Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Otago Medical School staff profiles

Professor Mark Richards

PositionProfessor
DepartmentDepartment of Medicine (Christchurch)
QualificationsMBChB MD PhD (Otago) FRACP
Research summaryCardioendocrinology

Research

Mark Richards is the director of the Christchurch Heart Institute. He coordinates and directs multi-disciplinary programmes of grant-funded translational cardiovascular research which seek to improve diagnostic, prognostic and therapeutic options in heart disease.

He is pursuing studies of epidemiological, molecular biological, neurohormonal and therapeutic aspects of acute and chronic cardiovascular disorders including hypertension, coronary syndromes, and the full spectrum of heart failure.

Richards holds the Heart Foundation of New Zealand’s Chair in Cardiovascular Studies. He also holds joint appointments at the University of Otago and the National University of Singapore’s Cardiovascular Research Institute. His research interests include:

  • Neurohormonal physiology and pathophysiology in cardiovascular health and disease
  • Heart Failure
  • Acute Coronary Syndromes
  • Hypertension
  • Vasoactive Hormones
  • The Cardiac Natriuretic Peptides

Publications

Aimo, A., Januzzi, Jr, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Edmin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1701

Yip, C., Seneviratna, A., Tan, S.-H., Khaing, T., Chan, S.-P., Loh, J., … Richards, A. M., & Chan, M. Y. (2020). Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Journal of Thrombosis & Thrombolysis. Advance online publication. doi: 10.1007/s11239-020-02066-y

MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Anand, I., Ling, L. H., Yap, J., … ASIAN-HF investigators, Richards, A. M., & Lam, C. S. P. (2020). Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: Outcomes in the ASIAN-HF registry. Journal of the American Heart Association, 9(1), e012199. doi: 10.1161/jaha.119.012199

Woo, C. C., Liu, W., Lin, X. Y., Dorajoo, R., Lee, K. W., Richards, A. M., … Sorokin, V. (2020). The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. International Journal of Molecular Sciences, 21, 11. doi: 10.3390/ijms21010011

Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta. Advance online publication. doi: 10.1016/j.cca.2020.02.009

Chapter in Book - Research

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.

Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.

Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.

Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.

Lainchbury, J. G., Richards, A. M., & Nicholls, M. G. (1997). Brain natriuretic peptide in heart failure. In Atrial Natriuretic Peptides. (pp. 151-158).

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

^ Top of page

Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

^ Top of page

Journal - Research Article

Aimo, A., Januzzi, Jr, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Edmin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1701

Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta. Advance online publication. doi: 10.1016/j.cca.2020.02.009

Woo, C. C., Liu, W., Lin, X. Y., Dorajoo, R., Lee, K. W., Richards, A. M., … Sorokin, V. (2020). The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. International Journal of Molecular Sciences, 21, 11. doi: 10.3390/ijms21010011

MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Anand, I., Ling, L. H., Yap, J., … ASIAN-HF investigators, Richards, A. M., & Lam, C. S. P. (2020). Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: Outcomes in the ASIAN-HF registry. Journal of the American Heart Association, 9(1), e012199. doi: 10.1161/jaha.119.012199

Yip, C., Seneviratna, A., Tan, S.-H., Khaing, T., Chan, S.-P., Loh, J., … Richards, A. M., & Chan, M. Y. (2020). Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Journal of Thrombosis & Thrombolysis. Advance online publication. doi: 10.1007/s11239-020-02066-y

Templeton, E. M., Cameron, V. A., Pickering, J. W., Richards, A. M., & Pilbrow, A. P. (2020). Emerging microRNA biomarkers for acute kidney injury in acute decompensated heart failure. Heart Failure Reviews. Advance online publication. doi: 10.1007/s10741-020-09928-w

Rademaker, M. T., Scott, N. J. A., Koh, C. Y., Manjunatha Kini, R., & Richards, A. M. (2020). Natriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failure. Cardiovascular Research. Advance online publication. doi: 10.1093/cvr/cvaa052

Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2020.02.001

Lin, Z., Lim, S. H., Chua, S. J. T., Tai, E. S., Chan, Y. H., & Richards, A. M. (2019). High-sensitivity troponin T and long-term adverse cardiac events among patients presenting with suspected acute coronary syndrome in Singapore. Singapore Medical Journal. Advance online publication. doi: 10.11622/smedj.2019013

Stamp, L. K., Frampton, C., Drake, J., Doughty, R. N., Troughton, R. W., & Richards, A. M. (2019). Associations of gout and baseline serum urate with cardiovascular outcomes: Analysis of the Coronary Disease Cohort Study. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41007

Gallart-Palau, X., Tan, L. M., Serra, A., Gao, Y., Ho, H. H., Richards, A. M., … Sze, S. K. (2019). Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Research Reviews. Advance online publication. doi: 10.1016/j.arr.2019.100909

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Wong, L. L., Saw, E. L., Lim, J. Y., Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA Let-7d-3p contributes to cardiac protection via targeting HMGA2. International Journal of Molecular Sciences, 20(7), 1522. doi: 10.3390/ijms20071522

Charles, C. J., Lee, P., Li, R. R., Yeung, T., Ibraham Mazlan, S. M., Tay, Z. W., … Richards, A. M. (2019). A porcine model of heart failure with preserved ejection fraction: Magnetic resonance imaging and metabolic energetics. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.12536

Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2019). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1660

Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067

Ong, C. W., Wee, I., Syn, N., Leo, H. L., Richards, A. M., & Choong, A. M. T. L. (2019). Computational fluid dynamics modelling of hemodynamic parameters in the human diseased aorta: A systematic review. Annals of Vascular Surgery. Advance online publication. doi: 10.1016/j.avsg.2019.04.032

Tromp, J., Lim, S. L., Tay, W. T., Teng, T.-H. K., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., … on behalf of the ASIAN-HF Investigators. (2019). Microvascular disease in patients with diabetes with heart failure and reduced ejection versus preserved ejection fraction. Diabetes Care. Advance online publication. doi: 10.2337/dc18-2515

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2019.05.010

Wong, L. L., Zou, R., Zhou, L., Lim, J. Y., Phua, D. C. Y., Liu, C., … Troughton, R., Cameron, V. A., … Richards, A. M. (2019). Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtypes. JACC, 73(11), 1300-1313. doi: 10.1016/j.jacc.2018.11.060

Patel, R. S., Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Association of chromosome 9p21 with subsequent coronary heart disease events: A GENIUS-CHD study of individual participant data. Circulation: Genomic & Precision Medicine, 12(4), 161-172. doi: 10.1161/circgen.119.002471

Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA-221 is cardioprotective and anti-fibrotic in a rat model of myocardial infarction. Molecular Therapy: Nucleic Acids. Advance online publication. doi: 10.1016/j.omtn.2019.05.018

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314077

Poppe, K. K., Doughty, R. N., Wells, S., Wu, B., Earle, N. J., Richards, A. M., Troughton, R. W., … Kerr, A. J. (2019). Development and validation of a cardiovascular risk score for patients in the community after acute coronary syndrome. Heart. Advance online publication. doi: 10.1136/heartjnl-2019-315809

Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2019). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides. Advance online publication. doi: 10.1016/j.peptides.2019.170192

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart. Advance online publication. doi: 10.1136/heartjnl-2019-315084

Yap, J., Tay, W. T., Teng, T.-H. K., Anand, I., Richards, A. M., Ling, L. H., … Lam, C. S. P. (2019). Association of diabetes mellitus on cardiac remodeling, quality of life, and clinical outcomes in heart failure with reduced and preserved ejection fraction. Journal of the American Heart Association, 8(17), e013114. doi: 10.1161/JAHA.119.013114

Tromp, J., Teng, T.-H., Tay, W. T., Hung, C. L., Narasimhan, C., Shimizu, W., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2019). Heart failure with preserved ejection fraction in Asia. European Journal of Heart Failure, 21(1), 23-36. doi: 10.1002/ejhf.1227

