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Otago Medical School staff profiles

Professor Greg Jones

PositionResearch Professor
DepartmentDepartment of Surgical Sciences (DSM)
QualificationsBSc PhD(Otago)
Research summaryVascular disease genetics, biomarker discovery, and histopathology

Research

Professor Jones' research group has a broad range of interests in the field of vascular biology, including population genetics, cardiovascular disease biomarkers, and vascular connective tissue biology. The group's research has a strong clinical emphasis, particularly in the areas of aortic aneurysm, coronary and peripheral arterial disease and varicose veins.

The Vascular Research Group has four main areas of research focus:

  • Genes associated with the initiation and progression of vascular diseases
  • Identifying circulating biomarkers to assess vascular disease risk
  • The early structural and molecular features of human arterial disease
  • The pathobiology of lower limb venous disease, including varicose veins, venous ulcers and post-operative recurrence
  • The techniques used in the Vascular Research Group include whole genome scanning, microRNA and mRNA microarray, proteomics, immunohistochemistry, cell culture, and functional assays.

The group is currently funded by the Health Research Council of New Zealand.

Publications

Pinard, A., Jones, G. T., & Milewicz, D. M. (2019). Genetics of thoracic and abdominal aortic diseases: Aneurysms, dissections, and ruptures. Circulation Research, 124(4), 588-606. doi: 10.1161/circresaha.118.312436

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Jones, G. T., Sandiford, P., Hill, G. B., Williams, M. J. A., Khashram, M., Tilyard, M. W., Hammond-Tooke, G. D., Krysa, J., & van Rij, A. M. (2019). Correcting for body surface area identifies the true prevalence of abdominal aortic aneurysm in screened women. European Journal of Vascular & Endovascular Surgery, 57(2), 221-228. doi: 10.1016/j.ejvs.2018.08.048

Jones, G. T., Hill, B. G., Curtis, N., Kabir, T. D., Wong, L. E., Tilyard, M. W., Williams, M. J. A., & van Rij, A. M. (2016). Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk. British Journal of Surgery, 103(9), 1139-1146. doi: 10.1002/bjs.10224

Jones, G. T. (2011). The pathohistology of abdominal aortic aneurysm. In R. T. Grundmann (Ed.), Diagnosis, screening and treatment of abdominal, thoracoabdominal and thoracic aortic aneurysms. (pp. 53-74). Rijeka, Croatia: InTech Europe. doi: 10.5772/746

Chapter in Book - Research

Jones, G. T. (2014). Matrix metalloproteinases in biologic samples. In G. S. Makowski (Ed.), Advances in clinical chemistry (Vol. 65). (pp. 199-219). Elsevier. doi: 10.1016/B978-0-12-800141-7.00007-3

Jones, G. T. (2011). The pathohistology of abdominal aortic aneurysm. In R. T. Grundmann (Ed.), Diagnosis, screening and treatment of abdominal, thoracoabdominal and thoracic aortic aneurysms. (pp. 53-74). Rijeka, Croatia: InTech Europe. doi: 10.5772/746

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Journal - Research Article

Nair, N., Kvizhinadze, G., Jones, G. T., Rush, R., Khashram, M., Roake, J., & Blakely, A. (2019). Health gains, costs and cost-effectiveness of a population-based screening programme for abdominal aortic aneurysms. British Journal of Surgery. Advance online publication. doi: 10.1002/bjs.11169

Pinard, A., Jones, G. T., & Milewicz, D. M. (2019). Genetics of thoracic and abdominal aortic diseases: Aneurysms, dissections, and ruptures. Circulation Research, 124(4), 588-606. doi: 10.1161/circresaha.118.312436

Jones, G. T., Sandiford, P., Hill, G. B., Williams, M. J. A., Khashram, M., Tilyard, M. W., Hammond-Tooke, G. D., Krysa, J., & van Rij, A. M. (2019). Correcting for body surface area identifies the true prevalence of abdominal aortic aneurysm in screened women. European Journal of Vascular & Endovascular Surgery, 57(2), 221-228. doi: 10.1016/j.ejvs.2018.08.048

Harrison, S. C., Holmes, M. V., Burgess, S., Asselbergs, F. W., Jones, G. T., Baas, A. F., … van Rij, A. M., … Humphries, S. E. (2018). Genetic association of lipids and lipid drug targets with abdominal aortic aneurysm: A meta-analysis. JAMA Cardiology, 3(1), 26-33. doi: 10.1001/jamacardio.2017.4293

