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Otago Medical School staff profiles

Associate Professor Andrew Harrison

PositionAssociate Professor
DepartmentDepartment of Medicine (UOW)
QualificationsMB ChB PhD FRACP
Research summaryRheumatology

Research

Andrew is a rheumatologist and is Clinical Head of the Wellington Regional Rheumatology Unit, practicing at Hutt, Wellington, Kenepuru and Bowen Hospitals. He is coordinator of the rheumatology component of the 5th year Musculoskeletal Module at the University of Otago Wellington. His current research interests include gout genetics and pathophysiology, ankylosing spondylitis and barriers to access to rheumatology treatment.

Publications

Benham, H., Rutherford, M., Kirby, S., Stebbings, S., White, D., Sim, D., & Harrison, A. (2019). Treat-to-target in rheumatoid arthritis: Evaluating the patient perspective using the Patient Opinion Real-Time Anonymous Liaison system: The RA T2T PORTAL study. International Journal of Rheumatic Diseases. Advance online publication. doi: 10.1111/1756-185x.13514

Roberts, R. L., Wallace, M. C., Harrison, A. A., White, D., Dalbeth, N., Stamp, L. K., … Highton, J., Merriman, T. R., … Stebbings, S. M. (2018). Association of Crohn's disease-related chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and faecal calprotectin. PeerJ, 6, e5088. doi: 10.7717/peerj.5088

GEO-RA Group, including Harrison, A. A., & Grainger, R. (2017). Latitude gradient influences the age of onset of rheumatoid arthritis: A worldwide survey. Clinical Rheumatology, 36(3), 485-497. doi: 10.1007/s10067-016-3481-9

Rasheed, H., Phipps-Green, A. J., Topless, R., Smith, M. D., Hill, C., Lester, S., … van Rij, A., Jones, G. T., McCormick, S. P., Harrison, A. A., Stamp, L. K., … Merriman, T. R. (2016). Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout. Rheumatology, 55(8), 1421-1430. doi: 10.1093/rheumatology/kew057

Robinson, P. C., Leo, P. J., Pointon, J. J., Harris, J., Cremin, K., Bradbury, L. A., … Stebbings, S., Harrison, A. A., … Brown, M. A. (2016). The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. Genes & Immunity, 17, 46-51. doi: 10.1038/gene.2015.49

Authored Book - Other

Harrison, A., Claridge, M., & Thomson, K. (2006). Arthritis and how to live with it. Auckland, New Zealand: Random House, 140p.

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Journal - Research Article

Benham, H., Rutherford, M., Kirby, S., Stebbings, S., White, D., Sim, D., & Harrison, A. (2019). Treat-to-target in rheumatoid arthritis: Evaluating the patient perspective using the Patient Opinion Real-Time Anonymous Liaison system: The RA T2T PORTAL study. International Journal of Rheumatic Diseases. Advance online publication. doi: 10.1111/1756-185x.13514

Roberts, R. L., Wallace, M. C., Harrison, A. A., White, D., Dalbeth, N., Stamp, L. K., … Highton, J., Merriman, T. R., … Stebbings, S. M. (2018). Association of Crohn's disease-related chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and faecal calprotectin. PeerJ, 6, e5088. doi: 10.7717/peerj.5088

GEO-RA Group, including Harrison, A. A., & Grainger, R. (2017). Latitude gradient influences the age of onset of rheumatoid arthritis: A worldwide survey. Clinical Rheumatology, 36(3), 485-497. doi: 10.1007/s10067-016-3481-9

Rasheed, H., Phipps-Green, A. J., Topless, R., Smith, M. D., Hill, C., Lester, S., … van Rij, A., Jones, G. T., McCormick, S. P., Harrison, A. A., Stamp, L. K., … Merriman, T. R. (2016). Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout. Rheumatology, 55(8), 1421-1430. doi: 10.1093/rheumatology/kew057

Robinson, P. C., Leo, P. J., Pointon, J. J., Harris, J., Cremin, K., Bradbury, L. A., … Stebbings, S., Harrison, A. A., … Brown, M. A. (2016). The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. Genes & Immunity, 17, 46-51. doi: 10.1038/gene.2015.49

