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Otago Medical School staff profiles

Dr Jane Girling

PositionLecturer
DepartmentDepartment of Anatomy
Research summaryUterine biology and endometriosis

Research

Jane joined the Department of Anatomy in 2018 after nearly 20 years working in Australia, most recently in the Gynaecology Research Centre at the University of Melbourne and Royal Women’s Hospital, Melbourne. Jane is a reproductive biologist with research interests in uterine biology and women’s health, with a particular focus on the common gynaecological disorder endometriosis.

In ongoing collaborative research with colleagues in Australia, Jane is investigating the functional role of genetic variants linked with the pathophysiology of endometriosis. She is also examining patient details and the phenotype endometriotic lesions with the goal of identifying characteristics that may assist clinicians with treatment decisions.

Jane also has an interest in the impact of menstrual pain and menstrual bleeding disorders on individuals and their families, and how we can better assist girls and young women to live a full and happy life.

Publications

Mortlock, S., Restuadi, R., Levien, R., Girling, J. E., Holdsworth-Carson, S. J., Healey, M., … Montgomery, G. W. (2019). Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clinical Epigenetics, 11, 49. doi: 10.1186/s13148-019-0648-7

Holdsworth-Carson, S. J., Colgrave, E. M., Donoghue, J. F., Fung, J. N., Churchill, M., Mortlock, S., … Girling, J. E., & Rogers, P. A. W. (2019). Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes. Molecular Human Reproduction. Advance online publication. doi: 10.1093/molehr/gaz006

Steele, E., Bush, D., Healey, M., Rapsey, C. M., Peate, M., & Girling, J. E. (2019). Investigating the care needs of those with endometriosis: Are we listening to the patients? Australian & New Zealand Journal of Obstetrics & Gynaecology. Advance online publication. doi: 10.1111/ajo.13080

Dior, U. P., Nisbet, D., Fung, J. N., Foster, G., Healey, M., Montgomery, G. W., … Girling, J. E. (2018). The association of sonographic evidence of adenomyosis with severe endometriosis and with gene expression in eutopic endometrium. Journal of Minimally Invasive Gynecology. Advance online publication. doi: 10.1016/j.jmig.2018.09.780

Fung, J. N., Mortlock, S., Girling, J. E., Holdsworth-Carson, S. J., Teh, W. T., Zhu, Z., … Montgomery, G. W. (2018). Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. Scientific Reports, 8, 11424 . doi: 10.1038/s41598-018-29462-y

Chapter in Book - Research

Girling, J. E., & Rogers, P. A. W. (2008). Endometrial angiogenesis, arteriogenesis, and lymphangiogenesis. In J. D. Aplin, A. T. Fazleabas, S. R. Glasser & L. C. Giudice (Eds.), The endometrium: Molecular, cellular, and clinical perspectives. (2nd ed.) (pp. 76-92). London, UK: Informa Healthcare.

Weston, G. C., Girling, J. E., Gargett, C. E., & Rogers, P. A. W. (2005). Hormonal effects on endometrial angiogenesis. In R. V. Zubar (Ed.), Trends in angiogenesis research. (pp. 71-102). New York, NY: Nova Science.

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Journal - Research Article

Mortlock, S., Restuadi, R., Levien, R., Girling, J. E., Holdsworth-Carson, S. J., Healey, M., … Montgomery, G. W. (2019). Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clinical Epigenetics, 11, 49. doi: 10.1186/s13148-019-0648-7

Holdsworth-Carson, S. J., Colgrave, E. M., Donoghue, J. F., Fung, J. N., Churchill, M., Mortlock, S., … Girling, J. E., & Rogers, P. A. W. (2019). Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes. Molecular Human Reproduction. Advance online publication. doi: 10.1093/molehr/gaz006

Dior, U. P., Nisbet, D., Fung, J. N., Foster, G., Healey, M., Montgomery, G. W., … Girling, J. E. (2018). The association of sonographic evidence of adenomyosis with severe endometriosis and with gene expression in eutopic endometrium. Journal of Minimally Invasive Gynecology. Advance online publication. doi: 10.1016/j.jmig.2018.09.780

