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Otago Medical School staff profiles

Professor Richard Troughton

PositionProfessor
DepartmentDepartment of Medicine (UOC)
QualificationsMB ChB(Auck) PhD(Otago) FRACP
Research summaryCardioendocrinology

Research

Richard Troughton is co-director of clinical studies at the Christchurch Heart Institute (CHI), a University of Otago research centre, and a cardiologist at Christchurch hospital. His research has focused on novel ways to monitor heart function and guide treatment for heart conditions. This research has included a landmark study using circulating blood levels of a heart hormone discovered by CHI researchers (called NT-proBNP) to guide the treatment of heart failure. He subsequently helped to lead an international collaboration of studies testing this novel treatment strategy. More recently he helped lead a team testing a new implantable sensor that allows patients to measure pressures within the heart to guide daily dosing of heart failure medications. His research interests extend to cardiac imaging and the use of new ultrasound techniques to assess heart function. Specific interests include:
  • Neurohormonal control of cardiovascular and renal function
  • Heart Failure
  • Echocardiography
  • Left Ventricular Diastolic Function
  • Novel monitoring devices for heart failure

Publications

Mulder, R., Zarifeh, J., Boden, J., Lacey, C., Tyrer, P., Tyrer, H., Than, M., & Troughton, R. (2019). An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain. International Journal of Cardiology. Advance online publication. doi: 10.1016/j.ijcard.2019.01.067

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314077

Grodin, J. L., Liebo, M. J., Butler, J., Metra, M., Felker, G. M., Hernandez, A. F., … Troughton, R. W., & Tang, W. H. W. (2019). Prognostic implications of changes in amino-terminal pro-B-type natriuretic peptide in acute decompensated heart failure: Insights from ASCEND-HF. Journal of Cardiac Failure. Advance online publication. doi: 10.1016/j.cardfail.2019.04.002

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

Chapter in Book - Research

Chan, W., & Troughton, R. (2014). Pulmonary hypertension and cardiac resynchronization therapy: Evaluation prior to implantation and response to therapy. In C.-M. Yu, D. L. Hayes & A. Auricchio (Eds.), Cases in cardiac resynchronization therapy. (pp. 295-300). Philadelphia, PA: Saunders.

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Troughton, R. W. (2010). Dilated cardiomyopathy. In M. J. Garcia (Ed.), Noninvasive cardiovascular imaging: A multimodality approach. (pp. 465-477). Philadelphia, PA: Lippincott Williams & Wilkins.

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Troughton, R. W., Ritzema-Carter, J., & Nicholls, M. G. (2008). Role of neurohormones. In A. L. Klein & M. J. Garcia (Eds.), Diastology: Clinical approach to diastolic heart failure. (pp. 345-366). Philadelphia, PA: Saunders.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

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Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Troughton, R., Lin, S., & Wong, J. (2004). Prosthetic heart valves. In Manual of Cardiovascular Medicine. (2nd ed.) (pp. 236-248). Philadelphia: Lippincott Williams and Wilkins.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

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Journal - Research Article

Mulder, R., Zarifeh, J., Boden, J., Lacey, C., Tyrer, P., Tyrer, H., Than, M., & Troughton, R. (2019). An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain. International Journal of Cardiology. Advance online publication. doi: 10.1016/j.ijcard.2019.01.067

Grodin, J. L., Liebo, M. J., Butler, J., Metra, M., Felker, G. M., Hernandez, A. F., … Troughton, R. W., & Tang, W. H. W. (2019). Prognostic implications of changes in amino-terminal pro-B-type natriuretic peptide in acute decompensated heart failure: Insights from ASCEND-HF. Journal of Cardiac Failure. Advance online publication. doi: 10.1016/j.cardfail.2019.04.002

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314077

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

Prickett, T. C. R., Darlow, B. A., Troughton, R. W., Cameron, V. A., Elliott, J. M., Martin, J., Horwood, L. J., & Espiner, E. A. (2018). New insights into cardiac and vascular natriuretic peptides: Findings from young adults born with very low birth weight. Clinical Chemistry, 64(2), 363-373. doi: 10.1373/clinchem.2017.280354

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology. Advance online publication. doi: 10.1001/jamacardio.2018.3368

