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Otago Medical School staff profiles

Dr Rory O'Brien

PositionResearch Fellow
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc PhD (Dub)
Research summaryMycobacterial diseases in NZ farmed deer

Research

Our research involves the heritable susceptibility to mycobacterial diseases in ruminants, mycobacterial Bacterial and Viral Genetics and molecular diagnostics, quantitative (real-time) PCR and gene expression analysis, and mycobacterial strain-typing.

Publications

Bates, A., O'Brien, R., Liggett, S., & Griffin, F. (2019). Control of Mycobacterium avium subsp. paratuberculosis infection on a New Zealand pastoral dairy farm. BMC Veterinary Research, 15, 266. doi: 10.1186/s12917-019-2014-6

Bates, A., O'Brien, R., Liggett, S., & Griffin, F. (2018). The effect of sub-clinical infection with Mycobacterium avium subsp. paratuberculosis on milk production in a New Zealand dairy herd. BMC Veterinary Research, 14, 93. doi: 10.1186/s12917-018-1421-4

Thomas, R. R., Brooks, H. J. L., & O'Brien, R. (2017). Prevalence of Shiga toxin-producing and enteropathogenic Escherichia coli marker genes in diarrhoeic stools in a New Zealand catchment area [Short report]. Journal of Clinical Pathology, 70(1), 81-84. doi: 10.1136/jclinpath-2016-203882

Mackintosh, C. G., Griffin, J. F. T., Scott, I. C., O'Brien, R., Stanton, J. L., Maclean, P., & Brauning, R. (2016). SOLiD SAGE sequencing shows differential gene expression in jejunal lymph node samples of resistant and susceptible red deer (Cervus elaphus) challenged with Mycobacterium avium subsp. paratuberculosis. Veterinary Immunology & Immunopathology, 169, 102-110. doi: 10.1016/j.vetimm.2015.10.009

Marfell, B. J., O'Brien, R., & Griffin, J. F. T. (2013). Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Myobacterium avium subspecies paratuberculosis infection. Developmental & Comparative Immunology, 40(2), 210-217. doi: 10.1016/j.dci.2013.02.004

Journal - Research Article

Bates, A., O'Brien, R., Liggett, S., & Griffin, F. (2019). Control of Mycobacterium avium subsp. paratuberculosis infection on a New Zealand pastoral dairy farm. BMC Veterinary Research, 15, 266. doi: 10.1186/s12917-019-2014-6

Bates, A., O'Brien, R., Liggett, S., & Griffin, F. (2018). The effect of sub-clinical infection with Mycobacterium avium subsp. paratuberculosis on milk production in a New Zealand dairy herd. BMC Veterinary Research, 14, 93. doi: 10.1186/s12917-018-1421-4

Mackintosh, C. G., Griffin, J. F. T., Scott, I. C., O'Brien, R., Stanton, J. L., Maclean, P., & Brauning, R. (2016). SOLiD SAGE sequencing shows differential gene expression in jejunal lymph node samples of resistant and susceptible red deer (Cervus elaphus) challenged with Mycobacterium avium subsp. paratuberculosis. Veterinary Immunology & Immunopathology, 169, 102-110. doi: 10.1016/j.vetimm.2015.10.009

Marfell, B. J., O'Brien, R., & Griffin, J. F. T. (2013). Global gene expression profiling of monocyte-derived macrophages from red deer (Cervus elaphus) genotypically resistant or susceptible to Myobacterium avium subspecies paratuberculosis infection. Developmental & Comparative Immunology, 40(2), 210-217. doi: 10.1016/j.dci.2013.02.004

Dobson, B., Liggett, S., O'Brien, R., & Griffin, J. F. T. (2013). Innate immune markers that distinguish red deer (Cervus elaphus) selected for resistant or susceptible genotypes for Johne’s disease. Veterinary Research, 44(1), 5. doi: 10.1186/1297-9716-44-5

O'Brien, R., Hughes, A., Liggett, S., & Griffin, F. (2013). Composite testing for ante-mortem diagnosis of Johne's disease in farmed New Zealand deer: Correlations between bacteriological culture, histopathology, serological reactivity and faecal shedding as determined by quantitative PCR. BMC Veterinary Research, 9, 72. doi: 10.1186/1746-6148-9-72

