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Otago Medical School staff profiles

Professor Andy Mercer

PositionEmeritus Professor
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc PhD (Otago)
Research summaryMolecular virology including virus - host interactions

Research

Professor Mercer 's research concerns characterisation of the immunogenic and pathogenic determinants of orf virus and the development of orf virus as a vaccine vector.

Publications

Lateef, Z., Stuart, G., Jones, N., Mercer, A., Fleming, S., & Wise, L. (2019). The cutaneous inflammatory response to thermal burn injury in a murine model. International Journal of Molecular Sciences, 20(3), 538. doi: 10.3390/ijms20030538

Sharif, S., Ueda, N., Nakatani, Y., Wise, L. M., Clifton, S., Lateef, Z., Mercer, A. A., & Fleming, S. B. (2019). Chemokine-binding proteins encoded by parapoxvirus of red deer of New Zealand display evidence of gene duplication and divergence of ligand specificity. Frontiers in Microbiology, 10, 1421. doi: 10.3389/fmicb.2019.01421

Wise, L. M., Bodaan, C. J., Stuart, G. S., Real, N. C., Lateef, Z., Mercer, A. A., … Theoret, C. L. (2018). Treatment of limb wounds of horses with orf virus IL-10 and VEGF-E accelerates resolution of exuberant granulation tissue, but does not prevent its development. PLoS ONE, 13(5), e0197223. doi: 10.1371/journal.pone.0197223

Wise, L. M., Stuart, G. S., Real, N. C., Fleming, S. B., & Mercer, A. A. (2018). VEGF receptor-2 activation mediated by VEGF-E limits scar tissue formation following cutaneous injury. Advances in Wound Care, 7(8), 283-297. doi: 10.1089/wound.2016.0721

Fleming, S. B., McCaughan, C., Lateef, Z., Dunn, A., Wise, L. M., Real, N. C., & Mercer, A. A. (2017). Deletion of the chemokine binding protein gene from the Parapoxvirus Orf virus reduces virulence and pathogenesis in sheep. Frontiers in Microbiology, 8, 46. doi: 10.3389/fmicb.2017.00046

Edited Book - Research

Mercer, A. A., Schmidt, A., & Weber, O. (Eds.). (2007). Poxviruses. Basel, Switzerland: Birkhäuser, 441p.

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Chapter in Book - Research

Skinner, M. A., Buller, R. M., Damon, I. K., Lefkowitz, E. J., McFadden, G., McInnes, C. J., Mercer, A. A., … Upton, C. (2012). Family: Poxviridae. In A. M. Q. King, M. J. Adams, E. B. Carstens & E. J. Lefkowitz (Eds.), Virus taxonomy: Classification and nomenclature of viruses: Ninth report of the International Committee on Taxonomy of Viruses. (pp. 291-309). San Diego, CA: Elsevier Academic Press.

Mercer, A., & Fleming, S. (2012). Parapoxvirus: Poxviridae, Chordopoxvirinae. In C. Tidona & G. Darai (Eds.), The Springer Index of Viruses. (pp. 1495-1504). New York: Springer. doi: 10.1007/978-0-387-95919-1_244

Fleming, S. B., & Mercer, A. A. (2010). Orf virus. In D. Liu (Ed.), Molecular detection of human viral pathogens. (pp. 1017-1027). CRC Press.

Haig, D., & Mercer, A. A. (2008). Parapoxviruses. In B. W. J. Mahy & M. H. V. van Regenmortel (Eds.), Encyclopedia of virology. (3rd ed.) (pp. 57-63). Elsevier. doi: 10.1016/B978-012374410-4.00461-1

Fleming, S. B., & Mercer, A. A. (2007). Genus Parapoxvirus. In A. A. Mercer, A. Schmidt & O. Weber (Eds.), Poxviruses. (pp. 127-166). Basel, Switzerland: Birkhäuser.

Buller, R. M., Arif, B. M., Black, D. N., Dumbell, K. R., Esposito, J. J., Lefkowitz, E. J., … Mercer, A. A., … Tripathy, D. N. (2005). Family Poxviridae. In C. M. Fauquet, M. A. Mayo, J. Maniloff, U. Desselberger & L. A. Ball (Eds.), Virus taxonomy: Classification and nomenclature of viruses: Eighth report of the International Committee on Taxonomy of Viruses. (pp. 117-133). San Diego, California: Elsevier Academic Press.