Roberts, R. L., Wallace, M. C., Seinen, M. L., van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., van Rij, A. M., … Kennedy, M. A., … Gearry, R. B., … Barclay, M. (2018). Nonsynonymous polymorphism in guanine monophosphate synthetase is a risk factor for unfavorable thiopurine metabolite ratios in patients with inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izy163

Khashram, M., Kvizhinadze, G., Khashram, Z., Williman, J. A., Jones, G. T., & Roake, J. A. (2018). Development and validation of a predictive model to aid in the management of intact abdominal aortic aneurysms. European Journal of Vascular & Endovascular Surgery, 56(1), 48-56. doi: 10.1016/j.ejvs.2018.03.013

Khashram, M., Pitama, S., Williman, J. A., Jones, G. T., & Roake, J. A. (2017). Survival disparity following abdominal aortic aneurysm repair highlights Inequality in ethnic and socio-economic status. European Journal of Vascular & Endovascular Surgery, 54(6), 689-696. doi: 10.1016/j.ejvs.2017.08.018

Telomeres Mendalian Randomization Collaboration, including van Rij, A., & Jones, G. T. (2017). Association between telomere length and risk of cancer and non-neoplastic diseases: A Mendelian randomization study. JAMA Oncology, 3(5), 636-651. doi: 10.1001/jamaoncol.2016.5945

Khashram, M., Williman, J. A., Hider, P. N., Jones, G. T., & Roake, J. A. (2017). Management of modifiable vascular risk factors improves late survival following abdominal aortic aneurysm repair? A systematic review and meta-analysis. Annals of Vascular Surgery, 39, 301-311. doi: 10.1016/j.avsg.2016.07.066

Khashram, M., Thomson, I. A., Jones, G. T., & Roake, J. A. (2017). Abdominal aortic aneurysm repair in New Zealand: A validation of the Australasian Vascular Audit. ANZ Journal of Surgery, 87(5), 394-398. doi: 10.1111/ans.13702

Jones, G. T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A. F., Giusti, B., … Phillips, L. V., Williams, M. J. A., Wei, W., … Thomson, I. A., Krysa, J., Hill, G. B., Roake, J., Merriman, T. R., … van Rij, A., … Bown, M. J. (2017). Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci. Circulation Research, 120, 341-353. doi: 10.1161/circresaha.116.308765

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Khashram, M., Tiong, L. C., Jones, G. T., & Roake, J. A. (2017). The impact of CT colonography on abdominal aortic aneurysm referrals in a tertiary hospital. Journal of Medical Imaging & Radiation Oncology, 61(2), 180-184. doi: 10.1111/1754-9485.12535

van 't Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., … Jones, G. T., … van Rij, A. M., … Vascular Research Consortium of New Zealand, including Phillips, L. V., Hill, G. B., Williams, M. J. A., Thomson, I. A., Krysa, J., Wilkins, G. T., Merriman, T. R., Lewis, D. R., … de Bakker, P. I. W. (2016). Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms. Journal of the American Heart Association, 5(7), e002603. doi: 10.1161/jaha.115.002603

Jones, G. T., Phillips, V., Williams, M. J. A., van Rij, A. M., & Kabir, T. D. (2016). Two C-C family chemokines, eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. Journal of the American Heart Association, 5(5), e002993. doi: 10.1161/jaha.115.002993

Khashram, M., Hider, P. N., Williman, J. A., Jones, G. T., & Roake, J. A. (2016). Does the diameter of abdominal aortic aneurysm influence late survival following abdominal aortic aneurysm repair? A systematic review and meta-analysis. Vascular, 24(6), 658-667. doi: 10.1177/1708538116650580

Rasheed, H., Phipps-Green, A. J., Topless, R., Smith, M. D., Hill, C., Lester, S., … van Rij, A., Jones, G. T., McCormick, S. P., Harrison, A. A., Stamp, L. K., … Merriman, T. R. (2016). Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout. Rheumatology, 55(8), 1421-1430. doi: 10.1093/rheumatology/kew057

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., … Katare, R. (2016). Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. International Journal of Cardiology, 202, 13-20. doi: 10.1016/j.ijcard.2015.08.111

