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Otago Medical School staff profiles

Professor Anthony Molteno

PositionEmeritus Professor
DepartmentDepartment of Medicine (DSM)
QualificationsONZM MB ChB(Cape Town) FRCSEd FRANZCO
Research summaryVision - glaucoma

Research

Emeritus Professor Anthony C B Molteno graduated in medicine from the University of Cape Town. He worked as an ophthalmologist at Baragwanath Hospital before becoming acting head of the Department of Ophthalmology at the University of Stellenbosch and Tygerberg Hospital.

He came to the University of Otago in 1977, and was head of ophthalmology at the University of Otago Dunedin School of Medicine from 1987 to 2014. He taught and examined medical students at undergraduate and postgraduate levels, and he and his wife, Tess, have mentored decades of ophthalmology registrars.

Anthony Molteno became a full Professor in 2002 and Emeritus Professor in 2012, and retired from clinical and teaching work at the end of 2014. He continues his active research programme, which has been partly funded in 2014 and 2015 by a Lotteries Health Translational Research Project Grant.

He is particularly known for developing the world's first glaucoma drainage implant, the Molteno implant, which is still considered the 'gold standard'. He also developed the bone-derived hydroxyapatite M-Sphere orbital implant used following enucleation, and a method of photoscreening for infants to detect early strabismus and anomalies in focusing.

He has earned an international reputation for his research, most notably about glaucoma and in the Otago Glaucoma Surgery Outcome Study in particular, focusing on the long-term clinical outcomes of glaucoma surgery and the histology and immunohistochemistry of the glaucoma drainage blebs.

Anthony Molteno’s wide-ranging research interests since 2000 have also included:

  • The clinical use and effect of intravitreal bevacizumab
  • Stereotactic radiotherapy in the treatment of uveal melanomas
  • Ultraviolet photography of the living human cornea
  • Star testing of intraocular lens optical quality
  • Fourier analysis of digital retinal images in estimation of cataract severity
  • The long term outcomes of bone-derived hydroxyapatite orbital implants
  • The histology of the tuatara pineal complex

Professor Molteno has received many awards including the Goldmann Medal from the International Glaucoma Societies in 1998 for the most significant contribution to the understanding and treatment of glaucoma, the 2014 International Society of Glaucoma Surgery Medal for outstanding achievement, and the 2015 American Glaucoma Society Innovator Award.

He was admitted as an Honorary Fellow of the College of Ophthalmologists of the Colleges of Medicine of South Africa in 2001 and an Emeritus Member of the Glaucoma Research Society in 2011.

Here in New Zealand he was awarded an Officer of the New Zealand Order of Merit in the New Year's Honours List in 2005 for his services to ophthalmology and people with glaucoma. He is a previous president of the Ophthalmological Society of New Zealand, and in 2009 received a Distinguished Service Award from the Royal Australian and New Zealand College of Ophthalmologists.

To recognize his innovation, research and dedication to public clinical ophthalmology, the Anthony Molteno Prize was established in 2011. This prize is for the highest ranking student in the Ophthalmic Optics paper of the Postgraduate Diploma in Ophthalmic Basic Sciences at either the University of Otago or University of Sydney.

See Citations

Publications

Abdul-Rahman, A. M., & Molteno, A. (2017). Late-onset inadvertent bleb formation following pars plana M3 Molteno implant tube obstruction. Case Reports in Ophthalmology, 8(1), 73-80. doi: 10.1159/000456536

Haji Mohd Yasin, N. A. B., Gray, A. R., Bevin, T. H., Kelly, L. E., & Molteno, A. C. (2016). Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience. Journal of Medical Imaging & Radiation Oncology, 60(6), 756-763. doi: 10.1111/1754-9485.12489

Molteno, A. C. B., Bevin, T. H., Dempster, A. G., & Devereux, F. (2015). Otago Glaucoma Surgery Outcome Study: Further histology and immunohistochemistry of Molteno implant blebs. Investigative Ophthalmology & Visual Science, 56(8), 4364-4374. doi: 10.1167/iovs.14-16257

Abdul-Rahman, A. M., & Molteno, A. (2015). Conjunctival microangiopathy in a patient with neovascular glaucoma. Case Reports in Ophthalmology, 6(2), 272-278. doi: 10.1159/000439266

Thompson, A. M., Molteno, A. C. B., Bevin, T. H., & Herbison, P. (2013). Otago Glaucoma Surgery Outcome Study: Comparative results for the 175-mm2 Molteno3 and double-plate Molteno implants. JAMA Ophthalmology, 131(2), 155-159.