Marchesseau, S., Totman, J. J., Fadil, H., Leek, F. A. A., Chaal, J., Richards, M., … Reilhac, A. (2019). Cardiac motion and spillover correction for quantitative PET imaging using dynamic MRI. Medical Physics, 46(2), 726-737. doi: 10.1002/mp.13345

Ellis, C. J., Gamble, G. D., Williams, M. J. A., Matsis, P., Elliott, J. M., Devlin, G., Mann, S., … for the Regional Cardiac Society NZ ACS Audit Group, including Richards, M., & Nixon, G. (2019). All-cause mortality following an acute coronary syndrome: 12-year follow-up of the comprehensive 2002 New Zealand Acute Coronary Syndrome Audit. Heart, Lung & Circulation, 28(2), 245-256. doi: 10.1016/j.hlc.2017.10.015

Tan, E. S. J., Chan, S. P., Xu, C. F., Yap, J., Richards, A. M., Ling, L. H., … Lim, T. W. (2019). Cornell product is an ECG marker of heart failure with preserved ejection fraction. Heart Asia, 11(1), e011108. doi: 10.1136/heartasia-2018-011108

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry. Advance online publication. doi: 10.1373/clinchem.2019.302547

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Subsequent event risk in individuals with established coronary heart disease: Design and rationale of the GENIUS-CHD Consortium. Circulation: Genomic & Precision Medicine, 12(4), 145-160. doi: 10.1161/CIRCGEN.119.002470

Chandramouli, C., Teng, T.-H. K., Tay, W. T., Yap, J., MacDonald, M. R., Tromp, J., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2019). Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry. European Journal of Heart Failure, 21(3), 297-307. doi: 10.1002/ejhf.1358

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

Jiang, X., Lew, K.-S., Chen, Q., Richards, A. M., & Wang, P. (2018). Human mesenchymal stem cell-derived exosomes reduce ischemia/reperfusion injury by the inhibitions of apoptosis and autophagy. Current Pharmaceutical Design, 24(44), 5334-5341. doi: 10.2174/1381612825666190119130441

Zhou, Y., Shiok, T. C., Richards, A. M., & Wang, P. (2018). MicroRNA-101a suppresses fibrotic programming in isolated cardiac fibroblasts and in vivo fibrosis following trans-aortic constriction. Journal of Molecular & Cellular Cardiology, 121, 266-276. doi: 10.1016/j.yjmcc.2018.07.251

Lam, C. S. P., Gamble, G. D., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Cameron, V. A., … Troughton, R., Richards, A. M., & Doughty, R. N. (2018). Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study. European Heart Journal, 39(20), 1170-1178. doi: 10.1093/eurheartj/ehy005

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3(11), 1108-1112. doi: 10.1001/jamacardio.2018.3368

Tromp, J., MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Hung, C.-L., Narasimhan, C., … Richards, A. M., … Lam, C. S. P. (2018). Heart failure with preserved ejection fraction in the young. Circulation, 138(24), 2763-2773. doi: 10.1161/CIRCULATIONAHA.118.034720

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation, 138(10), 989-999. doi: 10.1161/circulationaha.117.032003

Bayes-Genis, A., Voors, A. A., Zannad, F., Januzzi, J. L., Richards, A. M., & Díez, J. (2018). Transitioning from usual care to biomarker-based personalized and precision medicine in heart failure: Call for action. European Heart Journal, 39(30), 2793-2799. doi: 10.1093/eurheartj/ehx027

Tan, L.-L., Ting, J., Balakrishnan, I., Seneviratne, A., Gong, L., Chan, M. Y., … Richards, A. M., … Lee, C.-H. (2018). Sleep apnea evolution and left ventricular recovery after percutaneous coronary intervention for myocardial infarction. Journal of Clinical Sleep Medicine, 14(10), 1773-1781. doi: 10.5664/jcsm.7394

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports, 38(5), BSR20180513. doi: 10.1042/bsr20180513