Phipps-Green, A. J., Merriman, M. E., Topless, R., Altaf, S., Montgomery, G. W., Franklin, C., Jones, G. T., van Rij, A. M., … Stamp, L. K., … Merriman, T. R. (2016). Twenty-eight loci that influence serum urate levels: Analysis of association with gout. Annals of the Rheumatic Diseases, 75, 124-130. doi: 10.1136/annrheumdis-2014-205877

Coffey, S., Williams, M. J. A., Phillips, L. V., Galvin, I. F., Bunton, R. W., & Jones, G. T. (2016). Integrated microRNA and messenger RNA analysis in aortic stenosis. Scientific Reports, 6, 36904. doi: 10.1038/srep36904

Jones, G. T., Hill, B. G., Curtis, N., Kabir, T. D., Wong, L. E., Tilyard, M. W., Williams, M. J. A., & van Rij, A. M. (2016). Comparison of three targeted approaches to screening for abdominal aortic aneurysm based on cardiovascular risk. British Journal of Surgery, 103(9), 1139-1146. doi: 10.1002/bjs.10224

Khashram, M., Williman, J. A., Hider, P. N., Jones, G. T., & Roake, J. A. (2016). Systematic review and meta-analysis of factors influencing survival following abdominal aortic aneurysm repair. European Journal of Vascular & Endovascular Surgery, 51(2), 203-215. doi: 10.1016/j.ejvs.2015.09.007

Nioi, P., Sigurdsson, A., Thorleifsson, G., Helgason, H., Agustsdottir, A. B., Norddahl, G. L., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2016). Variant ASGR1 associated with a reduced risk of coronary artery disease. New England Journal of Medicine, 374, 2131-2141. doi: 10.1056/NEJMoa1508419

Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150

Khashram, M., Jones, G. T., & Roake, J. A. (2015). Prevalence of abdominal aortic aneurysm (AAA) in a population undergoing computed tomography colonography in Canterbury, New Zealand. European Journal of Vascular & Endovascular Surgery, 50(2), 199-205. doi: 10.1016/j.ejvs.2015.04.023

Coffey, S., Williams, M. J. A., Phillips, L. V., & Jones, G. T. (2015). Circulating microRNA profiling needs further refinement before clinical use in patients with aortic stenosis. Journal of the American Heart Association, 4(8), e002150. doi: 10.1161/jaha.115.002150

The Interleukin 1 Genetics Consortium, including Jones, G. T., & van Rij, A. (2015). Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis. Lancet Diabetes & Endocrinology, 3(4), 243-253. doi: 10.1016/S2213-8587(15)00034-0

Jin, C., Phillips, L. V., Williams, M. J. A., van Rij, A. M., & Jones, G. T. (2014). Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease. SpringerPlus, 3, 635. doi: 10.1186/2193-1801-3-635

Coffey, S., & Jones, G. T. (2014). MicroRNAs are central to osteogenesis: A review with a focus on cardiovascular calcification. microRNA Diagnostics & Therapeutics, 1, 113-125. doi: 10.2478/micrnat-2014-0005

Dennis, N. A., Jones, G. T., Chong, Y. H., van Rij, A. M., & McLennan, I. S. (2013). Serum anti-Müllerian hormone (AMH) levels correlate with infrarenal aortic diameter in healthy older men: Is AMH a cardiovascular hormone? Journal of Endocrinology, 219, 13-20. doi: 10.1530/joe-13-0125

Harrison, S. C., Zabaneh, D., Asselbergs, F. W., Drenos, F., Jones, G. T., Shah, S., … van Rij, A. M., … Humphries, S. E. (2013). A gene-centric study of common carotid artery remodeling. Atherosclerosis, 226(2), 440-446. doi: 10.1016/j.atherosclerosis.2012.11.002

Chong, Y. H., Dennis, N. A., Connolly, M. J., Teh, R., Jones, G. T., van Rij, A. M., … Campbell, A. J., & McLennan, I. S. (2013). Elderly men have low levels of anti-Müllerian hormone and inhibin B, but with high interpersonal variation: A cross-sectional study of the Sertoli cell hormones in 615 community-dwelling men. PLoS ONE, 8(8), e70967. doi: 10.1371/ journal.pone.0070967

Tarr, G. P., Williams, M. J. A., Wilkins, G. T., Chen, V. H. T., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2013). Intra-individual changes of active matrix metalloproteinase-9 are associated with clinical in-stent restenosis of bare metal stents. Cardiology, 124(1), 28-35. doi: 10.1159/000345591

