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Seminar: Clay Nanoparticles as Efficient Anti-bacterial Agents

Recently, clay nanoparticles, i.e. layered double hydroxides (LDHs) and hectorite (HEC), appear as effective adjuvants with desirable physicochemical properties. We investigated the vaccine formulations containing the essential infectious factor IB for enterohemorrhagic E. coli (EHEC) and enteropathogenic E. coli (EPEC) responsible for a series of human diseases worldwide. Both LDH and HEC nanoparticles are able to carry an appreciable amount of IB, and significantly facilitate the cellular internalization of IB. The medium size LDH (115 nm) and HEC (77 nm) both induced much stronger antibody and cell-mediated immune responses than those by commercial adjuvants, QuilA, and maintained much higher levels of specific antibody immune response for at least four months. Such immune response profiles in mice show a very strong immunity for the host cells against the target bacteria in the in vitro assays. The possible mechanism for the immunity promotion using clay nanoparticles as the adjuvant be relevant to the suitable structure of formed depots.

Date Monday, 8 April 2019
Time 12:00pm - 1:00pm
Audience Public,Alumni,All University
Event Category Health Sciences
Event Type Open Seminar
CampusDunedin
DepartmentMicrobiology and Immunology
LocationSeminar room 208, Microbiology Building, 720 Cumberland St
CostFree
Contact NameDepartment of Microbiology and Immunology
Contact Phone+64 3 479 7735
Contact Emailmicrobiology@otago.ac.nz
Websitehttps://micro.otago.ac.nz

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