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Otago Medical School staff profiles

Associate Professor Keith Ireton

PositionAssociate Professor
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc, PhD
Research summaryMedical microbiology and microbial pathogenesis, cellular microbiology

Research

My laboratory studies molecular mechanisms of virulence of the food-borne pathogen Listeria monocytogenes. One ongoing project focuses on understanding the process by which Listeria induces its internalization into host human cells. Another project examines how Listeria spreads from infected human cells to surrounding healthy cells.

Publications

Bhalla, M., Ngo, H. V., Gyanwali, G. C., & Ireton, K. (2018). The host scaffolding protein Filamin A and the exocyst complex control exocytosis during InlB-mediated entry of Listeria monocytogenes. Infection & Immunity. Advance online publication. doi: 10.1128/iai.00689-18

Bhalla, M., Law, D., Dowd, G. C., & Ireton, K. (2017). Host serine/threonine kinases mTOR and protein kinase C-α promote InlB-mediated entry of Listeria monocytogenes. Infection & Immunity, 85(7), e00087-17. doi: 10.1128/iai.00087-17

Ngo, H. V., Bhalla, M., Chen, D.-Y., & Ireton, K. (2017). A role for host cell exocytosis in InlB-mediated internalization of Listeria monocytogenes. Cellular Microbiology, 19(11), e12768. doi: 10.1111/cmi.12768

Dowd, G. C., Bhalla, M., Kean, B., Thomas, R., & Ireton, K. (2016). Role of host type IA Phosphoinositide 3-Kinase pathway components in invasin-mediated internalization of Yersinia enterocolitica. Infection & Immunity, 84(6), 1826-1841. doi: 10.1128/iai.00142-16

Ireton, K. (2016). Rickettsia evades a tense situation [Preview]. Cell Host & Microbe, 20(5), 549-550. doi: 10.1016/j.chom.2016.10.017

Journal - Research Article

Bhalla, M., Ngo, H. V., Gyanwali, G. C., & Ireton, K. (2018). The host scaffolding protein Filamin A and the exocyst complex control exocytosis during InlB-mediated entry of Listeria monocytogenes. Infection & Immunity. Advance online publication. doi: 10.1128/iai.00689-18

Bhalla, M., Law, D., Dowd, G. C., & Ireton, K. (2017). Host serine/threonine kinases mTOR and protein kinase C-α promote InlB-mediated entry of Listeria monocytogenes. Infection & Immunity, 85(7), e00087-17. doi: 10.1128/iai.00087-17

Ngo, H. V., Bhalla, M., Chen, D.-Y., & Ireton, K. (2017). A role for host cell exocytosis in InlB-mediated internalization of Listeria monocytogenes. Cellular Microbiology, 19(11), e12768. doi: 10.1111/cmi.12768

Dowd, G. C., Bhalla, M., Kean, B., Thomas, R., & Ireton, K. (2016). Role of host type IA Phosphoinositide 3-Kinase pathway components in invasin-mediated internalization of Yersinia enterocolitica. Infection & Immunity, 84(6), 1826-1841. doi: 10.1128/iai.00142-16

Gianfelice, A., Le, P. H. B., Rigano, L. A., Saila, S., Dowd, G. C., McDivitt, T., … Ireton, K. (2015). Host endoplasmic reticulum COPII proteins control cell-to-cell spread of the bacterial pathogen Listeria monocytogenes. Cellular Microbiology, 17(6), 876-892. doi: 10.1111/cmi.12409

Polle, L., Rigano, L. A., Julian, R., Ireton, K., & Schubert, W.-D. (2014). Structural details of human tuba recruitment by InlC of Listeria monocytogenes elucidate bacterial cell-cell spreading. Structure, 22(2), 304-314. doi: 10.1016/j.str.2013.10.017

Rigano, L. A., Dowd, G. C., Wang, Y., & Ireton, K. (2014). Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread. Cellular Microbiology, 16(7), 1068-1079. doi: 10.1111/cmi.12260

Leung, N., Gianfelice, A., Gray-Owen, S. D., & Ireton, K. (2013). Impact of the Listeria monocytogenes protein inlC on infection in mice. Infection & Immunity, 81(4), 1334-1340. doi: 10.1128/IAI.01377-12

