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Otago Medical School staff profiles

Dr Blair Lawley

PositionScientific Officer
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc (Hons) PhD
Research summaryGut microbiology

Research

Use of molecular and culture methods to study the structure and function of gut microbial communities in healthy and diseased individuals. Identification of functional genes, in gut microbes, using molecular probes.

Publications

Leong, C., Haszard, J. J., Heath, A.-L. M., Tannock, G. W., Lawley, B., Cameron, S. L., Szymlek-Gay, E. A., Gray, A. R., Taylor, B. J., Galland, B. C., Lawrence, J. A., Otal, A., Hughes, A., & Taylor, R. W. (2020). Using compositional principal component analysis to describe children's gut microbiota in relation to diet and body composition. American Journal of Clinical Nutrition, 111(1), 70-78. doi: 10.1093/ajcn/nqz270

Pathmanathan, S. G., Lawley, B., McConnell, M., Baird, M. A., & Tannock, G. W. (2020). Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells. Anaerobe, 61, 102112. doi: 10.1016/j.anaerobe.2019.102112

Heath, A.-L. M., Haszard, J. J., Galland, B. C., Lawley, B., Rehrer, N. J., Drummond, L. N., … Taylor, R. W., … Taylor, B., & Tannock, G. W. (2020). Association between the faecal short-chain fatty acid propionate and infant sleep [Brief communication]. European Journal of Clinical Nutrition. Advance online publication. doi: 10.1038/s41430-019-0556-0

Liu, Y., Heath, A.-L., Galland, B., Rehrer, N., Drummond, L., Wu, X.-Y., … Lawley, B., … Tannock, G. W. (2019). Prioritization of substrate use by a co-culture of five species of gut bacteria fed mixtures of arabinoxylan, xyloglucan, β-glucan, and pectin. Applied & Environmental Microbiology. Advance online publication. doi: 10.1128/aem.01905-19

Murphy, R., Morgan, X. C., Wang, X. Y., Wickens, K., Purdie, G., Fitzharris, P., Otal, A., Lawley, B., Stanley, T., Barthow, C., Crane, J., … Tannock, G. W. (2019). Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: Sub-sample analysis from a RCT. Beneficial Microbes, 10(1), 5-17. doi: 10.3920/bm2017.0191

Chapter in Book - Research

Lawley, B., & Tannock, G. W. (2017). Analysis of 16S rRNA gene amplicon sequences using the QIIME software package. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 153-163). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_9

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Journal - Research Article

Leong, C., Haszard, J. J., Heath, A.-L. M., Tannock, G. W., Lawley, B., Cameron, S. L., Szymlek-Gay, E. A., Gray, A. R., Taylor, B. J., Galland, B. C., Lawrence, J. A., Otal, A., Hughes, A., & Taylor, R. W. (2020). Using compositional principal component analysis to describe children's gut microbiota in relation to diet and body composition. American Journal of Clinical Nutrition, 111(1), 70-78. doi: 10.1093/ajcn/nqz270

Liu, Y., Heath, A.-L., Galland, B., Rehrer, N., Drummond, L., Wu, X.-Y., … Lawley, B., … Tannock, G. W. (2019). Prioritization of substrate use by a co-culture of five species of gut bacteria fed mixtures of arabinoxylan, xyloglucan, β-glucan, and pectin. Applied & Environmental Microbiology. Advance online publication. doi: 10.1128/aem.01905-19

Murphy, R., Morgan, X. C., Wang, X. Y., Wickens, K., Purdie, G., Fitzharris, P., Otal, A., Lawley, B., Stanley, T., Barthow, C., Crane, J., … Tannock, G. W. (2019). Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: Sub-sample analysis from a RCT. Beneficial Microbes, 10(1), 5-17. doi: 10.3920/bm2017.0191

Lawley, B., Otal, A., Moloney-Geany, K., Diana, A., Houghton, L., Heath, A.-L. M., Taylor, R. W., & Tannock, G. W. (2019). Fecal microbiotas of Indonesian and New Zealand children differ in complexity and bifidobacterial taxa during the first year of life. Applied & Environmental Microbiology, 85(19), e01105-1. doi: 10.1128/aem.01105-19

Centanni, M., Lawley, B., Butts, C. A., Roy, N. C., Lee, J., Kelly, W. J., & Tannock, G. W. (2018). Bifidobacterium pseudolongum in the ceca of rats fed Hi-Maize starch has characteristics of a keystone species in bifidobacterial blooms. Applied & Environmental Microbiology, 84(15), e00547-18. doi: 10.1128/AEM.00547-18

