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Otago Medical School staff profiles

Dr Anne von Zychlinski-Kleffman

PositionResearch Fellow
DepartmentDepartment of Biochemistry
QualificationsPhD
Research summaryProteomics and inhibition of lipoprotein(a)

Research

Inhibition of lipoprotein (a) formation. Elevated Lp(a) is associated with the development of cardiovascular diseases. To date no therapy that effectively lowers Lp(a) exists. We have screened different compounds for Lp(a) inhibitory activity and so far identified bacitracin, an old peptide antibiotic and DMPC as inhibitors for Lp(a) assembly. Also, proteomic analysis of lipoproteins in human plasma.

Publications

Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150

von Zychlinski, A., & Kleffmann, T. (2015). Dissecting the proteome of lipoproteins: New biomarkers for cardiovascular diseases? Translational Proteomics, 7, 30-39. doi: 10.1016/j.trprot.2014.12.001

von Zychilinski, A., Williams, M., McCormick, S., & Kleffmann, T. (2014). Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins. Journal of Proteomics, 106, 181-190. doi: 10.1016/j.jprot.2014.04.030

von Zychlinski, A., Kleffmann, T., Williams, M. J. A., & McCormick, S. P. (2011). Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. Journal of Proteomics, 74, 2881-2891. doi: 10.1016/j.jprot.2011.07.008

von Zychlinski, A., & Gruissem, W. (2009). Preparation and analysis of plastid proteomes by 2DE. In D. Sheehan & R. Tyther (Eds.), Two-dimensional electrophoresis protocols: Methods in molecular biology (Vol. 519). (pp. 205-220). Totowa, NJ: Humana Press. doi: 10.1007/978-1-59745-281-6_13

Chapter in Book - Research

von Zychlinski, A., & Gruissem, W. (2009). Preparation and analysis of plastid proteomes by 2DE. In D. Sheehan & R. Tyther (Eds.), Two-dimensional electrophoresis protocols: Methods in molecular biology (Vol. 519). (pp. 205-220). Totowa, NJ: Humana Press. doi: 10.1007/978-1-59745-281-6_13

von Zychilinski, A., Reiland, S., Gruissem, W., & Baginsky, S. (2008). Etioplast. In G. K. Agrawal & R. Rakwal (Eds.), Plant Proteomics: Technologies, strategies, and applications. (pp. 351-360). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9780470369630.ch24

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Journal - Research Article

Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150

von Zychlinski, A., & Kleffmann, T. (2015). Dissecting the proteome of lipoproteins: New biomarkers for cardiovascular diseases? Translational Proteomics, 7, 30-39. doi: 10.1016/j.trprot.2014.12.001

von Zychilinski, A., Williams, M., McCormick, S., & Kleffmann, T. (2014). Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins. Journal of Proteomics, 106, 181-190. doi: 10.1016/j.jprot.2014.04.030

von Zychlinski, A., Kleffmann, T., Williams, M. J. A., & McCormick, S. P. (2011). Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. Journal of Proteomics, 74, 2881-2891. doi: 10.1016/j.jprot.2011.07.008

Wang, Y.-T., von Zychlinski, A., & McCormick, S. P. A. (2009). Dimyristoylphosphotidylcholine induces conformational changes in apoB that lowers lipoprotein(a). Journal of Lipid Research, 50(5), 846-853. doi: 10.1194/jlr.M800428-JLR200

Kleffmann, T., von Zychlinski, A., Russenberger, D., Hirsch-Hoffmann, M., Gehrig, P., Gruissem, W., & Baginsky, S. (2007). Proteome dynamics during plastid differentiation in rice. Plant Physiology, 143, 912-923. doi: 10.1104/pp.106.090738

Baginsky, S., Kleffmann, T., von Zychlinski, A., & Gruissem, W. (2005). Analysis of shotgun proteomics and RNA profiling data from Arabidopsis thaliana chloroplasts. Journal of Proteome Research, 4(2), 637-640.

von Zychilinski, A., Kleffmann, T., Krishnamurthy, N., Sjolander, K., Baginsky, S., & Gruissem, W. (2005). Proteome analysis of the rice etioplast: Metabolic and regulatory networks and novel protein functions. Molecular & Cellular Proteomics, 4(8), 1072-1084.

Kleffmann, T., Russenberger, D., von Zychilinski, A., Sjolander, K., Gruissem, W., & Baginsky, S. (2004). The arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions. Current Biology, 14, 354-362.

More publications...