2025

Journal - Research Article

Xiong, Z., Yang, X., Wang, S., Smart, C. J., Sisson, H. M., Li, Z., … Jowsey, W. J., Cook, G. M., McNeil, M. B., … Zhang, B. (2025). Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis. Nature Communications, 16(1), 4976. doi: 10.1038/s41467-025-60365-5

Fountain, A. J., Waller, N. J. E., Cheung, C.-Y., Jowsey, W., Chrisp, M. T., Troll, M., … Cook, G. M., McNeil, M. B., & Ramakrishnan, L. (2025). Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity. PNAS, 122(16), e2426827122. doi: 10.1073/pnas.2426827122

Liang, Y., Bueler, S. A., Cook, G. M., & Rubinstein, J. L. (2025). Structure of mycobacterial NDH-2 bound to a 2-mercapto-quinazolinone inhibitor. Journal of Medicinal Chemistry. Advance online publication. doi: 10.1021/acs.jmedchem.5c00049

Di Trania, J. M., Yu, J., Courbon, G. M., Lopez Rodriguez, A. P., Cheung, C.-Y., Liang, Y., … Cook, G. M., … Rubinstein, J. L. (2025). Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria. PNAS, 122(8), e2423761122. doi: 10.1073/pnas.2423761122

Bundutidi, G. M., Mochizuki, K., Matsuo, Y., Hayashishita, M., Sakura, T., Ando, Y., Cook, G. M., … Inaoka, D. K. (2025). Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: Succinate CoA transferase in Mycobacterium smegmatis. Communications Biology, 8, 187. doi: 10.1038/s42003-025-07611-0

Tian, X., Gao, Y., Li, C., Ma, W., Zhang, J., Ju, Y., … Aung, H. L., … Cook, G. M., … Zhang, T. (2025). A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis. Frontiers in Pharmacology, 15, 1400436. doi: 10.3389/fphar.2024.1400436

2024

Journal - Research Article

Wang, X., Jowsey, W. J., Cheung, C.-Y., Smart, C. J., Klaus, H. R., Seeto, N. E. J., Waller, N. J. E., … Fineran, P. C., Cook, G. M., Jackson, S. A., & McNeil, M. B. (2024). Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis. Nature Communications, 15, 9791. doi: 10.1038/s41467-024-54072-w

Adolph, C., Hards, K., Williams, Z. C., Cheung, C.-Y., Keighley, L. M., Jowsey, W. J., Kyte, M., … McNeil, M. B., & Cook, G. M. (2024). Identification of chemical scaffolds that inhibit the Mycobacterium tuberculosis respiratory complex succinate dehydrogenase. ACS Infectious Diseases. Advance online publication. doi: 10.1021/acsinfecdis.3c00655

Tran, E., Cheung, C.-Y., Li, L., Carter, G. P., Gable, R. W., West, N. P., … Cook, G. M., … Jörg, M. (2024). Phenotypic-based discovery and exploration of a resorufin scaffold with activity against Mycobacterium tuberculosis. ChemMedChem. Advance online publication. doi: 10.1002/cmdc.202400482

Pidot, S. J., Klatt, S., Ates, L. S., Frigui, W., Sayes, F., Izumi, H., … Taiaroa, G., Cook, G. M., … Stinear, T. P. (2024). Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus. PLoS Pathogens, 20(8), e1012440. doi: 10.1371/journal.ppat.1012440

Na, T. U., Sander, V., Davidson, A. J., Lin, R., Hermant, Y. O., Hardie Boys, M. T., Pletzer, D., Campbell, G., Ferguson, S. A., Cook, G. M., … Cameron, A. J. (2024). Allenamides as a powerful tool to incorporate diversity: Thia-Michael lipidation of semisynthetic peptides and access to β-ketoamides. Angewandte Chemie International Edition. Advance online publication. doi: 10.1002/anie.202407764

Seitz, C., Ahn, S.-H., Wei, H., Kyte, M., Cook, G. M., Krause, K. L., & McCammon, J. A. (2024). Targeting tuberculosis: Novel scaffolds for inhibiting cytochrome bd oxidase. Journal of Chemical Information & Modeling. Advance online publication. doi: 10.1021/acs.jcim.4c00344

Jowsey, W. J., Cook, G. M., & McNeil, M. B. (2024). Antibiotic resistance in Mycobacterium tuberculosis alters tolerance to cell wall-targeting inhibitors. JAC: Antimicrobial Resistance, 6(3), dlae086. doi: 10.1093/jacamr/dlae086

Palpal-latoc, D., Horsfall, A. J., Cameron, A. J., Campbell, G., Ferguson, S. A., Cook, G. M., … Brimble, M. A. (2024). Synthesis, structure–activity relationship study, bioactivity, and nephrotoxicity evaluation of the proposed structure of the cyclic lipodepsipeptide brevicidine B. Journal of Natural Products. Advance online publication. doi: 10.1021/acs.jnatprod.3c00876

Zhao, Y., Duan, K., Fan, Y., Li, S., Huang, L., Tu, Z., … Cook, G. M., … Li, Z. (2024). Catalyst-free late-stage functionalization to assemble α-acyloxyenamide electrophiles for selectively profiling conserved lysine residues. Communications Chemistry, 7, 31. doi: 10.1038/s42004-024-01107-4

Adolph, C., Cheung, C.-Y., McNeil, M. B., Jowsey, W. J., Williams, Z. C., Hards, K., Harold, L. K., … Tyndall, J. D. A., … Cook, G. M. (2024). A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology, 31(4), 683-698. doi: 10.1016/j.chembiol.2023.12.002

Journal - Research Other

McNeil, M. B., Cook, G. M., & Krause, K. L. (2024). Dual transcriptional inhibition of glutamate and alanine racemase is synergistic in Mycobacterium tuberculosis. Microbiology, 170(8), 001484. doi: 10.1099/mic.0.001484

Cook, G. M., & McNeil, M. B. (2024). Enzyme blueprints will aid tuberculosis drug design. Nature, 631, 278-280. doi: 10.1038/d41586-024-02094-1

Christensen, P., Cinzah, R., Suwanarusk, R., Chua, A. C. Y., Kaneko, O., Kyle, D. E., Aung, H. L., Matheson, J., … Cook, G. M., … Russell, B. (2024). Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax. Antimicrobial Agents & Chemotherapy. Advance online publication. doi: 10.1128/aac.00280-24

2023

Journal - Research Article

Todd Rose, F. O., Darnell, R. L., Morris, S. M., Rose, O. E., Paxie, O., Campbell, G., Cook, G. M., & Gebhard, S. (2023). The two-component system CroRS acts as a master regulator of cell envelope homeostasis to confer antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis. Molecular Microbiology. Advance online publication. doi: 10.1111/mmi.15128

Kalia, N. P., Singh, S., Hards, K., Cheung, C.-Y., Sviriaeva, E., Banaei-Esfahani, A., … Cook, G. M., & Pethe, K. (2023). M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments. Cell Reports, 42, 112444. doi: 10.1016/j.celrep.2023.112444

Waller, N. J. E., Cheung, C.-Y., Cook, G. M., & McNeil, M. B. (2023). The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis. Nature Communications, 14, 1517. doi: 10.1038/s41467-023-37184-7

Grinter, R., Kropp, A., Venugopal, H., Senger, M., Badley, J., Cabotaje, P. R., … Cook, G. M., … Greening, C. (2023). Structural basis for bacterial energy extraction from atmospheric hydrogen. Nature, 615, 541-547. doi: 10.1038/s41586-023-05781-7

Zhou, Y., Shao, M., Wang, W., Cheung, C.-Y., Wu, Y., Yu, H., … Cook, G. M., … Lu, X. (2023). Discovery of 1-hydroxy-2-methylquinolin-4(1H)-one derivatives as new cytochrome bd oxidase inhibitors for tuberculosis therapy. European Journal of Medicinal Chemistry, 245, 114896. doi: 10.1016/j.ejmech.2022.114896

Journal - Research Other

Wang, S., Zhang, J., Adnan Hameed, H. M., Ding, J., Guan, P., Fang, X., … Cook, G. M., … Zhang, T. (2023). Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in mycobacteria [Observation]. Microbiology Spectrum, 11(6). doi: 10.1128/spectrum.02809-23

Conference Contribution - Published proceedings: Abstract

Paxie, O., Darnell, R., Todd Rose, F., Chueng, C.-Y., & Cook, G. (2023). Understanding the functional role of respiratory oxidase enzymes in the bacterial pathogen Enterococcus faecalis. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Tyler, C., Lawer, A., Tyndall, J. D. A., Cook, G. M., & Gamble, A. (2023). Design and synthesis of novel antitubercular inhibitors. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home

van Os, M., Cross, H., Kardailsky, O., Jeunen, G.-J., Collins, C., McDonald, K., Kinaston, R., Vlok, M., Walter, R., Cook, G., Aung, H. L., Matisoo-Smith, L., Buckley, H., & Knapp, M. (2023). The conundrum of related taxa: Detection and authentication of pathogen DNA in bioarchaeological samples from the Pacific. Proceedings of the 1st Australian & New Zealand Environmental DNA (eDNA) Conference: Innovation & Application. Retrieved from https://ednaconference.com.au

Conference Contribution - Verbal presentation and other Conference outputs

Voss, E. M., Williamson, J., McDougall, S., Karkaba, A., Harland, C., Ussher, J. E., Ferguson, S. A., Morales, S. E., Cook, G. M., & Couldrey, C. (2023, August). New Zealand wide genetic and phenotypic characteristics of bovine Staphylococcus aureus isolates. Verbal presentation at the Queenstown Molecular Biology (QMB) Microbiomes Satellite, Queenstown, New Zealand.

2022

Chapter in Book - Research

Darnell, R. L., Paxie, O., Todd Rose, F. O., Morris, S., Krause, A. L., Monk, I. R., Smith, M. J. B., … Cook, G. M., & Gebhard, S. (2022). Antimicrobial tolerance and its role in the development of resistance: Lessons from enterococci. In R. K. Poole & D. J. Kelly (Eds.), Advances in microbial physiology (Vol. 81). (pp. 25-65). London, UK: Elsevier. doi: 10.1016/bs.ampbs.2022.06.004

Journal - Research Article

Harris, P. W. R., Siow, A., Yang, S.-H., Wadsworth, A. D., Tan, L., Hermant, Y., … Ferguson, S. A., Mros, S., Hards, K., Cook, G. M., … Brimble, M. A. (2022). Synthesis, antibacterial activity, and nephrotoxicity of polymyxin B analogues modified at Leu-7, D-Phe-6, and the N-terminus enabled by S-lipidation. ACS Infectious Diseases, 8, 2413-2429. doi: 10.1021/acsinfecdis.1c00347

Fridianto, K. T., Gunawan, G. A., Hards, K., Sarathy, J. P., Cook, G. M., Dick, T., … Lam, Y. (2022). Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria. RSC Medicinal Chemistry, 13, 1605-1613. doi: 10.1039/d2md00251e

Al-Zubaidi, A., Cheung, C.-Y., Cook, G. M., Taiaroa, G., Mizrahi, V., Lott, J. S., & Dawes, S. S. (2022). RNase HI depletion strongly potentiates cell killing by rifampicin in mycobacteria. Antimicrobial Agents & Chemotherapy, 66(10). doi: 10.1128/aac.02091-21

Adnan Hameed, H. M., Fang, C., Liu, Z., Ju, Y., Han, X., Gao, Y., … Cook, G. M., … Zhang, T. (2022). Characterization of genetic variants associated with rifampicin resistance level in Mycobacterium tuberculosis clinical isolates collected in Guangzhou Chest Hospital, China. Infection & Drug Resistance, 15, 5655-5666. doi: 10.2147/IDR.S375869

Lawer, A., Tyler, C., Hards, K., Keighley, L. M., Cheung, C.-Y., Kierek, F., Su, S., … McInnes, T., Tyndall, J. D. A., Krause, K. L., Cook, G. M., & Gamble, A. B. (2022). Synthesis and biological evaluation of aurachin D analogues as inhibitors of Mycobacterium tuberculosis cytochrome bd oxidase. ACS Medicinal Chemistry Letters, 13, 1663-1669. doi: 10.1021/acsmedchemlett.2c00401

Adolph, C., McNeil, M. B., & Cook, G. M. (2022). Impaired succinate oxidation prevents growth and influences drug susceptibility in Mycobacterium tuberculosis. mBio, 13(4). doi: 10.1128/mbio.01672-22

Feng, S., Liang, L., Shen, C., Lin, D., Li, J., Lyu, L., … Cook, G. M., … Tian, G.-b. (2022). A CRISPR-guided mutagenic DNA polymerase strategy for the detection of antibiotic resistant mutations in M. tuberculosis. Molecular Therapy: Nucleic Acids, 29, 354-367. doi: 10.1016/j.omtn.2022.07.004

Allen, W. J., Corey, R. A., Watkins, D. W., Oliveira, A. S. F., Hards, K., Cook, G. M., & Collinson, I. (2022). Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion. eLIFE, 11, e77586. doi: 10.7554/eLife.77586

Christensen, P., Racklyeft, A., Ward, K. E., Matheson, J., Suwanarusk, R., Chua, A. C. Y., … Aung, H. L., … Cook, G. M., … Russell, B. (2022). Improving in vitro continuous cultivation of Plasmodium cynomolgi, a model for P. vivax. Parasitology International, 89, 102589. doi: 10.1016/j.parint.2022.102589

Grant, T. M., Rennison, D., Krause, A. L., Mros, S., Ferguson, S. A., Cook, G. M., … Svenson, J. (2022). Stereochemical effects on the antimicrobial properties of tetrasubstituted 2,5-diketopiperazines. ACS Medicinal Chemistry Letters, 13, 632-640. doi: 10.1021/acsmedchemlett.1c00683

Harold, L. K., Jinich, A., Hards, K., Cordeiro, A., Keighley, L. M., Cross, A., McNeil, M. B., … Cook, G. M. (2022). Deciphering functional redundancy and energetics of malate oxidation in mycobacteria. Journal of Biological Chemistry, 298(5), 101859. doi: 10.1016/j.jbc.2022.101859

Hawkins, P. M. E., Hoi, D. M., Cheung, C.-Y., Wang, T., Quan, D., Sasi, V. M., … Cook, G. M., … Payne, R. J. (2022). Potent bactericidal antimycobacterials targeting the chaperone ClpC1 based on the depsipeptide natural products ecumicin and Ohmyungsamycin A. Journal of Medicinal Chemistry, 65, 4893-4908. doi: 10.1021/acs.jmedchem.1c02122

Cheung, C.-Y., McNeil, M. B., & Cook, G. M. (2022). Utilization of CRISPR interference to investigate the contribution of genes to pathogenesis in a macrophage model of Mycobacterium tuberculosis infection. Journal of Antimicrobial Chemotherapy, 77, 615-619. doi: 10.1093/jac/dkab437