Lam, C. S. P., Gamble, G. D., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Cameron, V. A., … Troughton, R., Richards, A. M., & Doughty, R. N. (2018). Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study. European Heart Journal, 39(20), 1170-1178. doi: 10.1093/eurheartj/ehy005

Harris, S. L., More, K., Dixon, B., Troughton, R., Pemberton, C., Horwood, J., Ellis, N., & Austin, N. (2018). Factors affecting N-terminal pro-B-type natriuretic peptide levels in preterm infants and use in determination of haemodynamic significance of patent ductus arteriosus. European Journal of Pediatrics, 177(4), 521-532. doi: 10.1007/s00431-018-3089-y

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

de Carvalho, L., Fong, A., Troughton, R., Yan, B. P., Chin, C.-T., Poh, S.-C., … Frampton, C., Richards, A. M., & Chan, M. Y. (2018). Prognostic implications of dual platelet reactivity testing in acute coronary syndrome. Thrombosis & Haemostasis, 118(2), 415-426. doi: 10.1160/TH17-08-0564

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

de Carvalho, L. P., Tan, S. H., Ow, G.-S., Tang, Z., Ching, J., Kovalik, J.-P., … Richards, A. M., … Troughton, R. W., … Chan, M. Y. (2018). Plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction. JACC: Basic to Translational Science, 3(2), 163-175. doi: 10.1016/j.jacbts.2017.12.005

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation. Advance online publication. doi: 10.1161/circulationaha.117.032003

Kavsak, P. A., Neumann, J. T., Cullen, L., Than, M., Shortt, C., Greenslade, J. H., Pickering, J. W., … Troughton, R., … Worster, A. (2018). Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. CMAJ, 190(33), E974-E984. doi: 10.1503/cmaj.180144

McDonald, K., Troughton, R., Dahlström, U., Dargie, H., Krum, H., van der Meer, P., … Richards, M., & Doughty, R. (2018). Daily home BNP monitoring in heart failure for prediction of impending clinical deterioration: Results from the HOME HF study. European Journal of Heart Failure, 20(3), 474-480. doi: 10.1002/ejhf.1053

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Pemberton, C. J., Frampton, C. M., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2016). B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain. Clinical Biochemistry, 49, 645-650. doi: 10.1016/j.clinbiochem.2016.02.015

Young, J. M., Pickering, J. W., George, P. M., Aldous, S. J., Wallace, J., Frampton, C. M., Troughton, R. W., Richards, A. M., … Than, M. P. (2016). Heart Fatty Acid Binding Protein and cardiac troponin: Development of an optimal rule-out strategy for acute myocardial infarction. BMC Emergency Medicine, 16(1), 34. doi: 10.1186/s12873-016-0089-y

Pilbrow, A. P., Lewis, K. A., Perrin, M. H., Sweet, W. E., Moravec, C. S., Tang, W. H. W., … Troughton, R. W., & Cameron, V. A. (2016). Cardiac CRFR1 expression is elevated in human heart failure and modulated by genetic variation and alternative splicing. Endocrinology, 157(12), 4865-4874. doi: 10.1210/en.2016-1448

Tang, W. H. W., Wu, Y., Grodin, J. L., Hsu, A. P., Fernandez, A., Butler, J., … Troughton, R. W., … Starling, R. C. (2016). Prognostic value of baseline and changes in circulating soluble ST2 levels and the effects of nesiritide in acute decompensated heart failure. JACC: Heart Failure, 4(1), 68-77. doi: 10.1016/j.jchf.2015.07.015

Devlin, G., Williams, M., Elliott, J., White, H., French, J., Gamble, G., Matsis, P., Troughton, R., Richards, M., & Ellis, C. (2016). Management of non ST-elevation acute coronary syndrome patients in New Zealand: A longitudinal analysis: Results from the New Zealand Acute Coronary Syndrome national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 129(1428), 9-15. Retrieved from https://www.nzma.org.nz/journal

Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal

Pickering, J. W., Young, J. M., George, P., Aldous, S., Cullen, L., Greenslade, J. H., Richards, A. M., Troughton, R., Ardagh, M., Frampton, C. M., & Than, M. P. (2015). The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department. Clinical Biochemistry, 48(18), 1219-1224. doi: 10.1016/j.clinbiochem.2015.07.033

