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Otago Medical School staff profiles

Professor Mark Richards

PositionProfessor
DepartmentDepartment of Medicine (UOC)
QualificationsMBChB MD PhD (Otago) FRACP
Research summaryCardioendocrinology

Research

Mark Richards is the director of the Christchurch Heart Institute. He coordinates and directs multi-disciplinary programmes of grant-funded translational cardiovascular research which seek to improve diagnostic, prognostic and therapeutic options in heart disease.

He is pursuing studies of epidemiological, molecular biological, neurohormonal and therapeutic aspects of acute and chronic cardiovascular disorders including hypertension, coronary syndromes, and the full spectrum of heart failure.

Richards holds the Heart Foundation of New Zealand’s Chair in Cardiovascular Studies. He also holds joint appointments at the University of Otago and the National University of Singapore’s Cardiovascular Research Institute. His research interests include:

  • Neurohormonal physiology and pathophysiology in cardiovascular health and disease
  • Heart Failure
  • Acute Coronary Syndromes
  • Hypertension
  • Vasoactive Hormones
  • The Cardiac Natriuretic Peptides

Publications

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Wong, L. L., Saw, E. L., Lim, J. Y., Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA Let-7d-3p contributes to cardiac protection via targeting HMGA2. International Journal of Molecular Sciences, 20(7), 1522. doi: 10.3390/ijms20071522

Lin, Z., Lim, S. H., Chua, S. J. T., Tai, E. S., Chan, Y. H., & Richards, A. M. (2019). High-sensitivity troponin T and long-term adverse cardiac events among patients presenting with suspected acute coronary syndrome in Singapore. Singapore Medical Journal. Advance online publication. doi: 10.11622/smedj.2019013

Gallart-Palau, X., Tan, L. M., Serra, A., Gao, Y., Ho, H. H., Richards, A. M., … Sze, S. K. (2019). Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Research Reviews. Advance online publication. doi: 10.1016/j.arr.2019.100909

Stamp, L. K., Frampton, C., Drake, J., Doughty, R. N., Troughton, R. W., & Richards, A. M. (2019). Associations of gout and baseline serum urate with cardiovascular outcomes: Analysis of the Coronary Disease Cohort Study. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41007

Chapter in Book - Research

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.

Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.

Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.

Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.

Lainchbury, J. G., Richards, A. M., & Nicholls, M. G. (1997). Brain natriuretic peptide in heart failure. In Atrial Natriuretic Peptides. (pp. 151-158).

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

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Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

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Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Stamp, L. K., Frampton, C., Drake, J., Doughty, R. N., Troughton, R. W., & Richards, A. M. (2019). Associations of gout and baseline serum urate with cardiovascular outcomes: Analysis of the Coronary Disease Cohort Study. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41007

Gallart-Palau, X., Tan, L. M., Serra, A., Gao, Y., Ho, H. H., Richards, A. M., … Sze, S. K. (2019). Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Research Reviews. Advance online publication. doi: 10.1016/j.arr.2019.100909

Lin, Z., Lim, S. H., Chua, S. J. T., Tai, E. S., Chan, Y. H., & Richards, A. M. (2019). High-sensitivity troponin T and long-term adverse cardiac events among patients presenting with suspected acute coronary syndrome in Singapore. Singapore Medical Journal. Advance online publication. doi: 10.11622/smedj.2019013

Wong, L. L., Saw, E. L., Lim, J. Y., Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA Let-7d-3p contributes to cardiac protection via targeting HMGA2. International Journal of Molecular Sciences, 20(7), 1522. doi: 10.3390/ijms20071522

Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA-221 is cardioprotective and anti-fibrotic in a rat model of myocardial infarction. Molecular Therapy: Nucleic Acids. Advance online publication. doi: 10.1016/j.omtn.2019.05.018

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2019.05.010

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314077

Wong, L. L., Zou, R., Zhou, L., Lim, J. Y., Phua, D. C. Y., Liu, C., … Troughton, R., Cameron, V. A., … Richards, A. M. (2019). Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtypes. JACC, 73(11), 1300-1313. doi: 10.1016/j.jacc.2018.11.060

