Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Otago Medical School staff profiles

Associate Professor Jarek Maciaczyk

PositionAssociate Professor
DepartmentDepartment of Surgical Sciences (Dunedin)
Research summaryCancer research

Research

I have a strong clinical interest in the complex therapy of brain tumour patients and long-term experimental experience in brain tumour stem cell biology. My research focus is the investigation of molecular processes governing brain tumour stem cells, such as developmentally conserved stem cell pathways and therapy resistance mechanisms.

Publications

Suwala, A. K., Koch, K., Rios, D. H., Aretz, P., Uhlmann, C., Ogorek, I., … Maciaczyk, J. (2018). Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro. Oncotarget, 9(32), 22703-22716. doi: 10.18632/oncotarget.25210

Maciaczyk, D., Picard, D., Zhao, L., Koch, K., Herrera-Rios, D., Li, G., … Maciaczyk, J., & Kahlert, U. D. (2017). CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. British Journal of Cancer, 117, 102-112. doi: 10.1038/bjc.2017.157

Kahlert, U. D., Mooney, S. M., Natsumeda, M., Steiger, H.-J., & Maciaczyk, J. (2017). Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways. International Journal of Cancer, 140(1), 10-22. doi: 10.1002/ijc.30259

Koch, K., Hartmann, R., Schröter, F., Suwala, A. K., Maciaczyk, D., Krüger, A. C., … Maciaczyk, J. (2016). Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget, 7(45), 73414-73431. doi: 10.18632/oncotarget.12337

Herrlinger, U., Schäfer, N., Steinbach, J. P., Weyerbrock, A., Hau, P., Goldbrunner, R., … Maciaczyk, J., … Glas, M. (2016). Bevacizumab plus irinotecan versus temozolomide in newly diagnosed O6-Methylguanine-DNA methyltransferase nonmethylated glioblastoma: The randomized GLARIUS trial. Journal of Clinical Oncology, 34(14), 1611-1619. doi: 10.1200/jco.2015.63.4691

Journal - Research Article

Suwala, A. K., Koch, K., Rios, D. H., Aretz, P., Uhlmann, C., Ogorek, I., … Maciaczyk, J. (2018). Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro. Oncotarget, 9(32), 22703-22716. doi: 10.18632/oncotarget.25210

Maciaczyk, D., Picard, D., Zhao, L., Koch, K., Herrera-Rios, D., Li, G., … Maciaczyk, J., & Kahlert, U. D. (2017). CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. British Journal of Cancer, 117, 102-112. doi: 10.1038/bjc.2017.157

Koch, K., Hartmann, R., Schröter, F., Suwala, A. K., Maciaczyk, D., Krüger, A. C., … Maciaczyk, J. (2016). Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget, 7(45), 73414-73431. doi: 10.18632/oncotarget.12337

Herrlinger, U., Schäfer, N., Steinbach, J. P., Weyerbrock, A., Hau, P., Goldbrunner, R., … Maciaczyk, J., … Glas, M. (2016). Bevacizumab plus irinotecan versus temozolomide in newly diagnosed O6-Methylguanine-DNA methyltransferase nonmethylated glioblastoma: The randomized GLARIUS trial. Journal of Clinical Oncology, 34(14), 1611-1619. doi: 10.1200/jco.2015.63.4691

Hanaford, A. R., Archer, T. C., Price, A., Kahlert, U. D., Maciaczyk, J., Nikkhah, G., … Raabe, E. H. (2016). DiSCoVERing innovative therapies for rare tumors: Combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets. Clinical Cancer Research, 22(15), 3903-3914. doi: 10.1158/1078-0432.ccr-15-3011

Kahlert, U. D., Cheng, M., Koch, K., Marchionni, L., Fan, X., Raabe, E. H., Maciaczyk, J., … Eberhart, C. G. (2016). Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells. International Journal of Cancer, 138(5), 1246-1255. doi: 10.1002/ijc.29873

Kahlert, U. D., Suwala, A. K., Koch, K., Natsumeda, M., Orr, B. A., Hayashi, M., Maciaczyk, J., & Eberhart, C. G. (2015). Pharmacologic Wnt inhibition reduces proliferation, survival, and clonogenicity of glioblastoma cells. Journal of Neuropathology & Experimental Neurology, 74(9), 889-900. doi: 10.1097/nen.0000000000000227

