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Otago Medical School staff profiles

Dr Zoe Ashley

PositionResearch Fellow
DepartmentDepartment of Physiology
QualificationsPhD
Research summaryRole of CaMKII and estrogens on atherosclerosis
Memberships
  • European Society of Hypertension
  • Australian Vascular Biology Society

Research

My research focus is in vascular biology. My current research project is investigating the role of Calcium calmodulin kinase II (CaMKII) in the development of atherosclerotic lesions in the ApoE -/- mouse model. I am investigating whether inhibition of CaMKII reduces the progression of atherosclerotic lesions, either in terms of lesion size, stenosis, severity and morphology. In addition, the project involves examination of the role of estrogens and CaMKII in atherosclerosis. Overall research findings could highlight a potential pathway for the development of new therapies for the major underlying cause of cardiovascular disease.

Publications

Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Journal - Research Article

Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: Evaluation in pigs. Diseases of the Colon & Rectum, 53(4), 467-474. doi: 10.1007/DCR.0b013e3181bdbe91

Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: The influence of pattern. Muscle & Nerve, 38, 875-886. doi: 10.1002/mus.21020

Ashley, Z., Sutherland, H., Lanmüller, H., Russold, M. F., Unger, E., Bijak, M., … Jarvis, J. C. (2007). Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. American Journal of Physiology: Cell Physiology, 292, C440-C451. doi: 10.1152/ajpcell.00085.2006

Ashley, Z., Salmons, S., Boncompagni, S., Protasi, F., Russold, M., Lanmuller, H., … Jarvis, J. C. (2007). Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. Journal of Muscle Research & Cell Motility, 28, 203-217. doi: 10.1007/s10974-007-9119-4

Chilcott, R. P., Dalton, C. H., Ashley, Z., Allen, C. E., Bradley, S. T., ..., & Rice, P. (2007). Evaluation of barrier creams against sulphur mustard: (II) in vivo and in vitro studies using the domestic white pig. Cutaneous & Ocular Toxicology, 26, 235-247. doi: 10.1080/15569520701212373

Ramnarine, I. R., Capoccia, M., Ashley, Z., Sutherland, H., Russold, M., Summerfield, N., … Jarvis, J. C. (2006). Counterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations. Circulation, 114(Suppl. I), I-10-I-15. doi: 10.1161/CIRCULATIONAHA.105.000372

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