Roberts, R. L., Wallace, M. C., Harrison, A., Dalbeth, N., Merriman, T. R., & Stamp, L. K. (2015). A human leukocyte antigen locus haplotype confers risk for allopurinol-related adverse effects in Caucasian patients with gout. Pharmacogenetics & Genomics, 25(8), 412-415. doi: 10.1097/fpc.0000000000000147

Lau, C. S., Chia, F., Harrison, A., Hsieh, T.-Y., Jain, R., Jung, S. M., … Yeap, S. S. (2015). APLAR rheumatoid arthritis treatment recommendations. International Journal of Rheumatic Diseases, 18(7), 685-713. doi: 10.1111/1756-185X.12754

Harrison, A. A., Badenhorst, C., Kirby, S., White, D., Athens, J., & Stebbings, S. (2014). Comparison of rates of referral and diagnosis of axial spondyloarthritis before and after an ankylosing spondylitis public awareness campaign. Clinical Rheumatology, 33(7), 963-968. doi: 10.1007/s10067-014-2551-0

Batt, C., Phipps-Green, A. J., Black, M. A., Cadzow, M., Merriman, M. E., Topless, R., … Harrison, A., Highton, J., … Stamp, L., … Merriman, T. R. (2014). Sugar-sweetened beverage consumption: A risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout. Annals of the Rheumatic Diseases, 73(12), 2101-2106. doi: 10.1136/annrheumdis-2013-203600

Roberts, R. L., Wallace, M. C., Wright, D. F. B., Cadzow, M., Dalbeth, N., Jones, P. B., Stamp, L. K., Harrison, A. A., Black, M. A., & Merriman, T. R. (2014). Frequency of CYP2C9 polymorphisms in Polynesian people and potential relevance to management of gout with benzbromarone. Joint Bone Spine, 81(2), 160-163. doi: 10.1016/j.jbspin.2013.07.006

Milne, V., Kearns, R., & Harrison, A. (2014). Patient age, ethnicity and waiting times determine the likelihood of non-attendance at a first specialist rheumatology assessment. International Journal of Rheumatic Diseases, 17(1), 19-25. doi: 10.1111/1756-185X.12126

Grainger, R., McLaughlin, R. J., Harrison, A. A., & Harper, J. L. (2013). Hyperuricaemia elevates circulating CCL2 levels and primes monocyte trafficking in subjects with inter-critical gout. Rheumatology, 52(6), 1018-1021. doi: 10.1093/rheumatology/kes326

Roberts, R. L., Wallace, M. C., Jones, G. T., van Rij, A. M., Merriman, T. R., Harrison, A., … Stamp, L. K., … Highton, J., & Stebbings, S. M. (2013). Prevalence of HLA-B27 in the New Zealand population: Effect of age and ethnicity. Arthritis Research & Therapy, 15, R158. doi: 10.1186/ar4341

Chen-Xu, M., Topless, R., McKinney, C., Merriman, M. E., Phipps-Green, A., Dalbeth, N., … Harrison, A. A., Highton, J., … van Rij, A., Jones, G. T., … Stamp, L. K., … Merriman, T. R. (2012). Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets. Annals of the Rheumatic Diseases, 71(1), 155-157. doi: 10.1136/annrheumdis-2011-200591

Hollis-Moffatt, J. E., Phipps-Green, A. J., Chapman, B., Jones, G. T., van Rij, A., Gow, P. J., Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2012). The renal urate transporter SLC17A1 locus: Confirmation of association with gout. Arthritis Research & Therapy, 14(2), R92. doi: 10.1186/ar3816

Purdie, G. L., Purdie, D. J., & Harrison, A. A. (2011). Raynaud's phenomenon in medical laboratory workers who work with solvents. Journal of Rheumatology, 38(9), 1940-1946. doi: 10.3899/jrheum.101129