Sorrenson, B., Suetani, R. J., Williams, M. J. A., Bickley, V. M., George, P. M., Jones, G. T., & McCormick, S. P. A. (2013). Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate. Journal of Lipid Research, 54, 55-62. doi: 10.1194/jlr.M027193

Harrison, S. C., Smith, A. J. P., Jones, G. T., Swerdlow, D. I., Rampuri, R., Brown, M. J., … Humphries, S. E. (2013). Interleukin-6 receptor pathways in abdominal aortic aneurysm. European Heart Journal, 34(48), 3707-3716. doi: 10.1093/eurheartj/ehs354

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2013). Plasma active matrix metalloproteinase 9 and indices of diastolic function in patients with preserved systolic function. International Journal of Cardiology, 167(4), 1242-1246. doi: 10.1016/j.ijcard.2012.03.147

Bradley, D. T., Hughes, A. E., Badger, S. A., Jones, G. T., Harrison, S. C., Wright, B. J., … van Rij, A., … Bown, M. J. (2013). A variant in LDLR is associated with abdominal aortic aneurysm. Circulation: Cardiovascular Genetics, 6, 498-504. doi: 10.1161/CIRCGENETICS.113.000165

Roberts, R. L., Wallace, M. C., Jones, G. T., van Rij, A. M., Merriman, T. R., Harrison, A., … Stamp, L. K., … Highton, J., & Stebbings, S. M. (2013). Prevalence of HLA-B27 in the New Zealand population: Effect of age and ethnicity. Arthritis Research & Therapy, 15, R158. doi: 10.1186/ar4341

Jones, G. T., Bown, M. J., Gretarsdottir, S., Romaine, S. P. R., Helgadottir, A., Yu, G., … Jin, C., … Phillips, L. V., Williams, M. J. A., Topless, R., Merriman, T. R., … Lewis, D. R., … van Rij, A. M. (2013). A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Human Molecular Genetics, 22(14), 2941-2947. doi: 10.1093/hmg/ddt141

Rodger, E. J., Suetani, R. J., Jones, G. T., Kleffmann, T., Carne, A., Legge, M., & McCormick, S. P. A. (2012). Proteomic analysis of aortae from human lipoprotein(a) transgenic mice shows an early metabolic response independent of atherosclerosis. PLoS ONE, 7(1), e30383. doi: 10.1371/journal.pone.0030383

Helgadottir, A., Gretarsdottir, S., Thorleifsson, G., Holm, H., Patel, R. S., Gudnason, T., Jones, G. T., van Rij, A. M., … Stefansson, H. (2012). Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. JACC, 60(8), 722-729. doi: 10.1016/j.jacc.2012.01.078

Chen-Xu, M., Topless, R., McKinney, C., Merriman, M. E., Phipps-Green, A., Dalbeth, N., … Harrison, A. A., Highton, J., … van Rij, A., Jones, G. T., … Stamp, L. K., … Merriman, T. R. (2012). Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets. Annals of the Rheumatic Diseases, 71(1), 155-157. doi: 10.1136/annrheumdis-2011-200591

Dennis, N. A., Houghton, L. A., Jones, G. T., van Rij, A. M., Morgan, K., & McLennan, I. S. (2012). The level of serum anti-Müllerian hormone correlates with vitamin D status in men and women but not in boys. Journal of Clinical Endocrinology & Metabolism, 97(7), 2450-2455. doi: 10.1210/jc.2012-1213

Krysa, J., Jones, G. T., & van Rij, A. M. (2012). Evidence for a genetic role in varicose veins and chronic venous insufficiency. Phlebology, 27(7), 329-335. doi: 10.1258/phleb.2011.011030

Kardys, I., Oemrawsingh, R. M., Kay, P., Jones, G. T., McCormick, S. P. A., Daemen, J., … Serruys, P. (2012). Lipoprotein(a), interleukin-10, C-reactive protein, and 8-year outcome after percutaneous coronary intervention. Clinical Cardiology, 35(8), 482-489. doi: 10.1002/clc.21988

Hollis-Moffatt, J. E., Phipps-Green, A. J., Chapman, B., Jones, G. T., van Rij, A., Gow, P. J., Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2012). The renal urate transporter SLC17A1 locus: Confirmation of association with gout. Arthritis Research & Therapy, 14(2), R92. doi: 10.1186/ar3816