Mercer, A., & Fleming, S. (2002). Parapoxviruses. In Springer Index of Viruses. (pp. 896-901). Berlin: Springer Press.

Mercer, A. A., & Haig, D. M. (1999). Parapoxviruses. In A. Granoff & R. G. Webster (Eds.), Encyclopedia of Virology. (pp. 1140-1146). London: Academic Press.

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Journal - Research Article

Lateef, Z., Stuart, G., Jones, N., Mercer, A., Fleming, S., & Wise, L. (2019). The cutaneous inflammatory response to thermal burn injury in a murine model. International Journal of Molecular Sciences, 20(3), 538. doi: 10.3390/ijms20030538

Sharif, S., Ueda, N., Nakatani, Y., Wise, L. M., Clifton, S., Lateef, Z., Mercer, A. A., & Fleming, S. B. (2019). Chemokine-binding proteins encoded by parapoxvirus of red deer of New Zealand display evidence of gene duplication and divergence of ligand specificity. Frontiers in Microbiology, 10, 1421. doi: 10.3389/fmicb.2019.01421

Wise, L. M., Bodaan, C. J., Stuart, G. S., Real, N. C., Lateef, Z., Mercer, A. A., … Theoret, C. L. (2018). Treatment of limb wounds of horses with orf virus IL-10 and VEGF-E accelerates resolution of exuberant granulation tissue, but does not prevent its development. PLoS ONE, 13(5), e0197223. doi: 10.1371/journal.pone.0197223

Wise, L. M., Stuart, G. S., Real, N. C., Fleming, S. B., & Mercer, A. A. (2018). VEGF receptor-2 activation mediated by VEGF-E limits scar tissue formation following cutaneous injury. Advances in Wound Care, 7(8), 283-297. doi: 10.1089/wound.2016.0721

Fleming, S. B., McCaughan, C., Lateef, Z., Dunn, A., Wise, L. M., Real, N. C., & Mercer, A. A. (2017). Deletion of the chemokine binding protein gene from the Parapoxvirus Orf virus reduces virulence and pathogenesis in sheep. Frontiers in Microbiology, 8, 46. doi: 10.3389/fmicb.2017.00046

Chen, D.-Y., Fabrizio, J.-A., Wilkins, S. E., Dave, K. A., Gorman, J. J., Gleadle, J. M., Fleming, S. B., … Mercer, A. A. (2017). Ankyrin repeat proteins of orf virus influence the cellular hypoxia response pathway. Journal of Virology, 91(1), e01430-16. doi: 10.1128/jvi.01430-16

Sharif, S., Nakatani, Y., Wise, L., Corbett, M., Real, N. C., Stuart, G. S., Lateef, Z., Krause, K., Mercer, A. A., & Fleming, S. B. (2016). A broad-spectrum chemokine-binding protein of bovine papular stomatitis virus inhibits neutrophil and monocyte infiltration in inflammatory and wound models of mouse skin. PLoS ONE, 11(12), e0168007. doi: 10.1371/journal.pone.0168007

Bodaan, C. J., Wise, L. M., Wakelin, K. A., Stuart, G. S., Real, N. C., Mercer, A. A., … Theoret, C. (2016). Short-term treatment of equine wounds with orf virus IL-10 and VEGF-E dampens inflammation and promotes repair processes without accelerating closure. Wound Repair & Regeneration, 24(6), 966-980. doi: 10.1111/wrr.12488

Bennett, J. R., Lateef, Z., Fleming, S. B., Mercer, A. A., & Wise, L. M. (2016). Orf virus IL-10 reduces monocyte, dendritic cell and mast cell recruitment to inflamed skin. Virus Research, 213, 230-237. doi: 10.1016/j.virusres.2015.12.015

