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Molecular characterisation of the Fn14 gene promoter in neoplastic disease

A postgraduate research opportunity at the University of Otago.

Details

Close date
Thursday, 30 April 2020
Academic background
Sciences, Health Sciences
Host campus
Dunedin
Location
On-campus
Qualifications
Honours, Master’s
Department
Pathology (DSM)
Supervisor
Dr Heather Cunliffe

Overview

Fn14 is a member of the Tumour Necrosis Factor receptor superfamily, and aberrant overexpression of Fn14 (TNFRSF12A) is a known driver of malignant behaviour in a variety of cancers.  Mechanisms leading to Fn14 deregulation during malignant progression however, remain unclear. The aim of this project is to molecularly and functionally characterise the promoter of the Fn14 gene in normal vs malignant cells to gain insight into cancer cell mechanisms impacting aberrant Fn14 gene expression.

Contact

Heather Cunliffe
Email   heather.cunliffe@otago.ac.nz