Bown, M. J., Jones, G. T., Harrison, S. C., Wright, B. J., Bumpstead, S., Baas, A. F., … CARDIoGRAM Consortium, GLOBAL BPgen Consortium, DIAGRAM Consortium, VRCNZ Consortium, … van Rij, A., … Samani, N. J. (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. American Journal of Human Genetics, 89(5), 619-627. doi: 10.1016/j.ajhg.2011.10.002

Roberts, R. L., van Rij, A. M., Phillips, L. V., Young, S., McCormick, S. P. A., Merriman, T. R., & Jones, G. T. (2011). Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. Atherosclerosis, 218(1), 123-126. doi: 10.1016/j.atherosclerosis.2011.04.043

Kapustin, A., Davies, J. D., Reynolds, J. L., McNair, R., Jones, G. T., Sidibe, A., … Shanahan, C. M. (2011). Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circulation Research, 109, e1-e12. doi: 10.1161/CIRCRESAHA.110.238808

Biros, E., Norman, P. E., Jones, G. T., van Rij, A. M., Yu, G., Moxon, J. V., … Golledge, J. (2011). Meta-analysis of the association between single nucleotide polymorphisms in TGF-β receptor genes and abdominal aortic aneurysm. Atherosclerosis, 219, 218-223. doi: 10.1016/j.atherosclerosis.2011.07.105

Golledge, J., Biros, E., Warrington, N., Jones, G. T., Cooper, M., van Rij, A. M., … Norman, P. E. (2011). A population-based study of polymorphisms in genes related to sex hormones and abdominal aortic aneurysm. European Journal of Human Genetics, 19(3), 363-366. doi: 10.1038/ejhg.2010.182

Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Seasonal variation and stability of matrix metalloproteinase-9 activity and tissue inhibitor of matrix metalloproteinase-1 with storage at -80 oC. Clinical Biochemistry, 44(16), 1346-1348. doi: 10.1016/j.clinbiochem.2011.08.1139

Schunkert, H., König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., … Jones, G. T., … van Rij, A. M., … for the CARDIoGRAM Constortium. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics, 43(4), 333-340. doi: 10.1038/ng.784

Tarr, G. P., Williams, M. J. A., Phillips, L. V., van Rij, A. M., & Jones, G. T. (2011). Pro-MMP-9/TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity. Clinical Biochemistry, 44(17-18), 1480-1482. doi: 10.1016/j.clinbiochem.2011.09.019

Vincent, J. R., Jones, G. T., Hill, G. B., & van Rij, A. M. (2011). Failure of microvenous valves in small superficial veins is a key to the skin changes of venous insufficiency. Journal of Vascular Surgery, 54(6, Suppl. ), 62S-69S.e3. doi: 10.1016/j.jvs.2011.06.085

Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., … Jones, G. T., van Rij, A. M., … Stefansson, K. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), 448-453. doi: 10.1038/ng.573

Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J.-P. P. M., … van Rij, A. M., Williams, M. J. A., … Jones, G. T., … Stefansson, K. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nature Genetics, 42(8), 692-697. doi: 10.1038/ng.622

Thompson, A. R., Cooper, J. A., Jones, G. T., Drenos, F., van Bockxmeer, F. M., Biros, E., … van Rij, A. M., … Humphries, S. E. (2010). Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm. Atherosclerosis, 209, 367-373. doi: 10.1016/j.atherosclerosis.2009.09.073

Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2009). Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis. Atherosclerosis, 207(2), 603-607. doi: 10.1016/j.atherosclerosis.2009.05.036

Golledge, J., Clancy, P., Jones, G. T., Cooper, M., Palmer, L. J., van Rij, A. M., & Norman, P. E. (2009). Possible association between genetic polymorphisms in transforming growth factor β receptors, serum transforming growth factor β1 concentration and abdominal aortic aneurysm. British Journal of Surgery, 96(6), 628-632. doi: 10.1002/bjs.6633

Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., … Williams, M. J. A., van Rij, A. M., Jones, G. T., … Stefansson, K. (2009). Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41(3), 342-347. doi: 10.1038/ng.323

Chan, E. C., Jones, G. T., Dusting, G. J., Datla, S. R., & Jiang, F. (2009). Prevention of aortic elastic lamina defects by losartan in apolipoprotein E-deficient mouse. Clinical & Experimental Pharmacology & Physiology, 36(9), 919-924. doi: 10.1111/j.1440-1681.2009.05169.x