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Joo Yeo, T., Yeo, P. S. D., Hadi, F. A., Cushway, T., Lee, K. Y., Yin, F. F., … Richards, A. M., & Lam, C. S. P. (2018). Single-dose intravenous iron in Southeast Asian heart failure patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF). ESC Heart Failure, 5(2), 344-353. doi: 10.1002/ehf2.12250

de Carvalho, L., Fong, A., Troughton, R., Yan, B. P., Chin, C.-T., Poh, S.-C., … Frampton, C., Richards, A. M., & Chan, M. Y. (2018). Prognostic implications of dual platelet reactivity testing in acute coronary syndrome. Thrombosis & Haemostasis, 118(2), 415-426. doi: 10.1160/TH17-08-0564

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

de Carvalho, L. P., Tan, S. H., Ow, G.-S., Tang, Z., Ching, J., Kovalik, J.-P., … Richards, A. M., … Troughton, R. W., … Chan, M. Y. (2018). Plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction. JACC: Basic to Translational Science, 3(2), 163-175. doi: 10.1016/j.jacbts.2017.12.005

Goh, V. J., Tromp, J., Teng, T.-H., Tay, W. T., van der Meer, P., Ling, L. H., … Richards, M. A., … on behalf of the ASIAN-HF investigators. (2018). Prevalence, clinical correlates, and outcomes of anaemia in multi-ethnic Asian patients with heart failure with reduced ejection fraction. ESC Heart Failure, 5(4), 570-578. doi: 10.1002/ehf2.12279

de Hoog, V. C., Lim, S. H., Bank, I. E. M., Gijsberts, C., Ibrahim, I. B., Kuan, W. S., … Richards, A. M., … Timmers, L. (2018). HEART score performance in Asian and Caucasian patients presenting to the emergency department with suspected acute coronary syndrome. European Heart Journal, 7(7), 591-601. doi: 10.1177/2048872617700870

Teng, T.-H. K., Tromp, J., Tay, W. T., Anand, I., Ouwerkerk, W., Chopra, V., … Richards, A. M., … Lam, C. S. P. (2018). Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: A cohort study. Lancet Global Health, 6(9), e1008-e1018. doi: 10.1016/S2214-109X(18)30306-1

Wang, J., Tong, K. S., Wong, L. L., Liew, O.-W., Raghuram, D., Richards, A. M., & Chen, Y.-T. (2018). MicroRNA-143 modulates the expression of Natriuretic Peptide Receptor 3 in cardiac cells. Scientific Reports, 8, 7055. doi: 10.1038/s41598-018-25489-3

McDonald, K., Troughton, R., Dahlström, U., Dargie, H., Krum, H., van der Meer, P., … Richards, M., & Doughty, R. (2018). Daily home BNP monitoring in heart failure for prediction of impending clinical deterioration: Results from the HOME HF study. European Journal of Heart Failure, 20(3), 474-480. doi: 10.1002/ejhf.1053

Bosch, L., Lam, C. S. P., Gong, L., Chan, S. P., Sim, D., Yeo, D., … Richards, A. M., … Ling, L. H. (2017). Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction. European Journal of Heart Failure, 19(12), 1664-1671. doi: 10.1002/ejhf.873

Liebetrau, C., Gaede, L., Wolter, J. S., Homann, J., Meyer, A., Dörr, O., … Richards, A. M., & Pemberton, C. J. (2017). Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction. Biomarkers, 22(3-4), 304-310. doi: 10.1080/1354750X.2016.1252965

Richards, A. M. (2017). N-terminal B-type natriuretic peptide in heart failure. Heart Failure Clinics, 14(1), 27-39. doi: 10.1016/j.hfc.2017.08.004

Martinez, E. C., Lilyanna, S., Wang, P., Vardy, L. A., Jiang, X., Armugam, A., … Richards, A. M. (2017). MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease. Journal of Molecular & Cellular Cardiology, 112, 27-39. doi: 10.1016/j.yjmcc.2017.08.013

