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Jasoni Laboratory

Research interests

The focus of our research is on discovering how the maternal environment during pregnancy affects the formation of the fetal brain. With conditions such as obesity and diabetes on the rise in Western society, it is critical that we fully understand the health implications of these disorders for future generations.

At the Centre for Neuroendocrinology we seek to:

  • Discover epigenetic changes in the brains of the offspring of obese or diabetic mothers
  • Establish specifically how these changes bring about altered development of axon tracts in the offspring hypothalamus

Clinical conditions

Jasoni Laboratory staff & students

Kelly Glendining_webKelly Glendining, Assistant Research Fellow
Changes in neural circuitry and gene expression in the offspring of obese dams
Email kelly.glendining@otago.ac.nz

Yugo Watanabe_webYugo Watanabe, Postdoctoral Fellow
The origins of PCOS by prenatal androgen exposure
Email yugo.watanabe@otago.ac.nz

Matt Higgins_webMatt Higgins, PhD student
The mechanisms underpinning leptin signaling in maturation of arcuate nucleus body weight homeostasis neural circuitry
Email: matt.higgins@postgrad.otago.ac.nz

Lorryn Fisher, Research Technician
Changes in neural circuitry and gene expression in the offspring of obese dams
Email lorryn.fisher@otago.ac.nz

Emma Bultitude, Honours student

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Glendining, K. A., Higgins, M. B. A., Fisher, L. C., & Jasoni, C. L. (2020). Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, Behavior, & Immunity, 88, 151-160. doi: 10.1016/j.bbi.2020.03.006

Glendining, K. A., Fisher, L. C., & Jasoni, C. L. (2020). Maternal obesity modulates expression of Satb2 in hypothalamic VMN of female offspring [Communication]. Life, 10(4), 48. doi: 10.3390/life10040048

Campbell, S., Jasoni, C., & Longnecker, N. (2019). Drinking patterns and attitudes about alcohol among New Zealand adolescents. Kōtuitui, 14(2), 276-289. doi: 10.1080/1177083X.2019.1625934

Glendining, K. A., & Jasoni, C. L. (2019). Maternal high fat diet-induced obesity modifies histone binding and expression of Oxtr in offspring hippocampus in a sex-specific manner. International Journal of Molecular Sciences, 20(2), 329. doi: 10.3390/ijms20020329

Sati, A., Prescott, M., Desroziers, E., Jasoni, C. L., & Campbell, R. E. (2019, September). The impact of prenatal androgen excess on microglia in the female mouse brain. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Journal - Research Article

Glendining, K. A., Higgins, M. B. A., Fisher, L. C., & Jasoni, C. L. (2020). Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, Behavior, & Immunity, 88, 151-160. doi: 10.1016/j.bbi.2020.03.006

Campbell, S., Jasoni, C., & Longnecker, N. (2019). Drinking patterns and attitudes about alcohol among New Zealand adolescents. Kōtuitui, 14(2), 276-289. doi: 10.1080/1177083X.2019.1625934

Tan, C. L., Sheard, P. W., & Jasoni, C. L. (2018). Developing neurites from mouse basal forebrain gonadotropin-releasing hormone neurons use Sonic hedgehog to modulate their growth. International Journal of Developmental Neuroscience, 68, 89-97. doi: 10.1016/j.ijdevneu.2018.05.005

Glendining, K. A., Fisher, L. C., & Jasoni, C. L. (2018). Maternal high fat diet alters offspring epigenetic regulators, amygdala glutamatergic profile and anxiety. Psychoneuroendocrinology, 96, 132-141. doi: 10.1016/j.psyneuen.2018.06.015

Pace, P. E., Peskin, A. V., Konigstorfer, A., Jasoni, C. L., Winterbourn, C. C., & Hampton, M. B. (2018). Peroxiredoxin interaction with the cytoskeletal-regulatory protein CRMP2: Investigation of a putative redox relay. Free Radical Biology & Medicine, 129, 383-393. doi: 10.1016/j.freeradbiomed.2018.10.407

Thomson-Laing, G., Jasoni, C. L., & Lokman, P. M. (2018). The effects of migratory stage and 11-ketotestosterone on the expression of rod opsin genes in the shortfinned eel (Anguilla australis). General & Comparative Endocrinology, 257, 211-219. doi: 10.1016/j.ygcen.2017.06.025

Méneret, A., Franz, E. A., Trouillard, O., Oliver, T. C., Zagar, Y., Robertson, S. P., … Gardner, R. J. M., … Jasoni, C. L., … Markie, D. (2017). Mutations in the netrin-1 gene cause congenital mirror movements. Journal of Clinical Investigation, 127(11), 3923-3936. doi: 10.1172/jci95442

Glendining, K. A., Markie, D., Gardner, R. J. M., Franz, E. A., Robertson, S. P., & Jasoni, C. L. (2017). A novel role for the DNA repair gene Rad51 in Netrin-1 signalling. Scientific Reports, 7, 39823. doi: 10.1038/srep39823

