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Otago Medical School staff profiles

Professor Gillian Whalley

PositionProfessor of Clinical Sonography/Cardiology
DepartmentDepartment of Medicine (DSM)
QualificationsBAppSci MHSc(Hons) DMU PhD
TeachingSonography
ClinicalClinical echocardiography

Research

I am interested in the appropriate use of echocardiography to identify factors that may contribute to higher risk in patients and in at-risk populations. A key future focus will be community-based screening using ultrasound to identify individuals at higher risk of developing cardiovascular disease in order to introduce preventative methods early.

I have a long-term interest in the relationship between body composition and heart size and the impact of ethnicity upon that. I have recently completed an HRC-funded study evaluating heart size in Aotearoa/New Zealand, with a particular emphasis on determining what reference ranges should be applied in here.

I have experience of small single-centre and large multi-centre clinical trials, cohort studies, and prognostic studies, and have used meta-analytical methods widely. My interest in meta-analysis (both literature and individual patient approaches) extends towards linking echocardiography measurements with improved clinical correlation and prognosis in large population studies.

Publications

Prasad, S. B., Guppy-Coles, K., Stanton, T., Armstrong, J., Krishnaswamy, R., Whalley, G., … Thomas, L. (2019). Relation of left atrial volumes in patients with myocardial infarction to left ventricular filling pressures and outcomes. American Journal of Cardiology. Advance online publication. doi: 10.1016/j.amjcard.2019.05.007

Martin, J., Coffey, S., & Whalley, G. A. (2019). Identifying patients at risk post-infarct: Is it time for routine CMR? Heart, Lung & Circulation, 28(3), 354-357. doi: 10.1016/j.hlc.2019.01.002

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Prasad, S. B., Lin, A. K., Guppy-Coles, K. B., Stanton, T., Krishnasamy, R., Whalley, G. A., … Atherton, J. J. (2018). Diastolic dysfunction assessed using contemporary guidelines and prognosis following myocardial infarction. Journal of the American Society of Echocardiography, 31(10), 1127-1136. doi: 10.1016/j.echo.2018.05.016

Whalley, G. A. (2018). Surrogate survival: Battle between left ventricular ejection fraction and global longitudinal strain. JACC: Cardiovascular Imaging, 11(11), 1580-1582. doi: 10.1016/j.jcmg.2017.11.003

Journal - Research Article

Prasad, S. B., Guppy-Coles, K., Stanton, T., Armstrong, J., Krishnaswamy, R., Whalley, G., … Thomas, L. (2019). Relation of left atrial volumes in patients with myocardial infarction to left ventricular filling pressures and outcomes. American Journal of Cardiology. Advance online publication. doi: 10.1016/j.amjcard.2019.05.007

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Prasad, S. B., Lin, A. K., Guppy-Coles, K. B., Stanton, T., Krishnasamy, R., Whalley, G. A., … Atherton, J. J. (2018). Diastolic dysfunction assessed using contemporary guidelines and prognosis following myocardial infarction. Journal of the American Society of Echocardiography, 31(10), 1127-1136. doi: 10.1016/j.echo.2018.05.016

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Poppe, K. K., Doughty, R. N., Whalley, G. A., & Triggs, C. M. (2016). A new approach to assessment of the left ventricle. MethodsX, 3, 274-278. doi: 10.1016/j.mex.2016.03.014

Rigolli, M., Anandabaskaran, S., Christiansen, J. P., & Whalley, G. A. (2016). Bias associated with left ventricular quantification by multimodality imaging: A systematic review and meta-analysis. Open Heart, 3(1), e000388. doi: 10.1136/openhrt-2015-000388

Simioniuc, A., Carluccio, E., Ghio, S., Rosi, A., Biagiolo, P., Reboldi, G., … Whalley, G., … on behalf of the investigators of the Network Labs Ultrasound (NEBULA) in Heart Failure Study Group. (2016). Echo and natriuretic peptide guided therapy improves outcome and reduces worsening renal function in systolic heart failure: An observational study of 1137 outpatients. International Journal of Cardiology, 224, 416-423. doi: 10.1016/j.ijcard.2016.09.034

Berry, C., Poppe, K. K., Gamble, G. D., Earle, N. J., Ezekowitz, J. A., Squire, I. B., … Whalley, G. A., … on behalf of the MAGGIC Collaborative Group. (2016). Prognostic significance of anaemia in patients with heart failure with preserved and reduced ejection fraction: Results from the MAGGIC individual patient data meta-analysis. QJM, 109(6), 377-382. doi: 10.1093/qjmed/hcv087

