A postgraduate research opportunity at the University of Otago.
- Close date
- Sunday, 31 January 2021
- Academic background
- Health Sciences
- Host campus
- Postgraduate Diploma, Honours, Master’s
- Pathology (Dunedin)
- Dr Kunyu Li, Professor Antony Braithwaite
The p53 was originally known to function as a tumour suppressor gene that prevents cellular transformation and cancer development. Recent studies have shown that the p53 family also plays a regulatory role in the immune response. Our previous studies show that one of its isoforms, namely Δ133p53, has a pro-inflammatory function in both cancer and autoimmune conditions.
This project aims to determine the contribution of Δ133p53 isoform in Inflammatory Bowel Disease (IBD), using both a mouse model of colitis and samples from IBD patients. It includes the experimental study of tissue repairing, recruitment of immune cells, and establishment of chronic inflammation from acute colitis.
Students with substantial knowledge in IBD, inflammation, and immunology, and related laboratory skills/techniques are desired. However, Laboratory training will be provided.
Tel +64 3 479 7169