Fung, J. N., Mortlock, S., Girling, J. E., Holdsworth-Carson, S. J., Teh, W. T., Zhu, Z., … Montgomery, G. W. (2018). Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. Scientific Reports, 8, 11424 . doi: 10.1038/s41598-018-29462-y

Marshall, S. A., Hannan, N. J., Jelinic, M., Nguyen, T. P. H., Girling, J. E., & Parry, L. J. (2018). Animal models of preeclampsia: Translational failings and why. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 314(4), R499-R508. doi: 10.1152/ajpregu.00355.2017

Holdsworth-Carson, S. J., Dior, U. P., Colgrave, E. M., Healey, M., Montgomery, G. W., Rogers, P. A. W., & Girling, J. E. (2018). The association of body mass index with endometriosis and disease severity in women with pain. Journal of Endometriosis and Pelvic Pain Disorders, 10(2), 79-87. doi: 10.1177/2284026518773939

Girling, J. E., Hawthorne, S. C. J., Marino, J. L., Nur Azurah, A. G., Grover, S. R., & Jayasinghe, Y. L. (2018). Paternal understanding of menstrual concerns in young women. Journal of Pediatric & Adolescent Gynecology. Advance online publication. doi: 10.1016/j.jpag.2018.04.001

Girling, J. E., Lockhart, M. G., Olshansky, M., Paiva, P., Woodrow, N., Marino, J. L., … Rogers, P. A. W. (2017). Differential gene expression in menstrual endometrium from women with self-reported heavy menstrual bleeding. Reproductive Sciences, 24(1), 28-46. doi: 10.1177/1933719116648217

Marshall, S. A., Huei Leo, C., Girling, J. E., Tare, M., Beard, S., Hannan, N. J., & Parry, L. J. (2017). Relaxin treatment reduces angiotensin II-induced vasoconstriction in pregnancy and protects against endothelial dysfunction. Biology of Reproduction, 96(4), 895-906. doi: 10.1093/biolre/iox023

Fung, J. N., Girling, J. E., Lukowski, S. W., Sapkota, Y., Wallace, L., Holdsworth-Carson, S. J., … Montgomery, G. W. (2017). The genetic regulation of transcription in human endometrial tissue. Human Reproduction, 32(4), 893-904. doi: 10.1093/humrep/dex006

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., … Hedger, M. P. (2017). Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288. Andrology, 5(3), 578-588. doi: 10.1111/andr.12337

Holdsworth-Carson, S. J., Fung, J. N., Luong, H. T. T., Sapkota, Y., Bowdler, L. M., Wallace, L., … Girling, J. E., … Rogers, P. A. W. (2016). Endometrial vezatin and its association with endometriosis risk. Human Reproduction, 31(5), 999-1013. doi: 10.1093/humrep/dew047

Paiva, P., Lockhart, M. G., Girling, J. E., Olshansky, M., Woodrow, N., Marino, J. L., … Rogers, P. A. W. (2016). Identification of genes differentially expressed in menstrual breakdown and repair. Molecular Human Reproduction, 22(12), 898-912. doi: 10.1093/molehr/gaw060

Marshall, S. A., Ng, L., Unemori, E. N., Girling, J. E., & Parry, L. J. (2016). Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation. Reproductive Biology & Endocrinology, 14, 11. doi: 10.1186/s12958-016-0148-y

Marshall, S. A., Leo, C. H., Senadheera, S. N., Girling, J. E., Tare, M., & Parry, L. J. (2016). Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 310(9), R847-R857. doi: 10.1152/ajpregu.00506.2015

Fung, J. N., Holdsworth-Carson, S. J., Sapkota, Y., Zhao, Z. Z., Jones, L., Girling, J. E., … Montgomery, G. W. (2015). Functional evaluation of genetic variants associated with endometriosis near GREB1. Human Reproduction, 30(5), 1263-1275. doi: 10.1093/humrep/dev051

