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Otago Medical School staff profiles

Dr Kate N Thomas

PositionLecturer
DepartmentDepartment of Surgical Sciences (DSM)
QualificationsPhD BSc PGDipSM DMU (Vascular)
Research summaryExercise physiology and prescription, heat therapy, peripheral arterial disease

Research

  • Exercise physiology and prescription
  • Environmental stress
  • Heat therapy
  • Peripheral arterial disease
  • Venous disease
  • Ultrasound imaging for vascular diseases

Publications

Akerman, A. P., Thomas, K. N., van Rij, A. M., Body, E. D., Alfadhel, M., & Cotter, J. D. (2019). Heat therapy vs. supervised exercise therapy for peripheral arterial disease: A 12-week randomized, controlled trial. American Journal of Physiology: Heart & Circulatory Physiology. Advance online publication. doi: 10.1152/ajpheart.00151.2019

De Freitas, S., Hicks, C. W., Mouton, R., Garcia, S., Healy, D., Connolly, C., Thomas, K. N., & Walsh, S. R. (2019). Effects of ischemic preconditioning on abdominal aortic aneurysm repair: A systematic review and meta-analysis. Journal of Surgical Research, 235, 340-349. doi: 10.1016/j.jss.2018.09.049

Lucas, R. A. I., Wilson, L. C., Ainslie, P. N., Fan, J. L., Thomas, K. N., & Cotter, J. D. (2018). Independent and interactive effects of incremental heat strain, orthostatic stress, and mild hypohydration on cerebral perfusion. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 314(3), R415-R426. doi: 10.1152/ajpregu.00109.2017

Govind, D., Thomas, K. N., Hill, B. G., & van Rij, A. M. (2018). Microvenous reflux in the skin of limbs with superficial venous incompetence. Ultrasound in Medicine & Biology, 44(4), 756-761. doi: 10.1016/j.ultrasmedbio.2017.11.014

Millen, R. N., Thomas, K. N., Majumder, A., Hill, B. G., van Rij, A. M., & Krysa, J. (2018). Accuracy and repeatability of the Dopplex Ability. Expert Review of Medical Devices, 15(3), 247-251. doi: 10.1080/17434440.2018.1431121

Journal - Research Article

Akerman, A. P., Thomas, K. N., van Rij, A. M., Body, E. D., Alfadhel, M., & Cotter, J. D. (2019). Heat therapy vs. supervised exercise therapy for peripheral arterial disease: A 12-week randomized, controlled trial. American Journal of Physiology: Heart & Circulatory Physiology. Advance online publication. doi: 10.1152/ajpheart.00151.2019

De Freitas, S., Hicks, C. W., Mouton, R., Garcia, S., Healy, D., Connolly, C., Thomas, K. N., & Walsh, S. R. (2019). Effects of ischemic preconditioning on abdominal aortic aneurysm repair: A systematic review and meta-analysis. Journal of Surgical Research, 235, 340-349. doi: 10.1016/j.jss.2018.09.049

Lucas, R. A. I., Wilson, L. C., Ainslie, P. N., Fan, J. L., Thomas, K. N., & Cotter, J. D. (2018). Independent and interactive effects of incremental heat strain, orthostatic stress, and mild hypohydration on cerebral perfusion. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 314(3), R415-R426. doi: 10.1152/ajpregu.00109.2017

Millen, R. N., Thomas, K. N., Majumder, A., Hill, B. G., van Rij, A. M., & Krysa, J. (2018). Accuracy and repeatability of the Dopplex Ability. Expert Review of Medical Devices, 15(3), 247-251. doi: 10.1080/17434440.2018.1431121

Govind, D., Thomas, K. N., Hill, B. G., & van Rij, A. M. (2018). Microvenous reflux in the skin of limbs with superficial venous incompetence. Ultrasound in Medicine & Biology, 44(4), 756-761. doi: 10.1016/j.ultrasmedbio.2017.11.014

Thomas, K. N., van Rij, A. M., Lucas, S. J. E., & Cotter, J. D. (2017). Lower-limb hot-water immersion acutely induces beneficial hemodynamic and cardiovascular responses in peripheral arterial disease and healthy, elderly controls. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 312(3), R281-R291. doi: 10.1152/ajpregu.00404.2016

Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Repeated episodes of remote ischemic preconditioning for the prevention of myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(3), 140-146. doi: 10.1177/1538574416639150