Wakelin, K. A., Wise, L. M., Bodaan, C. J., Mercer, A. A., Riley, C. B., & Theoret, C. L. (2016). Orf virus interleukin-10 and vascular endothelial growth factor-E modulate gene expression in cultured equine dermal fibroblasts. Veterinary Determatology, 27(5), 434-438. doi: 10.1111/vde.12370

Fleming, S. B., Wise, L. M., & Mercer, A. A. (2015). Molecular genetic analysis of Orf virus: A poxvirus that has adapted to skin. Viruses, 7(3), 1505-1539. doi: 10.3390/v7031505

Lee, S., Chu, H. X., Kim, H. A., Real, N. C., Sharif, S., Fleming, S. B., Mercer, A. A., Wise, L. M., … Sobey, C. G. (2015). Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development. Stroke, 46, 537-544. doi: 10.1161/strokeaha.114.007298

Herbert, M. H., Squire, C. J., & Mercer, A. A. (2015). Poxviral ankyrin proteins. Viruses, 7(2), 709-738. doi: 10.3390/v7020709

Couñago, R. M., Knapp, K. M., Nakatani, Y., Fleming, S. B., Corbett, M., Wise, L. M., Mercer, A. A., & Krause, K. L. (2015). Structures of orf virus chemokine binding protein in complex with host chemokines reveal clues to broad binding specificity. Structure, 23(7), 1199-1213. doi: 10.1016/j.str.2015.04.023

Harvey, R., McCaughan, C., Wise, L. M., Mercer, A. A., & Fleming, S. B. (2015). Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway. Virus Research, 208, 180-188. doi: 10.1016/j.virusres.2015.06.014

Wise, L. M., Stuart, G. S., Real, N. C., Fleming, S. B., & Mercer, A. A. (2014). Orf virus IL-10 accelerates wound healing while limiting inflammation and scarring. Wound Repair & Regeneration, 22(3), 356-367. doi: 10.1111/wrr.12169

Weber, O., Mercer, A. A., Friebe, A., Knolle, P., & Volk, H.-D. (2013). Therapeutic immunomodulation using a virus: The potential of inactivated orf virus. European Journal of Clinical Microbiology & Infectious Diseases, 32, 451-460. doi: 10.1007/s10096-012-1780-x

Paulsen, D., Urban, A., Knorr, A., Hirth-Dietrich, C., Siegling, A., Volk, H.-D., Mercer, A. A., … Weber, O. (2013). Inactivated orf virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models. PLoS ONE, 8(9), e74605. doi: 10.1371/journal.pone.0074605

D'Costa, Z. J., Jolly, C., Androphy, E. J., Mercer, A., Matthews, C. M., & Hibma, M. H. (2012). Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. PLoS ONE, 7(11), e48954. doi: 10.1371/journal.pone.0048954

Dutton, S., Fleming, S. B., Ueda, N., Heath, D. D., Hibma, M. H., & Mercer, A. A. (2012). Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus. Parasite Immunology, 34(6), 312-317. doi: 10.1111/j.1365-3024.2012.01360.x

Rintoul, J. L., Lemay, C. G., Tai, L.-H., Stanford, M. M., Falls, T. J., de Souza, C. T., … Mercer, A. A., … Bell, J. C. (2012). ORFV: A novel oncolytic and immune stimulating Parapoxvirus therapeutic. Molecular Therapy, 20(6), 1148-1157. doi: 10.1038/mt.2011.301

Wise, L. M., Inder, M. K., Real, N. C., Stuart, G. S., Fleming, S. B., & Mercer, A. A. (2012). The vascular endothelial growth factor (VEGF)-E encoded by orf virus regulates keratinocyte proliferation and migration and promotes epidermal regeneration. Cellular Microbiology, 14(9), 1376-1390. doi: 10.1111/j.1462-5822.2012.01802.x

Mo, M., Shahar, S., Fleming, S. B., & Mercer, A. A. (2012). How viruses affect the cell cycle through manipulation of the APC/C. Trends in Microbiology, 20(9), 440-448. doi: 10.1016/j.tim.2012.05.007

Tan, J. L., Ueda, N., Heath, D., Mercer, A. A., & Fleming, S. B. (2012). Development of orf virus as a bifunctional recombinant vaccine: Surface display of Echinococcus granulosus antigen EG95 by fusion to membrane structural proteins. Vaccine, 30(2), 398-406. doi: 10.1016/j.vaccine.2011.10.079