Winnall, W. R., Lloyd, S. B., De Rose, R., Alcantara, S., Amarasena, T. H., Hedger, M. P., Girling, J. E., & Kent, S. J. (2015). Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis. Journal of Leukocyte Biology, 97(3), 599-609. doi: 10.1189/jlb.4A0914-438R

Holdsworth-Carson, S. J., Craythorn, R. G., Winnall, W. R., Dhaliwal, K., Genovese, R., Nowell, C. J., … Girling, J. E. (2015). Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus. Reproduction, Fertility & Development, 27(7), 985-999. doi: 10.1071/RD13372

Holdsworth-Carson, S. J., Zaitseva, M., Girling, J. E., Vollenhoven, B. J., & Rogers, P. A. W. (2014). Common fibroid-associated genes are differentially expressed in phenotypically dissimilar cell populations isolated from within human fibroids and myometrium. Reproduction, 147(5), 683-692. doi: 10.1530/REP-13-0580

Fu, L., Lockhart, M. G., Amir, M. M., Winnall, W. R., Rogers, P. A. W., & Girling, J. E. (2014). Differential TGFB1-signalling in endometrium from women with endometriosis: Importance of appropriate housekeeping genes. Journal of Endometriosis and Pelvic Pain Disorders, 6(1), 41-54. doi: 10.5301/je.5000171

Kaitu'u-Lino, T. J., Ye, L., Tuohey, L., Dimitriadis, E., Bulmer, J., Rogers, P., … Girling, J. E., … Tong, S. (2013). Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua. Human Reproduction, 28(5), 1172-1180. doi: 10.1093/humrep/det028

Winnall, W. R., Wu, H., Sarraj, M. A., Rogers, P. A. W., de Kretser, D. M., Girling, J. E., & Hedger, M. P. (2013). Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens. Reproduction, Fertility & Development, 25(3), 570-580. doi: 10.1071/RD11287

Gooi, J. H., Richardson, M. L., Jelinic, M., Girling, J. E., Wlodek, M. E., Tare, M., & Parry, L. J. (2013). Enhanced uterine artery stiffness in aged pregnant relaxin mutant mice is reversed with exogenous relaxin treatment. Biology of Reproduction, 89(1), 18. doi: 10.1095/biolreprod.113.108118

Craythorn, R. G., Winnall, W. R., Lederman, F., Gold, E. J., O'Connor, A. E., de Kretser, D. M., … Girling, J. E. (2012). Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus. Reproductive BioMedicine Online, 24(3), 364-374. doi: 10.1016/j.rbmo.2011.12.004

Kaitu'u-Lino, T. J., Ye, L., Salamonsen, L. A., Girling, J. E., & Gargett, C. E. (2012). Identification of label-retaining perivascular cells in a mouse model of endometrial decidualization, breakdown, and repair. Biology of Reproduction, 86(6), 184. doi: 10.1095/biolreprod.112.099309

Donoghue, J. F., McCavigan, C. J., Lederman, F. L., Cann, L. M., Fu, L., Dimitriadis, E., Girling, J. E., & Rogers, P. A. W. (2012). Dilated thin-walled blood and lymphatic vessels in human endometrium: A potential role for VEGF-D in progestin-induced break-through bleeding. PLoS ONE, 7(2), e30916. doi: 10.1371/journal.pone.0030916

Walter, L. M., Rogers, P. A. W., & Girling, J. E. (2010). Differential expression of vascular endothelial growth factor-A isoforms in the mouse uterus during early pregnancy. Reproductive BioMedicine Online, 21, 803-811. doi: 10.1016/j.rbmo.2010.07.005

Walter, L. M., Rogers, P. A. W., & Girling, J. E. (2010). Vascular endothelial growth factor-A isoform and (co)receptor expression are differentially regulated by 17β-oestradiol in the ovariectomised mouse uterus. Reproduction, 140, 331-341. doi: 10.1530/REP-10-0047

Girling, J. E., Donoghue, J. F., Lederman, F. L., Cann, L. M., Achen, M. G., Stacker, S. A., & Rogers, P. A. W. (2010). Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer. Reproductive Biology & Endocrinology, 8, 84. doi: 10.1186/1477-7827-8-84