Badve, S. V., Palmer, S. C., Strippoli, G. F. M., Roberts, M. A., Teixeira-Pinto, A., Boudville, N., … Whalley, G. A., … Johnson, D. W. (2016). The validity of left ventricular mass as a surrogate end point for all-cause and cardiovascular mortality outcomes in people with CKD: A systematic review and meta-analysis. American Journal of Kidney Diseases, 68(4), 554-563. doi: 10.1053/j.ajkd.2016.03.418

Yan, M. R., Parsons, A., Whalley, G. A., & Rush, E. C. (2016). Effects of a healthier snack on snacking habits and glycated Hb (HbA1c): A 6-week intervention study. British Journal of Nutrition, 116(12), 2169-2174. doi: 10.1017/S0007114516004372

Buckley, B., Farnworth, M. J., & Whalley, G. (2016). Echocardiography service provision in New Zealand: The implications of capacity modelling for the cardiac sonographer workforce. New Zealand Medical Journal, 129(1428), 16-24. Retrieved from https://www.nzma.org.nz/journal

Yan, M. R., Brown, D., Parsons, A., Whalley, G. A., Hamid, N., Kantono, K., … Rush, E. (2015). Branding, ingredients and nutrition information: Consumer liking of a healthier snack. Journal of Food Research, 4(5), 64-72. doi: 10.5539/jfr.v4n5p64

Pinkham, M. I., Whalley, G. A., Guild, S.-J., Malpas, S. C., & Barrett, C. J. (2015). Arterial baroreceptor reflex control of renal sympathetic nerve activity following chronic myocardial infarction in male, female, and ovariectomized female rats. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 309(2), R169-R178. doi: 10.1152/ajpregu.00026.2015

Simpson, J., Castagno, D., Doughty, R. N., Poppe, K. K., Earle, N., Squire, I., Richards, M., … Whalley, G. A., … on behalf of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC). (2015). Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation? Results from the MAGGIC meta-analysis. European Journal of Heart Failure, 17(11), 1182-1191. doi: 10.1002/ejhf.346

The EchoNoRMAL (Echocardiographic Normal Ranges Meta-Analysis of the Left Heart) Collaboration, including Whalley, G. A., Cameron, V., Richards, A. M., & Troughton, R. (2015). Ethnic-specific normative reference values for echocardiographic LA and LV size, LV mass, and systolic function: The EchoNoRMAL Study. JACC: Cardiovascular Imaging, 8(6), 656-665. doi: 10.1016/j.jcmg.2015.02.014

Teh, R. O., Kerse, N. M., Robinson, E. M., Whalley, G. A., Connolly, M. J., & Doughty, R. N. (2015). Left ventricular geometry and all-cause mortality in advanced age. Heart, Lung & Circulation, 24(1), 32-39. doi: 10.1016/j.hlc.2014.06.017

Jackson, C. E., Castagno, D., Maggioni, A. P., Køber, L., Squire, I. B., Swedberg, K., … Richards, A. M., … Whalley, G., … on behalf of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC). (2015). Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: Results from the MAGGIC individual patient meta-analysis. European Heart Journal, 36(18), 1106-1114. doi: 10.1093/eurheartj/ehu490

Rigolli, M., Rossi, A., Quintana, M., Klein, A. L., Yu, C.-M., Ghio, S., … Troughton, R. W., … Whalley, G. A., … on behalf of the MeRGE Collaborators. (2015). The prognostic impact of diastolic dysfunction in patients with chronic heart failure and post-acute myocardial infarction: Can age-stratified E/A ratio alone predict survival? International Journal of Cardiology, 181, 362-368. doi: 10.1016/j.ijcard.2014.12.051

Poppe, K. K., Whalley, G. A., Doughty, R. N., Woodward, M., Patel, A., Chow, C. K., … Triggs, C. M. (2015). The development and feasibility of a composite score of echocardiographic indices that may stratify outcome in patients with diabetes mellitus. International Journal of Cardiology, 182, 244-249. doi: 10.1016/j.ijcard.2014.12.087

Whalley, G. A., Pitama, S., Troughton, R. W., Doughty, R. N., Gamble, G. D., Gillies, T., Wells, J. E., Faatoese, A., Huria, T., Richards, M., & Cameron, V. A. (2015). Higher prevalence of left ventricular hypertrophy in two Māori cohorts: Findings from the Hauora Manawa/Community Heart Study. Australian & New Zealand Journal of Public Health, 39(1), 26-31. doi: 10.1111/1753-6405.12300

Buckley, B. A., Poppe, K., Farnworth, M. J., & Whalley, G. (2015). Regional differences in echocardiography provision in New Zealand: Results from the 2013 SCANZ Workforce Survey. New Zealand Medical Journal, 128(1408), 47-55. Retrieved from https://www.nzma.org.nz/journal