Sanders, T. R., Glendining, K. A., & Jasoni, C. L. (2017). Obesity during pregnancy in the mouse alters the Netrin-1 responsiveness of foetal arcuate nucleus neuropeptide Y neurones. Journal of Neuroendocrinology, 29(12), e12556. doi: 10.1111/jne.12556

Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016). Maternal obesity in the mouse compromises the blood-brain barrier in the arcuate nucleus of offspring. Endocrinology, 157(6), 2229-2242. doi: 10.1210/en.2016-1014

Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016). Maternal obesity leads to increased proliferation and numbers of astrocytes in the developing fetal and neonatal mouse hypothalamus. International Journal of Developmental Neuroscience, 53, 18-25. doi: 10.1016/j.ijdevneu.2016.06.005

Doynova, M. D., Berretta, A., Jones, M. B., Jasoni, C. L., Vickers, M. H., & O'Sullivan, J. M. (2016). Interactions between mitochondrial and nuclear DNA in mammalian cells are non-random. Mitochondrion, 30, 187-196. doi: 10.1016/j.mito.2016.08.003

Berretta, A., Gowing, E. K., Jasoni, C. L., & Clarkson, A. N. (2016). Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis. Scientific Reports, 6, 21896. doi: 10.1038/srep21896

Prescott, S. L., Allen, K., Armstrong, K., Collins, C., Dickinson, H., Gardiner, K., … Jasoni, C., … Craig, J. M. (2016). The establishment of DOHaD working groups in Australia and New Zealand. Journal of Developmental Origins of Health & Disease, 7(5), 433-439. doi: 10.1017/S2040174416000167

Hale, M. W., Spencer, S. J., Conti, B., Jasoni, C. L., Kent, S., Radler, M. E., … Sominsky, L. (2015). Diet, behavior and immunity across the lifespan. Neuroscience & Biobehavioral Reviews, 58, 46-62. doi: 10.1016/j.neubiorev.2014.12.009

Franz, E. A., Chiaroni-Clarke, R., Woodrow, S., Glendining, K. A., Jasoni, C. L., Robertson, S. P., Gardner, R. J. M., & Markie, D. (2015). Congenital mirror movements: Phenotypes associated with DCC and RAD51 mutations. Journal of the Neurological Sciences, 351(1-2), 140-145. doi: 10.1016/j.jns.2015.03.006

Jasoni, C. L., Sanders, T. R., & Kim, D. W. (2015). Do all roads lead to Rome? The role of neuro-immune interactions before birth in the programming of offspring obesity. Frontiers in Neuroscience, 8, 455. doi: 10.3389/fnins.2014.00455

Kim, D. W., Young, S. L., Grattan, D. R., & Jasoni, C. L. (2014). Obesity during pregnancy disrupts placental morphology, cell proliferation, and inflammation in a sex-specific manner across gestation in the mouse. Biology of Reproduction, 90(6), 130. doi: 10.1095/biolreprod.113.117259

Sanders, T. R., Kim, D. W., Glendining, K. A., & Jasoni, C. L. (2014). Maternal obesity and IL-6 lead to aberrant developmental gene expression and deregulated neurite growth in the fetal arcuate nucleus. Endocrinology, 155(7), 2566-2577. doi: 10.1210/en.2013-1968

Wyatt, A. K., Zavodna, M., Viljoen, J. L., Stanton, J.-A. L., Gemmell, N. J., & Jasoni, C. L. (2013). Changes in methylation patterns of Kiss1 and Kiss1r gene promoters across puberty. Genetics & Epigenetics, 5, 51-62.

Low, V. F., Fiorini, Z., Fisher, L., & Jasoni, C. L. (2012). Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium-dependent manner. PLoS ONE, 7(10), e46999. doi: 10.1371/journal.pone.0046999

Constantin, S., Jasoni, C., Romanò, N., Lee, K., & Herbison, A. E. (2012). Understanding calcium homeostasis in postnatal gonadotropin-releasing hormone neurons using cell-specific Pericam transgenics. Cell Calcium, 51(3-4), 267-276. doi: 10.1016/j.ceca.2011.11.005

Jasoni, C. L., & Campbell, S. R. S. (2011). Defining the cellular targets of IL6 in the fetal mouse brain. Journal of Developmental Origins of Health & Disease, 2(Suppl. 1), S77. doi: 10.1017/S2040174411000481

Fiorini, Z., & Jasoni, C. L. (2010). A novel developmental role for Kisspeptin in the growth of GnRH neurites to the median eminence in the mouse. Journal of Neuroendocrinology, 22(10), 1113-1125. doi: 10.1111/j.1365-2826.2010.02059.x

Jasoni, C. L., Romanò, N., Constantin, S., Lee, K., & Herbison, A. E. (2010). Calcium dynamics in gonadotropin-releasing hormone neurons. Frontiers in Neuroendocrinology, 31, 259-269. doi: 10.1016/j.yfrne.2010.05.005

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