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Biochemistry Special Seminar | Dr Ghader Bashiri School of Biological Sciences University of Auckland

Metabolic pathways: biosynthesis, regulation and application

Metabolism integrates and coordinates all cellular activities, forming a network of intertwined and densely connected pathways. My research programme investigates key metabolic pathways in microbes, their regulatory mechanisms and their application in biomedicine and agriculture.

In this talk, I will focus on the fundamental concepts of biochemistry that explain key microbial processes including cofactor F420 biosynthesis and iron-sulfur cluster metabolism. My first exemplar study reveals the mystery of how F420 is synthesised, identifying novel enzymatic activities and metabolites, and how this led to a completely rewritten biosynthesis pathway in prokaryotes. The second half of my seminar outlines my future research plan with a focus on iron-sulfur clusters – ancient protein cofactors that contribute to diverse biological processes across all domains of life. The oxygen sensitive nature of iron-sulfur clusters makes them exceptionally difficult to work with, leading me to establish a dedicated anaerobic facility to study these proteins.

Date Wednesday, 19 June 2019
Time 12:00pm - 1:00pm
Audience All University
Event Category Health Sciences
Event Type Seminar
LocationBiochemistry Seminar Room 231

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