Earle, N. J., Poppe, K. K., Pilbrow, A. P., Cameron, V. A., Troughton, R. W., Skinner, J. R., … Whalley, G. A., … Richards, A. M., & Doughty, R. N. (2015). Genetic markers of repolarization and arrhythmic events following acute coronary syndromes. American Heart Journal, 169(4), 579-586.e3. doi: 10.1016/j.ahj.2014.11.015

Teh, R. O., Kerse, N. M., Robinson, E. M., Doughty, R. N., & Whalley, G. A. (2014). Which cardiovascular risk factors are associated with cardiovascular disease and predict future events in advanced age in New Zealand? Australasian Journal on Ageing, 33(1), 14-21. doi: 10.1111/j.1741-6612.2012.00626.x

Padwal, R., McAlister, F. A., McMurray, J. J. V., Cowie, M. R., Rich, M., Pocock, S., … Whalley, G., … for the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) Investigators. (2014). The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: A meta-analysis of individual patient data. International Journal of Obesity, 38(8), 1110-1114. doi: 10.1038/ijo.2013.203

Wong, C. M., Hawkins, N. M., Petrie, M. C., Jhund, P. S., Gardner, R. S., Ariti, C. A., … Whalley, G. A., … on behalf of the MAGGIC Investigators. (2014). Heart failure in younger patients: The meta-analysis global group in chronic heart failure (MAGGIC). European Heart Journal, 35(39), 2714-2721. doi: 10.1093/eurheartj/ehu216

Poppe, K. K., Doughty, R. N., Walsh, H. J., Triggs, C. M., & Whalley, G. A. (2014). A comparison of the effects of indexation on standard echocardiographic measurements of the left heart in a healthy multi-racial population. International Journal of Cardiovascular Imaging, 30(4), 749-758. doi: 10.1007/s10554-014-0395-y

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Pilbrow, A. P., Cordeddu, L., Cameron, V. A., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Foo, R. S.-Y. (2014). Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. International Journal of Cardiology, 176, 375-385. doi: 10.1016/j.ijcard.2014.07.068

Whalley, G. A., Marwick, T. H., Doughty, R. N., Cooper, B. A., Johnson, D. W., Pilmore, A., … and the IDEAL Echo Substudy Investigators. (2013). Effect of early initiation of dialysis on cardiac structure and function: Results from the echo substudy of the IDEAL trial. American Journal of Kidney Diseases, 61(2), 262-270. doi: 10.1053/j.ajkd.2012.09.008

Pocock, S. J., Ariti, C. A., McMurray, J. J. V., Maggioni, A., Køber, L., Squire, I. B., … Whalley, G. A., … on behalf of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC). (2013). Predicting survival in heart failure: A risk score based on 39 372 patients from 30 studies. European Heart Journal, 34(19), 1404-1413. doi: 10.1093/eurheartj/ehs337

The Echocardiographic Normal Ranges Meta-Analysis of the Left Heart (EchoNoRMAL) Collaboration, including Whalley, G. A., Cameron, V., Richards, A. M., & Troughton, R. (2013). A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: The EchoNoRMAL study. European Heart Journal, 15, 341-348. doi: 10.1093/ehjci/jet240

Stehlin, E., Malpas, S. C., Budgett, D. M., Barrett, C. J., McCormick, D., Whalley, G., … Guild, S.-J. (2013). Chronic measurement of left ventricular pressure in freely moving rats. Journal of Applied Physiology, 115(11), 1672-1682. doi: 10.1152/japplphysiol.00683.2013

Poppe, K. K., Squire, I. B., Whalley, G. A., Køber, L., McAlister, F. A., McMurray, J. J. V., … on behalf of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC). (2013). Known and missing left ventricular ejection fraction and survival in patients with heart failure: A MAGGIC meta-analysis report. European Journal of Heart Failure, 15(11), 1220-1227. doi: 10.1093/eurjhf/hft101

Buckley, B., White, S., Poppe, K., & Whalley, G. (2013). The cardiac sonography workforce in New Zealand. Australasian Journal of Ultrasound in Medicine, 16(2), 77-85. doi: 10.1002/j.2205-0140.2013.tb00169.x

Stamp, L. K., Wells, J. E., Pitama, S., Faatoese, A., Doughty, R. N., Whalley, G., Richards, A. M., & Cameron, V. A. (2013). Hyperuricaemia and gout in New Zealand rural and urban Māori and non-Māori communities. Internal Medicine Journal, 43(6), 678-684. doi: 10.1111/imj.12062