Ireton, K. (2013). Molecular mechanisms of cell – cell spread of intracellular bacterial pathogens. Open Biology, 3, 130079. doi: 10.1098/rsob.130079

Jiwani, S., Wang, Y., Dowd, G. C., Gianfelice, A., Pichestapong, P., Gavicherla, B., … Ireton, K. (2012). Identification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes. Infection & Immunity, 80(3), 1252-1266. doi: 10.1128/IAI.06082-11

Ireton, K. (2010). Anthrax toxins: Roadblocks for exocytic trafficking. Developmental Cell, 19(5), 643-644. doi: 10.1016/j.devcel.2010.10.019

Taylor, M., Navarro-Garcia, F., Huerta, J., Burress, H., Massey, S., Ireton, K., & Teter, K. (2010). Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol. Journal of Biological Chemistry, 285(41), 31261-31267. doi: 10.1074/jbc.M110.148981

Gavicherla, B., Ritchey, L., Gianfelice, A., Kolokoltsov, A. A., Davey, R. A., & Ireton, K. (2010). Critical role for the host GTPase-activating protein ARAP2 in InIB-mediated entry of Listeria monocytogenes. Infection & Immunity, 78(11), 4532-4541. doi: 10.1128/IAI.00802-10

Rajabian, T., Gavicherla, B., Heisig, M., Müller-Altrock, S., Goebel, W., Gray-Owen, S. D., & Ireton, K. (2009). The bacterial virulence factor InIC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Nature Cell Biology, 11(10), 1212-1218. doi: 10.1038/ncb1964

Goldoni, S., Humphries, A., Nyström, A., Sattar, S., Owens, R. T., McQuillan, D. J., Ireton, K., & Iozzo, R. V. (2009). Decorin is a novel antagonistic ligand of the Met receptor. Journal of Cell Biology, 185(4), 743-754. doi: 10.1083/jcb.200901129

Gao, X., Lorinczi, M., Hill, K. S., Brooks, N. C., Dokainish, H., Ireton, K., & Elferink, L. A. (2009). Met receptor tyrosine kinase degradation is altered in response to the leucine-rich repeat of the Listeria invasion protein Internalin B. Journal of Biological Chemistry, 284(2), 774-783. doi: 10.1074/jbc.M805989200

Lee, W. L., Cosio, G., Ireton, K., & Grinstein, S. (2007). Role of CrkII in Fcγ receptor-mediated phagocytosis. Journal of Biological Chemistry, 282(15), 11135-11143. doi: 10.1074/jbc.M700823200

Li, N., Lorinczi, M., Ireton, K., & Elferink, L. A. (2007). Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase. Journal of Biological Chemistry, 282(23), 16764-16775. doi: 10.1074/jbc.M610835200

Ireton, K. (2007). Entry of the bacterial pathogen Listeria monocytogenes into mammalian cells. Cellular Microbiology, 9(6), 1365-1375. doi: 10.1111/j.1462-5822.2007.00933.x

Dokainish, H., Gavicherla, B., Shen, Y., & Ireton, K. (2007). The carboxyl-terminal SH3 domain of the mammalian adaptor CrkII promotes internalization of Listeria monocytogenes through activation of host phosphoinositide 3-kinase. Cellular Microbiology, 9(10), 2497-2516. doi: 10.1111/j.1462-5822.2007.00976.x

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Journal - Research Other

Ireton, K. (2016). Rickettsia evades a tense situation [Preview]. Cell Host & Microbe, 20(5), 549-550. doi: 10.1016/j.chom.2016.10.017

Ireton, K., Rigano, L. A., & Dowd, G. C. (2014). Role of host GTPases in infection by Listeria monocytogenes. Cellular Microbiology, 16(9), 1311-1320. doi: 10.1111/cmi.12324

Ireton, K., Rigano, L. A., Polle, L., & Schubert, W.-D. (2014). Molecular mechanism of protrusion formation during cell-to-cell spread of Listeria. Frontiers in Cellular & Infection Microbiology, 4, 21. doi: 10.3389/fcimb.2014.00021

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