Robinson, M. W., O'Brien, R., Mackintosh, C. G., Clark, R. G., & Griffin, J. F. T. (2011). Immunoregulatory cytokines are associated with protection from immunopathology following Mycobacterium avium subspecies paratuberculosis infection in red deer. Infection & Immunity, 79(5), 2089-2097. doi: 10.1128/IAI.00779-10

Gillan, S., O'Brien, R., Hughes, A. D., & Griffin, J. F. T. (2010). Identification of immune parameters to differentiate disease states among sheep infected with Mycobacterium avium subsp paratuberculosis. Clinical & Vaccine Immunology, 17(1), 108-117. doi: 10.1128/CVI.00359-09

Gillan, S., Hughes, A. D., O'Brien, R., & Griffin, J. F. T. (2010). Ovine immune parameters following immunisation against Mycobacterium avium ssp. paratuberculosis using a lipid-based live cell vaccine. Veterinary Immunology & Immunopathology, 137(1-2), 109-119. doi: 10.1016/j.vetimm.2010.04.020

Robinson, M. W., O'Brien, R., Mackintosh, C. G., & Griffin, J. F. T. (2010). Peripheral blood mononuclear cell population changes associated with age and Mycobacterium avium subspecies paratuberculosis infection in red deer (Cervus elaphus). Veterinary Immunology & Immunopathology, 136(3-4), 211-218. doi: 10.1016/j.vetimm.2010.03.009

Robinson, M., O'Brien, R., Mackintosh, C., & Griffin, F. (2008). Differential immune responses of red deer (Cervus elaphus) following experimental challenge with Mycobacterium avium subsp. paratuberculosis. Clinical & Vaccine Immunology, 15(6), 963-969. doi: 10.1128/CVI.00031-08

O'Brien, R., Mackintosh, C. G., Bakker, D., Kopecna, M., Pavlik, I., & Griffin, J. F. T. (2006). Immunological and molecular characterization of susceptibility in relationship to bacterial strain differences in Mycobacterium avium subsp. paratuberculosis infection in the red deer (Cervus elaphus). Infection & Immunity, 74(6), 3530-3537.

Begg, D. J., O'Brien, R., Mackintosh, C. G., & Griffin, J. F. T. (2005). Experimental infection model for Johne's disease in sheep. Infection & Immunity, 73(9), 5603-5611.

Cameron, H., O'Brien, R., Murray, A. S., Cryan, B., Hone, R., & Rogers, M. (2001). Evaluation of the micobacterium bovis restriction fragment length polymorphism probe pUCD, in combination with the direct repeat probe, for molecular typing of mycobacterium tuberculosis strains in Ireland. Journal of Clinical Microbiology, 39(12), 4404-4406.

O'Brien, R., Flynn, O., Costello, E., O'Grady, D., & Rogers, M. (2000). Identification of a novel DNA probe for strain typing Mycobacterium bovis by restriction fragment length polymorphism analysis. Journal of Clinical Microbiology, 38(5), 1723-1730.

O'Brien, R., Danilowicz, B., Bailey, L., Flynn, O., Costello, E., O'Grady, D., & Rogers, M. (2000). Characterization of the Mycobacterium bovis restriction fragment length polymorphism DNA probe pUCD and performance comparison with standard methods. Journal of Clinical Microbiology, 38(9), 3362-3369.

Costello, E., O'Grady, D., Flynn, O., O'Brien, R., Rogers, M., Quigley, F., … Griffin, J. (1999). Study of restriction fragment length polymorphism analysis and spoligotyping for epidemiological investigation of Mycobacterium bovis infection. Journal of Microbiology, 37(10), 3217-3222.

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Journal - Research Other

Thomas, R. R., Brooks, H. J. L., & O'Brien, R. (2017). Prevalence of Shiga toxin-producing and enteropathogenic Escherichia coli marker genes in diarrhoeic stools in a New Zealand catchment area [Short report]. Journal of Clinical Pathology, 70(1), 81-84. doi: 10.1136/jclinpath-2016-203882

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