Hards, K., Cheung, C.-Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., … Tyndall, J. D. A., McNeil, M. B., … Opel-Reading, H. K., Krause, K. L., … Berney, M., … Cook, G. M. (2022). An amiloride derivative is active against the F₁F_o-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology, 5, 166. doi: 10.1038/s42003-022-03110-8

McNeil, M. B., Ryburn, H. W., Tirados, J., Cheung, C.-Y., & Cook, G. M. (2022). Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes. iScience, 25(1), 103573. doi: 10.1016/j.isci.2021.103573

Journal - Research Other

Mulholland, C. V., Gimenez, G., Williamson, A., Steele, M., Thorpe, D., Karalus, N., … Cook, G. M., … Aung, H. L. (2022). Complete genome sequence of a New Zealand Mycobacterium tuberculosis strain responsible for ongoing transmission over the past 30 years. Microbiology Resource Announcements, 11(11). doi: 10.1128/mra.00781-22

McNeil, M. B., Cheung, C.-Y., Waller, N. J. E., Adolph, C., Chapman, C. L., Seeto, N. E. J., Jowsey, W., … Cook, G. M. (2022). Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis. Frontiers in Cellular & Infection Microbiology, 12, 980844. doi: 10.3389/fcimb.2022.980844

Conference Contribution - Published proceedings: Abstract

van Os, M., Cross, H., Kardailsky, O., Collins, C., Walter, R., Cook, G., Aung, H. L., Matisoo-Smith, L., Buckley, H., & Knapp, M. (2022). Pathogen hunters: Using ancient DNA to authenticate the presence of Mycobacterium tuberculosis and other microbes in early Polynesian settlers of Aotearoa New Zealand. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

van Os, M., Cross, H., Kardailsky, O., Collins, C., Walter, R., Cook, G., Aung, H. L., Matisoo-Smith, L., Buckley, H., & Knapp, M. (2022). Pathogen hunters: Using ancient DNA to authenticate the presence of Mycobacterium tuberculosis and other microbes in early Polynesian settlers of Aotearoa New Zealand. Proceedings of the New Zealand Archaeological Association (NZAA) Annual Conference. (pp. 39). Retrieved from https://nzarchaeology.org

Conference Contribution - Poster Presentation (not in published proceedings)

Jowsey, W. J., McNeil, M. B., & Cook, G. M. (2022, August). Exploiting metabolic dysregulation to potentiate antibiotic killing of resistant Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Wang, X. Y., Cheung, J., Jackson, S., & Cook, G. M. (2022, August). Metabolic dysregulation in drug-resistant Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Paxie, O., Todd Rose, F., Cheung, J., Cook, G., & Darnell, R. (2022, August). Investigating the functional role respiratory oxidases play in the bacterial pathogen Enterococcus faecalis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Chapman, C. L., McNeil, M. B., & Cook, G. M. (2022, August). Multiplex transcriptional repression to investigate genetic interactions between bioenergetic complexes in Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Smith, M. J. B., Cheung, C. Y., Cook, G. M., & Darnell, R. L. (2022, August). Investigation of antimicrobial tolerance in Enterococcus faecalis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Macbeth, E., Harbison-Price, N., Ferguson, S. A., & Cook, G. M. (2022, August). Disrupting bacterial metal ion homeostasis to break antimicrobial resistance. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Adolph, C. R., Cheung, C.-Y., McNeil, M. B., & Cook, G. M. (2022, August). Exploiting synergistic interactions in energy metabolism to combat drug resistant Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Cheung, C.-Y., & Cook, G. M. (2022, August). Targeting the cytochrome-bd terminal oxidase of Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Waller, N., Cheung, C., McNeil, M., & Cook, G. (2022, August). Drug resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Voss, E. M., Williamson, J., Gatenby, S., Pruden, S., Ling, H., Wallace, A., … Ferguson, S. A., Morales, S., Cook, G. M., & Couldrey, C. (2022, August-September). Genomics of Staphylococcus aureus strains in New Zealand dairy cows. Poster session presented at the 31st Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Tyler, C., Lawer, A., Gamble, A., & Cook, G. (2022, November). Design and synthesis of antitubercular agents. Verbal presentation at the School of Pharmacy Research Day, Dunedin, New Zealand.

Safarian, S., Opel-Reading, H. K., Hards, K., Harold, L. K., Cook, G. M., Krause, K. L., & Michel, H. (2022, August). BD oxidase is a game-changing drug discovery target for tuberculosis. Verbal presentation at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Van Zuylen, E. M., Ferguson, S. A., Hughes, A., Mros, S., Rennison, D., Brimble, M. A., & Cook, G. M. (2022, August). Novel inhibitors for combating obligate anaerobic pathogens. Verbal presentation at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Tran, W., Kusay, A. S., Hawkins, P. M. E., Cheung, C.-Y., Nagalingam, G., Pujari, V., … Cook, G. M., & Britton, W. J. (2021). Synthetic sansanmycin analogues as potent Mycobacterium tuberculosis translocase I inhibitors. Journal of Medicinal Chemistry, 64, 17326-17345. doi: 10.1021/acs.jmedchem.1c01407

Fridianto, K. T., Li, M., Hards, K., Negatu, D. A., Cook, G. M., Dick, T., … Go, M.-L. (2021). Functionalized dioxonaphthoimidazoliums: A redox cycling chemotype with potent bactericidal activities against Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 64, 15991-16007. doi: 10.1021/acs.jmedchem.1c01383

Aung, H. L., Nyunt, W. W., Fong, Y., Biggs, P. J., Winkworth, R. C., Lockhart, P. J., … Hill, P. C., Cook, G. M., & Aung, S. T. (2021). Genomic profiling of Mycobacterium tuberculosis strains, Myanmar. Emerging Infectious Diseases, 27(11), 2847-2855. doi: 10.3201/eid2711.210726.

Wu, Y., Cheung, C.-Y., Zhou, Y., Wang, Z., Tu, Z., Cook, G. M., & Lu, X. (2021). Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents. Bioorganic & Medicinal Chemistry, 49, 116426. doi: 10.1016/j.bmc.2021.116426

Badart, M. P., Barnes, E. M., Cording, A. P., Gilmer, S. C. L., Billinghurst, I. D., Edupuganti, V. V. S. R., … Bland, A. R., Bower, R. L., Rana, Z., Ferguson, S. A., Opel Reading, H. K., Cook, G. M., Rosengren, R. J., Krause, K. L., Gamble, A. B., Ashton, J. C., & Hawkins, B. C. (2021). Synthesis and biological evaluation of (-) and (+)-spiroleucettadine and analogues. ChemMedChem, 16, 1308-1315. doi: 10.1002/cmdc.202000954

Safarian, S., Opel-Reading, H. K., Wu, D., Mehdipour, A. R., Hards, K., Harold, L. K., … Stewart, I., … Cook, G. M., Krause, K. L., & Michel, H. (2021). The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications, 12(1), 5236. doi: 10.1038/s41467-021-25537-z

Kovalenko, N., Howard, G. K., Swain, J. A., Hermant, Y., Cameron, A. J., Cook, G. M., Ferguson, S. A., … Brimble, M. A. (2021). A concise synthetic strategy towards the novel calcium-dependent lipopeptide antibiotic, malacidin A and analogues. Frontiers in Chemistry, 9, 687875. doi: 10.3389/fchem.2021.687875

Long, F., Cheung, C.-Y., Whitman, W. B., Cook, G. M., & Ronimus, R. S. (2021). Using genome comparisons of wild-type and resistant mutants of Methanococcus maripaludis to help understand mechanisms of resistance to methane inhibitors. Access Microbiology, 3(7), 000244. doi: 10.1099/acmi.0.000244

McNeil, M. B., Keighley, L. M., Cook, J. R., Cheung, C.-Y., & Cook, G. M. (2021). CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis. Molecular Microbiology, 116, 1033-1043. doi: 10.1111/mmi.14790

Yu, W., Buhari, Y., Wang, S., Tian, X., Adnan Hameed, H. M., Lu, Z., … Cook, G. M., … Zhang, T. (2021). Sterilizing effects of novel regimens containing TB47, clofazimine and linezolid in a murine model of tuberculosis. Antimicrobial Agents & Chemotherapy, 65(10), e00706-21. doi: 10.1128/aac.00706-21

Van Zuylen, E. M., Ferguson, S. A., Hughes, A., Rennison, D., Brimble, M. A., & Cook, G. M. (2021). Disruption of metallostasis in the anaerobic human pathogen Fusobacterium nucleatum by the zinc ionophore PBT2. ACS Infectious Diseases, 7, 2285-2298. doi: 10.1021/acsinfecdis.0c00887

Zeng, S., Zhang, J., Sun, M., Zhang, X., Cook, G. M., & Zhang, T. (2021). Nitric oxide-dependent electron transport chain inhibition by the cytochrome bc₁ inhibitor and pretomanid combination kills Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 65(9), e00956-21. doi: 10.1128/aac.00956-21

Carere, C. R., Hards, K., Wigley, K., Carman, L., Houghton, K. M., Cook, G. M., & Stott, M. B. (2021). Growth on formic acid is dependent on intracellular pH homeostasis for the thermoacidophilic methanotroph Methylacidiphilum sp. RTK17.1. Frontiers in Microbiology, 12, 651744. doi: 10.3389/fmicb.2021.651744

Parker, H. A., Dickerhof, N., Forrester, L., Ryburn, H., Smyth, L., Messens, J., Aung, H. L., Cook, G. M., Kettle, A. J., & Hampton, M. B. (2021). Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes. Journal of Immunology, 206, 1901-1912. doi: 10.4049/jimmunol.2001084

Buckley, B. J., Aboelela, A., Majed, H., Bujaroski, R., White, K. L., Powell, A. K., … Cook, G. M., … Ranson, M. (2021). Systematic evaluation of structure–property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride. Bioorganic & Medicinal Chemistry, 37, 116116. doi: 10.1016/j.bmc.2021.116116

Davison, E. K., McGowan, J. E., Li, F. F., Harper, A. D., Young Jeong, J., Mros, S., Harbison-Price, N., Van Zuylen, E. M., Knottenbelt, M. K., Heikal, A., Ferguson, S. A., McConnell, M. A., Cook, G. M., Krittaphol, W., Walker, G. F., … Rennison, D. (2021). C-2 derivatized 8-sulfonamidoquinolines as antibacterial compounds. Bioorganic & Medicinal Chemistry, 29, 115837. doi: 10.1016/j.bmc.2020.115837

Journal - Research Other

Hards, K., Cook, G., & Jeuken, L. J. C. (2021). Bacterial respiration keeps amazing us in the 21st century. Biochemist, 43(6), 22-26. doi: 10.1042/bio_2021_185

Conference Contribution - Published proceedings: Abstract

Safarian, S., Opel-Reading, H. K., Hards, K., Harold, L. K., Cook, G. M., Krause, K. L., & Michel, H. (2021). Structure of BD oxidase from Mycobacteria as a game-changing target in TB drug design. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 303). Retrieved from https://www.faobmb2021.org

van Os, M., Cross, H., Kardailsky, O., Collins, C., McDonald, K., Kinaston, R., Vlok, M., Walter, R., Cook, G., Aung, H. L., Matisoo-Smith, L., Buckley, H., & Knapp, M. (2021). Tuberculosis or soil bacteria? Detection and authentication of highly degraded M. tuberculosis DNA in bioarchaeological remains from the Pacific. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2020

Chapter in Book - Research

McKinlay, J. B., Cook, G. M., & Hards, K. (2020). Microbial energy management: A product of three broad tradeoffs. In Advances in microbial physiology. (pp. 139-185). London, UK: Elsevier. doi: 10.1016/bs.ampbs.2020.09.001

Journal - Research Article

Lee, B. S., Hards, K., Engelhart, C. A., Hasenoehrl, E. J., Kalia, N. P., Mackenzie, J. S., … Cook, G. M., … Pethe, K. (2020). Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis. EMBO Molecular Medicine, 13, e13207. doi: 10.15252/emmm.202013207

De Oliveira, D. M. P., Bohlmann, L., Conroy, T., Jen, F. E.-C., Everest-Dass, A., Hansford, K. A., … Cook, G. M., … Walker, M. J. (2020). Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science Translational Medicine, 12(570), eabb3791. doi: 10.1126/scitranslmed.abb3791

de Jong, S. I., van den Broek, M. A., Merkel, A. Y., de la Torre Cortes, P., Kalamorz, F., Cook, G. M., … McMillan, D. G. G. (2020). Genomic analysis of Caldalkalibacillus thermarum TA2.A1 reveals aerobic alkaliphilic metabolism and evolutionary hallmarks linking alkaliphilic bacteria and plant life. Extremophiles, 24, 923-935. doi: 10.1007/s00792-020-01205-w

Yim, V., Kavianinia, I., Knottenbelt, M. K., Ferguson, S. A., Cook, G. M., Swift, S., … Brimble, M. A. (2020). "CLipP"ing on lipids to generate antibacterial lipopeptides. Chemical Science, 11(22), 5759-5765. doi: 10.1039/d0sc01814g

Hawkins, P. M. E., Tran, W., Nagalingam, G., Cheung, C.-Y., Giltrap, A. M., Cook, G. M., … Payne, R. J. (2020). Total synthesis and antimycobacterial activity of ohmyungsamycin A, deoxyecumicin, and ecumicin. Chemistry: A European Journal, 26(66), 15200-15205. doi: 10.1002/chem.202002408

Nizi, M. G., Desantis, J., Nakatani, Y., Massari, S., Mazzarella, M. A., Shetye, G., … Hards, K., … Cook, G. M., … Tabarrini, O. (2020). Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors. European Journal of Medicinal Chemistry, 201, 112420. doi: 10.1016/j.ejmech.2020.112420

Elnaas, A. R., Grice, D., Han, J., Feng, Y., Di Capua, A., Mak, T., … Cook, G., … Liu, M. (2020). Discovery of a natural product that binds to the Mycobacterium tuberculosis protein Rv1466 using native mass spectrometry. Molecules, 25(10), 2384. doi: 10.3390/molecules25102384

Grinter, R., Ney, B., Brammananth, R., Barlow, C. K., Cordero, P. R. F., Gillett, D. L., … Harold, L. K., Cook, G. M., … Greening, C. (2020). Cellular and structural basis of synthesis of the unique intermediate dehydro-F₄₂₀-0 in mycobacteria. mSystems, 5(3), e00389-20. doi: 10.1128/mSystems.00389-20

