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Otago Medical School staff profiles

Associate Professor John Leader

PositionAssociate Professor
DepartmentDepartment of Medicine (Dunedin)
QualificationsBA(Hons)(Cantab) PhD(Bristol)
Research summaryRenal Physiology

Research

Physiology and pathophysiology of water balance, renal function Cryobiology, chironomidae - systematic

Otago Kidney Research

Publications

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., … Walker, R. J., … Coward, R. J. M. (2019). Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. Nature Communications, 10, 403. doi: 10.1038/s41467-018-08235-1

Kalita-De Croft, P., Bedford, J. J., Leader, J. P., & Walker, R. J. (2018). Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, 23(1), 20-30. doi: 10.1111/nep.12929

Marti, H.-P., Jeffs, A., Scherer, A., Leader, J., Leader, C., Bedford, J., & Walker, R. (2016). Renal fibrosis mRNA classifier: Validation in experimental lithium-induced interstitial fibrosis in the rat kidney. PLoS ONE, 11(12), e0168240. doi: 10.1371/journal.pone.0168240

Cairns, S. P., Leader, J. P., Loiselle, D. S., Higgins, A., Lin, W., & Renaud, J.-M. (2015). Extracellular Ca2+-induced force restoration in K+-depressed skeletal muscle of the mouse involves an elevation of [K+]i: Implications for fatigue. Journal of Applied Physiology, 118(6), 662-674. doi: 10.1152/japplphysiol.00705.2013

Weiner, I. D., Leader, J. P., Bedford, J. J., Verlander, J. W., Ellis, G., Kalita, P., Vos, F., de Jong, S., & Walker, R. J. (2014). Effects of chronic lithium administration on renal acid excretion in humans and rats. Physiological Reports, 2(12), e12242. doi: 10.14814/phy2.12242

Chapter in Book - Research

Leader, J. P., & Neufeld, D. (2001). Haemolymph physiology. In L. H. Field (Ed.), Biology of Wetas, King Crickets and their Allies. (pp. 509-517). Oxon, UK: CAB International.

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Journal - Research Article

Hurcombe, J. A., Hartley, P., Lay, A. C., Ni, L., Bedford, J. J., Leader, J. P., … Walker, R. J., … Coward, R. J. M. (2019). Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function. Nature Communications, 10, 403. doi: 10.1038/s41467-018-08235-1

Kalita-De Croft, P., Bedford, J. J., Leader, J. P., & Walker, R. J. (2018). Amiloride modifies the progression of lithium-induced renal interstitial fibrosis. Nephrology, 23(1), 20-30. doi: 10.1111/nep.12929

Marti, H.-P., Jeffs, A., Scherer, A., Leader, J., Leader, C., Bedford, J., & Walker, R. (2016). Renal fibrosis mRNA classifier: Validation in experimental lithium-induced interstitial fibrosis in the rat kidney. PLoS ONE, 11(12), e0168240. doi: 10.1371/journal.pone.0168240

Cairns, S. P., Leader, J. P., Loiselle, D. S., Higgins, A., Lin, W., & Renaud, J.-M. (2015). Extracellular Ca2+-induced force restoration in K+-depressed skeletal muscle of the mouse involves an elevation of [K+]i: Implications for fatigue. Journal of Applied Physiology, 118(6), 662-674. doi: 10.1152/japplphysiol.00705.2013

Weiner, I. D., Leader, J. P., Bedford, J. J., Verlander, J. W., Ellis, G., Kalita, P., Vos, F., de Jong, S., & Walker, R. J. (2014). Effects of chronic lithium administration on renal acid excretion in humans and rats. Physiological Reports, 2(12), e12242. doi: 10.14814/phy2.12242

Walker, R. J., Leader, J. P., Bedford, J. J., Gobe, G., Davis, G., Vos, F. E., deJong, S., & Schollum, J. B. W. (2013). Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium. American Journal of Physiology: Renal Physiology, 304(3), F300-F307. doi: 10.1152/ajprenal.00182.2012

Cairns, S. P., Leader, J. P., & Loiselle, D. S. (2011). Exacerbated potassium-induced paralysis of mouse soleus muscle at 37°C vis-À-vis 25°C: Implications for fatigue. Pflügers Archiv: European Journal of Physiology, 461(4), 469-479. doi: 10.1007/s00424-011-0927-4

Bedford, J. J., Leader, J. P., Jing, R., Walker, L. J., Klein, J. D., Sands, J. M., & Walker, R. J. (2008). Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. American Journal of Physiology: Renal Physiology, 294, F812-F820. doi: 10.1152/ajprenal.00554.2007

Bourke, L., Hodgkinson, I., De Silva, L., & Leader, J. (2008). Chiral photonic film and flake. Optics Express, 16(21), 16889-16894.

Bedford, J. J., Weggery, S., Ellis, G., McDonald, F. J., Joyce, P. R., Leader, J. P., & Walker, R. J. (2008). Lithium-induced nephrogenic diabetes insipidus: Renal effects of amiloride. Clinical Journal of the American Society of Nephrology, 3(5), 1324-1331.

