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Jasoni Laboratory

Research interests

The focus of our research is on discovering how the maternal environment during pregnancy affects the formation of the fetal brain. With conditions such as obesity and diabetes on the rise in Western society, it is critical that we fully understand the health implications of these disorders for future generations.

At the Centre for Neuroendocrinology we seek to:

  • Discover epigenetic changes in the brains of the offspring of obese or diabetic mothers
  • Establish specifically how these changes bring about altered development of axon tracts in the offspring hypothalamus

Clinical conditions

Jasoni Laboratory staff & students

Yugo Watanabe_webYugo Watanabe, Postdoctoral Fellow
The origins of PCOS by prenatal androgen exposure
Email yugo.watanabe@otago.ac.nz

Matt Higgins_webMatt Higgins, PhD student
The mechanisms underpinning leptin signaling in maturation of arcuate nucleus body weight homeostasis neural circuitry
Email: matt.higgins@postgrad.otago.ac.nz

Lorryn Fisher, Research Technician
Changes in neural circuitry and gene expression in the offspring of obese dams
Email lorryn.fisher@otago.ac.nz

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Zhou, Y., Neyt, C., Batchelor, N. J., Kelley, R. L., Jaafar Amsak, K., Anderson, G. M., Oorschot, D. E., Jasoni, C., Girling, J. E., & Pankhurst, M. W. (2022). Fetal resorption coincides with dysregulated LH secretion in AMH-overexpressing mice. Journal of Endocrinology. Advance online publication. doi: 10.1530/joe-21-0430

Watanabe, Y., Prescott, M., Campbell, R. E., & Jasoni, C. L. (2021). Prenatal androgenization causes expression changes of progesterone and androgen receptor mRNAs in the arcuate nucleus of female mice across development. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13058

Freeman, A. K., Glendining, K. A., & Jasoni, C. L. (2021). Developmental genes controlling neural circuit formation are expressed in the early postnatal hypothalamus and cellular lining of the third ventricle. Journal of Neuroendocrinology, 33(9), e13020. doi: 10.1111/jne.13020

Sati, A., Prescott, M., Holland, S., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). Morphological evidence indicate a role for microglia in shaping the polycystic ovary syndrome (PCOS)-like brain. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12999

Sati, A., Prescott, M., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). The role of microglia in the polycystic ovary syndrome (PCOS)-like brain. Journal of the Endocrine Society, 5(Suppl. 1), (pp. A556). doi: 10.1210/jendso/bvab048.1133