Chapter in Book - Research

Thompson, A. M., Bevin, T. H., & Molteno, A. C. B. (2009). Surgical technique 1 (Molteno Glaucoma Implant). In T. M. Shaarawy, M. B. Sherwood, R. A. Hitchings & J. G. Crowston (Eds.), Glaucoma: Surgical management (Vol. 2). (pp. 403-416). Edinburgh, UK: Saunders.

Molteno, A. C. B., & Bevin, T. H. (2007). Double-plate Molteno implants. In T. C. Chen (Ed.), Glaucoma surgery. (pp. 123-141). Edinburgh: Saunders Elsevier.

Molteno, A. C. B., & Bevin, T. H. (2006). The use of Molteno implants to treat complex cases of glaucoma. In T. Shaarawy & A. Mermoud (Eds.), Atlas of glaucoma surgery. (pp. 77-101). New Delhi, India: Jaypee Brothers.

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Journal - Research Article

Haji Mohd Yasin, N. A. B., Gray, A. R., Bevin, T. H., Kelly, L. E., & Molteno, A. C. (2016). Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience. Journal of Medical Imaging & Radiation Oncology, 60(6), 756-763. doi: 10.1111/1754-9485.12489

Molteno, A. C. B., Bevin, T. H., Dempster, A. G., & Devereux, F. (2015). Otago Glaucoma Surgery Outcome Study: Further histology and immunohistochemistry of Molteno implant blebs. Investigative Ophthalmology & Visual Science, 56(8), 4364-4374. doi: 10.1167/iovs.14-16257

Thompson, A. M., Molteno, A. C. B., Bevin, T. H., & Herbison, P. (2013). Otago Glaucoma Surgery Outcome Study: Comparative results for the 175-mm2 Molteno3 and double-plate Molteno implants. JAMA Ophthalmology, 131(2), 155-159.

Molteno, A. C. B., Bevin, T. H., Dempster, A. G., Sarris, M., & McCluskey, P. (2013). Otago Glaucoma Surgery Outcome Study: Cytology and immunohistochemistry of trabeculectomy blebs. Investigative Ophthalmology & Visual Science, 54(7), 4991-4999. doi: 10.1167/iovs.12-11553

Molteno, A. C. B., Bevin, T. H., Herbison, P., & Husni, M. A. (2011). Long-term results of primary trabeculectomies and Molteno implants for primary open-angle glaucoma. Archives of Ophthalmology, 129(11), 1444-1450. doi: 10.1001/archophthalmol.2011.221

Dempster, A. G., Molteno, A. C. B., Bevin, T. H., & Thompson, A. M. (2011). Otago Glaucoma Surgery Outcome Study: Electron microscopy of capsules around Molteno implants. Investigative Ophthalmology & Visual Science, 52(11), 8300-8309. doi: 10.1167/iovs.11-7772

Abdul-Rahman, A. M., Molteno, A. C. B., & Bevin, T. H. (2011). The epidemiology of giant cell arteritis in Otago, New Zealand: A 9-year analysis. New Zealand Medical Journal, 124(1329). Retrieved from http://journal.nzma.org.nz/journal/124-1329/4533/content.pdf

Mccluskey, P., Molteno, A., Wakefield, D., & Di Girolamo, N. (2009). Otago Glaucoma Surgery Outcome Study: The pattern of expression of MMPs and TIMPs in bleb capsules surrounding Molteno implants. Investigative Ophthalmology & Visual Science, 50(5), 2161-2164. doi: 10.1167/iovs.08-2063

Molteno, A. C. B., Thompson, A. M., Bevin, T. H., & Dempster, A. G. (2009). Otago Glaucoma Surgery Outcome Study: Tissue matrix breakdown by apoptotic cells in capsules surrounding Molteno implants. Investigative Ophthalmology & Visual Science, 50(3), 1187-1197. doi: 10.1167/iovs.07-1424

Bevin, T. H., Molteno, A. C. B., & Herbison, P. (2008). Otago Glaucoma Surgery Outcome Study: Long-term results of 841 trabeculectomies. Clinical & Experimental Ophthalmology, 36, 731-737. doi: 10.1111/j.1442-9071.2008.01896.x

