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Jasoni Laboratory

Research interests

The focus of our research is on discovering how the maternal environment during pregnancy affects the formation of the fetal brain. With conditions such as obesity and diabetes on the rise in Western society, it is critical that we fully understand the health implications of these disorders for future generations.

At the Centre for Neuroendocrinology we seek to:

  • Discover epigenetic changes in the brains of the offspring of obese or diabetic mothers
  • Establish specifically how these changes bring about altered development of axon tracts in the offspring hypothalamus

Clinical conditions

Jasoni Laboratory staff & students

Kelly Glendining_webKelly Glendining, Assistant Research Fellow
Changes in neural circuitry and gene expression in the offspring of obese dams
Email kelly.glendining@otago.ac.nz

Yugo Watanabe_webYugo Watanabe, Postdoctoral Fellow
The origins of PCOS by prenatal androgen exposure
Email yugo.watanabe@otago.ac.nz

Matt Higgins_webMatt Higgins, PhD student
The mechanisms underpinning leptin signaling in maturation of arcuate nucleus body weight homeostasis neural circuitry
Email: matt.higgins@postgrad.otago.ac.nz

Lorryn Fisher, Research Technician
Changes in neural circuitry and gene expression in the offspring of obese dams
Email lorryn.fisher@otago.ac.nz

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Publications

Sati, A., Prescott, M., Holland, S., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). Morphological evidence indicate a role for microglia in shaping the polycystic ovary syndrome (PCOS)-like brain. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12999

Sati, A., Prescott, M., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). The role of microglia in the polycystic ovary syndrome (PCOS)-like brain. Journal of the Endocrine Society, 5(Suppl. 1), (pp. A556). doi: 10.1210/jendso/bvab048.1133

Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., … Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12972

Glendining, K. A., Fisher, L. C., & Jasoni, C. L. (2020). Maternal obesity modulates expression of Satb2 in hypothalamic VMN of female offspring [Communication]. Life, 10(4), 48. doi: 10.3390/life10040048

Glendining, K. A., Higgins, M. B. A., Fisher, L. C., & Jasoni, C. L. (2020). Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain, Behavior, & Immunity, 88, 151-160. doi: 10.1016/j.bbi.2020.03.006