Thomas, K. N., Cotter, J. D., Williams, M. J. A., & van Rij, A. M. (2016). Diagnosis, incidence, and clinical implications of perioperative myocardial injury in vascular surgery. Vascular & Endovascular Surgery, 50(4), 247-255. doi: 10.1177/1538574416637441

Graham, M. J., Lucas, S. J. E., Francois, M. E., Stavrianeas, S., Parr, E. B., Thomas, K. N., & Cotter, J. D. (2016). Low-volume intense exercise elicits post-exercise hypotension and subsequent hypervolemia, irrespective of which limbs are exercised. Frontiers in Physiology, 7, 199. doi: 10.3389/fphys.2016.00199

Thomas, K. N., van Rij, A. M., Lucas, S. J. E., Gray, A. R., & Cotter, J. D. (2016). Substantive hemodynamic and thermal strain upon completing lower-limb hot-water immersion: Comparisons with treadmill running. Temperature, 3(2), 286-297. doi: 10.1080/23328940.2016.1156215

Thomas, K. N., Lewis, N. C. S., Hill, B. G., & Ainslie, P. N. (2015). Technical recommendations for the use of carotid duplex ultrasound for the assessment of extracranial blood flow. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 309(7), R707-R720. doi: 10.1152/ajpregu.00211.2015

Hoiland, R. L., Foster, B. H. K., Donnelly, J., Stembridge, M., Willie, C. K., Smith, K., … Lucas, S. J. E., Cotter, J. D., Yeoman, D. J., Thomas, K. N., … Ainslie, P. N. (2015). Chemoreceptor responsiveness at sea level does not predict the pulmonary pressure response to high altitude. Chest, 148(1), 219-225. doi: 10.1378/chest.14-1992

Mündel, T., Perry, B. G., Ainslie, P. N., Thomas, K. N., Sikken, E. L. G., Cotter, J. D., & Lucas, S. J. E. (2015). Post-exercise orthostatic intolerance: Influence of exercise intensity. Experimental Physiology, 100(8), 915-925. doi: 10.1113/ep085143

Thomas, K. N., Cotter, J. D., Lucas, S. J. E., Hill, B. G., & van Rij, A. M. (2015). Reliability of contrast-enhanced ultrasound for the assessment of muscle perfusion in health and peripheral arterial disease. Ultrasound in Medicine & Biology, 41(1), 26-34. doi: 10.1016/j.ultrasmedbio.2014.06.012

Perry, B. G., Lucas, S. J. E., Thomas, K. N., Cochrane, D. J., & Mündel, T. (2014). The effect of hypercapnia on static cerebral autoregulation. Physiological Reports, 2(6), e12059. doi: 10.14814/phy2.12059

Burgess, K. R., Lucas, S. J. E., Shepherd, K., Dawson, A., Swart, M., Thomas, K. N., Lucas, R. A. I., Donnelly, J., Peebles, K. C., … Ainslie, P. N. (2014). Influence of cerebral blood flow on central sleep apnea at high altitude. Sleep, 37(10), 1679-1687. doi: 10.5665/sleep.4080

Lucas, S. J. E., Lewis, N. C. S., Sikken, E. L. G., Thomas, K. N., & Ainslie, P. N. (2013). Slow breathing as a means to improve orthostatic tolerance: A randomized sham-controlled trial. Journal of Applied Physiology, 115(2), 202-211. doi: 10.1152/japplphysiol.00128.2013

Burgess, K. R., Lucas, S. J. E., Shepherd, K., Dawson, A., Swart, M., Thomas, K. N., Lucas, R. A. I., Donnelly, J., Peebles, K. C., … Ainslie, P. N. (2013). Worsening of central sleep apnea at high altitude: A role for cerebrovascular function. Journal of Applied Physiology, 114(8), 1021-1028. doi: 10.1152/japplphysiol.01462.2012

Murrell, C. J., Cotter, J. D., Thomas, K. N., Lucas, S. J. E., Williams, M. J. A., & Ainslie, P. N. (2013). Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training. Age, 35(3), 905-920. doi: 10.1007/s11357-012-9414-x

Lucas, S. J. E., Ainslie, P. N., Murrell, C. J., Thomas, K. N., Franz, E. A., & Cotter, J. D. (2012). Effect of age on exercise-induced alterations in cognitive executive function: Relationship to cerebral perfusion. Experimental Gerontology, 47(8), 541-551. doi: 10.1016/j.exger.2011.12.002

