Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Nox4 ROS, a novel therapeutic target in Duchenne Muscular Dystrophy

Seminar presented by Dr Tanya Cully, Department of Physiology

Skeletal muscle function can be affected by Ca2+ regulation within a cellular microdomain known as the triad.

Reactive oxygen species (ROS) also can impact muscle function via oxidative stress and the regulation of signalling cascades. The interplay between ROS and Ca2+ signalling at the triad is poorly understood and may impact the performance of healthy and diseased muscle.

A mouse model of muscular dystrophy, the mdx mouse, displays both pathological increased Ca2+ leak via the Ryanodine receptor (RyR1), a calcium release channel, and increased NAD(P)H Oxidase (Nox) derived ROS.

Date Monday, 5 September 2022
Time 1:00pm - 2:00pm
Audience Staff,Postgraduate students
Event Category Health Sciences
Event Type Seminar
DepartmentMicrobiology and Immunology
LocationThe Biochemistry Building, 710 Cumberland Street, Ground Floor, Rm BIG13, Dunedin
Contact NameJennifer van Eunen
Contact Phone03 479 7734

Save this event