Sonnberg, S., Fleming, S. B., & Mercer, A. A. (2011). Phylogenetic analysis of the large family of poxvirus ankyrin-repeat proteins reveals orthologue groups within and across chordopoxvirus genera. Journal of General Virology, 92(11), 2596-2607. doi: 10.1099/vir.0.033654-0

Cross, M. L., Fleming, S. B., Cowan, P. E., Scobie, S., Whelan, E., Prada, D., Mercer, A. A., & Duckworth, J. A. (2011). Vaccinia virus as a vaccine delivery system for marsupial wildlife. Vaccine, 29(28), 4537-4543. doi: 10.1016/j.vaccine.2011.04.093

Friebe, A., Friederichs, S., Scholz, K., Janssen, U., Scholz, C., Schlapp, T., Mercer, A., … Weber, O. (2011). Characterization of immunostimulatory components of orf virus (parapoxvirus ovis). Journal of General Virology, 92(7), 1571-1584. doi: 10.1099/vir.0.028894-0

Lateef, Z., Baird, M. A., Wise, L. M., Young, S., Mercer, A. A., & Fleming, S. B. (2010). The chemokine binding protein encoded by the poxvirus orf virus inhibits recruitment of dendritic cells to sites of skin inflammation and migration to peripheral lymph nodes. Cellular Microbiology, 12(5), 665-676. doi: 10.1111/j.1462-5822.2009.01425.x

Mo, M., Fleming, S. B., & Mercer, A. A. (2010). Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex. Journal of General Virology, 91, 3010-3015. doi: 10.1099/vir.0.026054-0

Couñago, R. M., Fleming, S. B., Mercer, A. A., & Krause, K. L. (2010). Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae). Acta Crystallographica Section F, F66, 819-823. doi: 10.1107/S1744309110018166

Hautaniemi, M., Ueda, N., Tuimala, J., Mercer, A. A., Lahdenperä, J., & McInnes, C. J. (2010). The genome of pseudocowpoxvirus: Comparison of a reindeer isolate and a reference strain. Journal of General Virology, 91(6), 1560-1576. doi: 10.1099/vir.0.018374-0

Lateef, Z., Baird, M. A., Wise, L. M., Mercer, A. A., & Fleming, S. B. (2009). Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model. Journal of General Virology, 90(6), 1477-1482. doi: 10.1099/vir.0.009589-0

Deane, D., Ueda, N., Wise, L. M., Wood, A. R., Percival, A., Jepson, C., … Fleming, S. B., Mercer, A. A., & McInnes, C. J. (2009). Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins. Journal of General Virology, 90, 970-977. doi: 10.1099/vir.0.006692-0

Chang, S.-J., Hsiao, J.-C., Sonnberg, S., Chiang, C.-T., Yang, M.-H., Tzou, D.-L., Mercer, A. A., & Chang, W. (2009). Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-κB activation by tumor necrosis factor alpha but is independent of its host range function. Journal of Virology, 83(9), 4140-4152. doi: 10.1128/jvi.01835-08

Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1

Sonnberg, S., Fleming, S. B., & Mercer, A. A. (2009). A truncated two-α-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex. Journal of General Virology, 90, 1224-1228. doi: 10.1099/vir.0.009324-0

Tan, J. L., Ueda, N., Mercer, A. A., & Fleming, S. B. (2009). Investigation of orf virus structure and morphogenesis using recombinants expressing FLAG-tagged envelope structural proteins: Evidence for wrapped virus particles and egress from infected cells. Journal of General Virology, 90(3), 614-625. doi: 10.1099/vir.0.005488-0

Mo, M., Fleming, S. B., & Mercer, A. A. (2009). Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11. PNAS, 106(46), 19527-19532. doi: 10.1073/pnas.0905893106

Cébe-Suarez, S., Grünewald, F. S., Jaussi, R., Li, X., Claesson-Welsh, L., Spillmann, D., Mercer, A. A., … Ballmer-Hofer, K. (2008). Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR. FASEB Journal, 22(8), 3078-3086. doi: 10.1096/fj.08-107219