Volchek, M., Girling, J. E., Lash, G. E., Cann, L., Kumar, B., Robson, S. C., … Rogers, P. A. W. (2010). Lymphatic in the human endometrium disappear during decidualization. Human Reproduction, 25(10), 2455-2464. doi: 10.1093/humrep/deq224

Fu, L., Girling, J. E., & Rogers, P. A. W. (2008). Expression of Fox Head Protein 1 in human eutopic endometrium and endometriosis. Reproductive Sciences, 15(3), 243-252. doi: 10.1177/1933719107312626

Lin, S.-Y., Craythorn, R. G., O'Connor, A. E., Matzuk, M. M., Girling, J. E., Morrison, J. R., & de Kretser, D. M. (2008). Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms. Molecular Endocrinology, 22(2), 415-429. doi: 10.1210/me.2006-0529

Girling, J. E., Lederman, F. L., Walter, L. M., & Rogers, P. A. W. (2007). Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology, 148(11), 5433-5441. doi: 10.1210/en.2007-0856

Girling, J. E., & Jones, S. M. (2006). In vitro steroid production by adrenals and kidney-gonads from embryonic southern snow skinks (Niveoscincus microlepidotus): Implications for the control of the timing of parturition? General & Comparative Endocrinology, 145(2), 169-176. doi: 10.1016/j.ygcen.2005.08.012

Neaves, L., Wapstra, E., Birch, D., Girling, J. E., & Joss, J. M. P. (2006). Embryonic gonadal and sexual organ development in a small viviparous skink, Niveoscincus ocellatus. Journal of Experimental Zoology Part A: Comparative Experimental Biology, 305A(1), 74-82. doi: 10.1002/jez.a.249

Walter, L. M., Rogers, P. A. W., & Girling, J. E. (2005). The role of progesterone in endometrial angiogenesis in pregnant and ovariectomised mice. Reproduction, 129(6), 765-777. doi: 10.1530/rep.1.00625

Rogers, P. A. W., Martinez, F., Girling, J. E., Lederman, F., Cann, L., Farrell, E., … Patel, N. (2005). Influence of different hormonal regimens on endometrial microvascular density and VEGF expression in women suffering from breakthrough bleeding. Human Reproduction, 20(12), 3341-3347. doi: 10.1093/humrep/dei239

Heryanto, B., Girling, J. E., & Rogers, P. A. W. (2004). Intravascular neutrophils partially mediate the endometrial endothelial cell proliferative response to oestrogen in ovariectomised mice. Reproduction, 127(5), 613-620. doi: 10.1530/rep.1.00161

Girling, J. E., Heryanto, B., Patel, N., & Rogers, P. A. W. (2004). Effect of long-term progestin treatment on endometrial vasculature in normal cycling mice. Contraception, 70(4), 343-350. doi: 10.1016/j.contraception.2004.04.006

Girling, J. E., & Jones, S. M. (2003). In vitro progesterone production by maternal and embryonic tissues during gestation in the southern snow skink (Niveoscincus microlepidotus). General & Comparative Endocrinology, 133(1), 100-108. doi: 10.1016/S0016-6480(03)00147-3

Gartrell, B. D., Girling, J. E., Edwards, A., & Jones, S. M. (2002). Comparison of noninvasive methods for the evaluation of female reproductive condition in a large viviparous lizard, Tiliqua nigrolutea. Zoo Biology, 21(3), 253-268. doi: 10.1002/zoo.10017

Girling, J. E., Jones, S. M., & Swain, R. (2002). Delayed ovulation and parturition in a viviparous alpine lizard (Niveoscincus microlepidotus): Morphological data and plasma steroid concentrations. Reproduction, Fertility & Development, 14(1), 43-53. doi: 10.1071/RD01091

Girling, J. E. (2002). The reptilian oviduct: A review of structure and function and directions for future research. Journal of Experimental Zoology, 293(2), 141-170. doi: 10.1002/jez.10105