Rusinaru, D., Tribouilloy, C., Berry, C., Richards, A. M., Whalley, G. A., Earle, N., … on behalf of the MAGGIC Investigators. (2012). Relationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: An individual patient data meta-analysis. European Journal of Heart Failure, 14(10), 1139-1146. doi: 10.1093/eurjhf/hfs099

LeGrice, I. J., Pope, A. J., Sands, G. B., Whalley, G., Doughty, R. N., & Smaill, B. H. (2012). Progression of myocardial remodeling and mechanical dysfunction in the spontaneously hypertensive rat. American Journal of Physiology: Heart & Circulatory Physiology, 303(11), H1353-H1365. doi: 10.1152/ajpheart.00748.2011

Palmer, B. R., Frampton, C. M., Skelton, L., Yandle, T. G., Doughty, R. N., Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients. Journal of Cardiovascular Electrophysiology, 23(3), 319-324. doi: 10.1111/j.1540-8167.2011.02192.x

McAlister, F. A., Ezekowitz, J., Tarantini, L., Squire, I., Komajda, M., Bayes-Genis, A., … Whalley, G., … and Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) Investigators, including Richards, A. M. (2012). Renal dysfunction in patients with heart failure with preserved versus reduced ejection fraction: Impact of the new Chronic Kidney Disease-Epidemiology Collaboration Group formula. Circulation: Heart Failure, 5(3), 309-314. doi: 10.1161/CIRCHEARTFAILURE.111.966242

Martínez-Sellés, M., Doughty, R. N., Poppe, K., Whalley, G. A., Earle, N., Tribouilloy, C., … on behalf of the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC), including Richards, A. M. (2012). Gender and survival in patients with heart failure: Interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis. European Journal of Heart Failure, 14(5), 473-479. doi: 10.1093/eurjhf/hfs026

Cameron, V. A., Faatoese, A. F., Gillies, M. W., Robertson, P. J., Huria, T. M., Doughty, R. N., Whalley, G. A., … Richards, M. A., Troughton, R. W., Tikao-Mason, K. N., Wells, E. J., Sheerin, I. G., & Pitama, S. G. (2012). A cohort study comparing cardiovascular risk factors in rural Māori, urban Māori and non-Māori communities in New Zealand. BMJ Open, 2(3), e000799. doi: 10.1136/bmjopen-2011-000799

Ghio, S., Temporelli, P. L., Marsan, N. A., Poppe, K., Giannuzzi, P., Dini, F. L., … Whalley, G., on behalf of the MeRGE HF collaborators. (2012). Prognostic implications of left ventricular dilation in patients with nonischemic heart failure: Interactions with restrictive filling pattern and mitral regurgitation. Congestive Heart Failure, 18(4), 198-204. doi: 10.1111/j.1751-7133.2011.00281.x

Carrick-Ranson, G., Doughty, R. N., Whalley, G. A., Walsh, H. J., Gamble, G. D., & Baldi, J. C. (2012). The larger exercise stroke volume in endurance-trained men does not result from increased left ventricular early or late inflow or tissue velocities. Acta Physiologica, 205(4), 520-531. doi: 10.1111/j.1748-1716.2012.02430.x

Ellis, K. L., Palmer, B. R., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Pilbrow, A. P., Skelton, L., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2012). Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. Journal of Human Hypertension, 27, 237-244. doi: 10.1038/jhh.2012.24

Ellis, K. L., Pilbrow, A. P., Potter, H. C., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Palmer, B. R., Skelton, L., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). Association between endothelin type A receptor haplotypes and mortality in coronary heart disease. Personalized Medicine, 9(3), 341-349. doi: 10.2217/PME.12.10

Poppe, K. K., Edgerton Bachmann, M., Triggs, C. M., Doughty, R. N., & Whalley, G. A. (2012). Geographic variation in left ventricular mass and mass index: A systematic review. Journal of Human Hypertension, 26(7), 420-429. doi: 10.1038/jhh.2011.56

Ellis, K. L., Newton-Cheh, C., Wang, T. J., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Skelton, L., Davis, N., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2011). Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes. Journal of Molecular & Cellular Cardiology, 50(4), 695-701. doi: 10.1016/j.yjmcc.2011.01.010

ADVANCE Echocardiography Substudy Investigators, ADVANCE Collaborative Group, including Troughton, R., & Whalley, G. A. (2011). Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: The ADVANCE Echocardiography Substudy. Journal of Hypertension, 29(7), 1439-1447. doi: 10.1097/HJH.0b013e3283480fe9