McNeil, M. B., Ryburn, H. W. K., Harold, L. K., Tirados, J. F., & Cook, G. M. (2020). Transcriptional inhibition of the F₁F₀-type ATP synthase has bactericidal consequences on the viability of mycobacteria. Antimicrobial Agents & Chemotherapy, 64(8), e00492-20. doi: 10.1128/aac.00492-20

Shao, M., McNeil, M., Cook, G. M., & Lu, X. (2020). MmpL3 inhibitors as antituberculosis drugs. European Journal of Medicinal Chemistry, 200, 112390. doi: 10.1016/j.ejmech.2020.112390

Rineh, A., Soren, O., McEwan, T., Ravikumar, V., Han Poh, W., Azamifar, F., … Cheung, C.-Y., … Cook, G. M., … Kelso, M. J. (2020). Discovery of cephalosporin-3´-diazeniumdiolates that show dual antibacterial and antibiofilm effects against Pseudomonas aeruginosa clinical cystic fibrosis isolates and efficacy in a murine respiratory infection Model. ACS Infectious Diseases, 6, 1460-1479. doi: 10.1021/acsinfecdis.0c00070

Santoso, K. T., Brett, M. W., Cheung, C.-Y., Cook, G. M., Stocker, B. L., & Timmer, M. S. M. (2020). Synthesis of functionalised chromonyl-pyrimidines and their potential as antimycobacterial agents. ChemistrySelect, 5(14), 4347-4355. doi: 10.1002/slct.202000799

Harbison-Price, N., Ferguson, S. A., Heikal, A., Taiaroa, G., Hards, K., Nakatani, Y., … Cook, G. M. (2020). Multiple bactericidal mechanisms of the zinc ionophore PBT2. mSphere, 5(2), e00157-20. doi: 10.1128/mSphere.00157-20

McGowan, J. E., Harper, A. D., Davison, E. K., Jeong, J. Y., Mros, S., Harbison-Price, N., Van Zuylen, E. M., Knottenbelt, M. K., Heikal, A., Ferguson, S. A., McConnell, M. A., Cook, G. M., Krittaphol, W., Walker, G. F., … Rennison, D. (2020). Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds. Bioorganic & Medicinal Chemistry Letters, 30, 127110. doi: 10.1016/j.bmcl.2020.127110

Chong, S. M. S., Manimekalai, M. S. S., Sarathy, J. P., Williams, Z. C., Harold, L. K., Cook, G. M., … Grüber, G. (2020). Antituberculosis activity of the antimalaria cytochrome bcc oxidase inhibitor SCR0911. ACS Infectious Diseases, 6, 725-737. doi: 10.1021/acsinfecdis.9b00408

Lee, B. M., Harold, L. K., Almeida, D. V., Afrait-Jurnou, L., Aung, H. L., Forde, B. M., Hards, K., … Cook, G. M., & Jackson, C. J. (2020). Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathogens, 16(2), e1008287. doi: 10.1371/journal.ppat.1008287

Nakatani, Y., Shimaki, Y., Dutta, D., Muench, S. P., Ireton, K., Cook, G. M., & Jeuken, L. J. C. (2020). Unprecedented properties of phenothiazines unraveled by a NDH-2 bioelectrochemical assay platform. Journal of the American Chemical Society, 142(3), 1311-1320. doi: 10.1021/jacs.9b10254

Journal - Research Other

McDonald, S. K., Matisoo-Smith, E. A., Buckley, H. R., Walter, R. K., Aung, H. L., Collins, C. J., Cook, G. M., Kardailsky, O., Krause, K., & Knapp, M. (2020). 'TB or not TB': The conundrum of pre-European contact tuberculosis in the Pacific. Philosophical Transactions of the Royal Society B, 375, 20190583. doi: 10.1098/rstb.2019.0583

Tong, J. T. W., Kavianinia, I., Ferguson, S. A., Cook, G. M., Harris, P. W. R., & Brimble, M. A. (2020). Synthesis of paenipeptin C' analogues employing solution-phase CLipPA chemistry [Communication]. Organic & Biomolecular Chemistry, 18, 4381-4385. doi: 10.1039/d0ob00950d

Hards, K., Adolph, C., Harold, L. K., McNeil, M. B., Cheung, C.-Y., Jinich, A., … Cook, G. M. (2020). Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents. Progress in Biophysics & Molecular Biology, 152, 35-44. doi: 10.1016/j.pbiomolbio.2019.11.003

Conference Contribution - Published proceedings: Abstract

Darnell, R. L., Knottenbelt, M. K., Todd Rose, F. O., & Cook, G. M. (2020). Understanding antimicrobial tolerance in bacterial pathogens [Invited]. Proceedings of the Genetics Otago (GO) Zoom Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

2019

Journal - Research Article

Mulholland, C. V., Shockey, A. C., Aung, H. L., Cursons, R. T., O'Toole, R. F., Gautam, S. S., … Cook, G. M., … Arcus, V. L. (2019). Dispersal of Mycobacterium tuberculosis driven by historical European trade in the South Pacific. Frontiers in Microbiology, 10, 2778. doi: 10.3389/fmicb.2019.02778

Saw, W.-G., Wu, M.-L., Ragunathan, P., Biuković, G., Lau, A.-M., Shin, J., … Hards, K., … Cook, G. M., … Grüber, G. (2019). Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis. Scientific Reports, 9, 16759. doi: 10.1038/s41598-019-53107-3

Buckley, B. J., Majed, H., Aboelela, A., Minaei, E., Jiang, L., Fildes, K., Cheung, C.-Y., … Cook, G. M., … Kelso, M. J. (2019). 6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease. Bioorganic & Medicinal Chemistry Letters, 29(24), 126753. doi: 10.1016/j.bmcl.2019.126753

Cordero, P. R. F., Grinter, R., Hards, K., Cryle, M. J., Warr, C. G., Cook, G. M., & Greening, C. (2019). Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence. Journal of Biological Chemistry, 294(50), 18980-18991. doi: 10.1074/jbc.RA119.011076

Momin, M. A. M., Rangnekar, B., Sinha, S., Cheung, C.-Y., Cook, G. M., & Das, S. C. (2019). Inhalable dry powder of Bedaquiline for pulmonary tuberculosis: In vitro physiochemical characterization, antimicrobial activity and safety studies. Pharmaceutics, 11(10), 502. doi: 10.3390/pharmaceutics11100502

Hasenoehrl, E. J., Sajorda, D. R., Berney-Meyer, L., Johnson, S., Tufariello, J. M., Fuhrer, T., Cook, G. M., … Berney, M. (2019). Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection. Nature Communications, 10, 4215. doi: 10.1038/s41467-019-12224-3

Ferguson, S. A., Menorca, A., Van Zuylen, E. M., Cheung, C.-Y., McConnell, M. A., Rennison, D., … Cook, G. M., & Heikal, A. (2019). Microtiter screening reveals oxygen-dependent antimicrobial activity of natural products against mastitis-causing bacteria. Frontiers in Microbiology, 10, 1995. doi: 10.3389/fmicb.2019.01995

Petri, J., Nakatani, Y., Montgomery, M. G., Ferguson, S. A., Aragão, D., Leslie, A. G. W., Heikal, A., … Cook, G. M. (2019). Structure of F₁-ATPase from the obligate anaerobe Fusobacterium nucleatum. Open Biology, 9(6), 190066. doi: 10.1098/rsob.190066

Greening, C., Geier, R., Wang, C., Woods, L. C., Morales, S. E., McDonald, M. J., Rushton-Green, R., Morgan, X. C., … Cook, G. M., & Mackie, R. I. (2019). Diverse hydrogen production and consumption pathways influence methane production in ruminants. ISME Journal, 13, 2617-2632. doi: 10.1038/s41396-019-0464-2

Santoso, K. T., Menorca, A., Cheung, C.-Y., Cook, G. M., Stocker, B. L., & Timmer, M. S. M. (2019). The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents. Bioorganic & Medicinal Chemistry, 27, 3532-3545. doi: 10.1016/j.bmc.2019.06.002

Darnell, R. L., Knottenbelt, M. K., Todd Rose, F. O., Monk, I. R., Stinear, T. P., & Cook, G. M. (2019). Genomewide profiling of the Enterococcus faecalis transcriptional response to teixobactin reveals CroRS as an essential regulator of antimicrobial tolerance. mSphere, 4(3), e00228-19. doi: 10.1128/mSphere.00228-19

Rushton-Green, R., Darnell, R. L., Taiaroa, G., Carter, G. P., Cook, G. M., & Morgan, X. C. (2019). Agricultural origins of a highly persistent lineage of vancomycin-resistant Enterococcus faecalis in New Zealand. Applied & Environmental Microbiology, 85(13), e00137-19. doi: 10.1128/aem.00137-19

Smith, R. J., Bower, R. L., Ferguson, S. A., Rosengren, R. J., Cook, G. M., & Hawkins, B. C. (2019). The synthesis of (±)-oxyisocyclointegrin. European Journal of Organic Chemistry, (7), 1571-1573. doi: 10.1002/ejoc.201801751

Santoso, K. T., Cheung, C.-Y., Hards, K., Cook, G. M., Stocker, B. L., & Timmer, M. S. M. (2019). Synthesis and investigation of phthalazinones as antitubercular agents. Chemistry: An Asian Journal, 14, 1278-1285. doi: 10.1002/asia.201801805

Lu, X., Williams, Z., Hards, K., Tang, J., Cheung, C.-Y., Aung, H. L., … Cook, G. M. (2019). Pyrazolo[1,5-a]pyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resistant tuberculosis. ACS Infectious Diseases, 5(2), 239-249. doi: 10.1021/acsinfecdis.8b00225

Darnell, R. L., Nakatani, Y., Knottenbelt, M. K., Gebhard, S., & Cook, G. M. (2019). Functional characterization of BcrR: A one-component transmembrane signal transduction system for bacitracin resistance. Microbiology, 165, 475-487. doi: 10.1099/mic.0.000781

Zhang, A. T., Montgomery, M. G., Leslie, A. G. W., Cook, G. M., & Walker, J. E. (2019). The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs. PNAS, 116(10), 4206-4211. doi: 10.1073/pnas.1817615116

Hards, K., Molano Rodriguez, S., Cairns, C., & Cook, G. M. (2019). Alternate quinone coupling in a new class of succinate dehydrogenase may potentiate mycobacterial respiratory control. FEBS Letters, 593(5), 475-486. doi: 10.1002/1873-3468.13330

Harold, L. K., Antoney, J., Ahmed, F. H., Hards, K., Carr, P., Rapson, T., … Cook, G. M. (2019). FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress. Journal of Biological Chemistry, 294(8), 2903-2912. doi: 10.1074/jbc.RA118.006237

Journal - Research Other

Aung, H. L., Devine, T. J., Mulholland, C. V., Arcus, V. L., & Cook, G. M. (2019). Tackling tuberculosis in the indigenous people of New Zealand. Lancet Public Health, 4(10), e496. doi: 10.1016/S2468-2667(19)30180-X

McNeil, M. B., & Cook, G. M. (2019). Utilization of CRISPR interference to validate MmpL3 as a drug target in Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 63(8), e00629-19. doi: 10.1128/aac.00629-19

Conference Contribution - Published proceedings: Abstract

Rushton-Green, R., Darnell, R. L., Taiaroa, G., Carter, G. P., Cook, G. M., & Morgan, X. C. (2019). Persistence of a poultry-associated lineage of vancomycin-resistant enterocci. Proceedings of the MapNet Meeting. (pp. 32). Retrieved from http://mapnet2019.nz/

Taylor, J. T., Cook, G. M., Gimenez, G., & Aung, H. L. (2019). Otara: Fighting tuberculosis on the home front. In A. Finigan, P. Vakaoti, R. Richards & M. Schaaf (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices XVI. (pp. 31). Dunedin, New Zealand: The Pacific Islands Centre, University of Otago. Retrieved from https://www.otago.ac.nz/pacific

Conference Contribution - Verbal presentation and other Conference outputs

Greening, C., Grinter, R., Ahmed, F. H., Bashiri, G., Ney, B., Lee, B. M., Hards, K., … Cook, G. M., … Jackson, C. J. (2019, August-September). The hows and whys of cofactor F₄₂₀ biosynthesis in mycobacteria. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Alzubaidi, A., Mansfield, E., Cheung, J., Mizrahi, V., Cook, G., Lott, J. S., & Dawes, S. S. (2019, August-September). RNase HI activity provides metabolic flexibility under antibiotic stress in the mycobacteria. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

McNeil, M., Adolph, C., Cheung, C.-Y., Hards, K., Jinich, A., Rhee, K., & Cook, G. M. (2019, August-September). Essentiality of succinate metabolism in Mycobacterium tuberculosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Cheung, J., Adolph, C., Buckley, B. J., Majed, H., Aboelela, A., Bujaroski, R., … Hards, K., McNeil, M. B., … Cook, G. M. (2019, August-September). Next generation ATP synthase inhibitors to combat drug resistant tuberculosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Knapp, M., McDonald, S. K., Buckley, H., Kardailsky, O., Aung, H. L., Cross, H., Jeunen, G.-J., Matisoo-Smith, E., Walter, R., & Cook, G. M. (2019, August-September). Origin and evolution of tuberculosis in New Zealand. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Rushton-Green, R., Darnell, R. L., Taiaroa, G., Carter, G. P., Cook, G. M., & Morgan, X. C. (2019, August-September). Agricultural origins of a persistent lineage of vancomycin-resistant E. faecalis from New Zealand. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Cook, G. (2019, December). Bioactives in AgriTech. Verbal presentation at the Ag@Otago Symposium: New Zealand Agriculture 2050: Pathways of Innovation, Dunedin, New Zealand.