Centanni, M., Lawley, B., Butts, C. A., Roy, N., Lee, J., Kelly, W. J., & Tannock, G. W. (2018). Bifidobacterium pseudolongum has characteristics of a keystone species in bifidobacterial blooms in the ceca of rats fed Hi-Maize starch. Applied & Environmental Microbiology, 84(15), e00547-18. doi: 10.1128/aem.00547-18

Wilson, R., Willis, J., Gearry, R. B., Hughes, A., Lawley, B., Skidmore, P., Frampton, C., Fleming, E., Anderson, A., Jones, L., Tannock, G. W., & Carr, A. C. (2018). SunGold kiwifruit supplementation of individuals with prediabetes alters gut microbiota and improves Vitamin C status, anthropometric and clinical markers. Nutrients, 10, 895. doi: 10.3390/nu10070895

Leong, C., Haszard, J. J., Lawley, B., Otal, A., Taylor, R. W., Szymlek-Gay, E. A., Fleming, E. A., Daniels, L., Fangupo, L. J., Tannock, G. W., & Heath, A.-L. M. (2018). Mediation analysis as a means of identifying dietary components that affect the fecal microbiota of infants weaned by modified baby-led, compared to traditional, approaches. Applied & Environmental Microbiology. Advance online publication. doi: 10.1128/aem.00914-18

Lawley, B., Centanni, M., Watanabe, J., Sims, I., Carnachan, S., Broadbent, R., Lee, P. S., … Tannock, G. W. (2018). tuf gene sequence variation in Bifidobacterium longum subsp. infantis detected in the fecal microbiota of Chinese infants. Applied & Environmental Microbiology, 84(13), e00336-18. doi: 10.1128/aem.00336-18

Lawley, B., Munro, K., Hughes, A., Hodgkinson, A. J., Prosser, C. G., Lowry, D., … Tannock, G. W. (2017). Differentiation of Bifidobacterium longum subspecies longum and infantis by quantitative PCR using functional gene targets. PeerJ, 5, e3375. doi: 10.7717/peerj.3375

Taylor, R. W., Heath, A.-L. M., Galland, B. C., Cameron, S. L., Lawrence, J. A., Gray, A. R., Tannock, G. W., Lawley, B., Healey, D., Sayers, R. M., Hanna, M., Meredith-Jones, K., Hatch, B., & Taylor, B. J. (2016). Three-year follow-up of a randomised controlled trial to reduce excessive weight gain in the first two years of life: Protocol for the POI follow-up study. BMC Public Health, 16, 771. doi: 10.1186/s12889-016-3383-4

Ranjitkar, S., Lawley, B., Tannock, G., & Engberg, R. M. (2016). Bacterial successions in the broiler gastrointestinal tract. Applied & Environmental Microbiology, 82(8), 2399-2410. doi: 10.1128/aem.02549-15

Wilson, C. M., Loach, D., Lawley, B., Bell, T., Sims, I. M., O'Toole, P. W., … Tannock, G. W. (2014). Lactobacillus reuteri 100-23 modulates urea hydrolysis in the murine stomach. Applied & Environmental Microbiology, 80(19), 6104-6113. doi: 10.1128/aem.01876-14

Tannock, G. W., Lawley, B., Munro, K., Sims, I. M., Lee, J., Butts, C. A., & Roy, N. (2014). RNA-stable isotope probing shows utilization of carbon from inulin by specific bacterial populations in the rat large bowel. Applied & Environmental Microbiology, 80(7), 2240-2247. doi: 10.1128/aem.03799-13

Tannock, G. W., Taylor, C., Lawley, B., Loach, D., Gould, M., Dunn, A. C., McLellan, A. D., Black, M. A., McNoe, L., Dekker, J., … Collett, M. A. (2014). Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001. Applied & Environmental Microbiology, 80(9), 2851-2859. doi: 10.1128/aem.00336-14

Oswari, H., Prayitno, L., Dwipoerwantoro, P. G., Firmansyah, A., Makrides, M., Lawley, B., … Tannock, G. W. (2013). Comparison of stool microbiota compositions, stool alpha1-antitrypsin and calprotectin concentrations, and diarrhoeal morbidity of Indonesian infants fed breast milk or probiotic/prebiotic-supplemented formula. Journal of Paediatrics & Child Health, 49, 1032-1039. doi: 10.1111/jpc.12307