Meta-analysis Global Group in Chronic Heart Failure (MAGGIC), including Whalley, G. A. (2011). The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: An individual patient data meta-analysis: Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). European Heart Journal, 33(14), 1750-1757. doi: 10.1093/eurheartj/ehr254

Pitama, S., Wells, J. E., Faatoese, A., Tikao-Mason, K., Robertson, P., Huria, T., Gillies, T., … Whalley, G., Troughton, R., Sheerin, I., Richards, M., & Cameron, V. A. (2011). A Kaupapa Māori approach to a community cohort study of heart disease in New Zealand. Australian & New Zealand Journal of Public Health, 35(3), 249-255. doi: 10.1111/j.1753-6405.2011.00702.x

Ellis, K. L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Skelton, L., Thomson, J. A., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011). Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease. Circulation: Cardiovascular Genetics, 4(6), 636-646. doi: 10.1161/circgenetics.111.960336

Faatoese, A. F., Pitama, S. G., Gillies, T. W., Robertson, P. J., Huria, T. M., Tikao-Mason, K. N., … Whalley, G. A., Richards, A. M., Troughton, R. W., Sheerin, I. G., Wells, J. E., & Cameron, V. A. (2011). Community screening for cardiovascular risk factors and levels of treatment in a rural Māori cohort. Australian & New Zealand Journal of Public Health, 35(6), 517-523. doi: 10.1111/j.1753-6405.2011.00777.x

Somaratne, J. B., Whalley, G. A., Poppe, K. K., ter Bals, M. M., Wadams, G., Pearl, A., … Doughty, R. N. (2011). Screening for left ventricular hypertrophy in patients with type 2 diabetes mellitus in the community. Cardiovascular Diabetology, 10, 29. doi: 10.1186/1475-2840-10-29

Poppe, K. K., Whalley, G. A., Somaratne, J. B., Keelan, S., Bagg, W., Triggs, C. M., & Doughty, R. N. (2011). Role of echocardiographic left ventricular mass and carotid intima-media thickness in the cardiovascular risk assessment of asymptomatic patients with type 2 diabetes mellitus. Internal Medicine Journal, 41(5), 391-398. doi: 10.1111/j.1445-5994.2010.02305.x

Poppe, K. K., Doughty, R. N., Yu, C.-M., Quintana, M., Møller, J. E., Klein, A. L., … Whalley, G. A., on behalf of the MeRGE Collaborators. (2011). Understanding differences in results from literature-based and individual patient meta-analyses: An example from meta-analyses of observational data. International Journal of Cardiology, 148, 209-213. doi: 10.1016/j.ijcard.2009.09.566

Stewart, R. A. H., Kerr, A. J., Whalley, G. A., Legget, M. E., Zeng, I., Williams, M. J. A., Lainchbury, J., … Richards, M. A., … for the New Zealand Heart Valve Study Investigators. (2010). Left ventricular systolic and diastolic function assessed by tissue Doppler imaging and outcome in asymptomatic aortic stenosis. European Heart Journal, 31(18), 2216-2222. doi: 10.1093/eurheartj/ehq159

Jarvis, M. D., Palmer, B. R., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., … Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients. Clinical & Experimental Pharmacology & Physiology, 37(2), 193-198. doi: 10.1111/j.1440-1681.2009.05261.x

Ellis, K. L., Pilbrow, A. P., Frampton, C. M., Doughty, R. N., Whalley, G. A., Ellis, C. J., Palmer, B. R., Skelton, L., Yandle, T. G., Palmer, S. C., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2010). A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circulation: Cardiovascular Genetics, 3(3), 286-293. doi: 10.1161/circgenetics.109.917443

Poppe, K. K., Whalley, G. A., Richards, A. M., Wright, S. P., Triggs, C. M., & Doughty, R. N. (2010). Prediction of ACC/AHA stage B heart failure by clinical and neurohormonal profiling among patients in the community. Journal of Cardiac Failure, 16(12), 957-963. doi: 10.1016/j.cardfail.2010.07.247

Hotu, C., Bagg, W., Collins, J., Harwood, L., Whalley, G., Doughty, R., … on behalf of the DEFEND investigators. (2010). A community-based model of care improves blood pressure control and delays progression of proteinuria, left ventricular hypertrophy and diastolic dysfunction in Māori and Pacific patients with type 2 diabetes and chronic kidney disease: A randomized controlled trialC. Nephrology Dialysis Transplantation, 25, 3260-3266. doi: 10.1093/ndt/gfq168