2018

Journal - Research Article

Bohlmann, L., De Oliveira, D. M. P., El-Deeb, I. M., Brazel, E. B., Harbison-Price, N., Ong, C.-l. Y., … Cook, G. M., … Walker, M. J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9(6), e02391-18. doi: 10.1128/mBio.02391-18

Basu, I., Bower, J. E., Roberts, S. A., Henderson, G., Aung, H. L., Cook, G., … Newton, S. (2018). Utility of whole genome sequencing for multidrug resistant Mycobacterium tuberculosis isolates in a reference TB laboratory in New Zealand. New Zealand Medical Journal, 131(1487), 15-22. Retrieved from https://www.nzma.org.nz/journal

Buckley, B. J., Aboelela, A., Minaei, E., Jiang, L. X., Xu, Z., Ali, U., … Cheung, C.-Y., … Cook, G. M., … Kelso, M. J. (2018). 6-substituted hexamethylene amiloride (HMA) derivatives as potent and selective inhibitors of the human urokinase plasminogen activator for use in cancer. Journal of Medicinal Chemistry, 61(18), 8299-8320. doi: 10.1021/acs.jmedchem.8b00838

Hards, K., McMillan, D. G. G., Schurig-Briccio, L. A., Gennis, R. B., Lill, H., Bald, D., & Cook, G. M. (2018). Ionophoric effects of the antitubercular drug bedaquiline. PNAS, 115(28), 7326-7331. doi: 10.1073/pnas.1803723115

Heikal, A., Nakatani, Y., Jiao, W., Wilson, C., Rennison, D., Weimar, M. R., … Cook, G. M. (2018). ‘Tethering’ fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase. Bioorganic & Medicinal Chemistry Letters, 28(13), 2239-2243. doi: 10.1016/j.bmcl.2018.05.048

Henderson, G., Cook, G. M., & Ronimus, R. S. (2018). Enzyme- and gene-based approaches for developing methanogen-specific compounds to control ruminant methane emissions: A review. Animal Production Science, 58(6), 1017-1026. doi: 10.1071/an15757

Petri, J., Shimaki, Y., Jiao, W., Bridges, H. R., Parker, E. J., Aragão, D., Cook, G. M., & Nakatani, Y. (2018). Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. Biochimica et Biophysica Acta: Bioenergetics, 1859(7), 482-490. doi: 10.1016/j.bbabio.2018.03.014

Talaroa, G., Harbison-Price, N., Ferguson, S. A., Carter, G. P., Williamson, D. A., Macknight, R. C., Cook, G. M., & Helkal, A. (2018). Complete genome sequence of a New Zealand isolate of the bovine pathogen Streptococcus uberis. Genome Announcements, 6(9), e00119-18. doi: 10.1128/genomeA.00119-18

Mortuza, R., Aung, H. L., Taiaroa, G., Opel-Reading, H. K., Kleffmann, T., Cook, G. M., & Krause, K. L. (2018). Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion. Molecular Microbiology, 107(2), 198-213. doi: 10.1111/mmi.13877

Journal - Research Other

Aung, H. L., Nyunt, W. W., Fong, Y., Russell, B., Cook, G. M., & Aung, S. T. (2018). Acquired resistance to antituberculosis drugs. Emerging Infectious Diseases, 24(11), 2134. doi: 10.3201/eid2411.180465

Htuna, K. S., Fong, Y., Kyaw, A. A., Aung, S. T., Oo, K. Z., Zaw, T., … Russell, B., Cook, G. M., Aung, H. L., & Hlaing, T. M. (2018). Microbiome dataset from the upper respiratory tract of patients living with HIV, HIV/TB and TB from Myanmar [Data article]. Data in Brief, 21, 354-357. doi: 10.1016/j.dib.2018.10.003

Mulholland, C. V., Thorpe, D., Cursons, R. T., Karalus, N., Fong, Y., Arcus, V. L., Cook, G. M., & Aung, H. L. (2018). Evaluation of the rapid molecular diagnostic test for the New Zealand Mycobacterium tuberculosis Rangipo strain in a clinical setting. New Zealand Medical Journal, 131(1478), 70-72. Retrieved from https://www.nzma.org.nz/journal

Zhang, S., De Leon Rodriguez, L. M., Leung, I. K. H., Cook, G. M., Harris, P. W. R., & Brimble, M. A. (2018). Total synthesis and conformational study of callyaerin A: Anti-tubercular cyclic peptide bearing a rare rigidifying (Z)-2,3-diaminoacrylamide moiety. Angewandte Chemie International Edition, 57(14), 3631-3635. doi: 10.1002/anie.201712792

Aung, H. L., Tun, T., Nyunt, W. W., Fong, Y., Crump, J. A., Thinn, K. K., … Cook, G. M. (2018). Association between anti-tuberculosis drug resistance-conferring mutations and treatment outcomes in Myanmar. Infectious Diseases, 50(5), 388-390. doi: 10.1080/23744235.2017.1404632

Hards, K., & Cook, G. M. (2018). Targeting bacterial energetics to produce new antimicrobials. Drug Resistance Updates, 36, 1-12. doi: 10.1016/j.drup.2017.11.001

Conference Contribution - Published proceedings: Abstract

McKay Vercoe, R. B., & Cook, G. M. (2018). Understanding mechanisms and management of ion homeostatis inMycobacterium smegmatis. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 111). Retrieved from https://www.nzmsconference.org.nz

Harold, L. K., Antoney, J., Ahmed, F. H., Hards, K., Carr, P. D., Rapson, T., … Cook, G. M. (2018). Identification and characterization of a FAD chaperon required for mycobacterial survival under hypoxia. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 111). Retrieved from https://www.nzmsconference.org.nz

McNeil, M. B., & Cook, G. M. (2018). Deciphering the functions and interactions of complex II respiratory enzymes in Mycobacterium tuberculosis. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 89). Retrieved from https://www.nzmsconference.org.nz

Van Zuylen, E. M., Ferguson, S. A., Rennison, D., Brimble, M. A., & Cook, G. M. (2018). Investigating the antimicrobial properties of novel inhibitors against Fusobacteria. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 85). Retrieved from https://www.nzmsconference.org.nz

Russell, E. R., Shimaki, Y., Ireton, K., Nakatani, Y., & Cook, G. M. (2018). Elucidating the role of ndh2 in metabolism and virulence in Listeria monocytogenes. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 83). Retrieved from https://www.nzmsconference.org.nz

Ferguson, S. A., Van Zuylen, E., Harbison-Price, N., Heikal, A., Rennison, D., Mros, S., … McConnell, M. A., … Cook, G. M. (2018). Development of next-generation sanitisers for the control of bovine mastitis. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 79). Retrieved from https://www.nzmsconference.org.nz

Knottenbelt, M. K., Darnell, R., Todd-Rose, F., & Cook, G. M. (2018). Staying one step ahead: Understanding the development of resistance to new antimicrobial teixobactin using Enterococcus faecalis as a model. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 78). Retrieved from https://www.nzmsconference.org.nz

Wang, X., Greening, C., Cook, G. M., Morgan, X. C., Attwood, G. T., & Morales, S. E. (2018). Mitigating CH₄ emission through a better understanding of H₂ metabolism in the rumen. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 70). Retrieved from https://www.nzmsconference.org.nz

Krause, A., Ferguson, S., Williamson, D. S., Carter, G., Monk, I., Petridis, M., Shimaki, Y., Taiaroa, G., & Cook, G. (2018). Understanding the interplay between antibiotic and antiseptic resistance relationships in Staphylococcus aureus. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 68). Retrieved from https://www.nzmsconference.org.nz

Adolph, C., Cheung, J., Buckley, B. J., Aboelela, A., Hards, K., McNeil, M., … Cook, G. M. (2018). Identification of novel antimicrobials targeting succinate dehydrogenase in Mycobacterium tuberculosis. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 54-55). Retrieved from https://www.nzmsconference.org.nz

Mulholland, C. V., Aung, H. L., Karalus, N., Cursons, R. T., Roberts, S. A., Cook, G. M., … Arcus, V. L. (2018). Mycobacterium tuberculosis accompanies historic European trade expansion in the South Pacific. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 46). Retrieved from https://www.nzmsconference.org.nz

Harbison-Price, N., Ferguson, S. A., Heikal, A., Taiaroa, G., Hards, K., Mros, S., … Cook, G. M. (2018). Investigating the antimicrobial action of a zinc ionophore in the mastitis-causing pathogen Streptococcus uberis. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 39). Retrieved from https://www.nzmsconference.org.nz

McMillan, D. G. G., Hernandez, A. G., Nakatani, Y., Cook, G. M., Jeuken, L. J. C., & Noji, H. (2018). Are quinones directors or crew members during microbial respiratory adaptation? Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 36). Retrieved from https://www.nzmsconference.org.nz

Williams, Z., Hards, K., Li, X., Ding, K., & Cook, G. M. (2018). Next generation inhibitors to combat drug resistant tuberculosis infections. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 35). Retrieved from https://www.nzmsconference.org.nz

Playle, V. M., Basu, I., Cook, G. M., Aung, H. L., Crawshaw, S., Hay, D., & Roberts, S. (2018). The molecular epidemiology of a MIRU-VNTR linked Mycobacterium tuberculosis cluster in New Zealand. Proceedings of the Australasian Society for Infectious Diseases (ASID) New Zealand Annual Meeting. Retrieved from https://www.asid.net.au

McMillan, D. G. G., Knobel, K. C. C., Šubrtova, K., Marsden, S. R., Cook, G. M., Noji, H., … Schnaufer, A. (2018). ADP/ Mg²⁺ inhibition of F1 ATPases is tuned using Mg²⁺ affinity governed by species-specific γ subunit contacts to α and β subunits. Biochimica et Biophysica Acta: Bioenergetics, 1859, (pp. e80-e81). doi: 10.1016/j.bbabio.2018.09.241

Conference Contribution - Poster Presentation (not in published proceedings)

Kaldor, C., Parker, H., Cook, G., & Hampton, M. (2018, September). Streptococcus Pneumoniae adhered to neutrophil extracellular traps produce hydrogen peroxide which is converted into hypochlorous acid. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

Williams, Z., Li, X., Ding, K., & Cook, G. (2018, September). Next generation inhibitors to combat drug resistant tuberculosis infections. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Aung, H. L., Nyunt, W. W., Fong, Y., Cook, G. M., & Aung, S. T. (2018, November). A molecular weapon to combat tuberculosis: The role of next-generation sequencing in the management of tuberculosis in high burden settings. Verbal presentation at the Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules, Dunedin, New Zealand.

Furkert, D. P., Ferris, S., Brimble, M., Dawes, S., Nigon, L., Jiao, W., … Cook, G., & Johnston, J. (2018, August). Inhibitors of menaquinone biosynthesis for control of pathogenic bacteria. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Cook, G. (2018, August). Tackling drug-resistant tuberculosis by targeting multiple components of mycobacterial bioenergetics. Verbal presentation at the Australasian Tuberculosis Conference, Wellington, New Zealand.

Cook, G. (2018, September). Opportunities for infectious disease research in New Zealand: A biomedical perspective. Verbal presentation at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

2017

Journal - Research Article

Schumacher, C. E., Harris, P. W. R., Ding, X.-B., Krause, B., Wright, T. H., Cook, G. M., Furkert, D. P., & Brimble, M. A. (2017). Synthesis and biological evaluation of novel teixobactin analogues. Organic & Biomolecular Chemistry, 15, 8755-8760. doi: 10.1039/c7ob02169k

Nakatani, Y., Jiao, W., Aragão, D., Shimaki, Y., Petri, J., Parker, E. J., & Cook, G. M. (2017). Crystal structure of type II NADH:quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 Å. Acta Crystallographica Section F, 73(10), 541-549. doi: 10.1107/s2053230x17013073

Nakatani, Y., Opel-Reading, H. K., Merker, M., Machado, D., Andres, S., Kumar, S. S., … Aung, H. L., Cook, G. M., … Krause, K., & Köser, C. U. (2017). Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance. Antimicrobial Agents & Chemotherapy, 61(12), e01575-17. doi: 10.1128/aac.01575-17

Carere, C. R., Hards, K., Houghton, K. M., Power, J. F., McDonald, B., Collet, C., … Cook, G. M., … Stott, M. B. (2017). Mixotrophy drives niche expansion of verrucomicrobial methanotrophs. ISME Journal, 11, 2599-2610. doi: 10.1038/ismej.2017.112

Kalia, N. P., Hasenoehrl, E. J., Ab Rahman, N. B., Koh, V. H., Ang, M. L. T., Sajorda, D. R., Hards, K., … Cook, G. M., … Pethe, K. (2017). Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. PNAS, 114(28), 7426-7431. doi: 10.1073/pnas.1706139114

Cook, G. M., Hards, K., Dunn, E., Heikal, A., Nakatani, Y., Greening, C., … Berney, M. (2017). Oxidative phosphorylation as a target space for tuberculosis: Success, caution, and future directions. Microbiology Spectrum, 5(3), TBTB2-0014-2016. doi: 10.1128/microbiolspec.TBTB2-0014-2016

Weimar, M. R., Cheung, J., Dey, D., McSweeney, C., Morrison, M., Kobayashi, Y., … Cook, G. M. (2017). Development of multi-well plate methods using pure cultures of methanogens to identify new inhibitors for suppressing ruminant methane emissions. Applied & Environmental Microbiology, 83(15), e00396-17. doi: 10.1128/aem.00396-17

Mulholland, C. V., Ruthe, A., Cursons, R. T., Durrant, R., Karalus, N., Coley, K., … Permina, E., Coleman, M. J., … Cook, G. M., & Aung, H. L. (2017). Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand. Diagnostic Microbiology & Infectious Disease, 88(2), 138-140. doi: 10.1016/j.diagmicrobio.2017.03.012

Harris, P. W. R., Cook, G. M., Leung, I. K. H., & Brimble, M. A. (2017). An efficient chemical synthesis of lassomycin enabled by an on-resin lactamisation-off-resin methanolysis strategy and preparation of chemical variants. Australian Journal of Chemistry, 70(2), 172-183. doi: 10.1071/CH16499

Blaza, J. N., Bridges, H. R., Aragão, D., Dunn, E. A., Heikal, A., Cook, G. M., Nakatani, Y., & Hirst, J. (2017). The mechanism of catalysis by type-II NADH:quinone oxidoreductases. Scientific Reports, 7, 40165. doi: 10.1038/srep40165

Journal - Research Other

Nyunt, W. W., Aung, S. T., Cook, G. M., & Aung, H. L. (2017). Evaluation of the genotype MTBDRsl test for detection of second-line drug resistance in drug-resistant Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases, 49(11-12), 865-866. doi: 10.1080/23744235.2017.1341056

Aung, H. L., Nyunt, W. W., Fong, Y., Cook, G. M., & Aung, S. T. (2017). First 2 extensively drug-resistant tuberculosis cases from Myanmar treated with bedaquiline. Clinical Infectious Diseases, 65(3), 531-532. doi: 10.1093/cid/cix365

Nyunt, W. W., Aung, S. T., Lwin, T., Cook, G. M., & Aung, H. L. (2017). First- and second-line antituberculosis drug resistance patterns among previous treatment failure patients in Myanmar. Journal of Global Antimicrobial Resistance, 9, 34-35. doi: 10.1016/j.jgar.2017.02.007

Petridis, M., & Cook, G. M. (2017). Microarray dataset on the genome-wide expression profile of an M. smegmatis amtR mutant (JR258) compared to M. smegmatis mc²155 [Data article]. Data in Brief, 10, 38-40. doi: 10.1016/j.dib.2016.11.049

Tun, T., Aye, K. S., Nyunt, W. W., Crump, J. A., Nakajima, C., Suzuki, Y., … Cook, G. M., & Aung, H. L. (2017). Genotypic diversity of Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases, 49(3), 237-239. doi: 10.1080/23744235.2016.1231419

Conference Contribution - Published proceedings: Abstract

Carere, C. R., Hards, K., Houghton, K. M., Power, J. F., McDonald, B., Collet, C., … Cook, G. M., Greening, C., & Stott, M. B. (2017). Mixotrophy drives niche expansion of thermoacidopholic methanotrophs. Proceedings of the New Zealand Microbiological Society (NZMS) Annual Conference. 155. Retrieved from http://www.nzmsconference.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Opel-Reading, H., Nakatani, Y., Aung, H. L., Cook, G. M., & Krause, K. L. (2017, September). The impact of Mycobacterium tuberculosis alanine racemase mutations on D-cycloserine inhibition. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Williams, Z., Li, X., Ding, K., & Cook, G. M. (2017, September). Next generation inhibitors to combat drug resistant tuberculosis infections. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Harold, L. K., Ahmed, F. H., Antoney, J., Hards, K., Greening, C., Jackson, C. J., & Cook, G. M. (2017, September). MSMEG_5243: A succinate dehydrogenase flavination factor. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Cook, G. (2017, July). Is there life beyond conventional antimicrobials? Verbal presentation at the Royal New Zealand College of General Practitioners (RNZCGP) Conference for General Practice, Dunedin, New Zealand.

