Challenges of Antimicrobial Resistance
Elevated rates of antimicrobial resistance pose a major challenge to public health and agricultural productivity. As part of a multilateral response effort, the scientific community has been tasked with characterising the evolution of antimicrobial resistance, of developing new methods able to rapidly diagnose resistance, and of establishing novel compounds to supplement and support the current usage of antimicrobials.
In my doctoral research, I have made efforts in the above avenues. To characterise the evolution of resistance, I have used a range of genomic approaches to reveal the genetic basis of resistance in Streptococci, Enterococci, Staphylococci, Pseudomonads and Mycobacteria. I have made efforts to establish a rapid point of care DNA diagnostic method, able to detect fine signatures of resistance – this going on to be awarded the Otago University ‘Translational Research’ and ‘Proof of Concept’ awards. Lastly, I have gone on to show the reversal of metal resistances with the addition of ionophores, these being small molecules able to bypass the microbial resistance response.
In this talk, I will describe the above research and my motivation for study in this area, as well as how this is being carried forward.
|Date||Tuesday, 11 December 2018|
|Time||12:00pm - 1:00pm|
|Event Category||Health Sciences|
|Location||Biochemistry Seminar Room 231|