Hollis-Moffatt, J. E., Gow, P. J., Harrison, A. A., Highton, J., Jones, P. B. B., Stamp, L. K., … Merriman, T. R. (2011). The SLC2A9 nonsynonymous Arg265His variant and gout: Evidence for a population-specific effect on severity. Arthritis Research & Therapy, 13(3), R85. doi: 10.1186/ar3356

Hollis-Moffatt, J. E., Chen-Xu, M., Topless, R., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., … van Rij, A., Jones, G. T., Stamp, L. K., & Merriman, T. R. (2010). Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Research & Therapy, 12(3), R116. doi: 10.1186/ar3053

Rhodes, B., Merriman, M. E., Harrison, A., Nissen, M. J., Smith, M., Stamp, L., … Merriman, T. R., & Vyse, T. J. (2010). A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: Implications for clinical interpretation. PLoS Medicine, 7(9), e1000341. doi: 10.1371/journal.pmed.1000341

McKinney, C., Fanciulli, M., Merriman, M. E., Phipps-Green, A., Alizadeh, B. Z., Koeleman, B. P. C., … Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2010). Association of variation in Fcγ receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Annals of the Rheumatic Diseases, 69, 1711-1716. doi: 10.1136/ard.2009.123588

Wan Taib, W. R., Smyth, D. J., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., … Stamp, L., … Merriman, T. R. (2010). The PTPN22 locus and rheumatoid arthritis: No evidence for an effect on risk independent of Arg620Trp. PLoS ONE, 5(10), e13544. doi: 10.1371/journal.pone.0013544

Phipps-Green, A. J., Hollis-Moffatt, J. E., Dalbeth, N., Merriman, M. E., Topless, R., Gow, P. J., Harrison, A. A., Highton, J., … Stamp, L. K., & Merriman, T. R. (2010). A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets. Human Molecular Genetics, 19(24), 4813-4819. doi: 10.1093/hmg/ddq412

Martin, W. J., Grainger, R., Harrison, A., & Harper, J. L. (2010). Differences in MSU-induced superoxide responses by neutrophils from gout subjects compared to healthy controls and a role for environmental inflammatory cytokines and hyperuricemia in neutrophil function and survival. Journal of Rheumatology, 37(6), 1228-1235. doi: 10.3899/jrheum.091080

Hollis-Moffatt, J. E., Merriman, M. E., Green, R. A., Rowley, K. A., Chapman, P. T., Dalbeth, N., … Harrison, A. A., Highton, J., … O'Donnell, J. L., Stamp, L. K., & Merriman, T. R. (2009). Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(8), 1340-1344. doi: 10.1136/ard.2008.090142

Hollis-Moffatt, J. E., Xu, X., Dalbeth, N., Merriman, M. E., Topless, R., Waddell, C., … Harrison, A. A., Highton, J., … Stamp, L. K., & Merriman, T. R. (2009). Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets. Arthritis & Rheumatism, 60(11), 3485-3492. doi: 10.1002/art.24938

Hollis-Moffatt, J. E., Rowley, K. A., Phipps-Green, A. J., Merriman, M. E., Dalbeth, N., Gow, P., Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2009). The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets. Arthritis Research & Therapy, 11, R152. doi: 10.1186/ar2828

Purdie, G., Harrison, A., & Purdie, D. (2009). Prevalence of Raynaud's phenomenon in the adult New Zealand population. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3890/content.pdf

Taylor, W. J., Harrison, A. A., Highton, J., Chapman, P., Stamp, L., Dockerty, J., … Sew Hoy, M. (2008). Disease Activity Score 28-ESR bears a similar relationship to treatment decisions across different rheumatologists, but misclassification is too frequent to replace physician judgement. Rheumatology, 47, 514-518. doi: 10.1093/rheumatology/ken004

McKinney, C., Merriman, M. E., Chapman, P. T., Gow, P. J., Harrison, A. A., Highton, J., … O'Donnell, J. L., … Stamp, L. K., Willis, J., … Merriman, T. R. (2008). Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Annals of the Rheumatic Diseases, 67, 409-413. doi: 10.1136/ard.2007.075028

Steer, S., Abkevich, V., Gutin, A., Cordell, H. J., Gendall, K. L., Merriman, M. E., Green, R. A., Rowley, K. A., Chapman, P., … Harrison, A. A., Highton, J., … O'Donnell, J., Stamp, L., … Merriman, T. R. (2007). Genomic DNA pooling for whole-genome association scans in complex disease: Empirical demonstration of efficacy in rheumatoid arthritis. Genes & Immunity, 8, 57-68. doi: 10.1038/sj.gene.6364359

Pokorny, V., McQueen, F., Yeoman, S., Merriman, M., Merriman, A., Harrison, A., Highton, J., & McLean, L. (2005). Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis. Annals of the Rheumatic Diseases, 64, 487-490.