Ellis, C. J., Gamble, G. D., Williams, M. J. A., Matsis, P., Elliott, J. M., Devlin, G., Mann, S., … for the Regional Cardiac Society NZ ACS Audit Group, including Richards, M., & Nixon, G. (2019). All-cause mortality following an acute coronary syndrome: 12-year follow-up of the comprehensive 2002 New Zealand Acute Coronary Syndrome Audit. Heart, Lung & Circulation, 28, 245-256. doi: 10.1016/j.hlc.2017.10.015

Patel, R. S., Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Association of chromosome 9p21 with subsequent coronary heart disease events: A GENIUS-CHD study of individual participant data. Circulation: Genomic & Precision Medicine, 12(4), 161-172. doi: 10.1161/circgen.119.002471

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry. Advance online publication. doi: 10.1373/clinchem.2019.302547

Tan, E. S. J., Chan, S. P., Xu, C. F., Yap, J., Richards, A. M., Ling, L. H., … Lim, T. W. (2019). Cornell product is an ECG marker of heart failure with preserved ejection fraction. Heart Asia, 11(1), e011108. doi: 10.1136/heartasia-2018-011108

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Subsequent event risk in individuals with established coronary heart disease: Design and rationale of the GENIUS-CHD Consortium. Circulation: Genomic & Precision Medicine, 12(4), 145-160. doi: 10.1161/CIRCGEN.119.002470

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Lam, C. S. P., Gamble, G. D., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Cameron, V. A., … Troughton, R., Richards, A. M., & Doughty, R. N. (2018). Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study. European Heart Journal, 39(20), 1170-1178. doi: 10.1093/eurheartj/ehy005

Jiang, X., Lew, K.-S., Chen, Q., Richards, A. M., & Wang, P. (2018). Human mesenchymal stem cell-derived exosomes reduce ischemia/reperfusion injury by the inhibitions of apoptosis and autophagy. Current Pharmaceutical Design, 24(44), 5334-5341. doi: 10.2174/1381612825666190119130441

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology. Advance online publication. doi: 10.1001/jamacardio.2018.3368

Goh, V. J., Tromp, J., Teng, T.-H., Tay, W. T., van der Meer, P., Ling, L. H., … Richards, M. A., … on behalf of the ASIAN-HF investigators. (2018). Prevalence, clinical correlates, and outcomes of anaemia in multi-ethnic Asian patients with heart failure with reduced ejection fraction. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.12279

Zhou, Y., Shiok, T. C., Richards, A. M., & Wang, P. (2018). MicroRNA-101a suppresses fibrotic programming in isolated cardiac fibroblasts and in vivo fibrosis following trans-aortic constriction. Journal of Molecular & Cellular Cardiology, 121, 266-276. doi: 10.1016/j.yjmcc.2018.07.251

Tromp, J., MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Hung, C.-L., Narasimhan, C., … Richards, A. M., … Lam, C. S. P. (2018). Heart failure with preserved ejection fraction in the young. Circulation, 138(24), 2763-2773. doi: 10.1161/CIRCULATIONAHA.118.034720

Bayes-Genis, A., Voors, A. A., Zannad, F., Januzzi, J. L., Richards, A. M., & Díez, J. (2018). Transitioning from usual care to biomarker-based personalized and precision medicine in heart failure: Call for action. European Heart Journal, 39(30), 2793-2799. doi: 10.1093/eurheartj/ehx027

Marchesseau, S., Totman, J. J., Fadil, H., Leek, F. A. A., Chaal, J., Richards, M., … Reilhac, A. (2018). Cardiac motion and spillover correction for quantitative PET imaging using dynamic MRI. Medical Physics. Advance online publication. doi: 10.1002/mp.13345

Joo Yeo, T., Yeo, P. S. D., Hadi, F. A., Cushway, T., Lee, K. Y., Yin, F. F., … Richards, A. M., & Lam, C. S. P. (2018). Single-dose intravenous iron in Southeast Asian heart failure patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF). ESC Heart Failure, 5(2), 344-353. doi: 10.1002/ehf2.12250