Ellis, C., Hammett, C., Ranasinghe, I., French, J., Briffa, T., Devlin, G., Elliott, J., … Williams, M., Troughton, R., … on behalf of Bi-National Acute Coronary Syndromes (ACS) 'SNAPSHOT' Audit Group. (2015). Comparison of the management and in-hospital outcomes of acute coronary syndrome patients in Australia and New Zealand: Results from the binational SNAPSHOT acute coronary syndrome 2012 audit. Internal Medicine Journal, 45(5), 497-509. doi: 10.1111/imj.12739

Tang, W. H. W., Dupont, M., Hernandez, A. F., Voors, A. A., Hsu, A. P., Felker, G. M., … Troughton, R. W., … Starling, R. C. (2015). Comparative assessment of short-term adverse events in acute heart failure with cystatin C and other estimates of renal function: Results from the ASCEND-HF trial. JACC: Heart Failure, 3(1), 40-49. doi: 10.1016/j.jchf.2014.06.014

The EchoNoRMAL (Echocardiographic Normal Ranges Meta-Analysis of the Left Heart) Collaboration, including Whalley, G. A., Cameron, V., Richards, A. M., & Troughton, R. (2015). Ethnic-specific normative reference values for echocardiographic LA and LV size, LV mass, and systolic function: The EchoNoRMAL Study. JACC: Cardiovascular Imaging, 8(6), 656-665. doi: 10.1016/j.jcmg.2015.02.014

Lee, J., Young, J., Frampton, C. M., Aldous, S., Troughton, R. W., Than, M., Richards, A. M., & Pemberton, C. J. (2015). A novel troponin T peptide in humans: Assay, biochemistry and preliminary findings in acute coronary syndromes. International Journal of Cardiology, 190, 68-74. doi: 10.1016/j.ijcard.2015.04.145

Charles, C. J., Rademaker, M. T., Melton, I. C., Gutfinger, D., Eigler, N. L., Qu, F., & Troughton, R. W. (2015). Thoracic impedance measures tissue characteristics in the vicinity of the electrodes, not intervening lung water: Implications for heart failure monitoring. Journal of Clinical Monitoring & Computing, 29(1), 65-76. doi: 10.1007/s10877-014-9570-x

Lee, J., Than, M., Aldous, S., Troughton, R., Richards, M., & Pemberton, C. J. (2015). CNP signal peptide in patients with cardiovascular disease. Frontiers in Cardiovascular Medicine, 2, 28. doi: 10.3389/fcvm.2015.00028

Chan, W. Y. W., Charles, C. J., Frampton, C. M., Richards, A. M., Crozier, I. G., Troughton, R. W., & Jardine, D. L. (2015). Human muscle sympathetic nerve responses to urocortin-2 in health and stable heart failure. Clinical & Experimental Pharmacology & Physiology, 42(9), 888-895. doi: 10.1111/1440-1681.12449

Porter, T. R., Shillcutt, S. K., Adams, M. S., Desjardins, G., Glas, K. E., Olson, J. J., & Troughton, R. W. (2015). Guidelines for the use of echocardiography as a monitor for therapeutic intervention in adults: A report from the American Society of Echocardiography. Journal of the American Society of Echocardiography, 28(1), 40-56. doi: 10.1016/j.echo.2014.09.009

Brunner-La Rocca, H.-P., Eurlings, L., Richards, A. M., Januzzi, J. L., Pfisterer, M. E., Dahlström, U., … Frampton, C. M., Nicholls, M. G., & Troughton, R. W. (2015). Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials. European Journal of Heart Failure, 17(12), 1252-1261. doi: 10.1002/ejhf.401

Rigolli, M., Rossi, A., Quintana, M., Klein, A. L., Yu, C.-M., Ghio, S., … Troughton, R. W., … Whalley, G. A., … on behalf of the MeRGE Collaborators. (2015). The prognostic impact of diastolic dysfunction in patients with chronic heart failure and post-acute myocardial infarction: Can age-stratified E/A ratio alone predict survival? International Journal of Cardiology, 181, 362-368. doi: 10.1016/j.ijcard.2014.12.051