Kahlert, U. D., Suwala, A. K., Raabe, E. H., Siebzehnrubl, F. A., Suarez, M. J., Orr, B. A., … Maciaczyk, J., & Eberhart, C. G. (2015). ZEB1 promotes invasion in human fetal neural stem cells and hypoxic glioma neurospheres. Brain Pathology, 25(6), 724-732. doi: 10.1111/bpa.12240

Kahlert, U. D., Koch, K., Suwala, A. K., Hartmann, R., Cheng, M., Maciaczyk, D., … Maciaczyk, J. (2015). The effect of neurosphere culture conditions on the cellular metabolism of glioma cells. Folia Neuropathologica, 53(3), 219-225. doi: 10.5114/fn.2015.54422

Schmidt, M., Kahlert, U., Wessolleck, J., Maciaczyk, D., Merkt, B., Maciaczyk, J., … Steinhauser, M. O. (2014). Characterization of a setup to test the impact of high-amplitude pressure waves on living cells. Scientific Reports, 4(3849). doi: 10.1038/srep03849

Güzel, A., Rölz, R., Nikkhah, G., Kahlert, U. D., & Maciaczyk, J. (2014). A microsurgical procedure for middle cerebral artery occlusion by intraluminal monofilament insertion technique in the rat: a special emphasis on the methodology. Experimental & Translational Stroke Medicine, 6, 6. doi: 10.1186/2040-7378-6-6

Mao, X.-G., Hütt-Cabezas, M., Orr, B. A., Weingart, M., Taylor, I., Rajan, A. K. D., … Maciaczyk, J., … Raabe, E. H. (2013). LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Oncotarget, 4(7), 1050-1064. doi: 10.18632/oncotarget.1131

Rath, A., Klein, A., Papazoglou, A., Pruszak, J., Garcia, J., Krause, M., Maciaczyk, J., … Nikkhah, G. (2013). Survival and functional restoration of human fetal ventral mesencephalon following transplantation in a rat model of Parkinson's disease. Cell Transplantation, 22(7), 1281-1293. doi: 10.3727/096368912x654984

Lopez, W. O. C., Nikkhah, G., Kahlert, U. D., Maciaczyk, D., Bogiel, T., Moellers, S., … Maciaczyk, J. (2013). Clinical neurotransplantation protocol for Huntington's and Parkinson's disease. Restorative Neurology & Neuroscience, 31(5), 579-595. doi: 10.3233/rnn-130317

Kahlert, U. D., Bender, N. O., Maciaczyk, D., Bogiel, T., Bar, E. E., Eberhart, C. G., … Maciaczyk, J. (2012). CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like component. Folia Neuropathologica, 50(4), 357-368. doi: 10.5114/fn.2012.32365

Baxan, N., Kahlert, U., Maciaczyk, J., Nikkhah, G., Hennig, J., & von Elverfeldt, D. (2012). Microcoil-based MR phase imaging and manganese enhanced microscopy of glial tumor neurospheres with direct optical correlation. Magnetic Resonance in Medicine, 68(1), 86-97. doi: 10.1002/mrm.23208

Kahlert, U. D., Maciaczyk, D., Dai, F., Claus, R., Firat, E., Doostkam, S., … Maciaczyk, J. (2012). Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to an increase in a CD133-positive cell population in human glioblastomas in vitro. Journal of Neuropathology & Experimental Neurology, 71(12), 1086-1099. doi: 10.1097/NEN.0b013e3182772d83

Kahlert, U. D., Maciaczyk, D., Doostkam, S., Orr, B. A., Simons, B., Bogiel, T., … Maciaczyk, J. (2012). Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Cancer Letters, 325(1), 42-53. doi: 10.1016/j.canlet.2012.05.024

Raabe, E. H., Lim, K. S., Kim, J. M., Meeker, A., Mao, X.-G., Nikkhah, G., Maciaczyk, J., … Eberhart, C. G. (2011). BRAF activation induces transformation and then senescence in human neural stem cells: A pilocytic astrocytoma model. Clinical Cancer Research, 17(11), 3590-3599. doi: 10.1158/1078-0432.ccr-10-3349