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Tromp, J., Teng, T.-H., Tay, W. T., Hung, C. L., Narasimhan, C., Shimizu, W., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2018). Heart failure with preserved ejection fraction in Asia. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1227

Tan, L.-L., Ting, J., Balakrishnan, I., Seneviratne, A., Gong, L., Chan, M. Y., … Richards, A. M., … Lee, C.-H. (2018). Sleep apnea evolution and left ventricular recovery after percutaneous coronary intervention for myocardial infarction. Journal of Clinical Sleep Medicine, 14(10), 1773-1781. doi: 10.5664/jcsm.7394

de Carvalho, L., Fong, A., Troughton, R., Yan, B. P., Chin, C.-T., Poh, S.-C., … Frampton, C., Richards, A. M., & Chan, M. Y. (2018). Prognostic implications of dual platelet reactivity testing in acute coronary syndrome. Thrombosis & Haemostasis, 118(2), 415-426. doi: 10.1160/TH17-08-0564

de Hoog, V. C., Lim, S. H., Bank, I. E. M., Gijsberts, C., Ibrahim, I. B., Kuan, W. S., … Richards, A. M., … Timmers, L. (2018). HEART score performance in Asian and Caucasian patients presenting to the emergency department with suspected acute coronary syndrome. European Heart Journal, 7(7), 591-601. doi: 10.1177/2048872617700870

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation. Advance online publication. doi: 10.1161/circulationaha.117.032003

de Carvalho, L. P., Tan, S. H., Ow, G.-S., Tang, Z., Ching, J., Kovalik, J.-P., … Richards, A. M., … Troughton, R. W., … Chan, M. Y. (2018). Plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction. JACC: Basic to Translational Science, 3(2), 163-175. doi: 10.1016/j.jacbts.2017.12.005

Chandramouli, C., Teng, T.-H. K., Tay, W. T., Yap, J., MacDonald, M. R., Tromp, J., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2018). Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1358

Teng, T.-H. K., Tromp, J., Tay, W. T., Anand, I., Ouwerkerk, W., Chopra, V., … Richards, A. M., … Lam, C. S. P. (2018). Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: A cohort study. Lancet Global Health, 6(9), e1008-e1018. doi: 10.1016/S2214-109X(18)30306-1

Wang, J., Tong, K. S., Wong, L. L., Liew, O.-W., Raghuram, D., Richards, A. M., & Chen, Y.-T. (2018). MicroRNA-143 modulates the expression of Natriuretic Peptide Receptor 3 in cardiac cells. Scientific Reports, 8, 7055. doi: 10.1038/s41598-018-25489-3

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports. Advance online publication. doi: 10.1042/bsr20180513

McDonald, K., Troughton, R., Dahlström, U., Dargie, H., Krum, H., van der Meer, P., … Richards, M., & Doughty, R. (2018). Daily home BNP monitoring in heart failure for prediction of impending clinical deterioration: Results from the HOME HF study. European Journal of Heart Failure, 20(3), 474-480. doi: 10.1002/ejhf.1053

Bosch, L., Lam, C. S. P., Gong, L., Chan, S. P., Sim, D., Yeo, D., … Richards, A. M., … Ling, L. H. (2017). Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction. European Journal of Heart Failure, 19(12), 1664-1671. doi: 10.1002/ejhf.873

Liebetrau, C., Gaede, L., Wolter, J. S., Homann, J., Meyer, A., Dörr, O., … Richards, A. M., & Pemberton, C. J. (2017). Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction. Biomarkers, 22(3-4), 304-310. doi: 10.1080/1354750X.2016.1252965

Richards, A. M. (2017). N-terminal B-type natriuretic peptide in heart failure. Heart Failure Clinics, 14(1), 27-39. doi: 10.1016/j.hfc.2017.08.004

Scott, N. J. A., Ellmers, L. J., Pilbrow, A. P., Thomsen, L., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2017). Metabolic and blood pressure effects of walnut supplementation in a mouse model of the metabolic syndrome. Nutrients, 9, 722. doi: 10.3390/nu9070722

Ling, S. S. M., Chen, Y.-T., Wang, J., Richards, A. M., & Liew, O. W. (2017). Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential. International Journal of Molecular Sciences, 18(7), 1362. doi: 10.3390/ijms18071362

