.08.045

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