Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Otago Medical School staff profiles

Dr Wayne Sutherland

PositionSenior Research Fellow
DepartmentDepartment of Medicine (Dunedin)
QualificationsBSc(Hons) PhD
Research summaryLipoproteins and metabolism

Research

Research has focussed on lipoprotein levels and metabolism and the effects of exercise, diet in health and disease. Transport and metabolism of cholesterol in the blood has been of special interest.

Otago Kidney Research

Publications

Manning, P., Munasinghe, P. E., Bellae Papannarao, J., Gray, A. R., Sutherland, W., & Katare, R. (2019). Acute weight loss restores dysregulated circulating microRNAs in obese individuals. Journal of Clinical Endocrinology & Metabolism, 104(4), 1239-1248. doi: 10.1210/jc.2018-00684

Manning, P. J., Grattan, D., Merriman, T., Manning, T., Williams, S., & Sutherland, W. (2018). Pharmaceutical interventions for weight-loss maintenance: No effect from cabergoline. International Journal of Obesity. Advance online publication. doi: 10.1038/s41366-018-0165-3

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

De Ridder, D., Manning, P., Leong, S. L., Ross, S., Sutherland, W., Horwath, C., & Vanneste, S. (2016). The brain, obesity and addiction: An EEG neuroimaging study. Scientific Reports, 6, 34122. doi: 10.1038/srep34122

Manning, P. J., Sutherland, W. H. F., Williams, S. M., Walker, R. J., Berry, E. A., De Jong, S. A., & Ryalls, A. R. (2013). The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutrition, Metabolism & Cardiovascular Diseases, 23(6), 543-549. doi: 10.1016/j.numecd.2011.11.006

Chapter in Book - Research

Nishizawa, M., Sutherland, W., & Nukada, H. (1995). Gosha-jinki-gan treatment in experimental diabetic neuropathy. In N. Hotta, D. A. Greene, J. D. Ward, A. A. F. Sima & A. J. M. Boulton (Eds.), Diabetic Neuropathy: New Concepts and Insights. (pp. 311-313). Amsterdam: Elsevier.

^ Top of page

Journal - Research Article

Manning, P., Munasinghe, P. E., Bellae Papannarao, J., Gray, A. R., Sutherland, W., & Katare, R. (2019). Acute weight loss restores dysregulated circulating microRNAs in obese individuals. Journal of Clinical Endocrinology & Metabolism, 104(4), 1239-1248. doi: 10.1210/jc.2018-00684

Manning, P. J., Grattan, D., Merriman, T., Manning, T., Williams, S., & Sutherland, W. (2018). Pharmaceutical interventions for weight-loss maintenance: No effect from cabergoline. International Journal of Obesity. Advance online publication. doi: 10.1038/s41366-018-0165-3

Leong, S. L., De Ridder, D., Vanneste, S., Sutherland, W., Ross, S., & Manning, P. (2018). High definition transcranial pink noise stimulation of anterior cingulate cortex on food craving: An explorative study. Appetite, 120, 673-678. doi: 10.1016/j.appet.2017.10.034

De Ridder, D., Manning, P., Leong, S. L., Ross, S., Sutherland, W., Horwath, C., & Vanneste, S. (2016). The brain, obesity and addiction: An EEG neuroimaging study. Scientific Reports, 6, 34122. doi: 10.1038/srep34122

Manning, P. J., Sutherland, W. H. F., Williams, S. M., Walker, R. J., Berry, E. A., De Jong, S. A., & Ryalls, A. R. (2013). The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutrition, Metabolism & Cardiovascular Diseases, 23(6), 543-549. doi: 10.1016/j.numecd.2011.11.006

Manning, P. J., Sutherland, W. H. F., Williams, S. M., de Jong, S. A., & Hendry, G. P. (2013). Oral but not intravenous glucose acutely decreases circulating interleukin-6 concentrations in overweight individuals. PLoS ONE, 8(6), e66395. doi: 10.1371/journal.pone.0066395

Manning, P. J., De Jong, S. A., Ryalls, A. R., & Sutherland, W. H. F. (2012). Paraoxonase 1 activity in chylomicrons and VLDL: The effect of type 2 diabetes and meals rich in saturated fat and oleic acid. Lipids, 47(3), 259-267. doi: 10.1007/s11745-011-3640-3