Vijaysri, S., Jentarra, G., Heck, M. C., Mercer, A. A., McInnes, C. J., & Jacobs, B. L. (2008). Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Intra-nasal vaccination. Vaccine, 26(5), 664-676. doi: 10.1016/j.vaccine.2007.11.045

Inder, M. K., Wise, L. M., Fleming, S. B., & Mercer, A. A. (2008). The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1. FEBS Journal, 275(1), 207-217. doi: 10.1111/j.1742-4658.2007.06189.x

Fairley, R. A., Whelan, E. M., Pesavento, P. A., & Mercer, A. A. (2008). Recurrent localised cutaneous parapoxvirus infection in three cats. New Zealand Veterinary Journal, 56(4), 196-201.

Sonnberg, S., Seet, B. T., Pawson, T., Fleming, S. B., & Mercer, A. A. (2008). Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. PNAS, 105(31), 10955-10960. doi: 10.1073/pnas.0802042105

Wise, L. M., Savory, L. J., Dryden, N. H., Whelan, E. M., Fleming, S. B., & Mercer, A. A. (2007). Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin. Virus Research, 128, 115-125.

Wise, L., McCaughan, C., Tan, C. K., Mercer, A. A., & Fleming, S. B. (2007). Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes, but only partially impairs their proliferation. Journal of General Virology, 88, 1677-1682.

Inder, M. K., Ueda, N., Mercer, A. A., Fleming, S. B., & Wise, L. M. (2007). Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2. Journal of General Virology, 88, 781-791.

Dillon, S., Sasagawa, T., Crawford, A., Prestidge, J., Inder, M. K., Jerram, J., Mercer, A. A., & Hibma, M. (2007). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Journal of General Virology, 88, 803-813.

Fleming, S. B., Anderson, I. E., Thomson, J., Deane, D. L., McInnes, C. J., McCaughan, C. A., Mercer, A. A., & Haig, D. M. (2007). Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor. Journal of General Virology, 88, 1922-1927.

Snell, A. E., Graves, S., Kane, R., Ward, V., Slaney, D., Mercer, A., … Weinstein, P. (2007). Pilot testing a genus wide PCR-based system for arbovirus detection in mosquitoes in New Zealand. Weta, 33, 6-13.

Ueda, N., Inder, M. K., Wise, L. M., Fleming, S. B., & Mercer, A. A. (2007). Parapoxvirus of red deer in New Zealand encodes a variant of viral vascular endothelial growth factor. Virus Research, 124, 50-58.

Westphal, D., Ledgerwood, E. C., Hibma, M. H., Fleming, S. B., Whelan, E. M., & Mercer, A. A. (2007). A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus orf virus. Journal of Virology, 81(13), 7178-7188.

Hyun, J.-K., Coulibaly, F., Turner, A. P., Baker, E. N., Mercer, A. A., & Mitra, A. K. (2007). The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses. Journal of Virology, 81(20), 11075-11083.

Chan, A., Baird, M., Mercer, A. A., & Fleming, S. B. (2006). Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10. Journal of General Virology, 87, 3177-3181.

Mercer, A. A., Ueda, N., Friederichs, S.-M., Hofmann, K., Fraser, K. M., Bateman, T., & Fleming, S. B. (2006). Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation. Virus Research, 116, 146-158.

Mercer, A. A., Fleming, S. B., & Ueda, N. (2005). F-box-like domains are present in most poxvirus ankyrin repeat proteins. Virus Genes, 31(2), 127-133.

Tikkanen, M. K., McInnes, C. J., Mercer, A. A., Büttner, M., Tuimala, J., Hirvelä-Koski, V., … Huovilainen, A. (2004). Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus. Journal of General Virology, 85, 1413-1418.

Vijaysri, S., Talasela, L., Mercer, A. A., McInnes, C. J., Jacobs, B. L., & Langland, J. O. (2003). The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo. Virology, 314, 305-314.

Seet, B. T., McCaughan, C. A., Handel, T. M., Mercer, A. A., Brunetti, C., McFadden, G., & Fleming, S. B. (2003). Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. PNAS, 100(25), 15137-15142.