Ling, S. S. M., Chen, Y.-T., Wang, J., Richards, A. M., & Liew, O. W. (2017). Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential. International Journal of Molecular Sciences, 18(7), 1362. doi: 10.3390/ijms18071362

Scott, N. J. A., Ellmers, L. J., Pilbrow, A. P., Thomsen, L., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2017). Metabolic and blood pressure effects of walnut supplementation in a mouse model of the metabolic syndrome. Nutrients, 9, 722. doi: 10.3390/nu9070722

Leong, K. T. G., Wong, L. Y., Aung, K. C. Y., Macdonald, M., Cao, Y., Lee, S., … Richards, A. M. (2017). Risk stratification model for 30-day heart failure readmission in a multiethnic South East Asian community. American Journal of Cardiology, 119(9), 1428-1432. doi: 10.1016/j.amjcard.2017.01.026

Bank, I. E. M., Gijsberts, C. M., Teng, T.-H. K., Benson, L., Sim, D., Yeo, P. S. D., … Richards, A. M., … Lam, C. S. P. (2017). Prevalence and clinical significance of diabetes in Asian versus white patients with heart failure. JACC: Heart Failure, 5(1), 14-24. doi: 10.1016/j.jchf.2016.09.015

Chen, Y.-T., Wang, J., Tong, K. S., Wong, L. L., Liew, O. W., & Richards, A. M. (2017). The association of heart failure-related microRNAs with neurohormonal signaling. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1863(8), 2031-2040. doi: 10.1016/j.bbadis.2016.12.019

Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x

Luo, N., Teng, T.-H. K., Tay, W. T., Anand, I. S., Kraus, W. E., Liew, H. B., … Richards, A. M., … Mentz, R. J. (2017). Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure. American Heart Journal, 191, 75-81. doi: 10.1016/j.ahj.2017.06.016

Drum, C. L., Tan, W. K. Y., Chan, S.-P., Pakkiri, L. S., Chong, J. P. C., Liew, O.-W., … Richards, A. M. (2017). Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction. Journal of the American Heart Association, 6(6), e005586. doi: 10.1161/jaha.117.005586

Zhou, Y., Richards, A. M., & Wang, P. (2017). Characterization and standardization of cultured cardiac fibroblasts for ex vivo models of heart fibrosis and heart ischemia. Tissue Engineering Part C: Methods, 23(7), 422-433. doi: 10.1089/ten.tec.2017.0169

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Zewinger, S., Kleber, M. E., Tragante, V., McCubrey, R. O., Schmidt, A. F., Direk, K., … Pilbrow, A. P., Cameron, V. A., Richards, A. M., … on behalf of the GENIUS-CHD consortium, … Speer, T. (2017). Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: A molecular and genetic association study. Lancet Diabetes & Endocrinology, 5(7), 534-543. doi: 10.1016/S2213-8587(17)30096-7

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Ng, G., Boey, E., Frampton, C., Richards, A. M., Yeo, T.-C., & Lee, C.-H. (2017). Obstructive sleep apnea is associated with visit-to-visit variability in low-density lipoprotein-cholesterol in patients with coronary artery disease. Sleep & Breathing, 21(2), 271-278. doi: 10.1007/s11325-016-1394-0

Vasudevan, V., Low, A. J. J., Annamalai, S. P., Sampath, S., Poh, K. K., Totman, T., … Richards, A. M., … Yap, C. H. (2017). Flow dynamics and energy efficiency of flow in the left ventricle during myocardial infarction. Biomechanics & Modeling in Mechanobiology, 16(5), 1503-1517. doi: 10.1007/s10237-017-0902-x

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Hu, Y.-J., Schmidt, A. F., Dudbridge, F., Holmes, M. V., Brophy, J. M., Tragante, V., … on behalf of the GENIUS-CHD Consortium, including Cameron, V. A., Pilbrow, A. P., & Richards, A. M. (2017). Impact of selection bias on estimation of subsequent event risk. Circulation: Cardiovascular Genetics, 10(5), e001616. doi: 10.1161/CIRCGENETICS.116.001616

More publications...