Ainslie, P. N., Lucas, S. J. E., Fan, J.-L., Thomas, K. N., Cotter, J. D., Tzeng, Y. C., & Burgess, K. R. (2012). Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. Journal of Applied Physiology, 113(7), 1058-1067. doi: 10.1152/japplphysiol.00463.2012

Fan, J.-L., Burgess, K. R., Thomas, K. N., Lucas, S. J. E., Cotter, J. D., Kayser, B., Peebles, K. C., & Ainslie, P. N. (2012). Effects of acetazolamide on cerebrovascular function and breathing stability at 5050m. Journal of Physiology, 590(5), 1213-1225. doi: 10.1113/jphysiol.2011.219923

Lucas, S. J. E., Burgess, K. R., Thomas, K. N., Donnelly, J., Peebles, K. C., Lucas, R. A. I., Fan, J.-L., Cotter, J. D., … Ainslie, P. N. (2011). Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. Journal of Physiology, 589(3), 741-753. doi: 10.1113/jphysiol.2010.192534

Donnelly, J., Lucas, S. J. E., Thomas, K. N., Galvin, S. D., & Ainslie, P. N. (2011). Profound hyperventilation and development of periodic breathing during exceptional orthostatic stress in a 21-year-old man. Respiratory Physiology & Neurobiology, 177(1), 66-70. doi: 10.1016/j.resp.2011.02.012

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology, 111(3), 469-476. doi: 10.1007/s00421-010-1671-8

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt I: Influence of age and training status. Experimental Gerontology, 46(1), 9-17. doi: 10.1016/j.exger.2010.06.005

Fan, J.-L., Burgess, K. R., Thomas, K. N., Peebles, K. C., Lucas, S. J. E., Lucas, R. A. I., Cotter, J. D., & Ainslie, P. N. (2011). Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia. European Journal of Applied Physiology, 111(4), 601-610. doi: 10.1007/s00421-010-1679-0

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt II: Influence of age, training status and acute exercise. Experimental Gerontology, 46(1), 1-8. doi: 10.1016/j.exger.2010.06.004

Donnelly, J., Cowan, D. C., Yeoman, D. J., Lucas, S. J. E., Herbison, G. P., Thomas, K. N., Ainslie, P. N., & Taylor, D. R. (2011). Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude. Respiratory Physiology & Neurobiology, 177(3), 213-217. doi: 10.1016/j.resp.2011.04.008

Thomas, K. N., Burgess, K. R., Basnyat, R., Lucas, S. J. E., Cotter, J. D., Fan, J.-L., Peebles, K. C., Lucas, R. A. I., & Ainslie, P. N. (2010). Initial orthostatic hypotension at high altitude. High Altitude Medicine & Biology, 11(2), 163-167. doi: 10.1089/ham.2009.1056

Galvin, S. D., Celi, L. A., Thomas, K. N., Clendon, T. R., Galvin, I. F., Bunton, R. W., & Ainslie, P. N. (2010). Effects of age and coronary artery disease on cerebrovascular reactivity to carbon dioxide in humans. Anaesthesia & Intensive Care, 38(4), 710-717.

Cowan, D. C., Hewitt, R. S., Cowan, J. O., Palmay, R., Williamson, A., Lucas, S. J. E., Murrell, C. J., Thomas, K. N., & Taylor, D. R. (2010). Exercise-induced wheeze: Fraction of exhaled nitric oxide-directed management. Respirology, 15, 683-690. doi: 10.1111/j.1440-1843.2010.01740.x

Burgess, K. R., Fan, J.-L., Peebles, K., Thomas, K., Lucas, S., Lucas, R., … Swart, M., … Ainslie, P. (2010). Exacerbation of obstructive sleep apnea by oral indomethacin. Chest, 137(3), 707-710. doi: 10.1378/chest.09-1329

Fan, J.-L., Burgess, K. R., Thomas, K. N., Peebles, K. C., Lucas, S. J. E., Lucas, R. A. I., Cotter, J. D., & Ainslie, P. N. (2010). Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: The influence of PCO2 gradients. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 298, 1648-1658. doi: 10.1152/ajpregu.00721.2009