Working Paper; Discussion Paper; Technical Report

Cook, G., French, N., Hawke, G., Heinemann, J., Hendrickson, H., Le Heron, R., Leung, W., … Sullivan, T., … Williamson, D. (2017). Antimicrobial resistance: Implications for New Zealanders: Evidence update. Wellington, New Zealand: Royal Society Te Apārangi. 18p.

2016

Journal - Research Article

Aung, H. L., Tun, T., Permina, E., Nyunt, W. W., Aung, S. T., Thinn, K. K., Crump, J. A., & Cook, G. M. (2016). Draft genome sequences of two drug-resistant Mycobacterium tuberculosis isolates from Myanmar. Genome Announcements, 4(5), e00850-16. doi: 10.1128/genomeA.00850-16

Petridis, M., Vickers, C., Robson, J., McKenzie, J. L., Bereza, M., Sharrock, A., Aung, H. L., … Cook, G. M. (2016). Structure and function of AmtR in Mycobacterium smegmatis: Implications for post-transcriptional regulation of urea metabolism through a small antisense RNA. Journal of Molecular Biology, 428(21), 4315-4329. doi: 10.1016/j.jmb.2016.09.009

Ferguson, S. A., Cook, G. M., Montgomery, M. G., Leslie, A. G. W., & Walker, J. E. (2016). Regulation of the thermoalkaliphilic F₁-ATPase from Caldalkalibacillus thermarum. PNAS, 113(39), 10860-10865. doi: 10.1073/pnas.1612035113

McMillan, D. G. G., Watanabe, R., Ueno, H., Cook, G. M., & Noji, H. (2016). Biophysical characterization of a thermoalkaliphilic molecular motor with a high stepping torque gives insight into evolutionary ATP synthase adaptation. Journal of Biological Chemistry, 291(46), 23965-23977. doi: 10.1074/jbc.M116.743633

Kavianinia, I., Kunalingam, L., Harris, P. W. R., Cook, G. M., & Brimble, M. A. (2016). Total synthesis and stereochemical revision of the anti-tuberculosis peptaibol trichoderin A. Organic Letters, 18(15), 3878-3881. doi: 10.1021/acs.orglett.6b01886

Heikal, A., Hards, K., Cheung, C.-Y., Menorca, A., Timmer, M. S. M., Stocker, B. L., & Cook, G. M. (2016). Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death. Journal of Antimicrobial Chemotherapy, 71(10), 2840-2847. doi: 10.1093/jac/dkw244

Aung, H. L., Tun, T., Moradigaravand, D., Köser, C. U., Nyunt, W. W., Aung, S. T., … Crump, J. A., … Cook, G. M., & Hill, P. C. (2016). Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar. Journal of Global Antimicrobial Resistance, 6, 113-117. doi: 10.1016/j.jgar.2016.04.008

Medini, K., Harris, P. W. R., Menorca, A., Hards, K., Cook, G. M., & Brimble, M. A. (2016). Synthesis and activity of a diselenide bond mimetic of the antimicrobial protein caenopore-5. Chemical Science, 7(3), 2005-2010. doi: 10.1039/c5sc04187b

Holyoake, L. V., Hunt, S., Sanguinetti, G., Cook, G. M., Howard, M. J., Rowe, M. L., … Shepherd, M. (2016). CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress. Biochemical Journal, 473, 693-701. doi: 10.1042/bj20150536

Dunn, E. A., Cook, G. M., & Heikal, A. (2016). Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins. Journal of Microbiological Methods, 120, 41-43. doi: 10.1016/j.mimet.2015.11.012

Greening, C., Biswas, A., Carere, C. R., Jackson, C. J., Taylor, M. C., Stott, M. B., Cook, G. M., & Morales, S. E. (2016). Genomic and metagenomic surveys of hydrogenase distribution indicate H₂ is a widely utilised energy source for microbial growth and survival. ISME Journal, 10, 761-777. doi: 10.1038/ismej.2015.153

Journal - Research Other

Tun, T., Nyunt, W. W., Latt, K. Z., Samaranayaka, A., Crump, J. A., Thinn, K. K., Cook, G. M., & Aung, H. L. (2016). Drug-resistant tuberculosis among previously treated patients in Yangon, Myanmar. International Journal of Mycobacteriology, 5(3), 366-367. doi: 10.1016/j.ijmyco.2016.06.004

Dunn, E. A., Cook, G. M., & Heikal, A. (2016). Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening [Data article]. Data in Brief, 6, 275-278. doi: 10.1016/j.dib.2015.12.019

Journal - Professional & Other Non-Research Articles

Cook, G. M., & Poole, R. K. (2016). A bacterial oxidase like no other? Science, 352(6285), 518-519. doi: 10.1126/science.aaf5514

Conference Contribution - Published proceedings: Abstract

Cook, G. M. (2016). Generation of new anti-infectives for agritech applications: An update. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Buckley, H. R., Kinaston, R., Knapp, M., Cook, G., Collins, C., Walter, R., Halcrow, S., & Matisoo-Smith, L. (2016). An osteobiography of a middle aged male from Wairau Bar: Exploring metabolic and infectious disease in prehistoric Polynesians. Proceedings of the New Zealand Archaeological Association (NZAA) Conference. Retrieved from http://nzarchaeology.org/cms/index.php/conferences

Petri, J., Nakatani, Y., Aragao, D., Ferguson, S. A., Heikal, A., Montgomery, M. G., … Cook, G. M. (2016). Heterologous expression, characterisation and structural analysis of Fusobacterium nucleatum F₁-ATPase. Biochimica et Biophysica Acta: Bioenergetics, 1857(Suppl.), (pp. e58). doi: 10.1016/j.bbabio.2016.04.350

Lu, P., Heineke, M., Koul, A., Andries, K., Cook, G. M., Lill, H., … Bald, D. (2016). Cytochrome bd as survival factor in mycobacteria. Biochimica et Biophysica Acta: Bioenergetics, 1857(Suppl.), (pp. e120). doi: 10.1016/j.bbabio.2016.04.257

Hards, K., & Cook, G. M. (2016). Compartmentalization of succinate dehydrogenase function in the diverse lifestyle conditions of an actinobacterium. Biochimica et Biophysica Acta: Bioenergetics, 1857(Suppl.), (pp. e86-e87). doi: 10.1016/j.bbabio.2016.04.210

McMillan, D. G. G., Watanabe, R., Ueno, H., Cook, G. M., & Noji, H. (2016). Biophysical description of a thermoalkaliphilic F1 ATPase reveals an abnormally high torque. Biochimica et Biophysica Acta: Bioenergetics, 1857(Suppl.), (pp. e56). doi: 10.1016/j.bbabio.2016.04.130

Conference Contribution - Poster Presentation (not in published proceedings)

Taiaroa, G., Zhao, M., Macknight, R., Cook, G., Butler, M., & Poulter, R. (2016, August-September). Mobile herbicide resistance in the NZ pseudomonad pangenome. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Carere, C. R., Hards, K., Greening, C., Gapes, D., Sparling, R., Cook, G. M., & Stott, M. B. (2016, November). Hydrogen metabolism within the thermoacidophilic methane oxidising bacterium, Methylacidiphilum sp. RTK17.1. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

Harold, L. K., Ahmed, F. H., Antoney, J., Greening, C., Jackson, C. J., & Cook, G. M. (2016, November). Functional analysis of a novel FDOR gene from an Actinobacterium. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

Sang, C., Lunn, K., Cheung, J., Atua, R., Zhang, Y., Dey, D., Weimar, M., … Cook, G. M., … Ronimus, R. S. (2016, November). High-throughput screening to identify inhibitors for reducing ruminant methane emissions. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

Williams, Z. C., Hards, K., Aung, H. L., & Cook, G. M. (2016, November). Regulation of cytochrome bd in mycobacteria in response to carbon and oxygen availability. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

Cook, G., & Hards, K. (2016, August-September). New TB drugs work by a common mechanism: Uncouplers of the respiratory chain. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Petridis, M., Benjak, A., & Cook, G. M. (2015). Defining the nitrogen regulated transcriptome of Mycobacterium smegmatis using continuous culture. BMC Genomics, 16, 821. doi: 10.1186/s12864-015-2051-x

Zhang, X.-X., Gauntlett, J. C., Oldenburg, D. G., Cook, G. M., & Rainey, P. B. (2015). Role of the transporter-like sensor kinase CbrA in histidine uptake and signal transduction. Journal of Bacteriology, 197(17), 2867-2878. doi: 10.1128/JB.00361-15

Greening, C., Carere, C. R., Rushton-Green, R., Harold, L. K., Hards, K., Taylor, M. C., Morales, S. E., … Cook, G. M. (2015). Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging. PNAS, 112(33), 10497-10502. doi: 10.1073/pnas.1508385112

Lu, P., Heineke, M. H., Koul, A., Andries, K., Cook, G. M., Lill, H., … Bald, D. (2015). The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress. Scientific Reports, 5, 10333. doi: 10.1038/srep10333

Campen, R. L., Ackerley, D. F., Cook, G. M., & O'Toole, R. F. (2015). Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues. Tuberculosis, 95, 432-439. doi: 10.1016/j.tube.2015.03.012

Hards, K., Robson, J. R., Berney, M., Shaw, L., Bald, D., Koul, A., … Cook, G. M. (2015). Bactericidal mode of action of bedaquiline. Journal of Antimicrobial Chemotherapy, 70, 2028-2037. doi: 10.1093/jac/dkv054

Aung, H. L., Dixon, L. L., Smith, L. J., Sweeney, N. P., Robson, J. R., Berney, M., … Cook, G. M. (2015). Novel regulatory roles of cAMP receptor proteins in fast-growing environmental mycobacteria. Microbiology, 161(3), 648-661. doi: 10.1099/mic.0.000015

Greening, C., Constant, P., Hards, K., Morales, S. E., Oakeshott, J. G., Russell, R. J., … Cook, G. M. (2015). Atmospheric hydrogen scavenging: From enzymes to ecosystems. Applied & Environmental Microbiology, 81(4), 1190-1199. doi: 10.1128/aem.03364-14

Medini, K., Harris, P. W. R., Hards, K., Dingley, A. J., Cook, G. M., & Brimble, M. A. (2015). Chemical synthesis of a pore-forming antimicrobial protein, caenopore-5, by using native chemical ligation at a Glu-Cys site. ChemBioChem, 16(2), 328-336. doi: 10.1002/cbic.201402513

Journal - Research Other

Tran, T. T., Palmer, H. R., Weimar, M. R., Arias, C. A., Cook, G. M., & Murray, B. E. (2015). Oral bacitracin: A consideration for suppression of intestinal vancomycin-resistant enterococci (VRE) and for VRE bacteremia from an apparent gastrointestinal tract source. Clinical Infectious Diseases, 60(11), 1726-1728. doi: 10.1093/cid/civ130

Aung, H. L., Dey, D., Janssen, P. H., Ronimus, R. S., & Cook, G. M. (2015). A high-throughput screening assay for identification of inhibitors of the A₁A_o-ATP synthase of the rumen methanogen Methanobrevibacter ruminantium M₁ [Note]. Journal of Microbiological Methods, 110, 15-17. doi: 10.1016/j.mimet.2014.12.022

Conference Contribution - Published proceedings: Abstract

Krause, K., Poen, S., Mortuza, R., Nakatani, Y., Aung, H., Opel-Reading, H., & Cook, G. (2015). Glutamate racemase from Mycobacterium tuberculosis: New genetic and structural insights into a target for antituberculosis drug design. Open Forum Infectious Diseases, 2(Suppl. 1), 881. doi: 10.1093/ofid/ofv133.598

Nguyen, P. T. T., Challis, K. J., Cook, G. M., & Jack, M. W. (2015). A model for understanding the physics of energy coupling in multistep molecular motors. European Biophysics Journal, 44(Suppl. 1), (pp. S95). doi: 10.1007/s00249-015-1045-6

Cook, G., & Heikal, A. (2015). Generations of new anti-infectives for Agritech. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Aung, H. L., Tun, T., Moradigaravand, D., Köser, C. U., Nyunt, W. W., Aung, S. T., … Crump, J. A., … Cook, G. M., & Hill, P. C. (2015). Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis from Myanmar. Proceedings of the 8th Annual Otago International Health Research Network (OIHRN) Conference. (pp. 1). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth

Lunn, K. L., Muetzel, S., Tavendale, M. H., Carbone, V., Ganesh, S., Sang, C., … Cheung, J., … Cook, G. M., & Ronimus, R. S. (2015). Accelerating the development of inhibitors for the reduction of ruminant methane emissions using high-throughput screening methods. Proceedings of the New Zealand Microbiological Society (NZMS) 60th Conference. (pp. 55). Retrieved from http://www.nzmsconference.org.nz/

Whitman, W. B., Denny, W. A., Cook, G. M., Ganesh, S., Morrison, M., McSweeney, C., … Cheung, J., … Weimar, M. (2015). High throughput screening of rumen methanogens in aiding the development of methane mitigation agents. Proceedings of the New Zealand Microbiological Society (NZMS) 60th Conference. (pp. 29). Retrieved from http://www.nzmsconference.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Herron, R. L., Gebhard, S., & Cook, G. M. (2015, August-September). Defining the bacitracin-resistance retwork in Enterococcus faecalis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Petridis, M., Benjak, A., Vickers, C., Arcus, V. L., Tee, Z. S., & Cook, G. M. (2015, August-September). Global transcriptomic response to nitrogen limitation in Mycobacterium smegmatis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Heikal, A., Nakatani, Y., Dunn, E. A., Hards, K., Tee, Z. S., Lott, J. S., & Cook, G. M. (2015, August-September). Building a framework for OXPHOS inhibitor discovery: The structure and mechanism of type II NADH dehydrogenase. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Hards, K., & Cook, G. M. (2015, August-September). Novel mode of action for a new TB drug. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Aung, H. L., Tun, T., Moradigaravand, D., Köser, C. U., Nyunt, W. W., Aung, S. T., … Crump, J. A., … Cook, G. M., & Hill, P. C. (2015, August-September). Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis from Myanmar. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Chapter in Book - Research