Tuohy, J., & Harrison, A. (2005). Prenatal transfer of anticardiolipin antibodies associated with fatal neonatal aortic thrombosis. Australian & New Zealand Journal of Obstetrics & Gynaecology, 45, 175-176.

Simkins, H. M. A., Merriman, M. E., Highton, J., Chapman, P. T., O'Donnell, J. L., Jones, P. B. B., … Harrison, A. A., & Merriman, T. R. (2005). Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort. Arthritis & Rheumatism, 52(7), 2222-2225.

Grainger, R., & Harrison, A. (2005). TNF inhibitors for inflammatory arthritis in New Zealand [Special Series]. New Zealand Medical Journal, 118(1224). Retrieved from http://journal.nzma.org.nz/journal/118-1224/1706/content.pdf

Harrison, A. (2004). Provision of rheumatology services in New Zealand. New Zealand Medical Journal, 117(1192). Retrieved from http://journal.nzma.org.nz/journal/117-1192/846/content.pdf

Taylor, W. J., & Harrison, A. A. (2004). Could the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) be a valid measure of disease activity in patients with psoriatic arthritis? Arthritis & Rheumatism, 51(3), 311-315.

Hall, R. J., Merriman, M. E., Green, R. A., Markham, V. H., Smyth, D. J., Heward, J. M., … Braithwaite, A., … Darlow, B. A., … Harrison, A. A., Highton, J., Hunt, P. J., Manning, P. J., … Scott, R. S., Taylor, B. J., Willis, J., … Merriman, T. R. (2003). The Deleted in Colorectal Carcinoma (DCC) gene 201 R → G polymorphism: No evidence for genetic association with autoimmune disease. European Journal of Human Genetics, 11, 840-844.

Harrison, A. A. (2002). Arthritis. Medicine and the Internet. Current Therapeutics, September, 11-13.

Taylor, W. J., Rajapaske, C. N., Harris, K. A., Harrison, A., & Corkill, M. M. (1999). Inpatient treatment of rheumatoid arthritis with synacthen depot: a double blind placebo controlled trial with 6 month followup. Journal of Rheumatology, 26, 2544-2550.

Harrison, A. A., Stocker, C. J., Chapman, P. T., Tsang, Y. T., Huehns, T. T., Gundel, R. H., … George, A. J., … Haskard, D. O. (1997). Expression of vascular cell adhesion molecule-1 by vascular endothelial cells in immune and nonimmune inflammatory reactions in the skin. Journal of Immunology, 159(9), 4546-4554.

Chapman, P. T., Yarwood, H., Harrison, A., Stocker, C. J., Jamar, F., Gundel, R. H., … Haskard, D. O. (1997). Endothelial activation in monosodium urate monohydrate crystal-induced inflammation: in vitro and in vivo studies on the roles of tumor necrosis factor alpha and interleukin-1. Arthritis & Rheumatism, 40(5), 955-965.

Mason, J. C., Yarwood, H., Tarnok, A., Sugars, K., Harrison, A. A., Robinson, P. J., & Haskard, D. O. (1996). Human Thy-1 is cytokine-inducible on vascular endothelial cells and is a signaling molecule regulated by protein kinase C. Journal of Immunology, 157(2), 874-883.

Binns, R. M., Whyte, A., Licence, S. T., Harrison, A. A., Tsang, Y. T. M., Haskard, D. O., & Robinson, M. K. (1996). The role of E-selectin in lymphocyte and polymorphonuclear cell recruitement into cutaneous delayed hypersensitivity reactions in sensitized pigs. Journal of Immunology, 157(9), 4094-4099.

