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Otago Medical School staff profiles

Dr Michael MacAskill

PositionSenior Research Fellow
DepartmentDepartment of Medicine (Christchurch)
QualificationsBSc (Hons) PhD (Otago)
Research summaryNeurological disease

Research

I am the Research Director at the NZ Brain Research Institute. My training is in experimental psychology and my personal research interests lie mainly in the effects of neurological disease upon the control of fast eye movements (saccades). This has been extended to involve studies of the coordination of hand and eye movement in both lab-based and more natural tasks. I've also become involved in projects using structural and functional MR brain imaging to investigate Parkinson’s and Alzheimer’s diseases.

Publications

Blakemore, R. L., MacAskill, M. R., Myall, D. J., & Anderson, T. J. (2019). Volitional suppression of parkinsonian resting tremor. Movement Disorders Clinical Practice. Advance online publication. doi: 10.1002/mdc3.12801

Peirce, J., Gray, J. R., Simpson, S., MacAskill, M., Höchenberger, R., Sogo, H., … Lindeløv, J. K. (2019). PsychoPy2: Experiments in behavior made easy. Behavior Research Methods. Advance online publication. doi: 10.3758/s13428-018-01193-y

Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K.-L., … Pascoe, M., Almuqbel, M. M., … Miller, D. H., & Dalrymple-Alford, J. C. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s Disease. Frontiers in Neurology. Advance online publication. doi: 10.3389/fneur.2019.00391

Watanabe, M., Okada, K.-I., Hamasaki, Y., Funamoto, M., Kobayashi, Y., MacAskill, M., & Anderson, T. (2019). Ocular drift reflects volitional action preparation. European Journal of Neuroscience. Advance online publication. doi: 10.1111/ejn.14365

Alamri, Y., Pascoe, M., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. (2019). Sensorimotor integration assessment by the Symbol-Digit modalities test in patients with Parkinsons disease. Neurosciences, 24(2), 143-144. doi: 10.17712/nsj.2019.2.20190002

Authored Book - Other

Peirce, J., & MacAskill, M. (2018). Building experiments in PsychoPy. London, UK: Sage, 312p.

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Journal - Research Article

Blakemore, R. L., MacAskill, M. R., Myall, D. J., & Anderson, T. J. (2019). Volitional suppression of parkinsonian resting tremor. Movement Disorders Clinical Practice. Advance online publication. doi: 10.1002/mdc3.12801

Watanabe, M., Okada, K.-I., Hamasaki, Y., Funamoto, M., Kobayashi, Y., MacAskill, M., & Anderson, T. (2019). Ocular drift reflects volitional action preparation. European Journal of Neuroscience. Advance online publication. doi: 10.1111/ejn.14365

Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K.-L., … Pascoe, M., Almuqbel, M. M., … Miller, D. H., & Dalrymple-Alford, J. C. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s Disease. Frontiers in Neurology. Advance online publication. doi: 10.3389/fneur.2019.00391

Peirce, J., Gray, J. R., Simpson, S., MacAskill, M., Höchenberger, R., Sogo, H., … Lindeløv, J. K. (2019). PsychoPy2: Experiments in behavior made easy. Behavior Research Methods. Advance online publication. doi: 10.3758/s13428-018-01193-y

Pascoe, M., Alamri, Y., Dalrymple-Alford, J., Anderson, T., & MacAskill, M. (2018). The symbol-digit modalities test in mild cognitive impairment: Evidence from Parkinson's disease patients. European Neurology, 79, 206-210. doi: 10.1159/000485669

Pitcher, T. L., Myall, D. J., Pearson, J. F., Lacey, C. J., Dalrymple-Alford, J. C., Anderson, T. J., & MacAskill, M. R. (2018). Parkinson's disease across ethnicities: A nationwide study in New Zealand. Movement Disorders. Advance online publication. doi: 10.1002/mds.27389