Cook, G. M., Greening, C., Hards, K., & Berney, M. (2014). Energetics of pathogenic bacteria and opportunities for drug development. In Advances in microbial physiology. Elsevier. doi: 10.1016/bs.ampbs.2014.08.001

Journal - Research Article

Hartman, T., Weinrick, B., Vilchèze, C., Berney, M., Tufariello, J., Cook, G. M., & Jacobs, Jr, W. R. (2014). Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. PLoS Pathogens, 10(11), e1004510. doi: 10.1371/journal.ppat.1004510

Cook, G. M., Hards, K., Vilchèze, C., Hartman, T., & Berney, M. (2014). Energetics of respiration and oxidative phosphorylation in mycobacteria. Microbiology Spectrum, 2(3), MGM2-0015-2013. doi: 10.1128/microbiolspec.MGM2-0015-2013

Li, Y., Mortuza, R., Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2014). Investigation of the essentiality of glutamate racemase in Mycobacterium smegmatis. Journal of Bacteriology, 196(24), 4239-4244. doi: 10.1128/jb.02090-14

Pecsi, I., Hards, K., Ekanayaka, N., Berney, M., Hartman, T., Jacobs, Jr, W. R., & Cook, G. M. (2014). Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia. mBio, 5(4), e01093-14. doi: 10.1128/mBio.01093-14

Dunn, E. A., Roxburgh, M., Larsen, L., Smith, R. A. J., McLellan, A. D., Heikal, A., Murphy, M. P., & Cook, G. M. (2014). Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry, 22(19), 5320-5328. doi: 10.1016/j.bmc.2014.07.050

Greening, C., Villas-Bôas, S. G., Robson, J. R., Berney, M., & Cook, G. M. (2014). The growth and survival of Mycobacterium smegmatis is enhanced by co-metabolism of atmospheric H₂. PLoS ONE, 9(7), e103034. doi: 10.1371/journal.pone.0103034

Gebhard, S., Busby, J. N., Fritz, G., Moreland, N. J., Cook, G. M., Lott, J. S., … Money, V. A. (2014). Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis. Journal of Bacteriology, 196(19), 3472-3481. doi: 10.1128/jb.01965-14

Berney, M., Greening, C., Conrad, R., Jacobs, Jr, W. R., & Cook, G. M. (2014). An obligately aerobic soil bacterium activates fermentative hydrogen production to survive reductive stress during hypoxia. PNAS, 111(31), 11479-11484. doi: 10.1073/pnas.1407034111

Aung, H. L., Berney, M., & Cook, G. M. (2014). Hypoxia-activated cytochrome bd expression in Mycobacterium smegmatis is cyclic AMP receptor protein dependent. Journal of Bacteriology, 196(17), 3091-3097. doi: 10.1128/jb.01771-14

Kingston, A. W., Zhao, H., Cook, G. M., & Helmann, J. D. (2014). Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: Implications for the mechanism of resistance mediated by the BceAB transporter. Molecular Microbiology, 93(1), 37-49. doi: 10.1111/mmi.12637

Lagautriere, T., Bashiri, G., Paterson, N. G., Berney, M., Cook, G. M., & Baker, E. N. (2014). Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies. Acta Crystallographica Section D, 70(Pt 4), 968-980. doi: 10.1107/s1399004713034391

Portela, C. A. F., Smart, K. F., Tumanov, S., Cook, G. M., & Villas-Bôas, S. G. (2014). The global metabolic response of Enterococcus faecalis to oxygen. Journal of Bacteriology, 196(11), 2012-2022. doi: 10.1128/jb.01354-13

Fang, C., Stiegeler, E., Cook, G. M., Mascher, T., & Gebhard, S. (2014). Bacillus subtilis as a platform for molecular characterisation of regulatory mechanisms of Enterococcus faecalis resistance against cell wall antibiotics. PLoS ONE, 9(3), e93169. doi: 10.1371/journal.pone.0093169

Greening, C., & Cook, G. M. (2014). Integration of hydrogenase expression and hydrogen sensing in bacterial cell physiology [Review]. Current Opinion in Microbiology, 18, 30-38. doi: 10.1016/j.mib.2014.02.001

Greening, C., Berney, M., Hards, K., Cook, G. M., & Conrad, R. (2014). A soil actinobacterium scavenges atmospheric H₂ using two membrane-associated, oxygen-dependent [NiFe] hydrogenases. PNAS, 111(11), 4257-4261. doi: 10.1073/pnas.1320586111

Gebhard, S., Fang, C., Shaaly, A., Leslie, D. J., Weimar, M. R., Kalamorz, F., Carne, A., & Cook, G. M. (2014). Identification and characterization of a bacitracin resistance network in Enterococcus faecalis. Antimicrobial Agents & Chemotherapy, 58(3), 1425-1433. doi: 10.1128/AAC.02111-13

Berney, M., Greening, C., Hards, K., Collins, D., & Cook, G. M. (2014). Three different [NiFe] hydrogenases confer metabolic flexibility in the obligate aerobe Mycobacterium smegmatis. Environmental Microbiology, 16(1), 318-330. doi: 10.1111/1462-2920.12320

McNeil, M. B., Hampton, H. G., Hards, K. J., Watson, B. N. J., Cook, G. M., & Fineran, P. C. (2014). The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria. FEBS Letters, 588(3), 414-421. doi: 10.1016/j.febslet.2013.12.019

Heikal, A., Nakatani, Y., Dunn, E., Weimar, M. R., Day, C. L., Baker, E. N., … Cook, G. M. (2014). Structure of the bacterial type II NADH dehydrogenase: A monotopic membrane protein with an essential role in energy generation. Molecular Microbiology, 91(5), 950-964. doi: 10.1111/mmi.12507

Journal - Professional & Other Non-Research Articles

Arraiano, C. M., & Cook, G. M. (2014). Editorial overview: Cell regulation: Microbial cell regulation: Looking in from the outside. Current Opinion in Microbiology, 18, v-vii. doi: 10.1016/j.mib.2014.03.001

Conference Contribution - Published proceedings: Abstract

Palmer, H. R., Tran, T. T., Arias, C. A., Cook, G. M., & Murray, B. E. (2014). Can oral bacitracin (BAC) help with vancomycin-resistant (VR) Enterococcus faecium (Efm) bacteremia unresponsive to parenteral therapy? Proceedings of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Retrieved from http://www.asm.org/index.php/meetings

Krause, K. L., Poen, S., Mortuza, R., Li, Y., Aung, H., Milligan, D., Robson, J., Opel-Reading, H., … Cook, G. M. (2014). Glutamate racemase as a target for antibiotic design in tuberculosis. Proceedings of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Retrieved from http://www.asm.org/index.php/meetings

Cook, G. (2014). Targeting bacterial energetics to produce new antimicrobials. Biochimica et Biophysica Acta: Bioenergetics, 1837(Suppl. ), e126. doi: 10.1016/j.bbabio.2014.05.032

Conference Contribution - Verbal presentation and other Conference outputs

Cook, G. (2014, September). Discovery of inhibitors of energy generation in Mycobacterium tuberulosis: A game changer in the fight against MDR/XDR TB. Verbal presentation at the Infectious Disease Research Mini-Symposium, Wellington, New Zealand.

2013

Chapter in Book - Research

Arcus, V. L., & Cook, G. M. (2013). Type II toxin-antitoxins: Structural and functional aspects of type II loci in mycobacteria. In K. Gerdes (Ed.), Prokaryotic toxin-antitoxins. (pp. 137-156). Heidelberg, Gremany: Springer. doi: 10.1007/978-3-642-33253-1_8

Journal - Research Article

Schulz, S., Iglesias-Cans, M., Krah, A., Yildiz, Ö., Leone, V., Matthies, D., Cook, G. M., … Meier, T. (2013). A new type of Na⁺-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif. PLoS Biology, 11(6), e1001596. doi: 10.1371/journal.pbio.1001596

Tsai, C.-J., Tani, K., Irie, K., Hiroaki, Y., Shimomura, T., McMillan, D. G., Cook, G. M., … Li, X.-D. (2013). Two alternative conformations of a voltage-gated sodium channel. Journal of Molecular Biology, 425, 4074-4088. doi: 10.1016/j.jmb.2013.06.036

Wilson, J. L., Jesse, H. E., Hughes, B., Lund, V., Naylor, K., Davidge, K. S., Cook, G. M., … Poole, R. K. (2013). Ru(CO)₃Cl(glycinate) (CORM-3): A carbon monoxide–releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli. Antioxidants & Redox Signaling, 19(5), 497-509. doi: 10.1089/ars.2012.4784

Shaaly, A., Kalamorz, F., Gebhard, S., & Cook, G. M. (2013). Undecaprenyl pyrophosphate phosphatase confers low-level resistance to bacitracin in Enterococcus faecalis. Journal of Antimicrobial Chemotherapy, 68, 1583-1593. doi: 10.1093/jac/dkt048

Cook, G. M., Robson, J. R., Frampton, R. A., McKenzie, J., Przybilski, R., Fineran, P. C., & Arcus, V. L. (2013). Ribonucleases in bacterial toxin–antitoxin systems. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1829, 523-531. doi: 10.1016/j.bbagrm.2013.02.007

Conference Contribution - Poster Presentation (not in published proceedings)

Robson, J., Campen, R., Shaw, L., Berney, M., O'Toole, R., & Cook, G. M. (2013, August). Uncovering the mode of action of ATP synthase inhibitor bedaquiline in mycobacteria. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Aung, H. L., Robson, J. R., Berney, M., & Cook, G. M. (2013, August). Deciphering the physiological role of cAMP receptor proteins (CRP) in Mycobacterium smegmatis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Vickers, C. J., Andrews, E. S. V., Robson, J., Cook, G., Petridis, M., & Arcus, V. (2013, August). Regulation and biochemistry of VapBC systems via the transcriptional regulator AmtR. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Cook, G. (2013, August). Publish or perish: The key to obtaining science funding in New Zealand. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

McKenzie, J. L., Duyvestyn, J. M., Smith, T., Bendak, K., Mackay, J., Cursons, R., Cook, G. M., & Arcus, V. L. (2012). Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA, 18(6), 1267-1278. doi: 10.1261/rna.031229.111

Berney, M., Weimar, M. R., Heikal, A., & Cook, G. M. (2012). Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia. Molecular Microbiology, 84(4), 664-681. doi: 10.1111/j.1365-2958.2012.08053.x

McKenzie, J. L., Robson, J., Berney, M., Smith, T. C., Ruthe, A., Gardner, P. P., Arcus, V. L., & Cook, G. M. (2012). A vapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria. Journal of Bacteriology, 194(9), 2189-2204. doi: 10.1128/jb.06790-11

Zhang, X.-X., Chang, H., Tran, S. L., Gauntlett, J. C., Cook, G. M., & Rainey, P. B. (2012). Variation in transport explains polymorphism of histidine and urocanate utilization in a natural Pseudomonas population. Environmental Microbiology, 14(8), 1941-1951. doi: 10.1111/j.1462-2920.2011.02692.x

Frampton, R., Aggio, R. B. M., Villas-Bôas, S. G., Arcus, V. L., & Cook, G. M. (2012). Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival. Journal of Biological Chemistry, 287(8), 5340-5356. doi: 10.1074/jbc.M111.286856

Tannock, G. W., Wilson, C. M., Loach, D., Cook, G. M., Eason, J., O'Toole, P. W., … Lawley, B. (2012). Resource partitioning in relation to cohabitation of Lactobacillus species in the mouse forestomach. ISME Journal, 6, 927-938. doi: 10.1038/ismej.2011.161

Journal - Research Other

Cook, G. M., & Heikal, A. (2012). Bridging the gap between a TB drug and its target. Science Translational Medicine, 4(150), 150fs33. doi: 10.1126/scitranslmed.3004816

Conference Contribution - Published proceedings: Abstract

Zhang, A. T., Liu, S., Montgomery, M. G., Cook, G. M., & Walker, J. E. (2012). Studies of ATP synthase from mycobacteria. Biochimica et Biophysica Acta: Bioenergetics, 1817(Suppl.), (pp. S28). doi: 10.1016/j.bbabio.2012.06.085

Taniguchi, N., Suzuki, T., Berney, M., Yoshida, M., & Cook, G. M. (2012). Physiological importance of the ε subunit of bacterial FOF1-ATP synthase. Biochimica et Biophysica Acta: Bioenergetics, 1817(Suppl.), (pp. S25-S26). doi: 10.1016/j.bbabio.2012.06.079

2011

Journal - Research Article

Kalamorz, F., Keis, S., McMillan, D. G. G., Olsson, K., Stanton, J.-A., Stockwell, P., Black, M. A., … Cook, G. M. (2011). Draft genome sequence of the thermoalkaliphilic Caldalkalibacillus thermarum strain TA2.A1. Journal of Bacteriology, 193(16), 4290-4291. doi: 10.1128/jb.05035-11

Sims, I. M., Frese, S. A., Walter, J., Loach, D., Wilson, M., Appleyard, K., … Livingston, M., Baird, M., Cook, G., & Tannock, G. W. (2011). Structure and functions of exopolysaccharide produced by gut commensal Lactobacillus reuteri 100-23. ISME Journal, 5(7), 1115-1124. doi: 10.1038/ismej.2010.201

Taniguchi, N., Suzuki, T., Berney, M., Yoshida, M., & Cook, G. M. (2011). The regulatory C-terminal domain of subunit ε of F_oF₁ ATP synthase is dispensable for growth and survival of Escherichia coli. Journal of Bacteriology, 193(8), 2046-2052. doi: 10.1128/JB.01422-10

Arcus, V. L., McKenzie, J. L., Robson, J., & Cook, G. M. (2011). The PIN-domain ribonucleases and the prokaryotic VapBC toxin—antitoxin array. Protein Engineering, Design & Selection, 24(1-2), 33-40. doi: 10.1093/protein/gzq081

Yu, Z., Bekker, M., Tramonti, A., Cook, G. M., van Ulsen, P., Scheffers, D.-J., … Luirink, J. (2011). Activators of glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli. Journal of Bacteriology, 193(6), 1308-1316. doi: 10.1128/JB.01209-10

