Exploring microbiome dynamics in host-parasite interactions

Dr Priscila Madi Salloum – Department of Zoology.

The role of the microbiome in host-parasite interactions is only starting to be explored, but considering multi-player relationships instead of the traditional two-player host-parasite dynamics is revolutionising parasitology.

The tight evolutionary correlation between a host’s resistance to parasitism and a parasite’s ability to bypass such resistance may actually be modulated by microbial allies on both sides of this antagonistic relationship. In particular, helminth parasites have a complex life cycle, going through multiple hosts and environments to complete a single generation. Assuming that the success of a helminth parasite leads to the survival of its associated microbes, there may be an evolutionary advantage for microbial partners to team up with parasites to ensure the latter completes its life cycle. Parasites may use elaborate strategies, including manipulating their intermediate host’s behaviour, if that translates into higher chances of finding a definitive host.

In this talk, I will delve into our group’s work on microbiomes in parasitology. I will focus particularly on the bacterial communities associated with helminth parasites – and their potential role in manipulating the phenotype and behaviour of parasitised invertebrate hosts. Understanding the role of the microbiome in host-parasite interactions may offer valuable insight into broader effects of the microbiome in animal ecology and evolution.