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Otago Medical School staff profiles

Dr Margaret Ryan

PositionSenior Research Fellow
DepartmentDepartment of Anatomy
QualificationsBSc (Hons) PhD
Research summaryMemory and Alzheimer's disease

Research

Memory loss arising from neurodegenerative diseases such as Alzheimer's disease is devastating both to the individual and to their loved ones, robbing the individual of many of his/her uniquely identifiable characteristics. Dr Ryan's interest is in how memories are formed and stored in the brain at the molecular level and how this may be altered in Alzheimer's disease.

Publications

Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385

Nido, G. S., Ryan, M. M., Benuskova, L., & Williams, J. M. (2015). Dynamical properties of gene regulatory networks involved in long-term potentiation. Frontiers in Molecular Neuroscience, 8, 42. doi: 10.3389/fnmol.2015.00042

Ryan, M. M., Guévremont, D., Luxmanan, C., Abraham, W. C., & Williams, J. M. (2015). Aging alters long-term potentiation—related gene networks and impairs synaptic protein synthesis in the rat hippocampus. Neurobiology of Aging, 36(5), 1868-1880. doi: 10.1016/j.neurobiolaging.2015.01.012

Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376

Journal - Research Article

Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385

Nido, G. S., Ryan, M. M., Benuskova, L., & Williams, J. M. (2015). Dynamical properties of gene regulatory networks involved in long-term potentiation. Frontiers in Molecular Neuroscience, 8, 42. doi: 10.3389/fnmol.2015.00042

Ryan, M. M., Guévremont, D., Luxmanan, C., Abraham, W. C., & Williams, J. M. (2015). Aging alters long-term potentiation—related gene networks and impairs synaptic protein synthesis in the rat hippocampus. Neurobiology of Aging, 36(5), 1868-1880. doi: 10.1016/j.neurobiolaging.2015.01.012

Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376

Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538

Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770

Giger, T., Khaitovich, P., Somel, M., Lorenc, A., Lizano, E., Harris, L. W., Ryan, M. M., … Pääbo, S. (2010). Evolution of neuronal and endothelial transcriptomes in primates. Genome Biology & Evolution, 2, 284-292. doi: 10.1093/gbe/evq018

Harris, L. W., Wayland, M., Lan, M., Ryan, M., Giger, T., Lockstone, H., … Bahn, S. (2008). The cerebral microvasculature in schizophrenia: A laser capture microdissection study. PLoS ONE, 3(12), e3964. doi: 10.1371/journal.pone.0003964

Tkachev, D., Mimmack, M. L., Huffaker, S. J., Ryan, M., & Bahn, S. (2007). Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia. International Journal of Neuropsychopharmacology, 10, 557-563. doi: 10.1017/S1461145706007334

Ryan, M. M., Lockstone, H. E., Huffaker, S. J., Wayland, M. T., Webster, M. J., & Bahn, S. (2006). Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Molecular Psychiatry, 11, 965-978. doi: 10.1038/sj.mp.4001875

Franz, H., Ullmann, C., Becker, A., Ryan, M., Bahn, S., Arendt, T., & ... (2005). Systematic analysis of gene expression in human brains before and after death. Genome Biology, 6(13).

Prabakaran, S., Swatton, J. E., Ryan, M. M., Huffaker, S. J., Huang, J. T.-J., Griffin, J. L., & et al (2004). Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress. Molecular Psychiatry, 9, 684-697.

Ryan, M. M., Huffaker, S. J., Webster, M. J., Wayland, M., Freeman, T., & Bahn, S. (2004). Application and optimization of microarray technologies for human postmortem brain studies. Biological Psychiatry, 55, 329-336.

Wilson, K. E., Ryan, M. M., Prime, J. E., Pashby, D. P., Orange, P. R., O'Beirne, G., … Morris, C. M. (2004). Functional genomics and proteomics: Application in neurosciences. Journal of Neurology, Neurosurgery & Psychiatry, 75, 529-538. doi: 10.1136/jnnp.2003.026260

Marchbanks, R. M., Ryan, M., Day, I. N. M., Owen, M., McGuffin, P., & Whatley, S. A. (2003). A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophrenia Research, 65, 33-38.

Tkachev, D., Mimmack, M. L., Ryan, M. M., Wayland, M., Freeman, T., Jones, P. B., & ... (2003). Oligodendrocyte dysfunction in schizoprenia and bipolar disorder. Lancet, 362, 798-805.

Mimmack, M. L., Ryan, M., Baba, H., Navarro-Ruiz, J., Iritani, S., Faull, R. M. L., & ... (2002). Gene expression analysis in schizophrenia: Reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. PNAS, 99(7), 4680-4685.

Bahn, S., Mimmack, M., Ryan, M., Caldwell, M. A., Jauniaux, E., Starkey, M., & Svendsen, C. N. (2002). Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study. Lancet, 359, 310-315.

Bahn, S., Augood, S. J., Ryan, M., Standaert, D. G., Starkey, M., & Emson, P. C. (2001). Gene expression profiling in the post-mortem human brain: No cause for dismay. Journal of Chemical Neuroanatomy, 22, 79-94.

Ryan, M., Starkey, M., Faull, R., Emson, P., & Bahn, S. (2001). Indexing-based differential display: Studies on post-mortem Alzheimer's brain. Molecular Brain Research, 88, 199-202.

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