Meller, B., Cullen, L., Parsonage, W. A., Greenslade, J. H., Aldous, S., Reichlin, T., … Troughton, R., Pemberton, C. J., Richards, A. M., … Than, M., & Mueller, C. (2015). Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients. International Journal of Cardiology, 184C, 208-215. doi: 10.1016/j.ijcard.2015.02.006

Earle, N. J., Poppe, K. K., Pilbrow, A. P., Cameron, V. A., Troughton, R. W., Skinner, J. R., … Whalley, G. A., … Richards, A. M., & Doughty, R. N. (2015). Genetic markers of repolarization and arrhythmic events following acute coronary syndromes. American Heart Journal, 169(4), 579-586.e3. doi: 10.1016/j.ahj.2014.11.015

Whalley, G. A., Pitama, S., Troughton, R. W., Doughty, R. N., Gamble, G. D., Gillies, T., Wells, J. E., Faatoese, A., Huria, T., Richards, M., & Cameron, V. A. (2015). Higher prevalence of left ventricular hypertrophy in two Māori cohorts: Findings from the Hauora Manawa/Community Heart Study. Australian & New Zealand Journal of Public Health, 39(1), 26-31. doi: 10.1111/1753-6405.12300

Than, M., Flaws, D., Sanders, S., Doust, J., Glasziou, P., Kline, J., Aldous, S., Troughton, R., … Frampton, C., … Ardagh, M., … Cullen, L. (2014). Development and validation of the Emergency Department Assessment of Chest pain Score and 2 h accelerated diagnostic protocol. Emergency Medicine Australasia, 26, 34-44. doi: 10.1111/1742-6723.12164

Motoki, H., Borowski, A. G., Shrestha, K., Hu, B., Kusunose, K., Troughton, R. W., … Klein, A. L. (2014). Right ventricular global longitudinal strain provides prognostic value incremental to left ventricular ejection fraction in patients with heart failure. Journal of the American Society of Echocardiography, 27(7), 426-432. doi: 10.1016/j.echo.2014.02.007

Lever, M., George, P. M., Slow, S., Bellamy, D., Young, J. M., Ho, M., … Elmslie, J. L., … Troughton, R. W., Frampton, C. M., Richards, A. M., & Chambers, S. T. (2014). Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: An observational study. PLoS ONE, 9(12), e114969. doi: 10.1371/journal.pone.0114969

Richards, A. M., Januzzi, Jr, J. L., & Troughton, R. W. (2014). Natriuretic peptides in heart failure with preserved ejection fraction. Heart Failure Clinics, 10(3), 453-470. doi: 10.1016/j.hfc.2014.04.006

Troughton, R. W., Frampton, C. M., Brunner-La Rocca, H.-P., Pfisterer, M., Eurlings, L. W. M., Erntell, H., … Richards, A. M., … Nicholls, M. G. (2014). Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: An individual patient meta-analysis. European Heart Journal, 35, 1559-1567. doi: 10.1093/eurheartj/ehu090

Aldous, S., Richards, A. M., George, P. M., Cullen, L., Parsonage, W. A., Flaws, D., Florkowski, C. M., Troughton, R. W., … Than, M. (2014). Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction. International Journal of Cardiology, 177(1), 182-186. doi: 10.1016/j.ijcard.2014.09.026

Chan, C., Troughton, R., Elliott, J., Zarifeh, J., & Bridgman, P. (2014). One-year follow-up of the 2011 Christchurch Earthquake stress cardiomyopathy cases. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal

Troughton, R., Felker, G. M., & Januzzi, Jr, J. L. (2014). Natriuretic peptide-guided heart failure management. European Heart Journal, 35(1), 16-24. doi: 10.1093/eurheartj/eht463

Pilbrow, A. P., Cordeddu, L., Cameron, V. A., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Foo, R. S.-Y. (2014). Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. International Journal of Cardiology, 176, 375-385. doi: 10.1016/j.ijcard.2014.07.068

Than, M., Aldous, S., Lord, S. J., Goodacre, S., Frampton, C. M. A., Troughton, R., George, P., Florkowski, C. M., Ardagh, M., Smyth, D., Jardine, D. L., … Young, J., Hamilton, G., Deely, J. M., … Richards, A. M. (2014). A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Internal Medicine, 174(1), 51-58. doi: 10.1001/jamainternmed.2013.11362