Jones, G. T., Grant, M. W., Thomson, I. A., Hill, B. G., & van Rij, A. M. (2009). Characterization of a porcine model of chronic superficial varicose veins. Journal of Vascular Surgery, 49(6), 1554-1561. doi: 10.1016/j.jvs.2009.01.070

Jones, G. T., Thompson, A. R., van Bockxmeer, F. M., Hafez, H., Cooper, J. A., Golledge, J., … van Rij, A. M. (2008). Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arteriosclerosis, Thrombosis, & Vascular Biology, 28, 764-770. doi: 10.1161/ATVBAHA.107.155564

Jones, G. T., van Rij, A. M., Hill, G. B., Wilkins, G. T., & Williams, M. J. A. (2008). Common carotid intimal-medial thickness is associated with coronary in-stent restenosis. Journal for Vascular Ultrasound, 32(3), 129-132.

Jones, G. T. (2008). Animal models in chronic venous disease ″Interview with G. T. Jones, New Zealand″. Medicographia, 30(2), 154-156.

Slatter, T. L., Jones, G. T., Williams, M. J. A., van Rij, A. M., & McCormick, S. P. A. (2008). Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clinical Genetics, 73, 179-184. doi: 10.1111/j.1399-0004.2007.00940.x

Helgadottir, A., Thorleifsson, G., Magnusson, K. P., Grétarsdottir, S., Steinthorsdottir, V., Manolescu, A., Jones, G. T., … van Rij, A. M., … Stefansson, K. (2008). The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm [Letter]. Nature Genetics, 40(2), 217-224. doi: 10.1038/ng.72

van Rij, A. M., Jones, G. T., Hill, B. G., Amer, M., Thomson, I. A., Pettigrew, R. A., & Packer, S. G. K. (2008). Mechanical inhibition of angiogenesis at the saphenofemoral junction in the surgical treatment of varicose veins: Early results of a blinded randomized controlled trial. Circulation, 118, 66-74. doi: 10.1161/CIRCULATIONAHA.107.726869

Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., … Jones, G. T., … van Rij, A. M., … Stefansson, K. (2008). A variant associated with nicotine dependence, lung cancer and peripheral arterial disease [Letter]. Nature, 452, 638-642. doi: 10.1038/nature06846

Pascoe, K. C., Wlodek, M. E., & Jones, G. T. (2008). Increased elastic tissue defect formation in the growth restricted Brown Norway rat: A potential link between in utero condition and cardiovascular disease. Pediatric Research, 64, 125-130.

Jiang, F., Jones, G. T., & Dusting, G. J. (2007). Failure of antioxidants to protect against angiotensin II-induced aortic rupture in aged apolipoprotein(E)-deficient mice. British Journal of Pharmacology, 152, 880-890.

Jones, G. T., van Rij, A. M., Cole, J., Williams, M. J. A., Bateman, E. H., Marcovina, S. M., Deng, M., & McCormick, S. P. A. (2007). Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease. Clinical Chemistry, 53(4), 679-685.

Jones, G. T., Kay, I. P., Chu, J. W. S., Wilkins, G. T., Phillips, L. V., McCormick, M., van Rij, A. M., & Williams, M. J. A. (2006). Elevated plasma active matrix metalloproteinase-9 level is associated with coronary artery in-stent restenosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 26, e121-e125.

Jones, G. T., Harris, E. L., Phillips, L. V., & van Rij, A. M. (2005). The methylenetetrahydrofolate reductase C677T polymorphism does not associate with susceptibility to abdominal aortic aneurysm. European Journal of Vascular & Endovascular Surgery, 30(2), 137-142. doi: 10.1016/j.ejvs.2005.02.047

Jones, G. T., Jiang, F., McCormick, S. P. A., & Dusting, G. J. (2005). Elastic lamina defects are an early feature of aortic lesions in the apolipoprotein E knockout mouse. Journal of Vascular Research, 42, 237-246.

van Rij, A. M., Jones, G. T., Hill, G., & Jiang, P. (2004). Neovascularisation and recurrent varicose veins: More histologic and ultrasound evidence. Journal of Vascular Surgery, 40(2), 296-302.

Jiang, F., Jones, G. T., Husband, A. J., & Dusting, G. J. (2003). Cardiovascular protective effects of synthetic isoflavone derivatives in apolipoprotein E-deficient mice. Journal of Vascular Research, 40, 276-284.