Wasywich, C. A., Gamble, G. D., Whalley, G. A., & Doughty, R. N. (2010). Understanding changing patterns of survival and hospitalization for heart failure over two decades in New Zealand: Utility of 'days alive and out of hospital' from epidemiological data. European Journal of Heart Failure, 12, 462-468. doi: 10.1093/eurjhf/hfq027

Wasywich, C. A., Pope, A. J., Somaratne, J., Poppe, K. K., Whalley, G. A., & Doughty, R. N. (2010). Atrial fibrillation and the risk of death in patients with heart failure: A literature-based meta-analysis. Internal Medicine Journal, 40, 347-356. doi: 10.1111/j.1445-5994.2009.01991.x

Wasywich, C. A., Whalley, G. A., Walsh, H. A., Gamble, G. D., & Doughty, R. N. (2009). Changes in tissue-doppler echocardiographic assessment of left ventricular filling during NT-proBNP guided heart failure treatment titration: A pilot study. Heart, Lung & Circulation, 18(1), 38-44. doi: 10.1016/j.hlc.2008.07.002

Somaratne, J. B., Berry, C., McMurray, J. J. V., Poppe, K. K., Doughty, R. N., & Whalley, G. A. (2009). The prognostic significance of heart failure with preserved left ventricular ejection fraction: A literature-based meta-analysis. European Journal of Heart Failure, 11, 855-962. doi: 10.1093/eurjhf/hfp103

Whalley, G. A., Gusso, S., Hofman, P., Cutfield, W., Poppe, K. K., Doughty, R. N., & Baldi, J. C. (2009). Structural and functional cardiac abnormalities in adolescent girls with poorly controlled type 2 diabetes. Diabetes Care, 32(5), 883-888. doi: 10.2337/dc08-2005

Rossi, A., Temporelli, P. L., Quintana, M., Dini, F. L., Ghio, S., Hillis, G. S., … Whalley, G. A., on behalf of the MeRGE Heart Failure Collaborators, including Frampton, C. M., & Troughton, R. (2009). Independent relationship of left artial size and mortality in patients with heart failure: An individual patient meta-analysis of longitudinal data (MeRGE Heart Failure). European Journal of Heart Failure, 11, 929-936. doi: 10.1093/eurjhf/hfp112

Dini, F. L., Whalley, G., Poppe, K., Fontanive, P., Rosa, G. M., Doughty, R. N., & Di Bello, V. (2009). Plasma N‐terminal protype‐B natriuretic peptide and restrictive mitral flow to risk‐stratify patients with stage B heart failure. Clinical Cardiology, 32(12), 711-717. doi: 10.1002/clc.20617

Stewart, R. A., Kerr, A. J., Cowan, B. R., Young, A. A., Occleshaw, C., Richards, A. M., … Whalley, G. A., … for the ZEST Study Investigators. (2008). A randomized trial of the aldosterone-receptor antagonist eplerenone in asymptomatic moderate-severe aortic stenosis. American Heart Journal, 156, 348-355. doi: 10.1016/j.ahj.2008.03.012

Whalley, G. A., Wright, S. P., Pearl, A., Gamble, G. D., Walsh, H. J., Richards, M., & Doughty, R. N. (2008). Prognostic role of echocardiography and brain natriuretic peptide in symptomatic breathless patients in the community. European Heart Journal, 29(4), 509-516. doi: 10.1093/eurheartj/ehm647

Kerr, A. J., Raffel, O. C., Whalley, G. A., Zeng, I., & Stewart, R. A. (2008). Elevated B-type natriuretic peptide despite normal left ventricular function on rest and exercise stress echocardiography in mitral regurgitation. European Heart Journal, 29(3), 363-370. doi: 10.1093/eurheartj/ehm553

Meta-Analysis Research Group in Echocardiography (MeRGE) AMI Collaborators, including Whalley, G. A. (2008). Independent prognostic importance of a restrictive left ventricular filling pattern after myocardial infarction: An individual patient meta-analysis: Meta-analysis research group in echocardiography acute myocardial infarction. Circulation, 117, 2591-2598. doi: 10.1161/circulationaha.107.738625

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2008). Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. American Heart Journal, 156(4), 752-758. doi: 10.1016/j.ahj.2008.06.013

van Pelt, N. C., Kerr, A. J., Legget, M. E., Pasupati, S., Whalley, G., Wong, S., … Stewart, R. A. H. (2008). Increased B-type natriuretic peptide is associated with an abnormal blood pressure response to exercise in asymptomatic aortic stenosis. International Journal of Cardiology, 127(3), 313-320. doi: 10.1016/j.ijcard.2007.07.172