Journal - Research Other

McMillan, D. G. G., Ferguson, S. A., Dey, D., Schröder, K., Aung, H. L., Carbone, V., … Cook, G. M. (2011). A₁A_o-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry, 286(46), 39882-39892. doi: 10.1074/jbc.M111.281675

Conference Contribution - Poster Presentation (not in published proceedings)

Schofield, L. R., Zhang, Y., Al-Attar, S., Engelhart, R., Wolf, M., Beattie, A. K., … Cook, G. M., … Ronimus, R. S. (2011, September). Expression, purification, crystallisation, x-ray structure determination and in silico modelling of Methanobrevibacter ruminantium enzymes for the discovery of novel inhibitors. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2010

Journal - Research Article

Swe, P. M., Heng, N. C. K., Cook, G. M., Tagg, J. R., & Jack, R. W. (2010). Identification of Dysl, the immunity factor of the streptococcal bacteriocin dysgalacticin. Applied & Environmental Microbiology, 76(23), 7885-7889. doi: 10.1128/AEM.01707-10

McMillan, D. G. G., Velasquez, I., Nunn, B. L., Goodlett, D. R., Hunter, K. A., Lamont, I., Sander, S. G., & Cook, G. M. (2010). Acquisition of iron by alkaliphilic Bacillus species. Applied & Environmental Microbiology, 76(20), 6955-6961. doi: 10.1128/AEM.01393-10

Shepherd, M., Sanguinetti, G., Cook, G. M., & Poole, R. K. (2010). Compensations for diminished terminal oxidase activity in Escherichia coli: Cytochrome bd-II-mediated respiration and glutamate metabolism. Journal of Biological Chemistry, 285(24), 18464-18472. doi: 10.1074/jbc.M110.118448

Hümpel, A., Gebhard, S., Cook, G. M., & Berney, M. (2010). The SigF regulon in Mycobacterium smegmatis reveals roles in adaptation to stationary phase, heat and oxidative stress. Journal of Bacteriology, 192(10), 2491-2502. doi: 10.1128/JB.00035-10

Berney, M., & Cook, G. M. (2010). Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia. PLoS ONE, 5(1), e8614. doi: 10.1371/journal.pone.0008614

Conference Contribution - Published proceedings: Abstract

Ferguson, S. A., Cook, G. M., Montgomery, M. G., Leslie, A. G. W., & Walker, J. E. (2010). The structure with bound nucleotides of a thermoalkaliphilic F₁-ATPase from Bacillus TA2.A1. Biochimica et Biophysica Acta (BBA) - Bioenergetics. (Suppl. 1), 1797, (pp. 30-31). doi: 10.1016/j.bbabio.2010.04.109

Matthies, D., Preiss, L., Morgner, N., . . ., Cook, G. M., & et al (2010). Structural studies of the membrane-embedded c-ring of the F₁F_o-ATP synthase from a thermoalkaliphilic bacterium reveal a strategy for adaptation to alkaline environments. Biochimica et Biophysica Acta (BBA) - Bioenergetics. (Supplement 1), 1797, (pp. 36). doi: 10.1016/j.bbabio.2010.04.125

Cook, G. M. (2010). Energetics of mycobacteria: A fertile area for new anti-TB drugs. Biochimica et Biophysica Acta. (Suppl. 1), 1797, (pp. 111-112). doi: 10.1016/j.bbabio.2010.04.335

Conference Contribution - Verbal presentation and other Conference outputs

Cook, G. (2010, November). Proline metabolism by mycobacteria and its role in methylgloxal detoxification. Invited presentation at the Genetics Otago Symposium, Dunedin, New Zealand.

2009

Chapter in Book - Research

Cook, G. M., Berney, M., Gebhard, S., Heinemann, M., Cox, R. A., Danilchanka, O., & Niederweis, M. (2009). Physiology of mycobacteria. In R. K. Poole (Ed.), Advances in microbial physiology (Vol. 55). (pp. 83-183). London: Elsevier. doi: 10.1016/s0065-2911(09)05502-7

Journal - Research Article

Gebhard, S., Ekanayaka, N., & Cook, G. M. (2009). The low-affinity phosphate transporter PitA is dispensable for in vitro growth of Mycobacterium smegmatis. Respiratory Research, 10. doi: 10.1186/1471-2180-9-254

McMillan, D. G. G., Keis, S., Berney, M., & Cook, G. M. (2009). Nonfermentative thermoalkaliphilic growth is restricted to alkaline environments. Applied & Environmental Microbiology, 75(24), 7649-7654. doi: 10.1128/AEM.01639-09

Mesbah, N. M., Cook, G. M., & Wiegel, J. (2009). The halophilic alkalithermophile Natranaerobius thermophilus adapts to multiple environmental extremes using a large repertoire of Na⁺(K⁺)/H⁺ antiporters. Molecular Microbiology, 74(2), 270-281. doi: 10.1111/j.1365-2958.2009.06845.x

Gebhard, S., Gaballa, A., Helmann, J. D., & Cook, G. M. (2009). Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein. Molecular Microbiology, 73(3), 482-491. doi: 10.1111/j.1365-2958.2009.06787.x

Swe, P. M., Cook, G. M., Tagg, J. R., & Jack, R. W. (2009). Mode of action of dysgalacticin: A large heat-labile bacteriocin. Journal of Antimicrobial Chemotherapy, 63(4), 679-686. doi: 10.1093/jac/dkn552

Matthies, D., Preiss, L., Klyszejko, A. L., Muller, D. J., Cook, G. M., Vonck, J., & Meier, T. (2009). The C₁₃ ring from a thermoalkaliphilic ATP synthase reveals an extended diameter due to a special structural region. Journal of Molecular Biology, 388(3), 611-618. doi: 10.1016/j.jmb.2009.03.052

Robson, J., McKenzie, J. L., Cursons, R., Cook, G. M., & Arcus, V. L. (2009). The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. Journal of Molecular Biology, 390, 353-367. doi: 10.1016/j.jmb.2009.05.006

Conference Contribution - Published proceedings: Abstract

Czepluch, W., Everitt, C. L., Cook, G. M., & McLellan, A. D. (2009). Role of soluble factors released by coccoid forms of mycobacteria in the immune response. Proceedings of the Australasian Society for Immunology 39th Annual Scientific Meeting. ASI. Retrieved from http://www.asi2009.org/

Li, Y., Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2009). The glutamate racemase of Mycobacterium smegmatis is essential for growth in the absence of D-glutamate. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Frampton, R. A., Arcus, V. L., & Cook, G. M. (2009). Investigation into the role of the mazEF and phd/doc toxin-antitoxin systems of Mycobacterium smegmatis. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Shaaly, A., Gauntlett, J. C., Gebhard, S., & Cook, G. M. (2009). The uppP gene in Enterococcus faecalis contributes to low-level bacitracin resistance. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Ekanayaka, N. V., Cook, G. M., & Berney, M. (2009). Deciphering the transcriptional response of Mycobacterium smegmatis during growth on cholesterol at low growth rate. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

McKenzie, J., Robson, J., Cook, G., Cursons, R., Ruthe, A., & Arcus, V. (2009). The role of VapBC toxin-antitoxin proteins in Mycobacteria. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf

Berney, M., & Cook, G. M. (2009). Energy metabolism of slow-replicating Mycobacterium smegmatis. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf

Robson, J., McKenzie, J. L., Cursons, R., Cook, G. M., & Arcus, V. L. (2009). The vacBC operon from Mycobacterium smegmatis is a toxin-antitoxin module which controls growth via inhibition of translation. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Cutfield, S., Gauntlett, J., & Cook, G. (2009, August). Crystals of BcrR: A membrane-bound bacitracin sensor and DNA-binding protein. Poster session presented at the 25th European Crystallographic Meeting, Istanbul, Turkey.

Other Research Output

Cook, G. (2009, July). Bioenergetics of thermoalkaliphiles and their nanomolecular machines. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].

2008

Journal - Research Article

von Ballmoos, C., Cook, G. M., & Dimroth, P. (2008). Unique rotary ATP synthase and its biological diversity. Annual Review of Biophysics, 37, 43-64. doi: 10.1146/annurev.biophys.37.032807.130018

Gauntlett, J. C., Gebhard, S., Keis, S., Manson, J. M., Pos, K. M., & Cook, G. M. (2008). Molecular analysis of BcrR, a membrane-bound bacitracin sensor and DNA-binding protein from Enterococcus faecalis. Journal of Biological Chemistry, 283(13), 8591-8600. doi: 10.1074/jbc.M709503200

Gebhard, S., & Cook, G. M. (2008). Differential regulation of high-affinity phosphate transport systems of Mycobacterium smegmatis: Identification of PhnF, a repressor of the phnDCE operon. Journal of Bacteriology, 190(4), 1335-1343. doi: 10.1128/JB.01764-07

Gebhard, S., Hümpel, A., McLellan, A. D., & Cook, G. M. (2008). The alternative sigma factor SigF of Mycobacterium smegmatis is required for survival of heat shock, acidic pH and oxidative stress. Microbiology, 154(Pt 9), 2786-2795. doi: 10.1099/mic.0.2008/018044-0

Conference Contribution - Published proceedings: Abstract

Lee, S. M., Carne, A., & Cook, G. (2008). Comparative proteome analysis of vancomycin-resistant Enterococcus faecalis grown under aerobic and anaerobic conditions in continuous culture. New Zealand Medical Journal, 121(1278). Retrieved from http://journal.nzma.org.nz/journal/121-1278/3179/content.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Berney, M., & Cook, G. M. (2008, November). Energy metabolism of slow-replicating mycobacterium smegmatis. Verbal presentation at the Otago International Health Research Network Conference, Dunedin, New Zealand.

2007

Journal - Research Article

McMillan, D. G. G., Keis, S., Dimroth, P., & Cook, G. M. (2007). A specific adaptation in the a subunit of thermoalkaliphilic F₁F_o-ATP synthase enables ATP synthesis at high pH but not at neutral pH values. Journal of Biological Chemistry, 282(24), 17395-17404.

Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2007). The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine. Journal of Bacteriology, 189(22), 8381-8386.

Lee, S. M., Ender, M., Adhikari, R., Smith, J. M. B., Berger-Bächi, B., & Cook, G. M. (2007). Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture. Antimicrobial Agents & Chemotherapy, 51(4), 1497-1499.

Meier, T., Morgner, N., Matthies, D., Pogoryelov, D., Keis, S., Cook, G. M., … Brutschy, B. (2007). A tridecameric c ring of the adenosine triphosphate (ATP) synthase from the thermoalkaliphilic Bacillus sp. strain TA2.A1 facilitates ATP synthesis at low electrochemical proton potential. Molecular Microbiology, 65(5), 1181-1192.

Dufour, M., Manson, J. M., Bremer, P. J., Dufour, J.-P., Cook, G. M., & Simmonds, R. S. (2007). Characterization of monolaurin resistance in Enterococcus faecalis. Applied & Environmental Microbiology, 73(17), 5507-5515.

Stocker, A., Keis, S., Vonck, J., Cook, G. M., & Dimroth, P. (2007). The structural basis for unidirectional rotation of thermoalkaliphilic F₁-ATPase. Structure, 15, 904-914.

Cox, R. A., & Cook, G. M. (2007). Growth regulation in the mycobacterial cell. Current Molecular Medicine, 7, 231-245.

2006

Journal - Research Article

Gebhard, S., Tran, S. L., & Cook, G. M. (2006). The Phn system of Mycobacterium smegmatis: A second high-affinity ABC-transporter for phosphate. Microbiology, 152, 3453-3465.

Baker, M., Wilson, N., Ikram, R., Chambers, S., Shoemack, P., & Cook, G. (2006). Regulation of chicken contamination urgently needed to control New Zealand's serious campylobacteriosis epidemic. New Zealand Medical Journal, 119(1243). Retrieved from http://journal.nzma.org.nz/journal/119-1243/2264/content.pdf

Ferguson, S. A., Keis, S., & Cook, G. M. (2006). Biochemical and molecular characterization of a Na⁺-translocating F₁F_o-ATPase from the thermoalkaliphilic bacterium Clostridium paradoxum. Journal of Bacteriology, 188(14), 5045-5054.

Keis, S., Stocker, A., Dimroth, P., & Cook, G. M. (2006). Inhibition of ATP hydrolysis by thermoalkaliphilic F₁F_o-ATP synthase is controlled by the C terminus of the ε subunit. Journal of Bacteriology, 188(11), 3796-3804.

Meier, T., Ferguson, S. A., Cook, G. M., Dimroth, P., & Vonck, J. (2006). Structural investigations of the membrane-embedded rotor ring of the F-ATPase from Clostridium paradoxum. Journal of Bacteriology, 188(22), 7759-7764.

2005

Journal - Research Article

Smith, J. M. B., & Cook, G. M. (2005). A decade of community MRSA in New Zealand. Epidemiology & Infection, 133, 899-904.

Tran, S. L., & Cook, G. M. (2005). The F₁F₀-ATP synthase of Mycobacterium smegmatis is essential for growth. Journal of Bacteriology, 187(14), 5023-5038.

Tran, S. L., Rao, M., Simmers, C., Gebhard, S., Olsson, K., & Cook, G. M. (2005). Mutants of Mycobacterium smegmatis unable to grow at acidic pH in the presence of the protonophore carbonyl cyanide m-chlorophenylhydrazone. Microbiology, 151, 665-672.

Stocker, A., Keis, S., Cook, G. M., & Dimroth, P. (2005). Purification, crystallization, and properties of F₁-ATPase complexes from the thermoalkaliphilic Bacillus sp. strain TA2.A1. Journal of Structural Biology, 152, 140-145.

Tannock, G. W., Ghazally, S., Walter, J., Loach, D., Brooks, H., Cook, G., … Simmers, C., Bremer, P., … Hertel, C. (2005). Ecological behavior of Lactobacillus reuteri 100-23 is affected by mutation of the luxS gene. Applied & Environmental Microbiology, 71(12), 8419-8425.

van Klink, J. W., Larsen, L., Perry, N. B., Weavers, R. T., Cook, G. M., Bremer, P. J., … Kirikae, T. (2005). Triketones active against antibiotic-resistant bacteria: Synthesis, structure-activity relationships, and mode of action. Bioorganic & Medicinal Chemistry, 13, 6651-6662.

Conference Contribution - Poster Presentation (not in published proceedings)

Swe, P., Heng, N. C. K., Cook, G. M., & Jack, R. W. (2005, November). Preliminary effects of the antimicrobial protein dysgalacticin against Streptococcus pyogenes. Poster session presented at the 50th Annual General Meeting of the New Zealand Microbiological Society, University of Otago, Dunedin.

