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Otago Medical School staff profiles

Associate Professor David Jardine

PositionClinical Associate Professor
DepartmentDepartment of Medicine (UOC)
QualificationsBSc MBChB (Otago) DCH (Lond) FRACP
Research summarySudden death

Research

My main areas of research include sudden death, vasovagal syncope and autonomic failure in humans.

Publications

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Dhayalan, S., Jardine, D., Goh, T., & Lash, N. (2019). Acute compartment syndrome complicating deep venous thrombosis. New Zealand Medical Journal, 132(1493), 73-76. Retrieved from https://www.nzma.org.nz/journal

Jardine, D. L., Wieling, W., Brignole, M., Lenders, J. W. M., Sutton, R., & Stewart, J. (2018). The pathophysiology of the vasovagal response. Heart Rhythm, 15(6), 921-929. doi: 10.1016/j.hrthm.2017.12.013

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports. Advance online publication. doi: 10.1042/bsr20180513

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Jardine, D. L., Wieling, W., Brignole, M., Lenders, J. W. M., Sutton, R., & Stewart, J. (2018). The pathophysiology of the vasovagal response. Heart Rhythm, 15(6), 921-929. doi: 10.1016/j.hrthm.2017.12.013

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports. Advance online publication. doi: 10.1042/bsr20180513

Hoye, N. A., Wilson, L. C., Wilkins, G. T., Jardine, D. L., Putt, T. L., Samaranayaka, A., Schollum, J. B. W., & Walker, R. J. (2017). Endovascular renal denervation in end-stage kidney disease patients: Cardiovascular protection: A proof-of-concept study. Kidney International Reports, 2(5), 856-865. doi: 10.1016/j.ekir.2017.04.012

Jardine, D. L., McKenzie, J. M., & Wilkinson, T. J. (2017). Predicting medical students who will have difficulty during their clinical training. BMC Medical Education, 17, 43. doi: 10.1186/s12909-017-0879-2

Stewart, J. M., Medow, M. S., Sutton, R., Visintainer, P., Jardine, D. L., & Wieling, W. (2017). Mechanisms of vasovagal syncope in the young: Reduced systemic vascular resistance versus reduced cardiac output. Journal of the American Heart Association, 6(1), e004417. doi: 10.1161/jaha.116.004417

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Chieng, J. H. C., Hughes, L., Stewart, A., Frampton, C. M., Hanger, H. C., & Jardine, D. L. (2015). Introduction of the Pill Pruner to acute medical care: A simple medication guide to control polypharmacy. Australasian Journal on Ageing, 34(1), 58-61. doi: 10.1111/ajag.12183

Wieling, W., Jardine, D. L., de Lange, F. J., Brignole, M., Nielsen, H. B., Stewart, J., & Sutton, R. (2015). Cardiac output and vasodilatation in the vasovagal response: An analysis of the classical papers. Heart Rhythm, 13(3), 798-805. doi: 10.1016/j.hrthm.2015.11.023

Chan, W. Y. W., Charles, C. J., Frampton, C. M., Richards, A. M., Crozier, I. G., Troughton, R. W., & Jardine, D. L. (2015). Human muscle sympathetic nerve responses to urocortin-2 in health and stable heart failure. Clinical & Experimental Pharmacology & Physiology, 42(9), 888-895. doi: 10.1111/1440-1681.12449

Spencer, A., Cawood, T., Frampton, C., & Jardine, D. (2014). Heparin-based treatment to prevent symptomatic deep venous thrombosis, pulmonary embolism or death in general medical inpatients is not supported by best evidence. Internal Medicine Journal, 44(11), 1054-1065. doi: 10.1111/imj.12574

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Low-dose B-type natriuretic peptide raises cardiac sympathetic nerve activity in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(2), R206-R211. doi: 10.1152/ajpregu.00404.2013