Lucas, R. A. I., Ainslie, P. N., Fan, J.-L., Wilson, L. C., Thomas, K. N., & Cotter, J. D. (2010). Skin cooling aids cerebrovascular function more effectively under severe than moderate heat stress. European Journal of Applied Physiology, 109, 101-108. doi: 10.1007/s00421-009-1298-9

Fan, J.-L., Burgess, K. R., Basnyat, R., Thomas, K. N., Peebles, K. C., Lucas, S. J., Lucas, R. A., Donnelly, J., Cotter, J. D., & Ainslie, P. N. (2010). Influence of high altitude on cerebrovascular responsiveness to CO2. Journal of Physiology, 588(3), 539-549. doi: 10.1113/jphysiol.2009.184051

Wilson, L. C., Cotter, J. D., Fan, J.-L., Lucas, R. A. I., Thomas, K. N., & Ainslie, P. N. (2010). Cerebrovascular reactivity and dynamic autoregulation in tetraplegia. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 298, R1035-R1042. doi: 10.1152/ajpregu.00815.2009

Thomas, K. N., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2010). Identical pattern of cerebral hypoperfusion during different types of syncope. Journal of Human Hypertension, 24(7), 458-466. doi: 10.1038/jhh.2009.93

Lucas, S. J. E., Tzeng, Y. C., Galvin, S. D., Thomas, K. N., Ogoh, S., & Ainslie, P. N. (2010). Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension, 55, 698-705. doi: 10.1161/HYPERTENSIONAHA.109.146290

Thomas, K. N., Cotter, J. D., Galvin, S. D., Williams, M. J. A., Willie, C. K., & Ainslie, P. N. (2009). Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects. Journal of Applied Physiology, 107(2), 506-517. doi: 10.1152/japplphysiol.91650.2008

Murrell, C. J., Cotter, J. D., George, K. P., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., … Ainslie, P. N. (2009). Influence of age on syncope following prolonged exercise: Differential responses but similar orthostatic intolerance. Journal of Physiology, 587(24), 5959-5969. doi: 10.1113/jphysiol.2009.179549

Ainslie, P. N., Cotter, J. D., George, K. P., Lucas, S., Murrell, C., Shave, R., Thomas, K. N., Williams, M. J. A., & Atkinson, G. (2008). Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. Journal of Physiology, 586(16), 4005-4010. doi: 10.1113/jphysiol.2008.158279

Fan, J.-L., Cotter, J. D., Lucas, R. A. I., Thomas, K., Wilson, L., & Ainslie, P. N. (2008). Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: Effects of mild hypohydration. Journal of Applied Physiology, 105(2), 433-445.

Peng, T., Ainslie, P. N., Cotter, J. D., Murrell, C., Thomas, K., Williams, M. J. A., … Payne, S. J. (2008). The effects of age on the spontaneous low-frequency oscillations in cerebral and systemic cardiovascular dynamics. Physiological Measurement, 29, 1055-1069.

Peebles, K., Celi, L., McGrattan, K., Murrell, C., Thomas, K., & Ainslie, P. N. (2007). Human cerebrovascular and ventilatory CO2 reactivity to end-tidal, arterial and internal jugular vein PCO2. Journal of Physiology, 584(1), 347-357. doi: 10.1113/jphysiol.2007.137075

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Journal - Research Other

Woodfield, J., Zacharias, M., Wilson, G., Munro, F., Thomas, K., Gray, A., & Baldi, J. (2018). Protocol, and practical challenges, for a randomised controlled trial comparing the impact of high intensity interval training against standard care before major abdominal surgery: Study protocol for a randomised controlled trial. Trials, 19(1), 331. doi: 10.1186/s13063-018-2701-9

Thomas, K. N. (2017). Harnessing heat for health: A clinical application of heat stress. Temperature, 4(3), 208-210. doi: 10.1080/23328940.2017.1317379

Akerman, A. P., Thomas, K. N., & Cotter, J. D. (2016). The effect of hypohydration on endothelial function in healthy adults. European Journal of Nutrition, 55(5), 1989-1990. doi: 10.1007/s00394-016-1249-2

Cotter, J., Bradford, C., Lucas, S., Gerrard, D., Thomas, K., & Button, C. (2016). Immersing in thermal extremes: Hazards and opportunities. New Zealand Physical Educator, 49(1), 29-31.

Francois, M. E., & Thomas, K. N. (2016). Taking the heat out of exercise to improve vascular health [Review]. Journal of Physiology, 594(23), 6811-6812. doi: 10.1113/jp273554

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