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Otago Medical School staff profiles

Dr Magdalena Ratajska

PositionResearch Fellow
DepartmentDepartment of Pathology (Dunedin)
QualificationsMSc PhD
Research summaryCancer genetics

Research

Magdalena joined the Eccles lab group as a Research Fellow in October 2019. She is interested in utilising liquid biopsies in cancer research, including detection of lung cancer driver mutations and monitoring, and screening of genetic alterations in ovarian cancer (including analysis of predisposition, progression and treatment response).

As a key scientist in ctDNA lung cancer pilot study, she was responsible for the development of complete pipeline, from the optimal material collection, through ctDNA extraction, analysis and result verification. Later she used this experience in several joint-projects.

Recently, she has become interested in epigenetic alterations in cancer and finding a bridge between genetics and epigenetics to explore further cancer biology.

Publications

Suszynska, M., Ratajska, M., & Kozlowski, P. (2020). BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: Mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases. Journal of Ovarian Research, 13(1), 50. doi: 10.1186/s13048-020-00654-3

Suszynska, M., Kluzniak, W., Wokolorczyk, D., Jakubowska, A., Huzarski, T., Gronwald, J., … Ratajska, M., … Kozlowski, P. (2019). BARD1 is a low/moderate breast cancer risk gene: Evidence based on an association study of the Central European p.Q564x recurrent mutation. Cancers, 11(6), 740. doi: 10.3390/cancers11060740

Wiczling, P., Daghir-Wojtkowiak, E., Kaliszan, R., Markuszewski, M. J., Limon, J., Koczkowska, M., … Ratajska, M. (2019). Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects. PLoS ONE. Advance online publication. doi: 10.1371/journal.pone.0221764

Koczkowska, M., Krawczynska, N., Stukan, M., Kuzniacka, A., Brozek, I., Sniadecki, M., … Ratajska, M. (2018). Spectrum and prevalence of pathogenic variants in ovarian cancer susceptibility genes in a group of 333 patients. Cancers, 10(11), 442. doi: 10.3390/cancers10110442

Klonowska, K., Kluzniak, W., Rusak, B., Jakubowska, A., Ratajska, M., Krawczynska, N., … Kozlowski, P. (2017). The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population. Oncotarget, 8(44), 76357-76374. doi: 10.18632/oncotarget.19400

Journal - Research Article

Suszynska, M., Ratajska, M., & Kozlowski, P. (2020). BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: Mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases. Journal of Ovarian Research, 13(1), 50. doi: 10.1186/s13048-020-00654-3

Suszynska, M., Kluzniak, W., Wokolorczyk, D., Jakubowska, A., Huzarski, T., Gronwald, J., … Ratajska, M., … Kozlowski, P. (2019). BARD1 is a low/moderate breast cancer risk gene: Evidence based on an association study of the Central European p.Q564x recurrent mutation. Cancers, 11(6), 740. doi: 10.3390/cancers11060740

Wiczling, P., Daghir-Wojtkowiak, E., Kaliszan, R., Markuszewski, M. J., Limon, J., Koczkowska, M., … Ratajska, M. (2019). Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects. PLoS ONE. Advance online publication. doi: 10.1371/journal.pone.0221764

Koczkowska, M., Krawczynska, N., Stukan, M., Kuzniacka, A., Brozek, I., Sniadecki, M., … Ratajska, M. (2018). Spectrum and prevalence of pathogenic variants in ovarian cancer susceptibility genes in a group of 333 patients. Cancers, 10(11), 442. doi: 10.3390/cancers10110442

Klonowska, K., Kluzniak, W., Rusak, B., Jakubowska, A., Ratajska, M., Krawczynska, N., … Kozlowski, P. (2017). The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population. Oncotarget, 8(44), 76357-76374. doi: 10.18632/oncotarget.19400

Ratajska, M., Koczkowska, M., Żuk, M., Gorczyński, A., Kuźniacka, A., Stukan, M., … Wasąg, B. (2017). Detection of BRCA1/2 mutations in circulating tumor DNA from patients with ovarian cancer. Oncotarget, 8(60), 101325-101332. doi: 10.18632/oncotarget.20722

Pilyugin, M., André, P.-A., Ratajska, M., Kuzniacka, A., Limon, J., Tournier, B. B., … Irminger-Finger, I. (2017). Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability. Oncotarget, 8(6), 9339-9353. doi: 10.18632/oncotarget.14068

