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Shear force activation of the epithelial sodium channel (ENaC): role of the beta- and gamma-subunit

The epithelial sodium channel (ENaC) is involved in physiological processes such as salt/water homeostasis and blood pressure regulation. Commonly ENaC is built of three homologous subunits: α, β, γ or δ, β, γ and its activity is regulated by shear force (SF). In some tissues, the β- and γ-ENaC subunits are expressed without the α-subunit and there βγ-ENaC potentially facilitate response to mechanical forces on their own. However, little is known about the role of individual ENaC subunits for SF regulation. Therefore, this project characterised the role of the β- and γ-ENaC subunit for SF sensation. To address this question, different channel subunit combinations and newly generated β- and γ-ENaC mutations were expressed in Xenopus oocytes and measured by two-electrode voltage-clamp (TEVC). The study provides new insights about the role of the β- and γ-ENaC subunit for shear force sensation.

Date Monday, 3 December 2018
Time 1:00pm - 2:00pm
Audience All University
Event Category Health Sciences
Event Type Departmental Seminar
LocationHercus D'Ath Lecture Theatre, Great King Street, Dunedin

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