Wise, L., Ueda, N., Dryden, N. H., Fleming, S. B., Caesar, C., Roufail, S., … Mercer, A. A. (2003). Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens. Journal of Biological Chemistry, 278(39), 38004-38014.

Marsland, B. J., Tisdall, D. J., Heath, D. D., & Mercer, A. A. (2003). Construction of a recombinant orf virus that expresses an Echinococcus granulosus vaccine antigen from a novel genomic insertion site. Archives of Virology, 148(3), 555-562. doi: 10.1007/s00705-002-0948-6

Ueda, N., Wise, L., Stacker, S. A., Fleming, S. B., & Mercer, A. A. (2003). Pseudocowpox virus encodes a homolog of vascular endothelial growth factor. Virology, 305, 298-309.

Weber, O., Siegling, A., Friebe, A., Limmer, A., Schlapp, T., Knolle, P., Mercer, A. A., … Volk, H.-D. (2003). Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus. Journal of General Virology, 84, 1843-1852.

Lateef, Z., Fleming, S. B., Halliday, G., Faulkner, L., Mercer, A. A., & Baird, M. A. (2003). Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells. Journal of General Virology, 84, 1101-1109.

Haig, D. M., Thomson, J., McInnes, C. J., McCaughan, C. A., Imlach, W., Mercer, A. A., & Fleming, S. B. (2002). Orf virus immuno-modulation and the host immune response. Veterinary Immunology & Immunopathology, 87(3-4), 395-399.

Imlach, W., McCaughan, C. A., Mercer, A. A., Haig, D. M., & Fleming, S. B. (2002). Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages. Journal of General Virology, 83, 1049-1058.

Mercer, A. A., Wise, L. M., Scagliarini, A., McInnes, C. J., Buttner, M., Rziha, H. J., McCaughan, C. A., Fleming, S. B., Ueda, N., & Nettleton, P. F. (2002). Vascular endothelial growth factors encoded by orf virus show surprising sequence variation but have a conserved, functionally relevant structure. Journal of General Virology, 83, 2845-2855.

Haig, D. M., Thomson, J., McInnes, C. J., Deane, D. L., Anderson, I. E., McCaughan, C. A., Imlach, W., Mercer, A. A., & Fleming, S. B. (2002). A comparison of the anti-inflammatory and immuno-stimulatory activities of orf virus and ovine interleukin-10. Virus Research, 90(1-2), 303-316.

Makinen, T., Veikkola, T., Mustjoki, S., Karpanen, T., Catimel, B., Nice, E., Wise, L. M., Mercer, A. A., … Alitalo, K. (2001). Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO Journal, 20(17), 4762-4773.

Savory, L. J., Stacker, S. A., Fleming, S. B., Niven, B. E., & Mercer, A. A. (2000). Viral vascular endothelial growth factor plays a critical role in orf virus infection. Journal of Virology, 74(22), 10699-10706.

Deane, D., McInnes, C. J., Percival, A., Wood, A. R., Thomson, J., Lear, A., … Fleming, S. B., Mercer, A. A., & Haig, D. M. (2000). Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2. Journal of Virology, 74(3), 1313-1320.

Fleming, S. B., Haig, D. M., Nettleton, P., Reid, H. W., McCaughan, C. A., Wise, L. M., & Mercer, A. (2000). Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus. Virus Genes, 21(1-2), 85-95.

Nettleton, P. F., Gilray, J. A., Reid, H. W., & Mercer, A. A. (2000). Parapoxviruses are strongly inhibited in vitro by cidofovir. Antiviral Research, 48(3), 205-208.

Fleming, S. B., Haig, D. M., Nettleton, P. F., Reid, H. W., McCaughlan, C. A., Wise, L. M., & Mercer, A. A. (2000). Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus, orf virus. Virus Genes, 21(1/2), 85-90.

Wise, L. M., Veikkola, T., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., … Stacker, S. A. (1999). Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. PNAS, 96(6), 3071-3076. doi: 10.1073/pnas.96.6.3071

Housawi, F. M., Roberts, G. M., Gilray, J. A., Pow, I., Reid, H. W., Nettleton, P. F., … Hibma, M. H., & Mercer, A. A. (1998). The reactivity of monoclonal antibodies against orf virus with other parapoxviruses and the identification of a 39 kDa immunodominant protein. Archives of Virology, 143(12), 2289-2303.

