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The contribution of the Delta 133p53 isoform in immune regulations in the development of IBD

A postgraduate research opportunity at the University of Otago.

Details

Close date
Tuesday, 31 March 2020
Academic background
Health Sciences
Host campus
Dunedin
Qualification
Master’s
Department
Pathology (Dunedin)
Supervisors
Dr Kunyu Li, Professor Antony Braithwaite, Dr Tania Slatter

Overview

The p53 and its isoforms have been recently reported to have an immune regulatory function. Our previous studies in both animal and human studies show that one of the p53 isoforms, Δ133p53, had pro-inflammatory properties in immune regulation and tumorigenesis.

This project aims to determine the contribution of the Δ133p53 isoform in the development of IBD. This is a 12-month Second-year Master’s project involving experimental studies using colonic samples from IBD patients and an animal model of colitis.

The student is required to have a strong background in immunology/autoimmunity or IBD. Some knowledge in genetic, pathology and gut biology is desired.

Techniques that required to perform the experimental studies include animal handling, histological analysis, flow cytometry analysis, and PCR analysis. Student who is experienced in these laboratory skills is desired, however, training will be provided.

If you have a passion for medical research and would like to find a better solution for the life-long illness of IBD, please contact us to find out more.

Contact

Kunyu Li
Tel   +64 3 479 7169
Email   kunyu.li@otago.ac.nz