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Otago Medical School staff profiles

Dr Sharon Ladyman

PositionSenior Research Fellow
DepartmentDepartment of Anatomy
QualificationsBSc(Hons) PhD
Research summaryNeuroendocrinology

Research

The neuroendocrine regulation of maternal body weight, appetitie and glucose homeostasis duing pregnancy.

Her work focuses on the mechanisms underlying the altered response to leptin in the maternal brain and the role of pregnancy hormones in the development of maternal leptin resistance. Furthermore she is investigating the consequences of maternal leptin resistance, specifically the effects on maternal glucose homeostasis.

Publications

Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Gustafson, P., Knowles, P., Luque, G. M., Grattan, D. R., & Becu-Villalobos, D. (2020). Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake. FASEB Journal. Advance online publication. doi: 10.1096/fj.201902357R

Smiley, K. O., Ladyman, S. R., Gustafson, P., Grattan, D. R., & Brown, R. S. E. (2019). Neuroendocrinology and adaptive physiology of maternal care. In Current topics in behavioral neurosciences. Cham, Switzerland: Springer. doi: 10.1007/7854_2019_122

Aquino, N. S. S., Kokay, I. C., Perez, C. T., Ladyman, S. R., Henriques, P. C., Silva, J. F., … Grattan, D. R., & Szawka, R. E. (2019). Kisspeptin stimulation of prolactin secretion requires Kiss1 receptor but not in tuberoinfundibular dopaminergic neurons. Endocrinology, 160(3), 522-533. doi: 10.1210/en.2018-00932

Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E. (2019). The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction. Neuropharmacology. Advance online publication. doi: 10.1016/j.neuropharm.2019.107911

Gustafson, P., Ladyman, S. R., & Brown, R. S. E. (2019). Suppression of leptin transport into the brain contributes to leptin resistance during pregnancy in the mouse. Endocrinology. Advance online publication. doi: 10.1210/en.2018-01065

Chapter in Book - Research

Smiley, K. O., Ladyman, S. R., Gustafson, P., Grattan, D. R., & Brown, R. S. E. (2019). Neuroendocrinology and adaptive physiology of maternal care. In Current topics in behavioral neurosciences. Cham, Switzerland: Springer. doi: 10.1007/7854_2019_122

Woodside, B., Augustine, R. A., Ladyman, S. R., Naef, L., & Grattan, D. R. (2008). Role of prolactin in the metabolic adaptations to pregnancy and lactation. In R. S. Bridges (Ed.), Neurobiology of the parental brain. (pp. 249-267). London: Academic Press.

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Journal - Research Article

Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Gustafson, P., Knowles, P., Luque, G. M., Grattan, D. R., & Becu-Villalobos, D. (2020). Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake. FASEB Journal. Advance online publication. doi: 10.1096/fj.201902357R

Aquino, N. S. S., Kokay, I. C., Perez, C. T., Ladyman, S. R., Henriques, P. C., Silva, J. F., … Grattan, D. R., & Szawka, R. E. (2019). Kisspeptin stimulation of prolactin secretion requires Kiss1 receptor but not in tuberoinfundibular dopaminergic neurons. Endocrinology, 160(3), 522-533. doi: 10.1210/en.2018-00932

Gustafson, P., Ladyman, S. R., & Brown, R. S. E. (2019). Suppression of leptin transport into the brain contributes to leptin resistance during pregnancy in the mouse. Endocrinology. Advance online publication. doi: 10.1210/en.2018-01065

Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E. (2019). The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction. Neuropharmacology. Advance online publication. doi: 10.1016/j.neuropharm.2019.107911

Augustine, R. A., Knowles, P., Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2019). Impaired hypothalamic leptin sensitivity in pseudopregnant rats treated with chronic prolactin to mimic pregnancy. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12702

Ladyman, S. R., Khant Aung, Z., & Grattan, D. R. (2018). Impact of pregnancy and lactation on the long-term regulation of energy balance in female mice. Endocrinology. Advance online publication. doi: 10.1210/en.2018-00057

Ladyman, S. R., Carter, K. M., & Grattan, D. R. (2018). Energy homeostasis and running wheel activity during pregnancy in the mouse. Physiology & Behavior, 194, 83-94. doi: 10.1016/j.physbeh.2018.05.002

McEwen, H. J. L., Cognard, E., Ladyman, S. R., Khant-Aung, Z., Tups, A., Shepherd, P. R., & Grattan, D. R. (2018). Feeding and GLP-1 receptor activation stabilize beta-catenin in specific hypothalamic nuclei in male rats. Journal of Neuroendocrinology, 30(6), e12607, 1-10. doi: 10.1111/jne.12607

Ladyman, S. R., MacLeod, M. A., Khant Aung, Z., Knowles, P., Phillipps, H. R., Brown, R. S. E., & Grattan, D. R. (2017). Prolactin receptors in Rip-cre cells, but not in AgRP neurons, are involved in energy homeostasis. Journal of Neuroendocrinology, 29(10), e12474. doi: 10.1111/jne.12474