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., … Richards, A. M., Ungerer, J. P. J., Troughton, R. W., … Pemberton, C. J., Florkowski, C., … Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47(6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019

Gaggin, H. K., Truong, Q. A., Rehman, S. U., Mohammed, A. A., Bhardwaj, A., Parks, K. A., … Richards, A. M., Troughton, R. W., Lainchbury, J. G., … Januzzi, Jr, J. L. (2013). Characterization and prediction of natriuretic peptide “nonresponse” during heart failure management: Results from the ProBNP outpatient tailored chronic heart failure (PROTECT) and the NT-proBNP–assisted treatment to lessen serial cardiac readmissions and death (BATTLESCARRED) study. Congestive Heart Failure, 19(3), 135-142. doi: 10.1111/chf.12016

Giugliano, R. P., Ruff, C. T., Braunwald, E., Murphy, S. A., Wiviott, S. D., Halperin, J. L., … for the ENGAGE AF-TIMI 48 Investigators, including Green, B., Troughton, R., & Skelton, L. (2013). Edoxaban versus warfarin in patients with atrial fibrillation. New England Journal of Medicine, 369(22), 2093-2104. doi: 10.1056/NEJMoa1310907

Ellis, K. L., Cameron, V. A., Troughton, R. W., Frampton, C. M., Ellmers, L. J., & Richards, A. M. (2013). Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients. European Journal of Heart Failure, 15(10), 1138-1147. doi: 10.1093/eurjhf/hft078

Santhanakrishnan, R., Ng, T. P., Cameron, V. A., Gamble, G. D., Ling, L. H., Sim, D., … Troughton, R., Richards, A. M., … Lam, C. S. P. (2013). The Singapore Heart Failure Outcomes and Phenotypes (SHOP) study and Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction (PEOPLE) study: Rationale and design. Journal of Cardiac Failure, 19(3), 156-162. doi: 10.1016/j.cardfail.2013.01.007

Greenslade, J. H., Cullen, L., Kalinowski, L., Parsonage, W., Palmer, S., Aldous, S., Richards, M., … Troughton, R., Pemberton, C., & Than, M. (2013). Examining renal impairment as a risk factor for acute coronary syndrome: A prospective observational study. Annals of Emergency Medicine, 62(1), 38-46. doi: 10.1016/j.annemergmed.2013.01.011

Roberts, A., Trainor, K. E., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Integrated microscopy techniques for comprehensive pathology evaluation of an implantable left atrial pressure sensor. Journal of Histotechnology, 36(1), 17-27. doi: 10.1179/2046023613Y.0000000021

Ellis, C., Gamble, G., Devlin, G., Elliott, J., Hamer, A., Williams, M., Matsis, P., Troughton, R., … for the New Zealand Acute Coronary Syndromes (NZACS) 'SNAPSHOT' Audit Group. (2013). The management of acute coronary syndrome patients across New Zealand in 2012: Results of a third comprehensive nationwide audit and observations of current interventional care. New Zealand Medical Journal, 126(1387). Retrieved from http://www.nzma.org.nz/journal

Chan, C., Elliott, J., Troughton, R., Frampton, C., Smyth, D., Crozier, I., & Bridgman, P. (2013). Acute myocardial infarction and stress cardiomyopathy following the Christchurch earthquakes. PLoS ONE, 8(7), e68504. doi: 10.1371/journal.pone.0068504

Tang, W. H. W., Shrestha, K., Wang, Z., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2013). Diminished global arginine bioavailability as a metabolic defect in chronic systolic heart failure. Journal of Cardiac Failure, 19(2), 87-93. doi: 10.1016/j.cardfail.2013.01.001

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Palmer, S. C., Troughton, R. W., & Richards, A. M. (2013). Comparison of immunoassays for NTproBNP conducted on three analysis systems: Milliplex, Elecsys and RIA. Clinical Biochemistry, 46(4-5), 388-390. doi: 10.1016/j.clinbiochem.2012.11.022

Tang, W. H. W., Shrestha, K., Wang, Z., Borowski, A. G., Troughton, R. W., Klein, A. L., & Hazen, S. L. (2013). Protein carbamylation in chronic systolic heart failure: Relationship with renal impairment and adverse long-term outcomes. Journal of Cardiac Failure, 19(4), 219-224. doi: 10.1016/j.cardfail.2013.02.001