Fan, D., Alamri, Y., Liu, K., MacAskill, M., Harris, P., Brimble, M., … Anderson, T., & Guan, J. (2018). Supplementation of blackcurrant anthocyanins increased cyclic glycine-proline in the cerebrospinal fluid of Parkinson patients: Potential treatment to improve insulin-like growth factor-1 function. Nutrients, 10(6), 714. doi: 10.3390/nu10060714

Blakemore, R. L., MacAskill, M. R., Shoorangiz, R., & Anderson, T. J. (2018). Stress-evoking emotional stimuli exaggerate deficits in motor function in Parkinson's disease. Neuropsychologia, 112, 66-76. doi: 10.1016/j.neuropsychologia.2018.03.006

Myall, D. J., Pitcher, T. L., Pearson, J. F., Dalrymple-Alford, J. C., Anderson, T. J., & MacAskill, M. R. (2017). Parkinson's in the oldest old: Impact on estimates of future disease burden. Parkinsonism & Related Disorders, 42, 78-84. doi: 10.1016/j.parkreldis.2017.06.018

Jones, A. J., Kuijer, R. G., Livingston, L., Myall, D., Horne, K., MacAskill, M., Pitcher, T., … Anderson, T. J., & Dalrymple-Alford, J. C. (2017). Caregiver burden is increased in Parkinson's disease with mild cognitive impairment (PD-MCI). Translational Neurodegeneration, 6, 17. doi: 10.1186/s40035-017-0085-5

Wood, K.-L., Myall, D. J., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., … Anderson, T. J., & Dalrymple-Alford, J. C. (2016). Different PD-MCI criteria and risk of dementia in Parkinson's disease: A 4-year longitudinal study. npj Parkinson's Disease, 2, 15027. doi: 10.1038/npjparkd.2015.27

Almuqbel, M., Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Wood, K.-L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson’s disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. doi: 10.1016/j.parkreldis.2015.11.008

MacAskill, M. R., & Anderson, T. J. (2016). Eye movements in neurodegenerative diseases. Current Opinion in Neurology, 29(1), 61-68. doi: 10.1097/wco.0000000000000274

Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Watts, R., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLoS ONE, 10(12), e0143923. doi: 10.1371/journal.pone.0143923

Martin, T., Weatherall, M., Anderson, T. J., & MacAskill, M. R. (2015). A randomized controlled feasibility trial of a specific cueing program for falls management in persons with Parkinson disease and freezing of gait. Journal of Neurologic Physical Therapy, 39, 179-184. doi: 10.1097/npt.0000000000000093

Alamri, Y., MacAskill, M., Anderson, T., & Benamer, H. (2015). Parkinson's disease in the Gulf countries: An updated review. European Neurology, 74(3-4), 222-225. doi: 10.1159/000442283

Pitcher, T. L., MacAskill, M. R., & Anderson, T. J. (2014). Trends in antiparkinsonian medication use in New Zealand: 1995-2011. Parkinson's Disease, 2014, 379431. doi: 10.1155/2014/379431

Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., … Dalrymple-Alford, J. C., & Anderson, T. J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: An ASL-MRI study. Journal of Cerebral Blood Flow & Metabolism, 34, 964-970. doi: 10.1038/jcbfm.2014.40

Watanabe, M., Matsuo, Y., Zha, L., MacAskill, M. R., & Kobayashi, Y. (2014). Fixational saccades alter the gap effect. European Journal of Neuroscience, 39, 2098-2106. doi: 10.1111/ejn.12566

Toh, E. A., MacAskill, M. R., Dalrymple-Alford, J. C., Myall, D. J., Livingston, L., Macleod, S. A. D., & Anderson, T. J. (2014). Comparison of cognitive and UHDRS measures in monitoring disease progression in Huntington's disease: A 12-month longitudinal study. Translational Neurodegeneration, 3, 15. doi: 10.1186/2047-9158-3-15