Brown, R. S. E., Aoki, M., Ladyman, S. R., Phillipps, H. R., Wyatt, A., Boehm, U., & Grattan, D. R. (2017). Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. PNAS, 114(40), 10779-10784. doi: 10.1073/pnas.1708025114

Augustine, R. A., Ladyman, S. R., Bouwer, G. T., Alyousif, Y., Sapsford, T. J., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2017). Prolactin regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Physiology, 595(11), 3591-3605. doi: 10.1113/jp273712

Tups, A., Benzler, J., Sergi, D., Ladyman, S. R., & Williams, L. M. (2017). Central regulation of glucose homeostasis. Comprehensive Physiology, 7(2), 741-764. doi: 10.1002/cphy.c160015

Ladyman, S. R., & Grattan, D. R. (2017). Region-specific suppression of hypothalamic responses to insulin to adapt to elevated maternal insulin secretion during pregnancy. Endocrinology, 158(12), 4257-4269. doi: 10.1210/en.2017-00600

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., LeTissier, P., & Grattan, D. R. (2016). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Journal of Neuroscience, 36(35), 9173-9185. doi: 10.1523/jneurosci.1471-16.2016

Ladyman, S. R., & Grattan, D. R. (2016). Central effects of leptin on glucose homeostasis are modified during pregnancy in the rat. Journal of Neuroendocrinology, 28(10). doi: 10.1111/jne.12431

Brown, R. S. E., Wyatt, A. K., Herbison, R. E., Knowles, P. J., Ladyman, S. R., Binart, N., … Grattan, D. R. (2016). Prolactin transport into mouse brain is independent of prolactin receptor. FASEB Journal, 30(2), 1002-1010. doi: 10.1096/fj.15-276519

Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H., & Grattan, D. R. (2016). Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology, 594(4), 1087-1101. doi: 10.1113/jp271605

Ladyman, S., & Woodside, B. (2014). Food restriction during lactation suppresses Kiss1 mRNA expression and kisspeptin-stimulated LH release in rats. Reproduction, 147, 743-751. doi: 10.1530/rep-13-0426

Phillipps, H. R., Ladyman, S. R., & Grattan, D. R. (2013). Maintained expression of genes associated with metabolism in the ventromedial hypothalamic nucleus despite development of leptin resistance during pregnancy in the rat. Physiological Reports, 1(6), e00162. doi: 10.1002/phy2.162

Ladyman, S. R., & Grattan, D. R. (2013). JAK-STAT and feeding. JAK-STAT, 2(2), e23675. doi: 10.4161/jkst.23675

Ladyman, S. R., Fieldwick, D. M., & Grattan, D. R. (2012). Suppression of leptin-induced hypothalamic JAK/STAT signaling and feeding response during pregnancy in the mouse. Reproduction, 144(1), 83-90. doi: 10.1530/rep-12-0112

Ladyman, S. R., Sapsford, T. J., & Grattan, D. R. (2011). Loss of acute satiety response to cholecystokinin in pregnant rats. Journal of Neuroendocrinology, 23(11), 1091-1098. doi: 10.1111/j.1365-2826.2011.02191.x

Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010). Hormone interactions regulating energy balance during pregnancy. Journal of Neuroendocrinology, 22, 805-817. doi: 10.1111/j.1365-2826.2010.02017.x

Ladyman, S. R., & Woodside, B. (2009). Regulation of maternal food intake and mother-pup interactions by the Y5 receptor. Physiology & Behavior, 97, 91-97. doi: 10.1016/j.physbeh.2009.02.008

Ladyman, S. R., Tups, A., Augustine, R. A., Swahn-Azavedo, A., Kokay, I. C., & Grattan, D. R. (2009). Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance. Journal of Neuroendocrinology, 21(5), 449-456. doi: 10.1111/j.1365-2826.2009.01862.x

Augustine, R. A., Ladyman, S. R., & Grattan, D. R. (2008). From feeding one to feeding many: Hormone-induced changes in bodyweight homeostasis during pregnancy (Symposium report). Journal of Physiology, 586(2), 387-397. doi: 10.1113/jphysiol.2007.146316

Grattan, D. R., Ladyman, S. R., & Augustine, R. A. (2007). Hormonal induction of leptin resistance during pregnancy. Physiology & Behavior, 91, 366-374.

Ladyman, S. R., & Grattan, D. R. (2005). Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology, 146(9), 3868-3874.

Ladyman, S. R., & Grattan, D. R. (2004). Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology, 145(8), 3704-3711.

Augustine, R. A., Kokay, I. C., Andrews, Z. B., Ladyman, S. R., & Grattan, D. R. (2003). Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation. Journal of Molecular Endocrinology, 31, 221-232.

Todd, B. J., Ladyman, S. R., & Grattan, D. R. (2003). Suppression of pulsatile luteinizing hormone secretion but not luteinizing hormone surge in leptin resistant obese Zucker rats. Journal of Neuroendocrinology, 15, 61-68.

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Journal - Research Other

Ladyman, S. R. (2008). Leptin resistance during pregnancy in the rat. Journal of Neuroendocrinology, 20(269), 269-277. doi: 10.1111/j.1365-2826.2007.01628.x

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