Szutowicz-Kielińska, E., Konopa, K., Kowalczyk, A., Suszko-Każarnowicz, M., Duchnowska, R., Szczęsna, A., Ratajska, M., … Dziadziuszko, R. (2017). An open label phase II study evaluating first-line EGFR tyrosine kinase inhibitor erlotinib in non-small cell lung cancer patients with tumors showing high EGFR gene copy number. Oncotarget, 8(10), 17270-17278. doi: 10.18632/oncotarget.13793

Koczkowska, M., Zuk, M., Gorczynski, A., Ratajska, M., Lewandowska, M., Biernat, W., … Wasag, B. (2016). Detection of somatic BRCA1/2 mutations in ovarian cancer: Next-generation sequencing analysis of 100 cases. Cancer Medicine, 5(7), 1640-1646. doi: 10.1002/cam4.748

Ratajska, M., Matusiak, M., Kuzniacka, A., Wasag, B., Brozek, I., Biernat, W., … Irminger-Finger, I. (2015). Cancer predisposing BARD1 mutations affect exon skipping and are associated with overexpression of specific BARD1 isoforms. Oncology Reports, 34(5), 2609-2617. doi: 10.3892/or.2015.4235

Klonowska, K., Ratajska, M., Czubak, K., Kuzniacka, A., Brozek, I., Koczkowska, M., … Kozlowski, P. (2015). Analysis of large mutations in BARD1 in patients with breast and/or ovarian cancer: The Polish population as an example. Scientific Reports, 5, 10424. doi: 10.1038/srep10424

Ronowicz, A., Janaszak-Jasiecka, A., Skokowski, J., Madanecki, P., Bartoszewski, R., Bałut, M., … Ratajska, M., … Piotrowski, A. (2015). Concurrent DNA copy-number alterations and mutations in genes related to maintenance of genome stability in uninvolved mammary glandular tissue from breast cancer patients. Human Mutation, 36(11), 1088-1099. doi: 10.1002/humu.22845

Kreimann, E. L., Ratajska, M., Kuzniacka, A., Demacopulo, B., Stukan, M., & Limon, J. (2015). A novel splicing mutation in the SLC9A3R1 gene in tumors from ovarian cancer patients. Oncology Letters, 10(6), 3722-3726. doi: 10.3892/ol.2015.3796

Ratajska, M., Krygier, M., Stukan, M., Kuźniacka, A., Koczkowska, M., Dudziak, M., … Wasąg, B. (2015). Mutational analysis of BRCA1/2 in a group of 134 consecutive ovarian cancer patients. Novel and recurrent BRCA1/2 alterations detected by next generation sequencing. Journal of Applied Genetics, 56(2), 193-198. doi: 10.1007/s13353-014-0254-5

Kuzniacka, A., Wierzba, J., Ratajska, M., Lipska, B. S., Koczkowska, M., Malinowska, M., & Limon, J. (2013). Spectrum of NIPBL gene mutations in Polish patients with Cornelia de Lange syndrome. Journal of Applied Genetics, 54(1), 27-33. doi: 10.1007/s13353-012-0126-9

Brozek, I., Ratajska, M., Piatkowska, M., Kluska, A., Balabas, A., Dabrowska, M., … Limon, J. (2012). Limited significance of family history for presence of BRCA1 gene mutation in Polish breast and ovarian cancer cases. Familial Cancer, 11(3), 351-354. doi: 10.1007/s10689-012-9519-5

Ratajska, M., Antoszewska, E., Piskorz, A., Brozek, I., Borg, Å., Kusmierek, H., … Limon, J. (2012). Cancer predisposing BARD1 mutations in breast-ovarian cancer families. Breast Cancer Research & Treatment, 131(1), 89-97. doi: 10.1007/s10549-011-1403-8

Brozek, I., Cybulska, C., Ratajska, M., Piatkowska, M., Kluska, A., Balabas, A., … Limon, J. (2011). Prevalence of the most frequent BRCA1 mutations in Polish population. Journal of Applied Genetics, 52(3), 325-330. doi: 10.1007/s13353-011-0040-6