Bedford, J. J., & Leader, J. P. (2007). Organic osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part A, 147, 1047-1052. doi: 10.1016/j.cbpa.2007.03.015

Lowrey, S., De Silva, L., Hodgkinson, I., & Leader, J. (2007). Observation and modeling of polarized light from scarab beetles. Journal of the Optical Society of America A, 24(8), 2418-2425. doi: 10.1364/JOSAA.24.002418

O'Donnell, M. J., & Leader, J. P. (2006). Changes in fluid secretion rate alter net transepithelial transport of MRP2 and P-glycoprotein substrates in Malpighian tubules of Drosophila melanogaster. Archives of Insect Biochemistry & Physiology, 63, 123-134.

Samuelsson, L. M., Bedford, J. J., Smith, R. A. J., & Leader, J. P. (2005). A comparison of the counteracting effects of glycine betaine and TMAO on the activity of RNase A in aqueous urea solution. Comparative Biochemistry & Physiology Part A, 141, 22-28.

Walker, R. J., Weggery, S., Bedford, J. J., McDonald, F. J., Ellis, G., & Leader, J. P. (2005). Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers. Kidney International, 67, 291-294.

Every, S. G., Leader, J. P., Molteno, A. C., Bevin, T. H., & Sanderson, G. (2005). Ultraviolet photography of the in vivo human cornea unmasks the Hudson-Stähli line and physiologic vortex patterns. Investigative Ophthalmology & Visual Science, 46(10), 3616-3622.

De Silva, L., Hodgkinson, I., Murray, P., Wu, Q. H., Arnold, M., Leader, J., & McNaughton, A. (2005). Natural and nanoengineered chiral reflectors: Structural color of manuka beetles and titania coatings. Electromagnetics, 25(5), 391-408. doi: 10.1080/02726340590957399

Leader, J. P., & O'Donnell, M. J. (2005). Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: Confocal microscopic analysis of secreted fluid droplets. Journal of Experimental Biology, 208, 4363-4376.

Al-Dameh, A. O., Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Urinary aquaporin-2 levels in healthy volunteers. Nephrology, 8, 139-141.

Bedford, J. J., Leader, J. P., & Walker, R. J. (2003). Aquaporin expression in normal human kidney and in renal disease. Journal of the American Society of Nephrology, 14, 2581-2587.

Bedford, J. J., Burg, M. B., Peters, E., Smith, R. A. J., & Leader, J. P. (2002). Putative osmolytes in the kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 635-644.

Bedford, J. J., Schofield, J. C., Yancey, P. H., & Leader, J. P. (2002). The effects of hypoosmotic infusion on the composition of renal tissue of the Australian brush-tailed possum Trichosurus vulpecula. Comparative Biochemistry & Physiology Part B, 132, 645-652.

Bedford, J. J., Stanton, J.-A. L., & Leader, J. P. (2001). A taurine transporter isolated from rat cardiac muscle. Advances in Experimental Medicine & Biology, 483, 523-534.

Leader, J. P., & Bedford, J. J. (2000). What happens to an insect when it freezes and does it matter? New Zealand Science Monthly, 11(7), 6-8.

Palmer, H. R., Bedford, J. J., Leader, J. P., & Smith, R. A. J. (2000). 31P and 1H NMR studies of the effect of the counteracting osmolyte trimethylamine-N-oxide on interactions of urea with ribonuclease A. Journal of Biological Chemistry, 275, 27708-27711.

Neufeld, D., & Leader, J. P. (1998). Electrochemical characteristics of ion secretion in Malpighian tubules of the New Zealand alpine weta (Hemideina maori). Journal of Insect Physiology, 44, 39-48.

Neufeld, D., & Leader, J. P. (1998). Cold inhibition of cell volume regulation during the freezing of insect Malpighian tubules. Journal of Experimental Biology, 201, 2195-2204.

Neufeld, D., & Leader, J. P. (1998). Freezing survival by isolated Malpighian tubules of the New Zealand alpine weta, Hemideina maori. Journal of Experimental Biology, 201, 227-236.

Kovbasnjuk, O., Leader, J. P., Weinstein, A. M., & Spring, K. R. (1998). Water does not flow across the tight junctions of MDCK cell epithelium. PNAS, 95, 6526-6530.

Bedford, J. J., Harper, J. L., Leader, J. P., Yancey, P. H., & Smith, R. A. J. (1998). Betaine is the principal counteracting osmolyte in tissues of the elephant fish, Callorhincus millii (Elasmobranchii, Holocephali). Comparative Biochemistry & Physiology Part B, 119(3), 521-526.

Bedford, J. J., Harper, J. L., Leader, J. P., & Smith, R. A. J. (1998). Identification and measurement of methylamines in elasmobranch tissues using proton nuclear magnetic resonance (1H-NMR) spectroscopy. Journal of Comparative Physiology B, 168(2), 123-131.

Biyouki, M. A. A., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1998). Hydroxymethylation and carbamoylation of di- and tetramethylpyridines using radical (Minisci) reactions. Synthetic Communications, 28, 3817-3825.

Harper, J. L., Smith, R. A. J., Bedford, J. J., & Leader, J. P. (1997). Synthesis, acidity and 19F-NMR characteristics of 1-substituted fluoroimidazoles with potential application as probes for intracellular pH determination. Tetrahedron, 53(24), 8211-8224.

Wilson, P. W., & Leader, J. P. (1995). Stabilization of supercooled fluids by thermal hysteresis proteins. Biophysical Journal, 68(5), 2098-2107. doi: 10.1016/S0006-3495(95)80389-9

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