Lawley, B., Sims, I. M., & Tannock, G. W. (2013). Whole-transcriptome shotgun sequencing (RNA-seq) screen reveals upregulation of cellobiose and motility operons of Lactobacillus ruminis L5 during growth on tetrasaccharides derived from barley β-glucan. Applied & Environmental Microbiology, 79(18), 5661-5669. doi: 10.1128/aem.01887-13

Tannock, G. W., Lawley, B., Munro, K., Pathmanathan, S. G., Zhou, S. J., Makrides, M., … Hodgkinson, A. J. (2013). Comparison of the compositions of the stool microbiotas of infants fed goat milk formula in comparison to cow milk-based formula, or breast milk. Applied & Environmental Microbiology, 79(9), 3040-3048. doi: 10.1128/aem.03910-12

Balan, P., Han, K.-S., Lawley, B., & Moughan, P. J. (2013). Orally administered ovine serum immunoglobulins modulate the intestinal levels of lactobacillus and enterobacteria in the growing rat. Journal of Animal Science, 91(8), 3724-3732. doi: 10.2527/jas2012-6028

Young, W., Roy, N. C., Lee, J., Lawley, B., Otter, D., Henderson, G., & Tannock, G. W. (2013). Bowel microbiota moderate host physiological responses to dietary konjac in weanling rats1-3. Journal of Nutrition, 143, 1052-1060. doi: 10.3945/jn.113.174854

Tannock, G. W., Lawley, B., Munro, K., Lay, C., Taylor, C., Daynes, C., … Thompson-Fawcett, M. (2012). Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familial adenomatous polyposis pouches. Inflammatory Bowel Diseases, 18(5), 925-934. doi: 10.1002/ibd.21936

Lawley, B., & Tannock, G. W. (2012). Nucleic acid-based methods to assess the composition and function of the bowel microbiota. Gastroenterology Clinics of North America, 41(4), 855-868. doi: 10.1016/j.gtc.2012.08.010

Young, W., Roy, N. C., Lee, J., Lawley, B., Otter, D., Henderson, G., … Tannock, G. W. (2012). Changes in bowel microbiota induced by feeding weanlings resistant starch stimulate transcriptomic and physiological responses. Applied & Environmental Microbiology, 78(18), 6656-6664. doi: 10.1128/aem.01536-12

Tannock, G. W., Wilson, C. M., Loach, D., Cook, G. M., Eason, J., O'Toole, P. W., … Lawley, B. (2012). Resource partitioning in relation to cohabitation of Lactobacillus species in the mouse forestomach. ISME Journal, 6, 927-938. doi: 10.1038/ismej.2011.161

Tannock, G. W., Munro, K., Taylor, C., Lawley, B., Young, W., Byrne, B., … Louie, T. (2010). A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin. Microbiology, 156(11), 3354-3359. doi: 10.1099/mic.0.042010-0

Williamson, J. F., McLure, C. A., Baird, P. N., Male, D., Millman, J., Lawley, B., & et al (2008). Novel sequence elements define ancestral haplotypes of the region encompassing complement factor H. Human Immunology, 69, 207-219. doi: 10.1016/j.humimm.2008.01.016

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Journal - Research Other

Pathmanathan, S. G., Lawley, B., McConnell, M., Baird, M. A., & Tannock, G. W. (2020). Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells. Anaerobe, 61, 102112. doi: 10.1016/j.anaerobe.2019.102112

Heath, A.-L. M., Haszard, J. J., Galland, B. C., Lawley, B., Rehrer, N. J., Drummond, L. N., … Taylor, R. W., … Taylor, B., & Tannock, G. W. (2020). Association between the faecal short-chain fatty acid propionate and infant sleep [Brief communication]. European Journal of Clinical Nutrition. Advance online publication. doi: 10.1038/s41430-019-0556-0

Kindleysides, S., Kruger, R., Douwes, J., Tannock, G. W., Renall, N., Slater, J., Lawley, B., … Breier, B. H. (2019). PRedictors linking Obesity and the gut MIcrobiomE (the PROMISE study): Protocol and recruitment strategy for a cross-sectional study on pathways that affect the gut microbiome and its impact on obesity. JMIR Research Protocols, 8(8), e14529. doi: 10.2196/14529

Tannock, G. W., Lee, P. S., Wong, K. H., & Lawley, B. (2016). Why don’t all infants have bifidobacteria in their stool? Frontiers in Microbiology, 7, 834. doi: 10.3389/fmicb.2016.00834

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