Haig, D. M., McInnes, C. J., Thomson, J., Bunyan, A., & Mercer, A. A. (1998). The orf virus OVIFNR gene product is involved in interferon resistance and inhibits an interferon-inducible, dsRNA-dependent kinase. Immunology, 93(3), 335-340.

McInnes, C. J., Wood, A., & Mercer, A. A. (1998). Orf virus encodes a homologue of the vaccinia virus interferon-resistance gene E3L. Virus Genes, 17(2), 107-115.

Haig, D. M., & Mercer, A. A. (1998). Orf. Veterinary Research, 29(3-4), 311-326.

Fleming, S. B., McCaughan, C. A., Andrews, A. E., Nash, A. D., & Mercer, A. A. (1997). A homolog of interleukin-10 is encoded by the poxvirus orf virus. Journal of Virology, 71(6), 4857-4861.

Mercer, A. A., Yirrell, D. L., Whelan, E. M., Nettleton, P. F., Pow, I., Gilray, J. A., … Robinson, A. J. (1997). A novel strategy for determining protective antigens of the parapoxvirus, orf virus. Virology, 229(1), 193-200.

Mercer, A. A., Fleming, S. B., Robinson, A., Nettelton, P., & Reid, H. W. (1997). Molecular genetic analysis of parapoxviruses pathogenic for humans. Archives of Virology, Suppl 13, 25-34.

Haig, D. M., McInnes, C. J., Deane, D., Reid, H. W., & Mercer, A. A. (1997). The immune and inflammatory response to orf virus. Comparative Immunology, Microbiology & Infectious Diseases, 20(3), 197-204.

Haig, D. M., McInnes, C. J., Deane, D., Lear, A., Myatt, N., Reid, H. W., … Lyttle, D. J., & Mercer, A. A. (1996). Cytokines and their inhibitors in orf virus infection. Veterinary Immunology & Immunopathology, 54(1/4), 261-267.

Mercer, A. A., Fraser, K. M., & Esposito, J. J. (1996). Gene homology between orf virus and smallpox variola virus. Virus Genes, 13(2), 175-178.

Mercer, A. A., Green, G., Sullivan, J. T., Robinson, A. J., & Drillien, R. (1996). Location, DNA sequence and transcriptional analysis of the DNA polymerase gene of orf virus. Journal of General Virology, 77, 1563-1568.

Mercer, A. A., Lyttle, D. J., Whelan, E., Fleming, S. B., & Sullivan, J. T. (1995). The establishment of a genetic map of orf virus reveals a pattern of genomic organisation that is highly conserved among divergent poxviruses. Virology, 212, 698-704.

Sullivan, J. T., Fleming, S. B., Robinson, A. J., & Mercer, A. A. (1995). Sequence and transcriptional analysis of a near-terminal region of the orf virus genome. Virus Genes, 11, 21-29.

Fleming, S. B., Lyttle, D. J., Sullivan, J. T., Mercer, A. A., & Robinson, A. J. (1995). Genomic analysis of transposition-deletion variant of orf virus reveals a 3.3 kbp region of non-essential DNA. Journal of General Virology, 76, 2969-2978.

McConnell, M. A., Mercer, A. A., & Tannock, G. W. (1991). Transfer of plasmid pAMβl between members of the normal microflora inhabiting the murine digestive tract and modification of the plasmid in a Lactobacillus reuteri host. Microbial Ecology in Health & Disease, 4(6), 343-355.

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Journal - Research Other

Fairley, R. A., Mercer, A. A., Copland, C. I., Craig, S. M., & Heslip, P. A. (2013). Persistent pseudocowpox virus infection of the skin of a foot in a cat. New Zealand Veterinary Journal, 61(4), 242-243. doi: 10.1080/00480169.2012.757728

Mo, M., Fleming, S. B., & Mercer, A. A. (2010). Changing pace: Viral mimicry of an anaphase promoting complex subunit [Editorial]. Cell Cycle, 9(4), 632-633.

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