Ratajska, M., Wierzba, J., Pehlivan, D., Xia, Z., Brundage, E. K., Cheung, S. W., … Limon, J. (2010). Cornelia de Lange syndrome case due to genomic rearrangements including NIPBL. European Journal of Medical Genetics, 53(6), 378-382. doi: 10.1016/j.ejmg.2010.08.002

Niedoszytko, M., Ratajska, M., Chelmińska, M., Makowiecki, M., Malek, E., Siemińska, A., … Jassem, E. (2010). The angiotensinogen AGT p.M235T gene polymorphism may be responsible for the development of severe anaphylactic reactions to insect venom allergens. International Archives of Allergy & Immunology, 153(2), 166-172. doi: 10.1159/000312634

Brożek, I., Ochman, K., Dębniak, J., Morzuch, L., Ratajska, M., Stepnowska, M., … Limon, J. (2009). Loss of heterozygosity at BRCA1/2 loci in hereditary and sporadic ovarian cancers. Journal of Applied Genetics, 50(4), 379-384. doi: 10.1007/BF03195697

Ratajska, M., Brozek, I., Senkus-Konefka, E., Jassem, J., Stepnowska, M., Palomba, G., … Limon, J. (2008). BRCA1 and BRCA2 point mutations and large rearrangements in breast and ovarian cancer families in Northern Poland. Oncology Reports, 19(1), 263-268. doi: 10.3892/or.19.1.263

Brozek, I., Ochman, K., Debnik, J., Morzuch, L., Ratajska, M., Stepnowska, M., … Limon, J. (2008). High frequency of BRCA1/2 germline mutations in consecutive ovarian cancer patients in Poland. Gynecologic Oncology, 108(2), 433-437. doi: 10.1016/j.ygyno.2007.09.035

Brożek, I., Kardaś, I., Ochman, K., Dębniak, J., Stukan, M., Ratajska, M., … Limon, J. (2006). HER2 amplification has no prognostic value in sporadic and hereditary ovarian tumours. Hereditary Cancer in Clinical Practice, 4(1), 39-42. doi: 10.1186/1897-4287-4-1-39

Majdak, E. J., De Bock, G. H., Brozek, I., Perkowska, M., Ochman, K., Debniak, J., … Devilee, P. (2005). Prevalence and clinical correlations of BRCA1/BRCA2 unclassified variant carriers among unselected primary ovarian cancer cases: Preliminary report. European Journal of Cancer, 41(1), 143-150. doi: 10.1016/j.ejca.2004.10.011

Menkiszak, J., Gronwald, J., Górski, B., Jakubowska, A., Huzarski, T., Byrski, T., … Perkowska, M., … Lubiński, J. (2003). Hereditary ovarian cancer in Poland. International Journal of Cancer, 106(6), 942-945. doi: 10.1002/ijc.11338

Perkowska, M., Szczygieł, M., & Woźniak, A. (2001). Influence of diethylenetriamine (DETA) and sodium nitroprusside (NaNP) on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes. Journal of Applied Genetics, 42(2), 233-235.

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Journal - Research Other

Irminger-Finger, I., Ratajska, M., & Pilyugin, M. (2016). New concepts on BARD1: Regulator of BRCA pathways and beyond. International Journal of Biochemistry & Cell Biology, 72, 1-17. doi: 10.1016/j.biocel.2015.12.008

Bogdanova, N., Togo, A. V., Ratajska, M., Kluźniak, W., Takhirova, Z., Tarp, T., … Dörk, T. (2015). Prevalence of the BLM nonsense mutation, p.Q548X, in ovarian cancer patients from Central and Eastern Europe [Short communication]. Familial Cancer, 14(1), 145-149. doi: 10.1007/s10689-014-9748-x

Wierzba, J., Kuzniacka, A., Ratajska, M., Lipska, B. S., Kardas, I., Iliszko, M., & Limon, J. (2011). Cornelia de Lange syndrome associated with a de-novo novel NIPBL splice-site mutation and a coincidental inherited translocation t(3;5)(p13;q11). Clinical Dysmorphology, 20(4), 222-224. doi: 10.1097/MCD.0b013e3283455175

Perkowska, M., Brozek, I., Wysocka, B., Haraldsson, K., Sandberg, T., Johansson, U., … Limon, J. (2003). BRCA1 and BRCA2 mutation analysis in breast-ovarian cancer families from northeastern Poland. Human Mutation, 21(5), 553-554. doi: 10.1002/humu.9139

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