Todd, A. S., MacGinley, R. J., Schollum, J. B. W., Williams, S. M., Sutherland, W. H. F., Mann, J. I., & Walker, R. J. (2012). Dietary sodium loading in normotensive healthy volunteers does not increase arterial vascular reactivity or blood pressure. Nephrology, 17(3), 249-256. doi: 10.1111/j.1440-1797.2011.01550.x

Vos, F. E., Manning, P. J., Sutherland, W. H. F., Schollum, J. B., & Walker, R. J. (2011). Anti-inflammatory effect of an insulin infusion in patients on maintenance haemodialysis: A randomized controlled pilot study. Nephrology, 16(1), 68-75. doi: 10.1111/j.1440-1797.2010.01329.x

Taylor, R. W., Brooking, L., Williams, S. M., Manning, P. J., Sutherland, W. H., Coppell, K. J., Tipene-Leach, D., Dale, K. S., McAuley, K. A., & Mann, J. I. (2010). Body mass index and waist circumference cutoffs to define obesity in indigenous New Zealanders. American Journal of Clinical Nutrition, 92, 390-397. doi: 10.3945/ajcn.2010.29317

Sutherland, W. H. F., de Jong, S. A., Hessian, P. A., & Williams, M. J. A. (2010). Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles. Metabolism, 59(3), 446-453. doi: 10.1016/j.metabol.2009.07.033

Todd, A. S., MacGinley, R. J., Schollum, J. B. W., Johnson, R. J., Williams, S. M., Sutherland, W. H. F., Mann, J. I., & Walker, R. J. (2010). Dietary salt loading impairs arterial vascular reactivity. American Journal of Clinical Nutrition, 91(3), 557-564. doi: 10.3945/ajcn.2009.28645

Yoga, R., Theis, J.-C., Walton, M., & Sutherland, W. (2009). Interleukin-6 as an early marker for fat embolism. Journal of Orthopaedic Surgery & Research, 4. doi: 10.1186/1749-799X-4-18

Manning, P. J., Sutherland, W. H. F., Walker, R. J., Williams, S. M., de Jong, S. A., & Berry, E. A. (2008). The effect of rosiglitazone on oxidative stress and insulin resistance in overweight individuals. Diabetes Research & Clinical Practice, 81, 209-215.

Manning, P. J., Sutherland, W. H. F., Walker, R. J., de Jong, S. A., & Berry, E. A. (2008). The effect of glucose ingestion on inflammation and oxidative stress in obese individuals. Metabolism, 57, 1345-1349.

Manning, P. J., Sutherland, W. H. F., McGrath, M. M., de Jong, S. A., Walker, R. J., & Williams, M. J. A. (2008). Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity, 16(9), 2046-2052. doi: 10.1038/oby.2008.334

Sutherland, W. H., Williams, M. J., & de Jong, S. A. (2007). Plasma protein lipofuscin-like fluorophores in men with coronary artery disease treated with statins. Archives of Medical Research, 38, 757-763.

Sutherland, W. H. F., Manning, P. J., Walker, R. J., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2007). Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity, 15(2), 386-391. doi: 10.1038/oby.2007.546

Kerr, P. G., Sutherland, W. H. F., de Jong, S., Vaithalingham, I., Williams, S. M., & Walker, R. J. (2007). The impact of standard high-flux polysulfone versus novel high-flux polysulfone dialysis membranes on inflammatory markers: A randomized, single-blinded, controlled clinical trial. American Journal of Kidney Diseases, 49(4), 533-539. doi: 10.1053/j.ajkd.2006.12.019

Sutherland, W. H. F., Williams, M. J. A., de Jong, S. A., & McCormick, M. P. (2007). Ingestion of moderately thermally oxidized polyunsaturated fat decreases serum resistance to oxidation in men with coronary artery disease. Nutrition Research, 27, 265-272. doi: 10.1016/j.nutres.2006.12.014

Sutherland, W. H. F., de Jong, S. A., & Walker, R. J. (2007). Effect of dietary cholesterol and fat on cell cholesterol transfer to postprandial plasma in hyperlipidemic men. Lipids, 42, 901-911. doi: 10.1007/s11745-007-3101-1

Aitken, W. A. E., Chisholm, A. W.-A. H., Duncan, A. W., Harper, M. J., Humphries, S. E., Mann, J. I., Skeaff, C. M., Sutherland, W. H. F., Wallace, A. J., & Williams, S. M. (2006). Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat. Nutrition, Metabolism & Cardiovascular Diseases, 16(5), 353-363. doi: 10.1016/j.numecd.2005.06.007

Williams, M. J., Sutherland, W. H., McCormick, M. P., Yeoman, D. J., & de Jong, S. A. (2005). Aged garlic extract improves endothelial function in men with coronary artery disease. Phytotherapy Research, 19(4), 314-319.