Martinez, E. C., Lilyanna, S., Wang, P., Vardy, L. A., Jiang, X., Armugam, A., … Richards, A. M. (2017). MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease. Journal of Molecular & Cellular Cardiology, 112, 27-39. doi: 10.1016/j.yjmcc.2017.08.013

Leong, K. T. G., Wong, L. Y., Aung, K. C. Y., Macdonald, M., Cao, Y., Lee, S., … Richards, A. M. (2017). Risk stratification model for 30-day heart failure readmission in a multiethnic South East Asian community. American Journal of Cardiology, 119(9), 1428-1432. doi: 10.1016/j.amjcard.2017.01.026

Chen, Y.-T., Wang, J., Tong, K. S., Wong, L. L., Liew, O. W., & Richards, A. M. (2017). The association of heart failure-related microRNAs with neurohormonal signaling. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1863(8), 2031-2040. doi: 10.1016/j.bbadis.2016.12.019

Bank, I. E. M., Gijsberts, C. M., Teng, T.-H. K., Benson, L., Sim, D., Yeo, P. S. D., … Richards, A. M., … Lam, C. S. P. (2017). Prevalence and clinical significance of diabetes in Asian versus white patients with heart failure. JACC: Heart Failure, 5(1), 14-24. doi: 10.1016/j.jchf.2016.09.015

Drum, C. L., Tan, W. K. Y., Chan, S.-P., Pakkiri, L. S., Chong, J. P. C., Liew, O.-W., … Richards, A. M. (2017). Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction. Journal of the American Heart Association, 6(6), e005586. doi: 10.1161/jaha.117.005586

Luo, N., Teng, T.-H. K., Tay, W. T., Anand, I. S., Kraus, W. E., Liew, H. B., … Richards, A. M., … Mentz, R. J. (2017). Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure. American Heart Journal, 191, 75-81. doi: 10.1016/j.ahj.2017.06.016

Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x

Zhou, Y., Richards, A. M., & Wang, P. (2017). Characterization and standardization of cultured cardiac fibroblasts for ex vivo models of heart fibrosis and heart ischemia. Tissue Engineering Part C: Methods, 23(7), 422-433. doi: 10.1089/ten.tec.2017.0169

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Zewinger, S., Kleber, M. E., Tragante, V., McCubrey, R. O., Schmidt, A. F., Direk, K., … Pilbrow, A. P., Cameron, V. A., Richards, A. M., … on behalf of the GENIUS-CHD consortium, … Speer, T. (2017). Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: A molecular and genetic association study. Lancet Diabetes & Endocrinology, 5(7), 534-543. doi: 10.1016/S2213-8587(17)30096-7

Ng, G., Boey, E., Frampton, C., Richards, A. M., Yeo, T.-C., & Lee, C.-H. (2017). Obstructive sleep apnea is associated with visit-to-visit variability in low-density lipoprotein-cholesterol in patients with coronary artery disease. Sleep & Breathing, 21(2), 271-278. doi: 10.1007/s11325-016-1394-0

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Vasudevan, V., Low, A. J. J., Annamalai, S. P., Sampath, S., Poh, K. K., Totman, T., … Richards, A. M., … Yap, C. H. (2017). Flow dynamics and energy efficiency of flow in the left ventricle during myocardial infarction. Biomechanics & Modeling in Mechanobiology, 16(5), 1503-1517. doi: 10.1007/s10237-017-0902-x

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Chia, Y. M. F., Teng, T.-H. K., Tan, E. S. J., Tay, W. T., Richards, A. M., Chin, C. W. L., … Lam, C. S. P. (2017). Disparity between indications for and utilization of implantable cardioverter defibrillators in Asian patients with heart failure. Circulation: Cardiovascular Quality & Outcomes, 10(11), e004304. doi: 10.1161/circoutcomes.116.003651

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

Chen, Y.-T., Wang, J., Wee, A. S. Y., Yong, Q.-W., Tay, E. L.-W., Woo, C. C., … Richards, A. M., & Ling, L.-H. (2016). Differential MicroRNA expression profile in myxomatous mitral valve prolapse and fibroelastic deficiency valves. International Journal of Molecular Sciences, 17(5), 753. doi: 10.3390/ijms17050753