Jones, G. T., Phillips, L. V., Harris, E. L., Rossaak, J. I., & van Rij, A. M. (2003). Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. Journal of Vascular Surgery, 38, 1363-1367.

Harris, E. L., Stoll, M., Jones, G. T., Granados, M. A., Porteous, W. K., van Rij, A. M., & Jacob, H. J. (2001). Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Physiological Genomics, 6(3), 183-189.

Jones, G. T., Harris, E. L., Jacob, H. J., & van Rij, A. M. (2000). Spontaneous elastic tissue lesion in the rat abdominal aorta, a genetically determined phenotype. Journal of Vascular Research, 37, 73-81.

Jones, G. T., & van Rij, A. M. (2000). In situ von Willebrand factor staining in human arteries and veins. Thrombosis Research, 97(5), 369-374.

Jones, G. T., Solomon, C., Moaveni, A., van Rij, A. M., Thomson, I. A., & Galvin, I. (1999). Venous morphology predicts class of chronic venous insufficiency. European Journal of Vascular & Endovascular Surgery, 18(4), 349-354. doi: 10.1053/ejvs.1999.0902

Jones, G. T., van Rij, A. M., Packer, S. G., Walker, R. J., & Stehbens, W. E. (1998). Venous endothelial changes in therapeutic arteriovenous fistulae. Atherosclerosis, 137, 149-156.

Jones, G., van Rij, A. M., & Thomson, I. A. (1998). Endothelial cell ICAM-1 staining in human carotid arteries. Cardiovascular Pathology, 7(5), 245-250.

Jones, G., & Stehbens, W. E. (1995). Ultrastructure of the afferent arteries of experimental femoral arteriovenous fistulae in rabbits. Pathology, 27, 333-338.

Jones, G., & Stehbens, W. E. (1995). The ultrastructure of arteries proximal to chronic experimental carotid-jugular arteriovenous fistulae in rabbits. Pathology, 27, 36-42.

Jones, G. T., Stehbens, W. E., & Martin, B. J. (1994). Ultrastructural changes in arteries proximal to short-term experimental carotid—jugular arteriovenous fistulae in rabbits. International Journal of Experimental Pathology, 75, 225-232.

Jones, G. T., Martin, B. J., & Stehbens, W. E. (1993). Endothelium in the aorta and ilio-femoral arteries proximal to femoral arteriovenous fistulae in rabbits. Pathology, 25, 277-281.

Jones, G. T., Martin, B. J., & Stehbens, W. E. (1992). Endothelium and elastic tears in the afferent arteries of experimental arteriovenous fistulae in rabbits. International Journal of Experimental Pathology, 73, 405-416.

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Khashram, M., Jones, G. T., & Roake, J. A. (2016). Re: 'Self-referral to the NHS Abdominal Aortic Screening Programme'. European Journal of Vascular & Endovascular Surgery, 52(2), 270-271. doi: 10.1016/j.ejvs.2016.05.023

van Rij, A. M., & Jones, G. T. (2015). Aortic aneurysm screening. British Journal of Surgery, 102(8), 863-865. doi: 10.1002/bjs.9830

Kuivaniemi, H., Sakalihasan, N., Lederle, F. A., Jones, G. T., Defraigne, J.-O., Labropoulos, N., … Elefteriades, J. A. (2013). New insights into aortic disease: A report from the Third International Meeting on Aortic Diseases (IMAD3). Aorta, 1(1), 23-39. doi: 10.12945/j.aorta.2013.13.006

Chu, J. W., Jones, G. T., Tarr, G. P., Phillips, L. V., Wilkins, G. T., van Rij, A. M., & Williams, M. J. A. (2011). Plasma active matrix metalloproteinase 9 associated to diastolic dysfunction in patients with coronary artery disease [Letter]. International Journal of Cardiology, 147(2), 336-338. doi: 10.1016/j.ijcard.2010.12.093

Jones, G. T., Deng, M., Hammond-Tooke, G. D., McCormick, S. P. A., & van Rij, A. M. (2009). Increased plasma lipoprotein(a) found in large-artery atherosclerotic, but not small-artery occlusive, stroke [Letter to the editor]. Clinical Chemistry, 55(10), 1888-1890. doi: 10.1373/clinchem.2009.126771

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