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Otago Medical School staff profiles

Associate Professor Gerard Wilkins

PositionAssociate Professor
DepartmentDepartment of Medicine (DSM)
QualificationsMB ChB(Otago) FRACP
Research summaryInterventional Cardiology; Clinical trials

Research

I have several strands of research associated with clinical work including: 1) Collaborative research with the Heart Otago members in basic sciences and the Vascular Biology Group ; 2) Interventional device trials (new device development, often 'First in Man' Clinical Trials) 3) Involvement in multinational trials largely acting as Regional Primary Investigator, that frequently produce pivotal changes in clinical practice.

Publications

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2019). HIIT improves left ventricular exercise response in adults with type 2 diabetes. Medicine & Science in Sports & Exercise. Advance online publication. doi: 10.1249/mss.0000000000001897

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Leader, C. J., Clark, B. J., Hannah, A. R., Sammut, I. A., Wilkins, G. T., & Walker, R. J. (2018). Breeding characteristics and dose-dependent blood pressure responses of transgenic Cyp1a1-Ren2 rats. Comparative Medicine, 68(5), 360-366. doi: 10.30802/AALAS-CM-17-18000026

Lal, S., Pemberton, J., & Wilkins, G. T. (2018). Cough-induced takotsubo (stress) cardiomyopathy. CASE. Advance online publication. doi: 10.1016/j.case.2018.03.004

Worthley, S. G., Wilkins, G. T., Webster, M. W., Montarello, J. K., Delacroix, S., Whitbourn, R. J., & Warren, R. J. (2017). Safety and performance of the second generation EnligHTN™ Renal Denervation System in patients with drug-resistant, uncontrolled hypertension. Atherosclerosis, 262, 94-100. doi: 10.1016/j.atherosclerosis.2017.04.022

Journal - Research Article

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2019). HIIT improves left ventricular exercise response in adults with type 2 diabetes. Medicine & Science in Sports & Exercise. Advance online publication. doi: 10.1249/mss.0000000000001897

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Leader, C. J., Clark, B. J., Hannah, A. R., Sammut, I. A., Wilkins, G. T., & Walker, R. J. (2018). Breeding characteristics and dose-dependent blood pressure responses of transgenic Cyp1a1-Ren2 rats. Comparative Medicine, 68(5), 360-366. doi: 10.30802/AALAS-CM-17-18000026

Worthley, S. G., Wilkins, G. T., Webster, M. W., Montarello, J. K., Delacroix, S., Whitbourn, R. J., & Warren, R. J. (2017). Safety and performance of the second generation EnligHTN™ Renal Denervation System in patients with drug-resistant, uncontrolled hypertension. Atherosclerosis, 262, 94-100. doi: 10.1016/j.atherosclerosis.2017.04.022

Hoye, N. A., Wilson, L. C., Wilkins, G. T., Jardine, D. L., Putt, T. L., Samaranayaka, A., Schollum, J. B. W., & Walker, R. J. (2017). Endovascular renal denervation in end-stage kidney disease patients: Cardiovascular protection: A proof-of-concept study. Kidney International Reports, 2(5), 856-865. doi: 10.1016/j.ekir.2017.04.012

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Vaduganathan, M., Harrington, R. A., Stone, G. W., Deliargyris, E. N., Steg, G., Gibson, C. M., … on behalf of the CHAMPION Investigators, including Harding, S., Elliott, J., Wilkins, G., & Sasse, A. (2017). Cangrelor with and without glycoprotain IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention. JACC, 69(2), 176-185. doi: 10.1016/j.jacc.2016.10.055

van 't Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., … Jones, G. T., … van Rij, A. M., … Vascular Research Consortium of New Zealand, including Phillips, L. V., Hill, G. B., Williams, M. J. A., Thomson, I. A., Krysa, J., Wilkins, G. T., Merriman, T. R., Lewis, D. R., … de Bakker, P. I. W. (2016). Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms. Journal of the American Heart Association, 5(7), e002603. doi: 10.1161/jaha.115.002603

Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., … for the ROCKET AF Steering Committee & Investigators, including Richards, M., Mann, S., & Wilkins, G. (2016). Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrilation: Data from ROCKET AF. Journal of the American Heart Association, 5(3), e002197. doi: 10.1161/JAHA.115.002197

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal

Sakata, K., Koo, B.-K., Waseda, K., Nakatani, D., Yock, P. G., Whitbourn, R., … Wilkins, G. T., … Fitzgerald, P. J. (2015). A Y-shaped bifurcation-dedicated stent for the treatment of de novo coronary bifurcation lesions: An IVUS analysis from the BRANCH trial. EuroIntervention, 10(11). doi: 10.4244/eijy14m08_16

Majeed, K., Hamer, A. W., White, S. C., Pegg, T. J., Wilkins, G. T., Williams, S. M., … Williams, M. J. A. (2015). Prevalence of abdominal aortic aneurysm in patients referred for transthoracic echocardiography. Internal Medicine Journal, 45(1), 32-39. doi: 10.1111/imj.12592

Siriwardena, M., Pilbrow, A., Frampton, C., MacDonald, S. M., Wilkins, G. T., & Richards, A. M. (2015). Complications of intra-aortic balloon pump use: Does the final position of the IABP tip matter? Anaesthesia & Intensive Care, 43(1), 66-73.

Worthley, S. G., Wilkins, G. T., Webster, M. W., Montarello, J. K., Antonis, P. R., Whitbourn, R. J., & Warren, R. J. (2015). Safety and performance of the next generation EnligHTN™ renal denervation system in patients with drug-resistant, uncontrolled hypertension: The EnligHTN III first-in-human multicentre study. Clinical Trials & Regulatory Science in Cardiology, 8, 4-10. doi: 10.1016/j.ctrsc.2015.08.007

Blattner, K., Nixon, G., Horgan, C., Coutts, J., Rogers, M., Wong, B., … Wilkins, G. (2014). Evaluation of a rural primary-referred cardiac exercise tolerance test service. New Zealand Medical Journal, 127(1406). Retrieved from http://www.nzma.org.nz/journal

Hoye, N. A., Baldi, J. C., Putt, T. L., Schollum, J. B., Wilkins, G. T., & Walker, R. J. (2014). Endovascular renal denervation: A novel sympatholytic with relevance to chronic kidney disease. Clinical Kidney Journal, 7(1), 3-10. doi: 10.1093/ckj/sft130

Nicholls, S. J., Kastelein, J. J. P., Schwartz, G. M., Bash, D., Rosenson, R. S., Cavender, M. A., … for the VISTA-16 Investigators, including Elliott, J., Wilkins, G., & Harding, S. (2014). Varespladib and cardiovascular events in patients with an acute coronary syndrome: The VISTA-16 randomized clinical trial. JAMA, 311(3), 252-262. doi: 10.1001/jama.2013.282836

O'Donoghue, M. L., Braunwald, E., White, H. D., Steen, D. L., Lukas, M. A., Tarka, E., … for the SOLID-TIMI 52 Investigators, including Elliott, J., Wilkins, G., & Chen, V. (2014). Effect of darapladib on major coronary events after an acute coronary syndrome: The SOLID-TIMI 52 randomized clinical trial. JAMA, 312(10), 1006-1015. doi: 10.1001/jama.2014.11061

Tarr, G. P., Williams, M. J. A., Wilkins, G. T., Chen, V. H. T., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2013). Intra-individual changes of active matrix metalloproteinase-9 are associated with clinical in-stent restenosis of bare metal stents. Cardiology, 124(1), 28-35. doi: 10.1159/000345591

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2013). Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. International Journal of Cardiology, 167(4), 1242-1246. doi: 10.1016/j.ijcard.2012.03.147