Lepski, G., Maciaczyk, J., Jannes, C. E., Maciaczyk, D., Bischofberger, J., & Nikkhah, G. (2011). Delayed functional maturation of human neuronal progenitor cells in vitro. Molecular & Cellular Neuroscience, 47, 36-44. doi: 10.1016/j.mcn.2011.02.011

Lepski, G., Jannes, C. E., Maciaczyk, J., Papazoglou, A., Mehlhorn, A. T., Kaiser, S., … Nikkhah, G. (2010). Limited Ca2+ and PKA-pathway dependent neurogenic differentiation of human adult mesenchymal stem cells as compared to fetal neuronal stem cells. Experimental Cell Research, 316, 216-231. doi: 10.1016/j.yexcr.2009.08.006

Fan, X., Khaki, L., Zhu, T. S., Soules, M. E., Talsma, C. E., Gul, N., … Maciaczyk, J., … Eberhart, C. G. (2010). NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells, 28, 5-16. doi: 10.1002/stem.254

Maciaczyk, J., Singec, I., Maciaczyk, D., Klein, A., & Nikkhah, G. (2009). Restricted spontaneous in vitro differentiation and region-specific migration of long-term expanded fetal human neural precursor cells after transplantation into the adult rat brain. Stem Cells & Development, 18(7), 1043-1058. doi: 10.1089/scd.2008.0346

Sun, P., Xia, S., Lal, B., Eberhart, C. G., Quinones-Hinojosa, A., Maciaczyk, J., … Laterra, J. (2009). DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells, 27(7), 1473-1486. doi: 10.1002/stem.89

Maciaczyk, J., Singec, I., Maciaczyk, D., & Nikkhah, G. (2008). Combined use of BDNF, ascorbic acid, low oxygen, and prolonged differentiation time generates tyrosine hydroxylase-expressing neurons after long-term in vitro expansion of human fetal midbrain precursor cells. Experimental Neurology, 213, 354-362. doi: 10.1016/j.expneurol.2008.06.014

Singec, I., Knoth, R., Meyer, R. P., Maciaczyk, J., Volk, B., Nikkhah, G., … Snyder, E. Y. (2006). Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology. Nature Methods, 3(10), 801-806. doi: 10.1038/nmeth926

^ Top of page

Journal - Research Other

Kahlert, U. D., Mooney, S. M., Natsumeda, M., Steiger, H.-J., & Maciaczyk, J. (2017). Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways. International Journal of Cancer, 140(1), 10-22. doi: 10.1002/ijc.30259

Suwala, A. K., Hanaford, A., Kahlert, U. D., & Maciaczyk, J. (2016). Clipping the wings of glioblastoma: Modulation of WNT as a novel therapeutic strategy. Journal of Neuropathology & Experimental Neurology, 75(5), 388-396. doi: 10.1093/jnen/nlw013

Lopez, W. O. C., Nikkah, G., & Maciaczyk, J. (2014). Embryonic stem cells in neurology: Current clinical transplantation trials in Parkinson's (PD) and Huntington's (HD) disease. Arquivos de Neuro-Psiquiatria, 72(12), 978-979. doi: 10.1590/0004-282x20140154

Kahlert, U. D., Nikkhah, G., & Maciaczyk, J. (2013). Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas. Cancer Letters, 331(2), 131-138. doi: 10.1016/j.canlet.2012.12.010

Capetian, P., Knoth, R., Maciaczyk, J., Pantazis, G., Ditter, M., Bokla, L., … Nikkhah, G. (2009). Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation. Neuroscience, 160, 661-675. doi: 10.1016/j.neuroscience.2009.02.035

Guzel, A., Maciaczyk, J., Dohmen-Scheufler, H., Senturk, S., Volk, B., Ostertag, C. B., & Nikkhah, G. (2009). Multiple intracranial melanoma metastases: Case report and review of the literature. Journal of Neuro-Oncology, 93(3), 413-420. doi: 10.1007/s11060-008-9785-0

Guzel, A., Tatli, M., Maciaczyk, J., & Altinors, N. (2008). Primary cerebral intraventricular hydatid cyst: A case report and review of the literature. Journal of Child Neurology, 23(5), 585-588. doi: 10.1177/0883073807309791

More publications...