Abdul-Rahman, A. M., Molteno, T., & Molteno, A. C. B. (2008). Fourier analysis of digital retinal images in estimation of cataract severity. Clinical & Experimental Ophthalmology, 36, 637-645. doi: 10.1111/j.1442-9071.2008.01819.x

Toh, T., Bevin, T. H., & Molteno, A. C. B. (2008). Scleral wrap increases the long-term complication risk of bone-derived hydroxyapatite orbital implants. Clinical & Experimental Ophthalmology, 36, 756-761. doi: 10.1111/j.1442-9071.2008.01877.x

Deokule, S. P., Molteno, A. C. B., Bevin, T. H., & Herbison, P. (2007). Long-term results of Molteno implant insertion in cases of chronic angle closure glaucoma. Clinical & Experimental Ophthalmology, 35, 514-519.

Aird, J. J., Molteno, A. C. B., Bevin, T. H., Sanderson, G., & Wynn-Williams, G. (2006). Digital imaging of the human cornea in vivo with ultraviolet light. Australasian Physical & Engineering Sciences in Medicine, 29(2), 203-205.

Mitchell, L., Molteno, A. C. B., Bevin, T. H., & Sanderson, G. (2006). Star testing: A novel evaluation of intraocular lens optical quality. British Journal of Ophthalmology, 90, 586-592.

Every, S. G., Molteno, A. C. B., Bevin, T. H., & Herbison, P. (2006). Long-term results of Molteno implant insertion in cases of neovascular glaucoma. Archives of Ophthalmology, 124, 355-360.

Molteno, A. C. B., Suter, A. J., Fenwick, M., Bevin, T. H., & Dempster, A. G. (2006). Otago Glaucoma Surgery Outcome Study: Cytology and immunohistochemical staining of bleb capsules around Molteno implants. Investigative Ophthalmology & Visual Science, 47(5), 1975-1981.

Ah-Chan, J. J., Molteno, A. C. B., Bevin, T. H., & Herbison, P. (2005). Otago Glaucoma Surgery Outcome Study: Follow-up of young patients who underwent Molteno implant surgery. Ophthalmology, 112, 2137-2142.

Chew, G. S. M., Sanderson, G. F., & Molteno, A. C. B. (2005). The pressure phosphene tonometer: A clinical evaluation. Eye, 19(6), 683-685.

Every, S. G., Leader, J. P., Molteno, A. C., Bevin, T. H., & Sanderson, G. (2005). Ultraviolet photography of the in vivo human cornea unmasks the Hudson-Stähli line and physiologic vortex patterns. Investigative Ophthalmology & Visual Science, 46(10), 3616-3622.

Molteno, A. C. B., & Bevin, T. H. (2005). Gillies lecture: Comparative anatomy of V esotropia. Clinical & Experimental Ophthalmology, 33(6), 564-570.

Blanc, J.-P., Molteno, A. C. B., Fuller, J. R., Bevin, T. H., & Herbison, P. (2004). Life expectancy of patients with neovascular glaucoma drained by Molteno implants. Clinical & Experimental Ophthalmology, 32, 360-363. doi: 10.1111/j.1442-9071.2004.00837.x

Molteno, A. C. B., Whittaker, K. W., Bevin, T. H., & Herbison, P. (2004). Otago Glaucoma Surgery Outcome Study: Long term results of cataract extraction combined with Molteno implant insertion or trabeculectomy in primary glaucoma. British Journal of Ophthalmology, 88, 32-35.

Ung, C. Y.-J., & Molteno, A. C. B. (2004). An enigmatic eye: The histology of the tuatara pineal complex. Clinical & Experimental Ophthalmology, 32, 614-618.

Molteno, A. C. B., Wynn-Williams, G., Every, S. G., & Bevin, T. H. (2004). Photography of the living human cornea in ultraviolet light. Australasian Physical & Engineering Sciences in Medicine, 27(1), 22-24.

Vote, B., Fuller, J. R., Bevin, T. H., & Molteno, A. C. B. (2004). Systemic anti-inflammatory fibrosis suppression in threatened trabeculectomy failure. Clinical & Experimental Ophthalmology, 32, 81-86.

Whittaker, K. W., Molteno, A. C. B., & Bevin, T. H. (2003). Otago Glaucoma Surgery Outcome Study: Atypical late failure of drainage following clear cornea trabeculectomy. Clinical & Experimental Ophthalmology, 31, 129-132.

