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Otago Medical School staff profiles

Dr Cath Drummond

PositionResearch Fellow
DepartmentDepartment of Pathology (Dunedin)

Publications

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., … Laín, S. (2018). A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nature Communications, 9(1), 1107. doi: 10.1038/s41467-018-03441-3

Drummond, C. J., Hanna, J. A., García, M. R., Devine, D. J., Heyrana, A. J., Finkelstein, D., … Hatley, M. E. (2018). Hedgehog pathway drives fusion-negative rhabdomyosarcoma initiated from non-myogenic endothelial progenitors. Cancer Cell, 33(1), 108-124. doi: 10.1016/j.ccell.2017.12.001

Ladds, M. J. G. W., Pastor-Fernández, A., Popova, G., van Leeuwen, I. M. M., Eng, K. E., Drummond, C. J., … Laín, S. (2018). Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib. PLoS ONE, 13(4), e0195956. doi: 10.1371/journal.pone.0195956

Drummond, C. J., & Hatley, M. E. (2018). A case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells. Molecular & Cellular Oncology, 5(4), e1448246. doi: 10.1080/23723556.2018.1448246

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., … Laín, S. (2018). A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nature Communications, 9(1), 1107. doi: 10.1038/s41467-018-03441-3

Ladds, M. J. G. W., Pastor-Fernández, A., Popova, G., van Leeuwen, I. M. M., Eng, K. E., Drummond, C. J., … Laín, S. (2018). Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib. PLoS ONE, 13(4), e0195956. doi: 10.1371/journal.pone.0195956

Drummond, C. J., Hanna, J. A., García, M. R., Devine, D. J., Heyrana, A. J., Finkelstein, D., … Hatley, M. E. (2018). Hedgehog pathway drives fusion-negative rhabdomyosarcoma initiated from non-myogenic endothelial progenitors. Cancer Cell, 33(1), 108-124. doi: 10.1016/j.ccell.2017.12.001

Hanna, J. A., Drummond, C. J., Garcia, M. R., Go, J. C., Finkelstein, D., Rehg, J. E., & Hatley, M. E. (2017). Biallelic Dicer1 loss mediated by aP2-Cre drives angiosarcoma. Cancer Research, 77(22), 6109-6118. doi: 10.1158/0008-5472.Can-17-1262

Drummond, C. J., Esfandiari, A., Liu, J., Lu, X., Hutton, C., Jackson, J., … Lunec, J. (2016). TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation. Oncotarget, 7(29), 46203-46218. doi: 10.18632/oncotarget.10073

Sachweh, M. C. C., Stafford, W. C., Drummond, C. J., McCarthy, A. R., Higgins, M., Campbell, J., … Laín, S. (2015). Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. Oncotarget, 6(18), 16488-16506. doi: 10.18632/oncotarget.4108

Darekar, S. D., Mushtaq, M., Gurrapu, S., Kovalevska, L., Drummond, C., Petruchek, M., … Kashuba, E. (2015). Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts. Oncotarget, 6(25), 21016-21028. doi: 10.18632/oncotarget.4123

Sachweh, M. C. C., Drummond, C. J., Higgins, M., Campbell, J., & Laín, S. (2013). Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression. Cell Death & Disease, 4(3), e533. doi: 10.1038/cddis.2013.61

McCarthy, A. R., Sachweh, M. C. C., Higgins, M., Campbell, J., Drummond, C. J., van Leeuwen, I. M. M., … Laín, S. (2013). Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner. Molecular Cancer Therapeutics, 12(4), 352-360. doi: 10.1158/1535-7163.MCT-12-0900

Watson, A. F., Liu, J., Bennaceur, K., Drummond, C. J., Endicott, J. A., Golding, B. T., … Hardcastle, I. R. (2011). MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones. Bioorganic & Medicinal Chemistry Letters, 21(19), 5916-5919. doi: 10.1016/j.bmcl.2011.07.084

Hardcastle, I. R., Liu, J., Valeur, E., Watson, A., Ahmed, S. U., Blackburn, T. J., … Drummond, C., … Lunec, J. (2011). Isoindolinone inhibitors of the murine double minute 2 (MFM2)-p53 protein-protein interaction: Structure-activity studies leading to improved potency. Journal of Medicinal Chemistry, 54(5), 1233-1243. doi: 10.1021/jm1011929

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Journal - Research Other

Drummond, C. J., & Hatley, M. E. (2018). A case of mistaken identity: Rhabdomyosarcoma development from endothelial progenitor cells. Molecular & Cellular Oncology, 5(4), e1448246. doi: 10.1080/23723556.2018.1448246

Drummond, C. J., Finlay, G. J., Broome, L., Marshall, E. S., Richardson, E., & Baguley, B. C. (2011). Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: Comparison with doxorubicin and etoposide [Short report]. Investigational New Drugs, 29(5), 1102-1110. doi: 10.1007/s10637-010-9473-8

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