Sutherland, W. H. F., de Jong, S. A., & Walker, R. J. (2005). Hypochlorous acid and 3,4-dihydroxyphenylalanine increase the formation of serum protein lipofuscin-like fluorophores in vitro. Renal Failure, 27, 239-246.

Whelan, A. P., Sutherland, W. H. F., McCormick, M. P., Yeoman, D. J., de Jong, S. A., & Williams, M. J. A. (2004). Effects of white and red wine on endothelial function in subjects with coronary artery disease. Internal Medicine Journal, 34, 224-228.

Walker, R. J., Sutherland, W. H., & De Jong, S. A. (2004). Effect of changing from a cellulose acetate to a polysulphone dialysis membrane on protein oxidation and inflammation markers. Clinical Nephrology, 61(3), 198-206. doi: 10.5414/CNP61198

Manning, P. J., Sutherland, W. H., Walker, R. J., Williams, S. M., de Jong, S. A., Ryalls, A. R., & Berry, E. A. (2004). Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects. Diabetes Care, 27(9), 2166-2171.

Manning, P. J., Sutherland, W. H., Hendry, G., de Jong, S. A., McGrath, M., & Williams, S. M. (2004). Changes in circulating postprandial proinflammatory cytokine concentrations in diet-controlled type 2 diabetes and the effect of ingested fat. Diabetes Care, 27(10), 2509-2511.

Williams, M. J. A., Sutherland, W. H. F., Whelan, A. P., McCormick, M. P., & de Jong, S. A. (2004). Acute effect of drinking red and white wines on circulating levels of inflammation-sensitive molecules in men with coronary artery disease. Metabolism, 53(3), 318-323.

Sutherland, W. H. F., de Jong, S. A., & Walker, R. J. (2004). Hypochlorous acid and low serum paraoxonase activity in haemodialysis patients: An in vitro study. Nephrology Dialysis Transplantation, 19(1), 75-82.

Manning, P. J., Sutherland, W. H. F., Allum, A. R., de Jong, S. A., & Jones, S. (2003). HRT does not improve urinary albumen excretion in postmenopausal diabetic women. Diabetes Research & Clinical Practice, 60(1), 33-39.

Sutherland, W. H. F., Gieseg, S. P., Walker, R. J., de Jong, S. A., Firth, C. A., & Scott, N. (2003). Serum protein-bound 3,4-dihydroxyphenylalanine and related products of protein oxidation and chronic hemodialysis. Renal Failure, 25(6), 997-1009.

Sutherland, W. H. F., de Jong, S. A., Walker, R. J., Williams, M. J. A., Skeaff, C. M., Duncan, A., & Harper, M. J. (2002). Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis, 160, 195-203.

Sutherland, W. H. F., De Jong, S. A., Walker, R. J., Williams, M. J. A., Skeaff, C. M., Duncan, A., & Harper, M. J. (2002). Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis, 160, 195-203.

Sutherland, W. H. F., de Jong, S. A., Walker, R. J., & Williams, S. M. (2002). Release of cholesterol from cell membranes to postprandial plasma from mildly hypercholesterolemic subjects: The effect of meals rich in olive and safflower oils. Metabolism, 51(10), 1306-1312.

Manning, P. J., Sutherland, W. H. F., Allum, A. R., de Jong, S. A., & Jones, S. D. (2002). The effect of hormone replacement therapy on inflammation-sensitive proteins in post-menopausal women with Type 2 diabetes. Diabetic Medicine, 19(10), 847-852. doi: 10.1046/j.1464-5491.2002.00808.x

Sutherland, W. H. F., Walker, R. J., De Jong, S. A., & Williams, S. M. (2002). Release of cholesterol from cell membranes to postprandial plasma from mildly hypercholesterolemic subjects: the effect of meals rich in olive and safflower oils. Metabolism, 51(10), 1306-1312.

Wallace, A. J., Sutherland, W. H. F., Mann, J., & Williams, S. M. (2001). The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxanase activity in patients with diabetes. European Journal of Clinical Nutrition, 55, 951-958.