2004

Chapter in Book - Research

Dimroth, P., & Cook, G. M. (2004). Bacterial Na⁺- or H⁺ -coupled ATP synthases operating at low electrochemical potential. In Advances in Microbial Physiology, Vol. 49. (pp. 175-210). London: Academic Press.

Journal - Research Article

Manson, J. M., Smith, J. M. B., & Cook, G. M. (2004). Persistence of vancomycin-resistant enterococci in New Zealand broilers after discontinuation of avoparcin use. Applied & Environmental Microbiology, 70(10), 5764-5768.

Anderson, C. R., & Cook, G. M. (2004). Isolation and characterization of arsenate-reducing bacteria from arsenic-contaminated sites in New Zealand. Current Microbiology, 48, 341-347.

Keis, S., Kaim, G., Dimroth, P., & Cook, G. M. (2004). Cloning and molecular characterization of the atp operon encoding for the F₁F_o-ATP synthase from a thermoalkaliphilic Bacillus sp. strain TA2.A1. Biochimica et Biophysica Acta: Gene Structure & Expression, 1676, 112-117.

Manson, J. M., Keis, S., Smith, J. M. B., & Cook, G. M. (2004). Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR. Antimicrobial Agents & Chemotherapy, 48(10), 3743-3748.

Adhikari, R. P., Scales, G. C., Kobayashi, K., Smith, J. M. B., Berger-Bächi, B., & Cook, G. M. (2004). Vancomycin-induced deletion of the methicillin resistance gene mecA in Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 54, 360-363.

Cruz-Ramos, H., Cook, G. M., Wu, G., Cleeter, M. W., & Poole, R. K. (2004). Membrane topology and mutational analysis of Escherichia coli CydDC, an ABC-type cysteine exporter required for cytochrome assembly. Microbiology, 150, 3415-3427.

Monk, I. R., Cook, G. M., Monk, B. C., & Bremer, P. J. (2004). Morphotypic conversion in Listeria monocytogenes biofilm formation: Biological significance of rough colony isolates. Applied & Environmental Microbiology, 70(11), 6686-6694.

Conference Contribution - Published proceedings: Abstract

Dufour, M., Manson, J. M., Bremer, P. J., Cook, G. M., & Simmonds, R. S. (2004). Characterization of monolaurin resistance in Enterococcus faecalis. Proceedings of the NZMS Conference: Microbes Outside the Square. (pp. 172). [Abstract]

2003

Journal - Research Article

Olsson, K., Keis, S., Morgan, H. W., Dimroth, P., & Cook, G. M. (2003). Bioenergetic properties of the thermoalkaliphilic Bacillus sp. strain TA2.A1. Journal of Bacteriology, 185(2), 461-465.

Young, K., Seale, R. B., Olsson, K., Aislabie, J., & Cook, G. M. (2003). Amino acid transport by Sphingomonas sp. strain Ant 17 isolated from oil-contaminated Antarctic soil. Polar Biology, 26, 560-566.

Manson, J. M., Keis, S., Smith, J. M. B., & Cook, G. M. (2003). A clonal lineage of VanA-type Enterococcus faecalis predominates in vancomycin-resistant enterococci isolated in New Zealand. Antimicrobial Agents & Chemotherapy, 47(1), 204-210. doi: 10.1128/AAC.47.1.204-210.2003

Manson, J. M., Keis, S., Smith, J. M. B., & Cook, G. M. (2003). Characterization of a vancomycin-resistant Enterococcus faecalis (VREF) isolate from a dog with mastitis: Further evidence of a clonal lineage of VREF in New Zealand. Journal of Clinical Microbiology, 41(7), 3331-3333. doi: 10.1128/JCM.41.7.3331-3333.2003

Cook, G. M., Keis, S., Morgan, H. W., von Ballmoos, C., Matthey, U., Kaim, G., & Dimroth, P. (2003). Purification and biochemical characterization of the F₁F_o-ATP synthase from thermoalkaliphilic Bacillus sp. strain TA2.A1. Journal of Bacteriology, 185(15), 4442-4449.

Conference Contribution - Published proceedings: Abstract

Monk, I., Cook, G. M., Monk, B. C., & Bremer, P. J. (2003). Smooth to rough morphotypic variation in listeria monocytogenes biofilms. Proceedings of the American Society for Microbiology Conference: Biofilms 2003. (pp. 174). Victoria, Canada: ASM. [Abstract]

Monk, I., Cook, G. M., Monk, B. C., & Bremer, P. J. (2003). Exploring the role of bacterial biofilms in phenotypic variatio. Abstracts of the Combined Annual Scientific Meeting and Exhibition of the Australian and New Zealand Societies for Microbiology: MicroNZ 2003 - Art in science. (pp. 53). Auckland: ASM/NZMS. [Abstract]

2002

Chapter in Book - Research

Tannock, G. W., & Cook, G. (2002). Enterococci as members of the intestinal microflora of humans. In M. S. Gilmore & et al (Eds.), The Enterococci: Pathogenesis, Molecular Biology, and Antibiotic Resistance. (pp. 101-132). Washington, DC: ASM Press.

Journal - Research Article

Adhikari, R. P., Cook, G. M., Lamont, I., Lang, S., Heffernan, H., & Smith, J. M. B. (2002). Phenotypic and molecular characterization of community occurring, Western Samoan phage pattern methicillin-resistant Staphyococcus aureus. Journal of Antimicrobial Chemotherapy, 50, 825-831.

Cook, G. M., Cruz-Ramos, H., Moir, A. J. G., & Poole, R. K. (2002). A novel haem compound accumulated in Escherichia coli overexpressing the cydDC operon, encoding an ABC-type transporter required for sytochrome assembly. Archives of Microbiology, 178, 358-369.

2001

Journal - Research Article

Rao, M., Streur, T. L., Aldwell, F., & Cook, G. M. (2001). Intracellular pH regulation by Mycobacterium smegmatis and Mycobacterium bovis BCG. Microbiology, 147, 1017-1024.

Smith, J. M. B., & Cook, G. M. (2001). Loss of methicillin resistance in MRSA. New Ethicals Journal, 4(12), 57-62.

Journal - Professional & Other Non-Research Articles

Cook, G. M., Manson, J. M., & Smith, J. M. B. (2001). First report of vancomycin-resistant enterococci from poultry in New Zealand. Antibiotics Chemotherapy, 5(2), 17-18.

Smith, J. M. B., & Cook, G. (2001). The Staphylococcus 'superbug'. New Ethicals Journal, 4(4), 61-65.

Conference Contribution - Published proceedings: Abstract

Shirley, M. J., McDougal, R. L., Aislabie, J., Ronson, C. W., & Cook, G. M. (2001). Characterization of the biphenyl/DDE degradation genes of terrabacter sp.strain DDE-1. Proceedings of the 9th International Symposium on Microbial Ecology. (pp. 357-358). Amsterdam, Netherlands: Eurocongres Conference Management. [Abstract]

Manson, J. M., Smith, S., & Cook, G. M. (2001). Isolation and characterization of vancomycin-resistant enterococci from chickens in New Zealand. New Zealand Medical Journal, 114(1141), (pp. 456). Retrieved from https://www.nzma.org.nz/journal

Monk, I., Bremer, P. J., & Cook, G. M. (2001). Listeria monocytogenes in food processing environments: Are all cells created equal? NZIFST Annual Meeting. (pp. 34). Dunedin New Zealand: NZIFST. [Abstract]

2000

Chapter in Book - Research

Poole, R. K., & Cook, G. M. (2000). Redundancy of oxidase function in bacteria? Routes, reasons and regulation. In R. K. Poole (Ed.), Advances in Microbial Physiology. (pp. 165-224). London: Academic Press.

Journal - Research Article

Cook, G. M., & Poole, R. K. (2000). Oxidase and periplasmic cytochrome assembly in Escherichia coli K-12: CydDC and CcmAB are not required for haem-membrane association. Microbiology, 146, 527-536.

Kobayashi, K., Rao, M., Keis, S., Rainey, F. A., Smith, J. M. B., & Cook, G. M. (2000). Enterococci with reduced susceptibility to vancomycin in New Zealand. Journal of Antimicrobial Chemotherapy, 46, 405-410.

Peddie, C. J., Cook, G. M., & Morgan, H. W. (2000). Sucrose transport by the alkaliphilic, thermophilic Bacillus sp. strain TA2.A1 is dependent on a sodium gradient. Extremophiles, 4, 291-296.

Cook, G. M. (2000). The intracellular pH of the thermophilic bacterium Thermoanaerobacter wiegelii during growth and production of fermentation acids. Extremophiles, 4, 279-284.

Lindqvist, A., Membrillo-Hernandez, J., Poole, R. K., & Cook, G. M. (2000). Roles of respiratory oxidases in protecting Escherichia coli K 12 from oxidative stress. Antonie van Leeuwenhoek, 78(1), 23-31. doi: 10.1023/A:1002779201379

Conference Contribution - Published proceedings: Abstract

Cook, G. M. (2000). Bacterial genome sequencing and drug target discovery. In H. Brooks (Ed.), Proceedings of the University of Otago Medical School. 78(1), (pp. 1). Dunedin: Otago Medical Research Foundation. [Abstract]

1999

Journal - Research Article

Peddie, C. J., Cook, G. M., & Morgan, H. W. (1999). Sodium-dependent glutamate uptake by an alkaliphilic, thermophilic Bacillus strain TA2.A1. Journal of Bacteriology, 181, 3172-3177.

Kobayashi, K., Rao, M., Smith, J. M. B., & Cook, G. M. (1999). Vancomycin resistant enterococci in New Zealand. New Zealand Medical Journal, 112, 105.

Trainor, V. C., Udy, R., Bremer, P. J., & Cook, G. M. (1999). Survival of Streptococcus pyogenes under stress and starvation. FEMS Microbiology Letters, 176, 421-428.

Journal - Professional & Other Non-Research Articles

Cook, G. M., Kobayashi, K., Rao, M., Scales, G. S., & Smith, J. M. B. (1999). When anibiotics fail: vancomycin-resistant MRSA. New Zealand Microbiology, 4, 33-34.

Conference Contribution - Published proceedings: Abstract

Cook, G. M., Kobayashi, K., Rao, M., & Smith, J. M. B. (1999). Characterization of enterococci with reduced susceptibility to vancomycin in Dunedin Hospital. Proceedings of the University of Otago Medical School, 77, (pp. 29). [Abstract]

1998

Journal - Research Article

Paradise, M. R., Cook, G. M., Poole, R. K., & Rather, P. N. (1998). Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2'-N-acetyltransferase. Antimicrobial Agents & Chemotherapy, 42, 959-962.

Cook, G. M., Loder, C., Stafford, G. P., Membrillo-Hernçndez, J., & Poole, R. K. (1998). A factor produced by Escherichia coli K-12 inhibits the growth of E. coli mutants defective in the cytochrome bd quinol oxidase complex: enterochelin rediscovered. Microbiology, 144, 3297-3308.

Macinga, D. R., Cook, G. M., Poole, R. K., & Rather, P. N. (1998). Identification and characterization aarF, a locus required for the production of ubiquinone in Providencia stuartii and Escherichia coli and for expresssion of the 2'-N-acetyltransferase in Providencia stuartii. Journal of Bacteriology, 180, 128-135.

Conference Contribution - Published proceedings: Abstract

Trainor, V. T., Bremer, P. J., & Cook, G. M. (1998). The starvation stress response of Streptococcus pyogenes. Proceedings of the Joint Annual Meeting of the New Zealand Microbiological Society and the New Zealand Society for Biochemistry and Molecular Biology. (pp. 34). [Abstract]

1997

Journal - Research Article

Cook, G. M., Membrillo-Hernandez, J., & Poole, R. K. (1997). Transcriptional regulation of the cydDC operon, encoding a heterodimeric ABC transporter required for assembly of cytochromes c and bd in Escherichia coli K12: regulation by oxygen and alternative electron acceptors. Journal of Bacteriology, 179(20), 6525-6530.

Membrillo-Hernandez, J., Kim, S. O., Cook, G. M., & Poole, R. K. (1997). Paraquat regulation of hmp (flavohemoglobin) gene expression in Escherichia coli K-12 is SoxRS independent but modulated by sigma(s). Journal of Bacteriology, 179(10), 3164-3170.

Membrillo-Hernandez, J., Cook, G. M., & Poole, R. K. (1997). Roles of RpoS (sigma(s)), IHF and ppGpp in the expression of the hmp encoding the flavohemoglobin (HMP) of Escherichia coli K-12. Molecular & General Genetics, 254(5), 599-603.

1996

Journal - Research Article

Saier, Jr, M. H., Chauvaux, S., Cook, G. M., Deutscher, J., Paulsen, I. T., Reizer, J., & Ye, J. J. (1996). Catabolite repression and inducer control in gram-positive bacteria. Microbiology, 142(2), 217-230.

Cook, G. M., Rainey, F. A., Patel, B. K. C., & Morgan, H. W. (1996). Characterization of a new obligately anaerobic thermophile, Thermonanaerobacter wiegelii sp. nov. International Journal of Systematic Bacteriology, 46(1), 123-127. doi: 10.1099/00207713-46-1-123

Russell, J. B., Bond, D. R., & Cook, G. M. (1996). The fructose diphosphate/phosphate regulation of carbohydrate metabolism in low G+C gram-positive anaerobes. Research in Microbiology, 147(6-7), 528-535.

Kearns, D. B., Cook, G. M., & Russell, J. B. (1996). Inducer expulsion is not a determinant of diauxic growth in Streptococcus bovis. Current Microbiology, 32(4), 221-224.

Carneiro de Melo, A. M. S., Cook, G. M., Miles, R. J., & Poole, R. K. (1996). Nisin stimulates oxygen consumption by Staphylococcus aureus and Escherichia coli. Applied & Environmental Microbiology, 62(5), 1831-1834.

Cook, G. M., Russell, J. B., Reichert, A., & Wiegel, J. (1996). The intracellular pH of Clostridium paradoxum, an anaerobic, alkaliphilic and thermophilic bacterium. Applied & Environmental Microbiology, 62(12), 4576-4579.

1995

Journal - Research Article

Cook, G. M., Ye, J. J., Russell, J. B., & Saier, Jr, M. H. (1995). Properties of two sugar phosphate phosphatases from Streptococcus bovis and their potential involvement in inducer expulsion. Journal of Bacteriology, 177(23), 7007-7009.

Russell, J. B., & Cook, G. M. (1995). Energetics of bacterial growth: balance of anabolic and catabolic reactions. Microbiological Reviews, 59(1), 48-62.

Cook, G. M., Kearns, D. B., Russell, J. B., Reizer, J., & Saier, M. H. J. (1995). Regulation of the lactose phosphotransferase system of Streptococcus bovis by glucose: the independance of inducer exclusion and expulsion mechanisms. Microbiology, 141(9), 2261-2269.