Santhanakrishnan, R., Wang, N., Larson, M. G., Magnani, J. M., Vasan, R. S., Wang, T. J., … Richards, A. M., … Ho, J. E. (2016). Racial differences in electrocardiographic characteristics and prognostic significance in Whites versus Asians. Journal of the American Heart Association, 5(3), e002956. doi: 10.1161/jaha.115.002956

de Hoog, V. C., Lim, S. H., Bank, I. E. M., Gijsberts, C. M., Ibrahim, I. B., Kuan, W. S., … Richards, A. M., … Timmers, L. (2016). Ethnic differences in clinical outcome of patients presenting to the emergency department with chest pain. European Heart Journal, 5(7), 32-40. doi: 10.1177/2048872615623064

Zhou, Y., Chen, Q., Lew, K. S., Richards, A. M., & Wang, P. (2016). Discovery of potential therapeutic miRNA targets in cardiac ischemia-reperfusion injury. Journal of Cardiovascular Pharmacology & Therapeutics, 21(3), 296-309. doi: 10.1177/1074248415604463

Chan, M. M. Y., Santhanakrishnan, R., Chong, J. P. C., Chen, Z., Tai, B. C., Liew, O. W., … Richards, A. M., & Lam, C. S. P. (2016). Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction. European Journal of Heart Failure, 18(1), 81-88. doi: 10.1002/ejhf.431

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Chen, Q., Zhou, Y., Richards, A. M., & Wang, P. (2016). Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways. Biochemical & Biophysical Research Communications, 474(1), 168-174. doi: 10.1016/j.bbrc.2016.04.090

Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., … for the ROCKET AF Steering Committee & Investigators, including Richards, M., Mann, S., & Wilkins, G. (2016). Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrilation: Data from ROCKET AF. Journal of the American Heart Association, 5(3), e002197. doi: 10.1161/JAHA.115.002197

Pemberton, C. J., Frampton, C. M., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2016). B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain. Clinical Biochemistry, 49, 645-650. doi: 10.1016/j.clinbiochem.2016.02.015

Wang, J., Liew, O. W., Richards, A. M., & Chen, Y.-T. (2016). Overview of microRNAs in cardiac hypertrophy, fibrosis, and apoptosis. International Journal of Molecular Sciences, 17(5), 749. doi: 10.3390/ijms17050749

Bayes-Genis, A., Barallat, J., & Richards, A. M. (2016). A test in context: Neprilysin: Function, inhibition, and biomarker. JACC, 68(6), 639-653. doi: 10.1016/j.jacc.2016.04.060

Tan, E. S. J., Yap, J., Xu, C. F., Feng, L., Nyunt, S. Z., Santhanakrishnan, R., … Richards, A. M., … Lam, C. S. P. (2016). Association of age, sex, body size and ethnicity with electrocardiographic values in community-based older Asian adults. Heart, Lung & Circulation, 25(7), 705-711. doi: 10.1016/j.hlc.2016.01.015

Young, J. M., Pickering, J. W., George, P. M., Aldous, S. J., Wallace, J., Frampton, C. M., Troughton, R. W., Richards, A. M., … Than, M. P. (2016). Heart Fatty Acid Binding Protein and cardiac troponin: Development of an optimal rule-out strategy for acute myocardial infarction. BMC Emergency Medicine, 16(1), 34. doi: 10.1186/s12873-016-0089-y

Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341

Gijsberts, C. M., Benson, L., Dahlström, U., Sim, D., Yeo, D. P. S., Ong, H. Y., … Richards, A. M., … Lam, C. S. P. (2016). Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure. Heart, 102(18), 1464-1471. doi: 10.1136/heartjnl-2015-309212

Wong, L. L., Wang, J., Liew, O. W., Richards, A. M., & Chen, Y.-T. (2016). MicroRNA and heart failure. International Journal of Molecular Sciences, 17(4), 502, 502. doi: 10.3390/ijms17040502

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