Bridgman, P. G., Ashrafi, A. N., Mann, S., Whalley, G. A., on behalf of the SCANZ collaborators. (2008). Survey of clinical echocardiography in New Zealand (SCANZ). New Zealand Medical Journal, 121(1269). Retrieved from http://journal.nzma.org.nz/journal/121-1269/2924/content.pdf

Meta-analysis Research Group in Echocardiography (MeRGE) Heart Failure Collaborators, including Whalley, G. A. (2008). Independence of restrictive filling pattern and LV ejection fraction with mortality in heart failure: An individual patient meta-analysis. European Journal of Heart Failure, 10, 786-792. doi: 10.1016/j.ejheart.2008.06.005

van Pelt, N., Stewart, R. A. H., Legget, M. E., Whalley, G. A., Wong, S. P., Zeng, I., … Kerr, A. J. (2007). Longitudinal left ventricular contractile dysfunction after exercise in aortic stenosis. Heart, 93(6), 732-738. doi: 10.1136/hrt.2006.100164

Whalley, G. A., Gamble, G. D., & Doughty, R. N. (2007). The prognostic significance of restrictive diastolic filling associated with heart failure: A meta-analysis. International Journal of Cardiology, 116(1), 70-77. doi: 10.1016/j.ijcard.2006.03.032

Whalley, G. A., Gamble, G. D., Dini, F. L., Klein, A. L., Møller, J. E., Quintana, M., … on behalf of the Meta-Analysis Research Group in Echocardiography (MeRGE) Collaborators. (2007). Individual patient meta-analyses of restrictive diastolic filling pattern and mortality in patients post acute myocardial infarction and in patients with chronic heart failure. International Journal of Cardiology, 122, 207-215. doi: 10.1016/j.ijcard.2006.11.080

Astley, C. M., Portelli, L., Whalley, G. A., & Davidson, P. M. (2007). Coming of age: Affiliate member profile and participation in the Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. Heart, Lung & Circulation, 16(6), 447-451. doi: 10.1016/j.hlc.2007.02.088

Somaratne, J. B., Whalley, G. A., Gamble, G. D., & Doughty, R. N. (2007). Restrictive filling pattern is a powerful predictor of heart failure events postacute myocardial infarction and in established heart failure: A literature-based meta-analysis. Journal of Cardiac Failure, 13(5), 346-352. doi: 10.1016/j.cardfail.2007.01.010

Bruch, C., Reinecke, H., Scheld, H. H., Whalley, G. A., Stypmann, J., Breithardt, G., … Gradaus, R. (2007). Transmitral flow patterns and the presence of chronic kidney disease provide independent and incremental prognostic information in patients with heart failure and systolic dysfunction. Journal of the American Society of Echocardiography, 20(8), 989-997. doi: 10.1016/j.echo.2007.01.013

Wasywich, C. A., Whalley, G. A., Gamble, G. D., Wright, S. P., & Doughty, R. N. (2006). Does rhythm matter? The prognostic importance of atrial fibrillation in heart failure. Heart, Lung & Circulation, 15(6), 353-357. doi: 10.1016/j.hlc.2006.07.011

Whalley, G. A., Gamble, G. D., & Doughty, R. N. (2006). Restrictive diastolic filling predicts death after acute myocardial infarction: Systematic review and meta-analysis of prospective studies. Heart, 92(11), 1588-1594. doi: 10.1136/hrt.2005.083055

Bagg, W., Aoina, J., Cross, P. A. R., Whalley, G. A., Gamble, G. D., Doughty, R. N., & Holdaway, I. M. (2006). Serum IGF-I levels are similar in Samoan, Māori and European populations despite differences in body composition. Growth Hormone & IGF Research, 16, 57-60. doi: 10.1016/j.ghir.2005.11.002

Baldi, J. C., Aoina, J. L., Whalley, G. A., Carrick-Ranson, G., Walsh, H., O'Shaughnessy, H., … Doughty, R. N. (2006). The effect of type 2 diabetes on diastolic function. Medicine & Science in Sports & Exercise, 38(8), 1384-1388. doi: 10.1249/01.mss.0000228954.90591.95

Whalley, G. A., Walsh, H. J., Gamble, G. D., & Doughty, R. N. (2005). Comparison of different methods for detection of diastolic filling abnormalities. Journal of the American Society of Echocardiography, 18(7), 710-717. doi: 10.1016/j.echo.2005.03.038

Whalley, G. A., Gamble, G. D., Walsh, H. J., Sharpe, N., & Doughty, R. N. (2005). Quantitative evaluation of regional endocardial visualisation with second harmonic imaging and contrast left ventricular opacification in heart failure patients. European Journal of Echocardiography, 6, 134-143. doi: 10.1016/j.euje.2004.08.003

Whalley, G. A., Doughty, R. N., Gamble, G. D., Oxenham, H. C., Walsh, H. J., Reid, I. R., & Baldi, J. C. (2004). Association of fat-free mass and training status with left ventricular size and mass in endurance-trained athletes. JACC, 44(4), 892-896. doi: 10.1016/j.jacc.2004.04.051

Wasywich, C. A., Bagg, W., Whalley, G., Aoina, J., Walsh, H., Gamble, G., … Doughty, R. (2004). Test-retest reproducibility of the wideband external pulse device. Journal of Applied Research, 4(2), 245-251.