Girling, J. E., Bennett, E. J., Henderson, K., & Cockrem, J. (2002). Persistence of pregnant mare serum gonadotrophin in plasma of Japanese quail (Coturnix coturnix japonica). Reproduction, Fertility & Development, 14(5), 287-290. doi: 10.1071/RD01048

Girling, J. E., Bennett, E. J., & Cockrem, J. F. (2002). Administration of pregnant mare serum gonadotropin to Japanese quail (Coturnix coturnix japonica): Dose response over seven days and comparison of delivery by daily injection or osmotic pump. New Zealand Veterinary Journal, 50(3), 115-121. doi: 10.1080/00480169.2002.36293

Girling, J. E., Jones, S. M., & Swain, R. (2002). Induction of parturition in snow skinks: can low temperatures inhibit the actions of AVT? Journal of Experimental Zoology, 293(5), 525-531. doi: 10.1002/jez.90007

Girling, J. E., Guillette, Jr, L. J., & Cree, A. (2000). Ultrastructure of the uterus in an ovariectomized gecko (Hemidactylus turcicus) after administration of exogenous estradiol. Journal of Experimental Zoology, 286, 76-89.

Girling, J. E., Cree, A., & Guillette, L. J. J. (1998). Oviducal structure in four species of gekkonid lizard differing in parity mode and eggshell structure. Reproduction, Fertility & Development, 10, 139-154.

Girling, J. E., Cree, A., & Guillette, Jr, L. J. (1997). Oviductal structure in a viviparous New Zealand gecko, Hoplodactylus maculatus. Journal of Morphology, 234(1), 51-68.

Girling, J. E., & Cree, A. M. (1995). Plasma corticosterone levels are not significantly related to reproductive stage in female common geckos (Hoplodactylus maculatus). General & Comparative Endocrinology, 100, 273-281.

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Journal - Research Other

Steele, E., Bush, D., Healey, M., Rapsey, C. M., Peate, M., & Girling, J. E. (2019). Investigating the care needs of those with endometriosis: Are we listening to the patients? Australian & New Zealand Journal of Obstetrics & Gynaecology. Advance online publication. doi: 10.1111/ajo.13080

Marshall, S. A., Senadheera, S. N., Parry, L. J., & Girling, J. E. (2017). The role of relaxin in normal and abnormal uterine function during the menstrual cycle and early pregnancy. Reproductive Sciences, 24(3), 342-354. doi: 10.1177/1933719116657189

Girling, J. E., & Rogers, P. A. W. (2012). The endometrial lymphatic vasculature: Function and dysfunction. Reviews in Endocrine & Metabolic Disorders, 13(4), 265-275. doi: 10.1007/s11154-012-9224-6

Craythorn, R. G., Girling, J. E., Hedger, M. P., Rogers, P. A. W., & Winnall, W. R. (2009). An RNA spiking method demonstrates that 18S rRNA is regulated by progesterone in the mouse uterus. Molecular Human Reproduction, 15(11), 757-761. doi: 10.1093/molehr/gap058

Rogers, P. A. W., Donoghue, J. F., Walter, L. M., & Girling, J. E. (2009). Endometrial angiogenesis, vascular maturation, and lymphangiogenesis. Reproductive Sciences, 16(2), 147-151. doi: 10.1177/1933719108325509

Girling, J. E., & Rogers, P. A. W. (2009). Regulation of endometrial vascular remodelling: Role of the vascular endothelial growth factor family and the angiopoietin-TIE signalling system. Reproduction, 138(6), 883-893. doi: 10.1530/rep-09-0147

Girling, J. E., & Hedger, M. P. (2007). Toll-like receptors in the gonads and reproductive tract: Emerging roles in reproductive physiology and pathology. Immunology & Cell Biology, 85(6), 481-489. doi: 10.1038/sj.icb.7100086

Girling, J. E., & Rogers, P. A. W. (2005). Recent advances in endometrial angiogenesis research. Angiogenesis, 8(2), 89-99. doi: 10.1007/s10456-005-9006-9

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