Than, M., Aldous, S., Lord, S. J., Goodacre, S., Frampton, C. M. A., Troughton, R., George, P., Florkowski, C. M., Ardagh, M., Smyth, D., Jardine, D. L., … Young, J., Hamilton, G., Deely, J. M., … Richards, A. M. (2014). A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Internal Medicine, 174(1), 51-58. doi: 10.1001/jamainternmed.2013.11362

McLachlan, C. Y. L., Yi, M., Ling, A., & Jardine, D. L. (2014). Adverse drug events are a major cause of acute medical admission. Internal Medicine Journal, 44(7), 633-638. doi: 10.1111/imj.12455

Jardine, D. L. (2013). Vasovagal syncope: New physiologic insights. Cardiology Clinics, 31(1), 75-87. doi: 10.1016/j.ccl.2012.10.010

Wieling, W., Krediet, C. T. P., Solari, D., de Lange, F. J., van Dijk, N., Thijs, R. D., … Jardine, D. L. (2013). At the heart of the arterial baroreflex: A physiological basis for a new classification of carotid sinus hypersensitivity. Journal of Internal Medicine, 273(4), 345-358. doi: 10.1111/joim.12042

Jensen, B. P., Roberts, R. L., Vyas, R., Bonke, G., Jardine, D. L., & Begg, E. J. (2012). Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers. British Journal of Clinical Pharmacology, 73(4), 619-628. doi: 10.1111/j.1365-2125.2011.04126.x

Rozenberg, J., Wieling, W., Schon, I. K., Westerhof, B., Frampton, C., & Jardine, D. (2012). MSNA during prolonged post-faint hypotension. Clinical Autonomic Research, 22(4), 167-173. doi: 10.1007/s10286-012-0159-5

Krediet, C. T. P., Parry, S. W., Jardine, D. L., Benditt, D. G., Brignole, M., & Wieling, W. (2011). The history of diagnosing carotid sinus hypersensitivity: Why are the current criteria too sensitive? Europace, 13(1), 14-22. doi: 10.1093/europace/euq409

Wieling, W., Rozenberg, J., Go-Schön, I. K., Karemaker, J. M., Westerhof, B. E., & Jardine, D. L. (2011). Hemodynamic mechanisms underlying prolonged post-faint hypotension. Clinical Autonomic Research, 21(6), 405-413. doi: 10.1007/s10286-011-0134-6

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, M. (2011). Urocortin 3 inhibits cardiac sympathetic nerve activity in conscious sheep. Journal of Cardiovascular Pharmacology, 58(4), 418-423. doi: 10.1097/FJC.0b013e31822707a4

Krediet, C. T. P., Jardine, D. L., & Wieling, W. (2011). Dissection of carotid sinus hypersensitivity: The timing of vagal and vasodepressor effects and the effect of body position. Clinical Science, 121, 389-396. doi: 10.1042/cs20100607

Busweiler, L., Jardine, D. L., Frampton, C. M., & Wieling, W. (2010). Sleep syncope: Important clinical associations with phobia and vagotonia. Sleep Medicine, 11(9), 929-933. doi: 10.1016/j.sleep.2010.04.013

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2010). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Journal of Endocrinology, 204, 181-189. doi: 10.1677/JOE-08-0505

Jardine, D. L., Krediet, C. T. P., Cortelli, P., Frampton, C. M., & Wieling, W. (2009). Sympatho-vagal responses in patients with sleep and typical vasovagal syncope. Clinical Science, 117, 345-353. doi: 10.1042/CS20080497

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2008). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Journal of Hypertension, 26(1), 53-60.

Jardine, D. L., Charles, C. J., Frampton, C. M., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. American Journal of Physiology: Heart & Circulatory Physiology, 293, H433-H439. doi: 10.1152/ajpheart.01262.2006

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Journal of Endocrinology, 187, 275-281.