MacAskill, M. R., & Anderson, T. J. (2013). Whose name is it anyway? Varying patterns of possessive usage in eponymous neurodegenerative diseases. PeerJ, 1, e67. doi: 10.7717/peerj.67

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology, 80(8), 1841-1849. doi: 10.1212/WNL.0b013e3182929f62

Anderson, T. J., & MacAskill, M. R. (2013). Eye movements in patients with neurodegenerative disorders. Nature Reviews Neurology, 9, 74-85. doi: 10.1038/nrneurol.2012.273

van Stockum, S., MacAskill, M. R., Myall, D., & Anderson, T. J. (2013). A perceptual discrimination task results in greater facilitation of voluntary saccades in Parkinson's disease patients. European Journal of Neuroscience, 37(1), 163-172. doi: 10.1111/ejn.12033

Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., … Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Reduced striatal volumes in Parkinson's disease: A magnetic resonance imaging study. Translational Neurodegeneration, 1(1), 17. doi: 10.1186/2047-9158-1-17

van Stockum, S., MacAskill, M. R., & Anderson, T. J. (2012). Impairment of voluntary saccades and facilitation of reflexive saccades do not co-occur in Parkinson's disease. Journal of Clinical Neuroscience, 19(8), 1119-1124. doi: 10.1016/j.jocn.2011.10.014

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 83, 188-194. doi: 10.1136/jnnp-2011-300828

MacAskill, M. R., Graham, C. F., Pitcher, T. L., Myall, D. J., Livingston, L., van Stockum, S., Dalrymple-Alford, J. C., & Anderson, T. J. (2012). The influence of motor and cognitive impairment upon visually-guided saccades in Parkinson's disease. Neuropsychologia, 50(14), 3338-3347. doi: 10.1016/j.neuropsychologia.2012.09.025

van Stockum, S., MacAskill, M. R., & Anderson, T. J. (2011). Bottom-up effects modulate saccadic latencies in well-known eye movement paradigm. Psychological Research, 75(4), 272-278. doi: 10.1007/s00426-010-0305-4

van Stockum, S., MacAskill, M. R., Myall, D., & Anderson, T. J. (2011). A perceptual discrimination task abnormally facilitates reflexive saccades in Parkinson's disease. European Journal of Neuroscience, 33(11), 2091-2100. doi: 10.1111/j.1460-9568.2011.07697.x

Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., … Dalrymple-Alford, J. C., & Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease. Brain, 134(3), 845-855. doi: 10.1093/brain/awq377

Dalrymple-Alford, J. C., Livingston, L., MacAskill, M. R., Graham, C., Melzer, T. R., Porter, R. J., … Anderson, T. J. (2011). Characterizing mild cognitive impairment in Parkinson's disease. Movement Disorders, 26(4), 629-636. doi: 10.1002/mds.23592

Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., … Keenan, R., Wells, S., Porter, R. J., … Anderson, T. J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson disease. Neurology, 75(19), 1717-1725. doi: 10.1212/WNL.0b013e3181fc29c9

Webb, A., Knott, A., & MacAskill, M. R. (2010). Eye movements during transitive action observation have sequential structure. Acta Psychologica, 133, 51-56. doi: 10.1016/j.actpsy.2009.09.001

van Stockum, S., MacAskill, M., Anderson, T., & Dalrymple-Alford, J. (2008). Don't look now or look away: Two sources of saccadic disinhibition in Parkinson's disease? Neuropsychologia, 46(13), 3108-3115. doi: 10.1016/j.neuropsychologia.2008.07.002

Myall, D. J., MacAskill, M. R., Davidson, P. R., Anderson, T. J., & Jones, R. D. (2008). Design of a modular and low-latency virtual-environment platform for applications in motor adaptation research, neurological disorders, and neurorehabilitation. IEEE Transactions on Neural Systems & Rehabilitation Engineering, 16(3), 298-309. doi: 10.1109/TNSRE.2008.922676

Le Heron, C. J., MacAskill, M. R., & Anderson, T. J. (2005). Memory-guided saccades in Parkinson's disease: Long delays can improve performance. Experimental Brain Research, 161, 293-298.