Manning, P. J., Allum, A., Jones, S., Sutherland, W. H. F., & Williams, S. M. (2001). The effect of hormone replacement therapy on cardiovascular risk factors in type 2 diabetes: A randomised controlled trial. Archives of Internal Medicine, 161, 1772-1776.

Walker, R. J., Lewis-Barned, N. J., Sutherland, W. H. F., Goulding, A., Edwards, E. A., de Jong, S. A., Gold, E. J., & Walker, H. (2001). The effects of sequential combined oral 17β-estradiol-Norethisterone acetate on insulin sensitivity and body composition in healthy postmenopausal women: A randomized single blind placebo-controlled study. Menopause, 8, 27-32.

Williams, M. J. A., Sutherland, W. H. F., McCormick, M., Yeoman, D., de Jong, S. A., & Walker, R. J. (2001). Normal endothelial function after meals rich in olive or safflower oil previously used for deep frying. Nutrition, Metabolism & Cardiovascular Diseases, 11, 147-152.

Sutherland, W. H., Manning, P. J., de Jong, S. A., Allum, A. R., Jones, S. D., & Williams, S. M. (2001). Hormone replacement therapy increases serum paraoxonase arylesterase activity in diabetic postmenopausal women. Metabolism, 50, 319-324.

Williams, M. J. A., Sutherland, W. H. F., McCormick, M., de Jong, S. A., McDonald, J. R., & Walker, R. J. (2001). Vitamin C improves endothelial dysfunction in renal allograft recipients. Nephrology Dialysis Transplantation, 16, 1251-1255.

Upritchard, J., Sutherland, W. H. F., & Mann, J. (2000). Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care, 23, 733-738.

Wallace, A. J., Humphries, S. E., Fisher, R. M., Mann, J., Chisholm, A., & Sutherland, W. H. F. (2000). Genetic factors associated with response of LDL subfractions to change in the nature of dietary fat. Atherosclerosis, 149, 387-394.

Lewis-Barned, N. J., Sutherland, W. H. F., Walker, R. J., de Jong, S. A., Walker, H. L., Edwards, E. A., Markham, V. H., & Goulding, A. (2000). Plasma cholesterol ester fatty acid composition, insulin sensitivity, the menopause and hormone replacement therapy. Journal of Endocrinology, 165, 649-655.

Wallace, A. J., Mann, J. I., Sutherland, W. H. F., Williams, S., Chisholm, A., Skeaff, C. M., … Humphries, S. E. (2000). Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change. Atherosclerosis, 152(2), 327-336. doi: 10.1016/S0021-9150(99)00490-6

Wallace, A. J., Mann, J., Sutherland, W. H. F., Williams, S. M., Chisholm, A., & Skeaff, C. M. (1999). Variation in plasma cholesterol response to dietary change. Nutrition, Metabolism & Cardiovascular Diseases, 9, 176-183.

Sutherland, W. H. F., Williams, M. J. A., Nye, E. R., Restieaux, N. J., de Jong, S. A., & Walker, H. (1999). Associations of plasma noncholesterol sterol levels with severity of coronary artery disease. Nutrition, Metabolism & Cardiovascular Diseases, 8, 386-391.

Williams, M. J., Sutherland, W. H. F., McCormick, M. P., de Jong, S. A., Walker, R. J., & Wilkins, G. T. (1999). Impaired endothelial function after a meal rich in used cooking fat. JACC, 33, 1050-1055.

Sutherland, W. H. F., Walker, R. J., de Jong, S. A., & Upritchard, J. E. (1999). Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low density lipoproteins from renal transplant recipients. Clinical Nephrology, 52, 30-36.

Sutherland, W. H. F., Walker, R. J., de Jong, S. A., van Rij, A. M., Phillips, L. V., & Walker, H. (1999). Reduced postprandial serum paraoxonase activity after a meal rich in used cooking fat. Arteriosclerosis, Thrombosis, & Vascular Biology, 19, 1340-1347.

Lewis-Barned, N. J., Sutherland, W. H. F., Walker, R. J., Walker, H. L., de Jong, S. A., Edwards, E. A., & Markham, V. H. (1999). Plasma cholesteryl esterification and transfer, the menopause and hormone replacement therapy in women. Journal of Clinical Endocrinology & Metabolism, 84, 3534-3538.