Doughty, R. N., Whalley, G. A., Walsh, H. A., Gamble, G. D., Lopéz-Sendón, J., Sharpe, N., on behalf of the CAPRICORN Echo Substudy Investigators. (2004). Effects of carvedilol on left ventricular remodeling after acute myocardial infarction: The CAPRICORN Echo Substudy. Circulation, 109, 201-206. doi: 10.1161/01.CIR.0000108928.25690.94

Fonseca, C. G., Dissanayake, A. M., Doughty, R. N., Whalley, G. A., Gamble, G. D., Cowan, B. R., … Young, A. A. (2004). Three-dimensional assessment of left ventricular systolic strain in patients with type 2 diabetes mellitus, diastolic dysfunction, and normal election fraction. American Journal of Cardiology, 94(11), 1391-1395. doi: 10.1016/j.amjcard.2004.07.143

Whalley, G. A., Gamble, G. D., Walsh, H. J., Wright, S. P., Agewall, S., Sharpe, N., & Doughty, R. N. (2004). Effect of tissue harmonic imaging and contrast upon between observer and test-restest reproducibility of left ventricular ejection fraction measurement in patients with heart failure. European Journal of Heart Failure, 6, 85-93. doi: 10.1016/j.ejheart.2003.09.011

Wright, S. P., Walsh, H., Ingley, K. M., Muncaster, S. A., Gamble, G. D., Pearl, A., Whalley, G. A., … Doughty, R. N. (2003). Uptake of self-management strategies in a heart failure management programme. European Journal of Heart Failure, 5, 371-380. doi: 10.1016/s1388-9842(03)00039-4

Baldi, J. C., McFarlane, K., Oxenham, H. C., Whalley, G. A., Walsh, H. J., & Doughty, R. N. (2003). Left ventricular diastolic filling and systolic function of young and older trained and untrained men. Journal of Applied Physiology, 95, 2570-2575. doi: 10.1152/japplphysiol.00441.2003

Wright, S. P., Doughty, R. N., Pearl, A., Gamble, G. D., Whalley, G. A., Walsh, H., … Yandle, T. G., Richards, A. M., & Sharpe, N. (2003). Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: A randomized, controlled trial. JACC, 42(10), 1793-1800. doi: 10.1016/j.jacc.2003.05.011

Whalley, G. A., Doughty, R. N., Gamble, G. D., Wright, S. P., Walsh, H. J., Muncaster, S. A., & Sharpe, N. (2002). Pseudonormal mitral filling pattern predicts hospital re-admission in patients with congestive heart failure. JACC, 39(11), 1787-1795. doi: 10.1016/s0735-1097(02)01868-5

Doughty, R. N., Wright, S. P., Pearl, A., Walsh, H. J., Muncaster, S., Whalley, G. A., … Sharpe, N. (2002). Randomized, controlled trial of integrated heart failure management: The Auckland heart failure management study. European Heart Journal, 23, 139-146. doi: 10.1053/euhj.2001.2712

Agewall, S., Doughty, R. N., Bagg, W., Whalley, G. A., & Sharpe, N. (2001). Comparison of ultrasound assessment of flow-mediated dilatation in the radial and brachial artery with upper and forearm cuff positions. Clinical Physiology, 21(1), 9-14. doi: 10.1046/j.1365-2281.2001.00302.x

Bagg, W., Whalley, G. A., Gamble, G., Drury, P. L., Sharpe, N., & Braatvedt, G. D. (2001). Effects of improved glycaemic control on endothelial function in patients with type 2 diabetes. Internal Medicine Journal, 31, 322-328. doi: 10.1046/j.1445-5994.2001.00072.x

Bagg, W., Whalley, G. A., Sathu, A., Gamble, G., Sharpe, N., & Braatvedt, G. D. (2000). The effect of acute hyperglycaemia on brachial artery flow mediated dilatation in normal volunteers. Australian & New Zealand Journal of Medicine, 30(3), 344-350. doi: 10.1111/j.1445-5994.2000.tb00836.x

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