Motoki, H., Borowski, A. G., Shrestha, K., Troughton, R. W., Martin, M. G., Tang, W. H. W., & Klein, A. L. (2013). Impact of left ventricular diastolic function on left atrial mechanics in systolic heart failure. American Journal of Cardiology, 112(6), 821-826. doi: 10.1016/j.amjcard.2013.05.007

Edwards, A. L., Gunningham, S. P., Clare, G. C., Hayman, M. W., Smith, M., Frampton, C. M. A., Robinson, B. A., Troughton, R. W., & Beckert, L. E. L. (2013). Professional killer cell deficiencies and decreased survival in pulmonary arterial hypertension. Respirology, 18(8), 1271-1277. doi: 10.1111/resp.12152

Trainor, K. E., Roberts, A., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Comparative pathology of an implantable left atrial pressure sensor. ASAIO Journal, 59(5), 486-492. doi: 10.1097/MAT.0b013e31829bdffd

The Echocardiographic Normal Ranges Meta-Analysis of the Left Heart (EchoNoRMAL) Collaboration, including Whalley, G. A., Cameron, V., Richards, A. M., & Troughton, R. (2013). A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: The EchoNoRMAL study. European Heart Journal, 15, 341-348. doi: 10.1093/ehjci/jet240

Tang, W. H. W., Shrestha, K., Tong, W., Wang, Z., Troughton, R. W., Borowski, A. G., … Hazen, S. L. (2013). Nitric oxide bioavailability and adiponectin production in chronic systolic heart failure: Relation to severity of cardiac dysfunction. Translational Research, 162(1), 26-33. doi: 10.1016/j.trsl.2013.02.005

Schluter, P. J., Spittlehouse, J. K., Cameron, V. A., Chambers, S., Gearry, R., Jamieson, H. A., Kennedy, M., Lacey, C. J., Murdoch, D. R., Pearson, J., Porter, R. J., Richards, M., Skidmore, P. M. L., Troughton, R., Vierck, E., & Joyce, P. R. (2013). Canterbury Health, Ageing and Life Course (CHALICE) study: Rationale, design and methodology. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

Chan, W. Y. W., Frampton, C. M., Crozier, I. G., Troughton, R. W., & Richards, A. M. (2013). Urocortin-2 infusion in acute decompensated heart failure: Findings from the UNICORN Study. JACC: Heart Failure, 1(5), 433-441. doi: 10.1016/j.jchf.2013.07.003

Cullen, L., Mueller, C., Parsonage, W. A., Wildi, K., Greenslade, J. H., Twerenbold, R., Aldous, S., … Troughton, R., … George, P., … Pemberton, C. J., Richards, A. M., … Florkowski, C., Deely, J. M., & Than, M. (2013). Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. JACC, 62(14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078

Januzzi, Jr, J. L., & Troughton, R. (2013). Are serial BNP measurements useful in heart failure management? Serial natriuretic peptide measurements are useful in heart failure management. Circulation, 127(4), 500-508. doi: 10.1161/circulationaha.112.120485

Schwartz, G. G., Olsson, A. G., Abt, M., Ballantyne, C. M., Barter, P. J., Brumm, J., … for the dal-OUTCOMES Investigators, including Troughton, R., Wilkins, G., & Harding, S. (2012). Effects of dalcetrapib in patients with a recent acute coronary syndrome. New England Journal of Medicine, 367(22), 2089-2099. doi: 10.1056/NEJMoa1206797

Shrestha, K., Borowski, A. G., Troughton, R. W., Klein, A. L., & Tang, W. H. W. (2012). Association between systemic neutrophil gelatinase-associated lipocalin and anemia, relative hypochromia, and inflammation in chronic systolic heart failure. Congestive Heart Failure, 18(5), 239-244. doi: 10.1111/j.1751-7133.2012.00287.x

Felker, G. M., Hasselblad, V., Tang, W. H. W., Hernandez, A. F., Armstrong, P. W., Fonarow, G. C., … Troughton, R. W., … O'Connor, C. M. (2012). Troponin I in acute decompensated heart failure: Insights from the ASCEND-HF study. European Journal of Heart Failure, 14(11), 1257-1264. doi: 10.1093/eurjhf/hfs110