Chapman, P. T., Jamar, F., Harrison, A., Schofield, J. B., Peters, A. M., Binns, R. M., & Haskard, D. O. (1996). Characterization of E-selectin expression, leucocyte traffic and clinical sequelae in urate crystal-induced inflamation: an insight into gout. British Journal of Rheumatology, 35, 323-334.

Binns, R. M., Licence, S. T., Harrison, A., Keelan, E. T. M., Robinson, M. K., & Haskard, D. O. (1996). In vivo E-selection upregulation correlates early with infiltration of PMN, later with PBL entry: MAbs block both. American Journal of Physiology: Heart & Circulatory Physiology, 270(1 pt.2), H183-H193.

Jamar, F., Chapman, P. T., Harrison, A., Binns, R. M., Haskard, D. O., & Peters, A. M. (1995). Inflamatory arthritis: imaging of endothelial cell activation with an indium-111-labeled F(ab')2 fragment of anti-E-selectin monoclonal. Radiology, 194, 843-850.

Davies, K. M., Chapman, P. T., Norsworthy, P. J., Jamar, F., Athanassiou, P., Keelan, E. T. M., Harrison, A., … Walport, P. J. (1995). Clearance pathways of soluble immune complexes in the pig: insights into the adaptive nature of antigen clearance in humans. Journal of Immunology, 155, 5760-5768.

Roy, C. W., Sands, R., Hill, L. D., Harrison, A., & Marshall, S. W. (1995). The effect of shoulder pain on outcome of acute hemiplegia. Clinical Rehabilitation, 9, 21-27.

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Journal - Research Other

Lester, S., Hewitt, A. W., Ruediger, C. D., Bradbury, L., De Smit, E., Wiese, M. D., … Harrison, A., … Merriman, T. R., … Hill, C. L. (2016). PTPN22 R620W minor allele is a genetic risk factor for giant cell arteritis [Short report]. RMD Open, 2, e000246. doi: 10.1136/rmdopen-2016-000246

Grainger, R., & Harrison, A. A. (2015). Rules of engagement: Turning recommendations into results in the diagnosis and management of gout. International Journal of Rheumatic Diseases, 18(3), 261-263. doi: 10.1111/1756-185x.12665

Hsu, A., Dalbeth, N., Gow, P., Harrison, A., Highton, J., Jones, P. B., Stamp, L. K., & Merriman, T. R. (2012). No evidence for association of Chr 9p21 variant rs1333049 with gout in New Zealand case-control sample sets. Rheumatology, 51, 1129-1130. doi: 10.1093/rheumatology/kes029

Stamp, L. K., Harrison, A., Frampton, C., & Corkill, M. M. (2012). Does a joint count calibration exercise make a difference? Implications for clinical trials and training. Journal of Rheumatology, 39(4), 877-878. doi: 10.3899/jrheum.111224

Phipps-Green, A., McKinney, C., Rossol, M., Merriman, M. E., Topless, R., Hollis-Moffatt, J. E., Wan Taib, W. R., … Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2011). Analysis of association of DNASE2 promoter variation with rheumatoid arthritis in European Caucasians [Letter]. Annals of the Rheumatic Diseases, 70(8), 1512-1514. doi: 10.1136/ard.2010.138727

Phipps-Green, A. J., Topless, R. K. G., Merriman, M. E., Dalbeth, N., Gow, P. J., Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2009). No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian population [Letter to the editor]. Rheumatology, 48(12), 1614-1615. doi: 10.1093/rheumatology/kep254

Harrison, A. (2005). COX-2 inhibitors: Second, do some good [Letter]. New Zealand Medical Journal, 118(1212). Retrieved from http://journal.nzma.org.nz/journal/118-1212/1395/content.pdf

Porter, D., & Harrison, A. (2003). Minocycline-induced lupus: A case series [Case report]. New Zealand Medical Journal, 116(1170). Retrieved from http://journal.nzma.org.nz/journal/116-1171/384/content.pdf

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