Schwartz, G. G., Olsson, A. G., Abt, M., Ballantyne, C. M., Barter, P. J., Brumm, J., … for the dal-OUTCOMES Investigators, including Troughton, R., Wilkins, G., & Harding, S. (2012). Effects of dalcetrapib in patients with a recent acute coronary syndrome. New England Journal of Medicine, 367(22), 2089-2099. doi: 10.1056/NEJMoa1206797

Nadarasa, K., Robertson, M. C., Wong, C.-K., Green, B. K. W., Chen, V. H. T., Wilkins, G. T., & Williams, M. J. A. (2012). Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention: Effect on vascular access site complications. Catheterization & Cardiovascular Interventions, 79(4), 589-594. doi: 10.1002/ccd.23120

Slaughter, R. J., Beasley, D. M. G., Lambie, B. S., Wilkins, G. T., & Schep, L. J. (2012). Poisonous plants in New Zealand: A review of those that are most commonly enquired about to the National Poisons Centre. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Miller, J. C., Thomson, C. D., Williams, S. M., van Havre, N., Wilkins, G. T., Morison, I. M., Ludgate, J. L., & Skeaff, C. M. (2012). Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: A randomized controlled trial. American Journal of Clinical Nutrition, 96, 923-931. doi: 10.3945/ajcn.112.043125

Nixon, G., Blattner, K., Dawson, J., Dovey, S., Black, M. A., Wilkins, G., Dunn, A. C., & McLellan, A. D. (2011). Streptokinase antibodies in patients presenting with acute coronary syndrome in three rural New Zealand populations. Journal of Clinical Pathology, 64, 426-429. doi: 10.1136/jcp.2010.085837

Meredith, I. T., Worthley, S. G., Whitbourn, R., Walters, D., McClean, D., Ormiston, J., … Wilkins, G. T., … Matsis, P., … Cutlip, D. E. (2010). Long-term clinical outcomes with the next-generation Resolute Stent System: A report of the two-year follow-up from the RESOLUTE clinical trial. EuroIntervention, 5(6), 692-697.

Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036

Jones, G. T., van Rij, A. M., Hill, G. B., Wilkins, G. T., & Williams, M. J. A. (2008). Common carotid intimal-medial thickness is associated with coronary in-stent restenosis. Journal for Vascular Ultrasound, 32(3), 129-132.

Al-Sallami, H., Ferguson, R., Wilkins, G., Gray, A., & Medlicott, N. J. (2008). Bleeding events in patients receiving enoxaparin for the management of non-ST-elevation acute coronary syndrome (NSTEACS) at Dunedin Public Hospital, New Zealand. New Zealand Medical Journal, 121(1285). Retrieved from http://journal.nzma.org.nz/journal/121-1285/3342/content.pdf

Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Toff, W. D., Tonkin, A. M., … for the HAT Investigators, including Wilkins, G., & Gulliver, L. (2008). Home use of automated external defibrillators for sudden cardiac arrest. New England Journal of Medicine, 358, 1793-1804. doi: 10.1056/NEJMoa0801651

Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Toff, W. D., Tonkin, A. M., … for the HAT Investigators, including Wilkins, G., Gulliver, L., & Oskam-Schmidt, R. (2008). Rationale and design of the Home Automatic External Defibrillator Trial (HAT). American Heart Journal, 155(3), 445-454. doi: 10.1016/j.ahj.2007.12.008

Tie, S., Wong, C.-K., Yap, J., Wilkins, G., Williams, M., & Kay, P. (2007). Timing of thrombotic events in patients receiving 2 weeks of clopidogrel therapy post bare metal coronary artery stenting: A New Zealand retrospective study. New Zealand Medical Journal, 120(1255). Retrieved from http://journal.nzma.org.nz/journal/120-1255/2553/content.pdf

Jones, G. T., Kay, I. P., Chu, J. W. S., Wilkins, G. T., Phillips, L. V., McCormick, M., van Rij, A. M., & Williams, M. J. A. (2006). Elevated plasma active matrix metalloproteinase-9 level is associated with coronary artery in-stent restenosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 26, e121-e125.