Heitger, M. H., MacAskill, M. R., Jones, R. D., & Anderson, T. J. (2005). The impact of mild closed head injury on involuntary saccadic adaptation: Evidence for the preservation of implicit motor learning. Brain Injury, 19(2), 109-117.

MacAskill, M. R., Jones, R. D., & Anderson, T. J. (2003). Saccadic suppression of displacement: Effects of illumination and background manipulation. Perception, 32, 463-474.

Muir, S. R., MacAskill, M. R., Herron, D., Goelz, H., Anderson, T. J., & Jones, R. D. (2003). EMMA - an eye movement measurement and analysis system. Australasian Physical & Engineering Sciences in Medicine, 26(1), 18-24.

MacAskill, M. R., Anderson, T. J., & Jones, R. D. (2002). Saccadic adaptation in neurological disorders. Progress in Brain Research, 140, 419-433. Oxford: Elsevier Science.

MacAskill, M., Anderson, T. J., & Jones, R. D. (2002). Adaptive modification of saccade amplitude in Parkinson's disease. Brain, 125, 1570-1582.

MacAskill, M. R., Anderson, T. J., & Jones, R. D. (2000). Suppression of displacement in severely slowed saccades. Vision Research, 40, 3405-3413.

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Journal - Research Other

Alamri, Y., Pascoe, M., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. (2019). Sensorimotor integration assessment by the Symbol-Digit modalities test in patients with Parkinsons disease. Neurosciences, 24(2), 143-144. doi: 10.17712/nsj.2019.2.20190002

Horne, K.-L., Myall, D. J., MacAskill, M. R., Anderson, T. J., & Dalrymple-Alford, J. C. (2018). Response to “Parkinson's disease mild cognitive impairment classifications and neurobehavioral symptoms”. International Psychogeriatrics, 30(9), 1415. doi: 10.1017/S1041610218000091

Alamri, Y., MacAskill, M., & Anderson, T. (2017). Aiming for study comparability in Parkinson's disease: Proposal for a modular set of biomarker assessments to be used in longitudinal studies. Frontiers in Aging Neuroscience, 8, 331. doi: 10.3389/fnagi.2016.00331

Alamri, Y., Anderson, T., Dalrymple-Alford, J., & MacAskill, M. (2017). Errors on the MoCA's animal-naming: Findings from Parkinson's disease patients. International Psychogeriatrics, 29(7), 1227-1228. doi: 10.1017/S1041610217000345

Alamri, Y., MacAskill, M., & Anderson, T. (2016). Repeated lumbar punctures for non-clinical indications: How do patients feel? European Neurology, 76(3/4), 123-124. doi: 10.1159/000449056

Alamri, Y., Al-Busaidi, I. S., MacAskill, M., & Anderson, T. (2015). Anxiety and depression in Parkinson's disease patients in Saudi Arabia Global neurology. Journal of the Neurological Sciences, 358(1-2), 457-458. doi: 10.1016/j.jns.2015.07.051

MacAskill, M. R., Myall, D. J., & Anderson, T. J. (2013). “Ocular Tremor” in Parkinson's disease: A technology-dependent artifact of universal head motion? Movement Disorders, 28(8), 1165-1166. doi: 10.1002/mds.25602

Dalrymple-Alford, J. C., Nakas, C. T., MacAskill, M. R., Livingston, L., & Anderson, T. J. (2011). [Reply to the letter to the editor The MoCA: Well-suited screen for cognitive impairment in Parkinson disease]. Neurology, 76(22), 1944-1945. doi: 10.1212/WNL.0b013e318219dc77

MacAskill, M. R., Koga, K., & Anderson, T. J. (2011). Japanese street performer mimes violation of Hering's Law. Neurology, 76, 1186-1187.

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