Upritchard, J. E., & Sutherland, W. H. F. (1999). Oxidation of heparin-treated low density lipoprotein by peroxidases. Atherosclerosis, 146, 211-219.

Sutherland, W. H. F., Restieaux, N. J., Nye, E. R., Williams, M. J. A., de Jong, S. A., Robertson, M. C., & Walker, H. (1998). IDL composition and angiographically determined progression of atherosclerotic lesions during simvastin therapy. Arteriosclerosis, Thrombosis, & Vascular Biology, 18, 577-583.

Sutherland, W. H., Walker, H. L., & Ball, M. J. (1998). Cholesteryl ester transfer during posprandial lipemia: the effect of the type of fat in the meal. Nutrition, Metabolism & Cardiovascular Diseases, 8(1), 13-20.

Chisholm, A., Mann, J., Skeaff, M., Frampton, C., Sutherland, W., Duncan, A., & Tiszavari, S. (1998). A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. European Journal of Clinical Nutrition, 52, 12-16.

Cox, C. M., Sutherland, W., Mann, J., de Jong, S., Chisholm, A., & Skeaff, M. (1998). Effects of dietary coconut oil, butter and safflower oil on plasma lipids, lipoproteins and lathosterol levels. European Journal of Clinical Nutrition, 52, 650-654.

Manning, P. J., Sutherland, W. H. F., & Mann, J. (1997). Late diagnosis of diabetic ketoacidosis and underlying disease influence response to treatment. British Medical Journal, 314, 63.

Walker, R. J., Sutherland, W. H. F., Walker, H. L., MacMahon, S., & Robson, R. A. (1997). Effect of treatment with simvastatin on serum cholesteryl ester transfer in patients on dialysis. Nephrology Dialysis Transplantation, 12(1), 87-92. doi: 10.1093/ndt/12.1.87

Manning, P. J., Sutherland, W. H. F., & Mann, J. (1997). Hyperchylomicronaemia might have resolved anyway. British Medical Journal, 314, 65.

Sutherland, W. H., Ball, M. J., & Walker, H. (1997). The effect of increased egg consumption on plasma cholesteryl ester transfer activity in healthy subjects. European Journal of Clinical Nutrition, 51(3), 172-176.

Chisholm, A., Mann, J., Sutherland, W., Duncan, A., Skeaff, M., & Frampton, C. (1996). Effect on lipoprotein profile of replacing butter with margarine in a low fat diet: Randomised crossover study with hypercholesterolaemic subjects. British Medical Journal, 312(7036), 931-934. doi: 10.1136/bmj.312.7036.931

Humphries, S. E., Talmud, P. J., Cox, C. M., Sutherland, W. H., & Mann, J. (1996). Genetic factors affecting the consistency and magnitude of changes in plasma cholesterol in response to dietary challenge. QJM, 89, 671-680.

Cox, C. M., Sutherland, W. H., Ball, M. J., & Mann, J. (1996). Response of plasma lathosterol concentration to change in the quality of dietary fat in men and women. European Journal of Clinical Nutrition, 50, 358-363.

Nishizawa, M., Sutherland, W. H., & Nukada, H. (1995). Gosha-jinki-gan (herbal medicine) in streptozocin-induced diabetic neuropathy. Journal of the Neurological Sciences, 132, 177-181.

Sanderson, K. J., van Rij, A. M., Wade, C. R., & Sutherland, W. H. F. (1995). Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease. Atherosclerosis, 118, 45-51.

Cox, C. M., Mann, J., Sutherland, W. H., & Ball, M. J. (1995). Individual variation in plasma cholesterol response to dietary saturated fat. British Medical Journal, 311, 1260-1264.

Sanderson, K. J., van Rij, A. M., Wade, C. R., & Sutherland, W. H. (1995). Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease. Atherosclerosis, 118, 45-51.

Sutherland, W. H. F., Shilton, M. E., Nye, E. R., Gillies, M. E., Bakini, I., & Robertson, M. C. (1995). Urban/rural differences in red blood cell fatty acid composition, plasma lipids and diet in Melanesian Fijians. European Journal of Clinical Nutrition, 49, 233-241.

^ Top of page

Journal - Research Other

Manning, P. J., Sutherland, W. H. F., & Walker, R. J. (2005). Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects [Response to Vale]. Diabetes Care, 28(1), 230-231.

More publications...