Jardine, D. L., Charles, C. J., Ashton, R. K., Bennett, S. I., Whitehead, M., Frampton, C. M., & Nicholls, M. G. (2005). Increased cardiac sympathetic nerve activity following acute myocardial infarction in a sheep model. Journal of Physiology, 565(1), 325-333. doi: 10.1113/jphysiol.2004.082198

Krediet, C. T. P., Jardine, D. L., Cortelli, P., Visman, A. G. R., & Wieling, W. (2004). Vasovagal syncope interrupting sleep? Heart, 90(e25). Retrieved from http://www.heartjnl.com/cgi/content/full/90/5/e25/

Jardine, D. L., Krediet, C. T. P., & Robinson, B. A. (2004). Baroreflex failure secondary to paraneoplastic encephalomyelitis in a 17 year old woman with neuroblastoma. Journal of Neurology, Neurosurgery & Psychiatry, 75, 1650-1651.

Griffith, J. C., Jardine, D. L., Bailey, W., & Florkowski, C. M. (2004). Variegate porphyria presenting with acute autonomic dysfunction, intussusception and renal infarction. Scandinavian Journal of Gastroenterology, 39(5), 500-503. doi: 10.1080/00365520410008395

Jardine, D., Hurrell, M., & Anderson, T. J. (2003). A bad dose of the 'flu. Lancet, 362, 1198.

Jardine, D., Charles, C. J., Forrester, M. D., Whitehead, M., & Nicholls, M. G. (2003). A neural mechanism for sudden death after myocardial infarction. Clinical Autonomic Research, 13, 339-341.

Tang, E. W., Jardine, D., Rodins, K., & Evans, J. (2003). Respiratory failure secondary to diabetic neuropathy affecting the phrenic nerve. Diabetic Medicine, 20, 599-601.

Jardine, D., Charles, C. J., Melton, I., May, C. N., Forrester, M. D., Frampton, C. M., … Ikram, H. (2002). Continual recordings of cardiac sympathetic nerve activity in conscious sheep. American Journal of Physiology: Heart & Circulatory Physiology, 282, H93-H99.

Jardine, D., Melton, I., Crozier, I., English, S., Bennett, S. I., Frampton, C. M., & Ikram, H. (2002). Decrease in cardiac output and muscle sympathetic activity during vasovagal syncope. American Journal of Physiology: Heart & Circulatory Physiology, 282, H1804-H1809.

Jardine, D., & Colls, B. M. (2002). Hodgkins's disease following methotrexate therapy for rheumatoid arthritis. New Zealand Medical Journal, 115, 293-294.

Jardine, D. L., Davis, P. J., Robert, A., Lamont, D. L., & Wilton, G. N. (2001). Spontaneous cholesterol embolization complicated by pulmonary fat embolism. Internal Medicine Journal, 31, 319-320.

Jardine, D. L., Crozier, I. G., & Ikram, H. (2001). Paroxysmal hypertension during a complex partial seizure. Journal of Neurology, Neurosurgery & Psychiatry, 71, 129-137.

McGregor, D. O., Buttimore, A. L., Lynn, K. L., Nicholls, M. G., & Jardine, D. L. (2001). A comparative study of blood pressure control with short in-center versus long home hemodialysis. Blood Purification, 19, 293-300.

Phillips, A. M., Jardine, D., Parkin, P. J., Hughes, T. H., & Ikram, H. (2000). Brainstem stroke causing baroreflex failure and paroxysmal hypertension. Stroke, 31, 1997-2001.

Grayling, M., Jardine, D. L., McClintock, A. D., Spar, J., & Wilton, G. N. (2000). Symptomatic epidural lipomatosis following cyproterone acetate therapy. Australian & New Zealand Journal of Surgery, 70, 233-235.

Jardine, D., Melton, I., Bennett, S. I., Crozier, I. G., Donaldson, I. M., & Ikram, H. (2000). Baroreceptor denervation presenting as part of a vagal mononeuropathy. Clinical Autonomic Research, 10, 69-75.

