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Otago Medical School staff profiles

Dr Stephanie Lee

PositionAssistant Research Fellow
DepartmentDepartment of Pathology (Dunedin)
QualificationsPhD
Research summaryThe role of meiotic cohesin sub-units in gametogenesis and fertility in the zebrafish model

Research

My research background is in sexual differentiation and determination in teleosts. We have observed sexual differences in the expression profiles of many genes in zebrafish brains and gonads.

Of particular interest are the meiotic cohesin sub-units. The cohesin complex is involved in sister chromatid cohesion and segregation, DNA repair, chromosome synapsis and chromosome axis formation. Defects in meiotic cohesin sub-units lead to aneuploidy and infertility.

My current work entails characterising the meiotic cohesin sub-units in zebrafish with the aim of understanding their roles in gametogenesis and fertility.

Publications

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., & Gemmell, N. J. (2018). Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinisation using 17α-methyltestoterone. Biology of Reproduction, 99(2), 446-460. doi: 10.1093/biolre/iox175

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., Fisher, A., & Gemmell, N. J. (2017). Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics, 18, 557. doi: 10.1186/s12864-017-3915-z

Journal - Research Article

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., & Gemmell, N. J. (2018). Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinisation using 17α-methyltestoterone. Biology of Reproduction, 99(2), 446-460. doi: 10.1093/biolre/iox175

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., Fisher, A., & Gemmell, N. J. (2017). Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics, 18, 557. doi: 10.1186/s12864-017-3915-z

More publications...