Tang, E. W., Wong, C.-K., Restieaux, N. J., Herbison, P., Williams, M. J. A., Kay, P., & Wilkins, G. T. (2006). Clinical outcome of older patients with acute coronary syndrome over the last three decades. Age & Ageing, 35, 280-285.

Tang, E. W., Wong, C.-K., Wilkins, G., Herbison, P., Williams, M., Kay, P., & Restieaux, N. (2005). Use of evidence-based management for acute coronary syndrome. New Zealand Medical Journal, 118(1223). Retrieved from http://journal.nzma.org.nz/journal/118-1223/1678/content.pdf

Parry, D. J., Winburn, I. C., Wilkins, G. T., & Bunton, R. W. (2005). Expanding retrograde saphenous vein graft aneurysm treated with endovascular coiling. Annals of Thoracic Surgery, 80, 2374-2376.

Skinner, M. A., Choudhury, M. S., Homan, S. D., Cowan, J. O., Wilkins, G. T., & Taylor, D. R. (2005). Accuracy of monitoring for sleep-related breathing disorders in the coronary care unit. Chest, 127(1), 66-71.

Chu, J., Wilkins, G., & Williams, M. (2004). Review of 65 cases of infective endocarditis in Dunedin Public Hospital. New Zealand Medical Journal, 117(1200). Retrieved from http://journal.nzma.org.nz/journal/117-1200/1021/content.pdf

Pfeffer, M. A., McMurray, J. J. V., Velazquez, E. J., Rouleau, J.-L., Køber, L., Maggioni, A. P., … Wilkins, G., Williams, M., & Wong, C. K. (2003). Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. New England Journal of Medicine, 349(20), 1893-1906. doi: 10.1056/NEJMoa032292

Williams, M. J. A., Low, C., Wilkins, G. T., & Stewart, R. A. (2000). Randomised comparison of the effects of nicardipine and esmolol on coronary artery wall stress: implications for the risk of plaque rupture and acute coronary events. Heart, 84, 383-389.

Williams, M. J., Sutherland, W. H. F., McCormick, M. P., de Jong, S. A., Walker, R. J., & Wilkins, G. T. (1999). Impaired endothelial function after a meal rich in used cooking fat. JACC, 33, 1050-1055.

Williams, M. J. A., Stewart, R. A., Low, C., & Wilkins, G. T. (1999). Assessment of the mechanical properties of coronary arteries using intravascular ultrasound: an in vivo study. International Journal of Cardiac Imaging, 15, 287-294.

Williams, M. J. A., Kay, I. P., & Wilkins, G. T. (1998). Spontaneous coronary artery dissection presenting as unstable angina. Journal of Invasive Cardiology, 10, 274-276.

Stewart, R. A., Robertson, M. C., Low, C., Wilkins, G. T., & Restieaux, N. J. A. (1997). Differences in easily recognised coronary risk factors by age at first myocardial infarction. New Zealand Medical Journal, 110(1051), 339-340.

Kerr, A. J., Williams, M. J. A., & Wilkins, G. T. (1997). Primary stenting as treatment for coronary-subclavian steal syndrome. Australian & New Zealand Journal of Medicine, 27(1), 80-81.

Stewart, R. A., Robertson, M. C., Wilkins, G. T., Low, C. J., & Restieaux, N. J. A. (1997). Association between activity at onset of symptoms and outcome of acute myocardial infarction. JACC, 29(2), 250-253.

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Journal - Research Other

Lal, S., Pemberton, J., & Wilkins, G. T. (2018). Cough-induced takotsubo (stress) cardiomyopathy. CASE. Advance online publication. doi: 10.1016/j.case.2018.03.004

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2011). Plasma active matrix metalloproteinase 9 associated to diastolic dysfunction in patients with coronary artery disease [Letter]. International Journal of Cardiology, 147(2), 336-338. doi: 10.1016/j.ijcard.2010.12.093

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