Aldous, S., Pemberton, C., Richards, A. M., Troughton, R., & Than, M. (2012). High-sensitivity troponin T for early rule-out of myocardial infarction in recent onset chest pain. Emergency Medicine Journal, 29(10), 805-810. doi: 10.1136/emermed-2011-200222

Motoki, H., Borowski, A. G., Shrestha, K., Troughton, R. W., Tang, W. H. W., Thomas, J. D., & Klein, A. L. (2012). Incremental prognostic value of assessing left ventricular myocardial mechanics in patients with chronic systolic heart failure. JACC, 60(20), 2074-2081. doi: 10.1016/j.jacc.2012.07.047

Lever, M., George, P. M., Atkinson, W., Elmslie, J. L., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments. PLoS ONE, 7(3), e32460. doi: 10.1371/journal.pone.0032460

Palmer, B. R., Frampton, C. M., Skelton, L., Yandle, T. G., Doughty, R. N., Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients. Journal of Cardiovascular Electrophysiology, 23(3), 319-324. doi: 10.1111/j.1540-8167.2011.02192.x

Lever, M., George, P. M., Elmslie, J. L., Atkinson, W., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). Betaine and secondary events in an acute coronary syndrome cohort. PLoS ONE, 7(5), e37883. doi: 10.1371/journal.pone.0037883

Pilbrow, A. P., Folkersen, L., Pearson, J. F., Brown, C. M., McNoe, L., Wang, N. M., … Black, M. A., Troughton, R. W., Richards, A. M., … Cameron, V. A. (2012). The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues. PLoS ONE, 7(6), e39574. doi: 10.1371/journal.pone.0039574

Than, M., Cullen, L., Aldous, S., Parsonage, W. A., Reid, C. M., Greenslade, J., … Ardagh, M. W., Troughton, R., … Richards, A. M. (2012). 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT trial. JACC, 59(23), 2091-2098. doi: 10.1016/j.jacc.2012.02.035

Ellis, K. L., Pilbrow, A. P., Potter, H. C., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Palmer, B. R., Skelton, L., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). Association between endothelin type A receptor haplotypes and mortality in coronary heart disease. Personalized Medicine, 9(3), 341-349. doi: 10.2217/PME.12.10

Ellis, K. L., Palmer, B. R., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Pilbrow, A. P., Skelton, L., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2012). Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. Journal of Human Hypertension, 27, 237-244. doi: 10.1038/jhh.2012.24

Cameron, V. A., Faatoese, A. F., Gillies, M. W., Robertson, P. J., Huria, T. M., Doughty, R. N., Whalley, G. A., … Richards, M. A., Troughton, R. W., Tikao-Mason, K. N., Wells, E. J., Sheerin, I. G., & Pitama, S. G. (2012). A cohort study comparing cardiovascular risk factors in rural Māori, urban Māori and non-Māori communities in New Zealand. BMJ Open, 2(3), e000799. doi: 10.1136/bmjopen-2011-000799

Ellis, K. L., Newton-Cheh, C., Wang, T. J., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Skelton, L., Davis, N., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2011). Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes. Journal of Molecular & Cellular Cardiology, 50(4), 695-701. doi: 10.1016/j.yjmcc.2011.01.010

Richards, A. M., & Troughton, R. W. (2011). Use of natriuretic peptides to guide and monitor heart failure therapy. Clinical Chemistry, 58(1), 62-71. doi: 10.1373/clinchem.2011.165704

Ritzema, J. L., Richards, A. M., Crozier, I. G., Frampton, C., Melton, I. C., Doughty, R. N., … Troughton, R. W. (2011). Serial Doppler echocardiography and tissue Doppler imaging in the detection of elevated directly measured left atrial pressure in ambulant subjects with chronic heart failure. JACC: Cardiovascular Imaging, 4(9), 927-934. doi: 10.1016/j.jcmg.2011.07.004

Tang, W. H. W., Shrestha, K., Mullens, W., Borowski, A. G., Martin, M. G., Troughton, R. W., & Klein, A. L. (2011). Impact of left ventricular remodeling on diagnostic and prognostic value of tissue Doppler indices in chronic systolic heart failure. Journal of Cardiac Failure, 17(2), 128-134. doi: 10.1016/j.cardfail.2010.10.001

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