Molteno, A. C. B., Fucik, M., Dempster, A. G., & Bevin, T. H. (2003). Otago Glaucoma Surgery Outcome Study: Factors controlling capsule fibrosis around Molteno implants with histopathological correlation. Ophthalmology, 110, 2198-2206.

Fuller, J. R., Bevin, T. H., Molteno, A. C. B., Vote, B. J. T., & Herbison, P. (2002). Anti-inflammatory fibrosis suppression in threatened trabeculectomy bleb failure produces good long term control of intraocular pressure without risk of sight threatening complications. British Journal of Ophthalmology, 86, 1352-1355.

Suter, A. J., Molteno, A. C. B., Bevin, T. H., Fulton, J. D., & Herbison, P. (2002). Long-term follow-up of bone derived hydroxyapatite orbital implants. British Journal of Ophthalmology, 86, 1287-1292.

Fuller, J. R., Bevin, T. H., & Molteno, A. C. B. (2001). Long-term follow-up of traumatic glaucoma treated with Molteno implants. Ophthalmology, 108(10), 1796-1800.

Ah-Chan, J. J., Sanderson, G., Vote, B. J. T., & Molteno, A. C. B. (2001). Undergraduate ophthalmology education survey of New Zealand ophthalmologists, general practitioners and optometrists. Clinical & Experimental Ophthalmology, 29, 416-425.

Fuller, J. R., Molteno, A. C. B., & Bevin, T. H. (2001). Iris creep producing correctopia in response to Molteno implants. Archives of Ophthalmology, 119, 304.

Molteno, A. C. B., Sayawat, N., & Herbison, P. (2001). Otago Glaucoma Surgery Outcome Study. Long-term results of uveitis with secondary glaucoma drained by Molteno implants. Ophthalmology, 108, 605-613.

Molteno, A. C. B., Bevin, T. H., Herbison, P., & Houliston, M. J. (2001). Otago Glaucoma Surgery Outcome Study: Long-term follow-up of cases of primary glaucoma with additional risk factors drained by Molteno implants. Ophthalmology, 108(12), 2193-2200.

Molteno, A. C. B., & Kindon, R. (2000). A comparative trial of Gobin's method versus conventional surgery for refractive/accommodative esotropia uncorrected by non-surgical methods. Binocular Vision & Strabismus Quarterly, 15(4), 351-356.

Molteno, A. C. B., Dempster, A. G., & Carne, A. (1999). Molteno implants: the principles of bleb management. Australian & New Zealand Journal of Ophthalmology, 27, 350-353.

Molteno, A. C. B., Bosma, N. J., & Kittelson, J. M. (1999). Otago Glaucoma Surgery Outcome Study. Long-term results of trabeculectomy - 1976 to 1995. Ophthalmology, 106(9), 1742-1750.

Cunnliffe, I. A., & Molteno, A. C. B. (1998). Long-term follow up of Molteno drains used in the treatment of glaucoma presenting in childhood. Eye.

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Journal - Research Other

Abdul-Rahman, A. M., & Molteno, A. (2017). Late-onset inadvertent bleb formation following pars plana M3 Molteno implant tube obstruction. Case Reports in Ophthalmology, 8(1), 73-80. doi: 10.1159/000456536

Abdul-Rahman, A. M., & Molteno, A. (2015). Conjunctival microangiopathy in a patient with neovascular glaucoma. Case Reports in Ophthalmology, 6(2), 272-278. doi: 10.1159/000439266

Abeysiri, P., Johnston, N. R., & Molteno, A. C. B. (2010). The use of topical tacrolimus 0.1% skin ointment for anterior segment conditions: A case series. Ophthalmology & Eye Diseases, 2, 5-8.

Abeysiri, P., Johnston, N. R., & Molteno, A. C. B. (2010). Price of bevacizumab for intravitreal injection in New Zealand [Letter to the editor]. Clinical & Experimental Ophthalmology, 38(1), 84. doi: 10.1111/j.1442-9071.2010.02196.x

Ah-Chan, J. J., Molteno, A. C. B., & Bevin, T. H. (2006). Anti-inflammatory fibrosis suppression in threatened trabeculectomy bleb failure. Archives of Ophthalmology, 124, 603.

Bevin, T. H., Derrett, S., & Molteno, A. C. B. (2004). Cataracts and driving: Experiences of a New Zealand eye clinic population [Letters to the editor]. Clinical & Experimental Ophthalmology, 32, 551-552.

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