Jardine, D. L., Melton, I. C., Crozier, I. G., Bennett, S. L., Donald, R. A., & Ikram, H. (1997). Neurohormonal response to head-up tilt and its role in vasovagal syncope. American Journal of Cardiology, 79(9), 1302-1306.

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Journal - Research Other

Dhayalan, S., Jardine, D., Goh, T., & Lash, N. (2019). Acute compartment syndrome complicating deep venous thrombosis. New Zealand Medical Journal, 132(1493), 73-76. Retrieved from https://www.nzma.org.nz/journal

Hoye, N. A., Wilson, L. C., Jardine, D. L., & Walker, R. J. (2018). Sympathetic overactivity in dialysis patients: Underappreciated and clinically consequential. Seminars in Dialysis. Advance online publication. doi: 10.1111/sdi.12756

Wieling, W., de Lange, F. J., & Jardine, D. L. (2014). The heart cannot pump blood that it does not receive. Frontiers in Physiology, 5, 360. doi: 10.3389/fphys.2014.00360

Wong, J., Miller, A., Cross, N., Grundy, K., O'Keefe, M., & Jardine, D. (2014). Calciphylaxis: Fatal arteriosclerosis of uncertain mechanism. Internal Medicine Journal, 44(10), 1040-1041. doi: 10.1111/imj.12562

Betteridge, T. M., Frampton, C. M., & Jardine, D. L. (2012). Polypharmacy: We make it worse! A cross-sectional study from an acute admissions unit [Brief communication]. Internal Medicine Journal, 42(2), 208-211. doi: 10.1111/j.1445-5994.2011.02690.x

McNally, A., Pithie, A., & Jardine, D. (2012). Cefepime: A rare cause of encephalopathy. Internal Medicine Journal, 42(6), 732-733. doi: 10.1111/j.1445-5994.2012.02800.x

Wieling, W., Rozenberg, J., Schon, I. K., Karemaker, J. M., Westerhof, B. E., & Jardine, D. L. (2011). Prolonged post-faint hypotension can be reversed by dynamic tension. Clinical Autonomic Research, 21(6), 415-418. doi: 10.1007/s10286-011-0133-7

Huelsen-Katz, A. M., Schouten, B. J., Jardine, D. L., Soule, S. G., & Liu, H. (2010). Pictorial evolution of bilateral adrenal haemorrhage [Letter to the editor]. Internal Medicine Journal, 40(1), 87-88. doi: 10.1111/j.1445-5994.2009.02117.x

Macdonald, C. A., Jardine, D. L., Hurrell, M. A., & Pithie, A. D. (2009). The worm that turned [Case report]. Transactions of the Royal Society of Tropical Medicine & Hygiene, 103(10), 1065-1067. doi: 10.1016/j.trstmh.2009.05.007

Chen, H. K., Jardine, D., & Beckert, L. (2009). Orthopnoea and arm weakness. Thorax, 64(12), 1031. doi: 10.1136/thx.2009.121632

Hutchinson, C. D., Jardine, D. L., & Hurrell, M. (2008). Vagolysis [Case report]. Age & Ageing, 37, 602-604. doi: 10.1093/ageing/afn105

Jardine, D. L., Hurrell, M. A., & Fink, J. (2007). Tilt-test diagnosis of hypotensive transient ischaemic attacks. Internal Medicine Journal, 37(7), 498-501.

Jardine, D. L., & Laing, A. D. (2004). Delayed pulmonary hypertension following splenectomy for congenital spherocytosis [Clinical-scientific note]. Internal Medicine Journal, 34(4), 214-216.

Archibald, N., Dalzell, K. G. B., Fernando, C., & Jardine, D. (2003). Infectious mononucleosis complicated by mediastinal lymphadenopathy causing transient pulmonary artery stenosis [Letter to the editor]. Internal Medicine Journal, 33(7), 324-325. doi: 10.1046/j.1445-5994.2003.00409.x

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